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Hydroxyzine: profile and news
Skin Problems in Horses Feb 1, 2006 Skin Problems in Horses Feb 1, 2006 Woman's trial in son's deathset to start Jan 29, 2006 Worrying all the time? Aug 31, 2005 Acute Akathisia Associated With Quetiapine Use Jul 6, 2005 Acute Akathisia Associated With Quetiapine Use Jul 6, 2005 TeenScreen sets up shop In Illinois Jun 20, 2005 Common skin conditions and treatments Jun 16, 2005 TeenScreen sets up shop In Illinois Jun 20, 2005 Common skin conditions and treatments Jun 16, 2005 Computer program Apr 12, 2005 Police And Fire Mar 29, 2005 Police beat Apr 4, 2005 Pets' allergies can be tough to treat Apr 4, 2005 FDA Safety Labeling Changes: Vistaril, Estraderm, Nolvadex Mar 2, 2005 Itching, Remedies Itching Causes, Skin Problems Feb 23, 2005 Other information Indication For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria. Pharmacology Hydroxyzine, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Hydroxyzine is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Hydroxyzine's active metabolite, cetirizine, is also used as an H1-antagonist. Mechanism Of Action Hydroxyzine competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic. Drug Category Antipruritics; Histamine H1 Antagonists; Anxiolytics sedatives and hypnotics; ATC:N05BB01 Brand Names/Synonyms Alamon; Atara; Atarax; Atarax Base; Ataraxoid; Atarazoid; Atarox; Atazina; Aterax; CHEMBANK2612; Deinait; Durrax; Equipoise; Equipose; Fenarol; HSDB 3098; Hidroxizina [Inn-Spanish]; Hy-Pam 25; Hychotine; Hydroksyzyny; Hydroksyzyny [Polish]; Hydroxine; Hydroxizine; Hydroxizinum; Hydroxycine; Hydroxyzin; Hydroxyzine; Hydroxyzine Base; Hydroxyzine Hcl; Hydroxyzine Pamoate; Hydroxyzinum [Inn-Latin]; Hydroxyzyne; Idrossizina; Idrossizina [Dcit]; Masmoran; NP 212; Neo-Calma; Neurozina; Nevrolaks; Orgatrax; Pamazone; Parenteral; Paxistil; Placidol; Plaxidol; Quiess; Tran-Q; Tranquizine; Traquizine; U.C.B 4492; U.CB 4492; UCB 4492; UCB 492; UCB-4492; Vesparaz-Wirkstoff; Vistaril; Vistaril Pamoate; Vistazine Dosage Forms CAPSULE; LIQUID; SOLUTION; SYRUP Absorption Rapidly absorbed from the gastrointestinal tract Interactions Interactions for Hydroxyzine: THE POTENTIATING ACTION OF HYDROXYZINE MUST BE CONSIDERED WHEN THE DRUG IS USED IN CONJUNCTION WITH CENTRAL NERVOUS SYSTEM DEPRESSANTS SUCH AS NARCOTICS, NON-NARCOTIC ANALGESICS AND BARBITURATES. Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced. Since drowsiness may occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery while taking Atarax. Patients should be advised against the simultaneous use of other CNS depressant drugs, and cautioned that the effect of alcohol may be increased. Chemical IUPAC Name 2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol Chemical Formula C21H27ClN2O2 Half Life 20 to 25 hours Drug Type Approved Drug # Accession No APRD00688 CAS Registry Number 68-88-2 |
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