Hydroxyurea: profile and news
Simple Test Could Predict Major Complications in Sickle Cell ... 07 Mar 2006
Interestingly, these correlations held whether or not patients were taking hydroxyurea, the standard treatment for the disease, and LDH values were not ... - U.S. Newswire (press release),
Yuet Wai Kan, MD Sickle Cell and Thalassemia Pioneer Feb 28, 2006
Hydroxyurea seems to work in some people, but not primarily by stimulating fetal hemoglobin. We really don't understand exactly how hydroxyurea works yet. ... - Journal of American Medical Association (subscription),
Icagen Reports Fourth Quarter and Full Year 2005 Financial Results Mar 1, 2006
...the largest study of a potential new drug conducted for patients with sickle cell disease since the landmark Multicenter Study of Hydroxyurea conducted in the ... - Genetic Engineering News,
Icagen Reports Fourth Quarter and Full Year 2005 Financial Results Mar 1, 2006
...study, the largest study of a potential new drugconducted for patients with sickle cell disease since the landmarkMulticenter Study of Hydroxyurea conducted in ... - Finanzen.net,
GenoMed Trial Results: Sickle Cell Disease - From Daily Pain to ... Feb 22, 2006
Vicodin ... "She continues on hydroxyurea, Plavix, and Lovenox bid because of the hypercoagulability [excess tendency for blood to clot]. ... - International News Service,
The Susceptibility of Granulosa Cells to Apoptosis is Influenced ... Feb 14, 2006
...effect of E2; blocking progression from G1 to S phase with the cdk2 inhibitor, roscovitine, or blocking cells in S phase with hydroxyurea, prevented protection ... - Journal of Endocrinology
Warning for Blood Drug Hydroxyurea Jan 27, 2006
Drug company Bristol-Myers Squibb is alerting doctors about the risk of serious skin complications, including ulcers and gangrene, with its drug hydroxyurea. ... - WebMD
Stroke risk returns when children with sickle cell disease stop ... Jan 15, 2006
He noted data on nine patients in the halted transfusion arm were censored because they either resumed transfusion or began taking Hydroxyurea, a drug to treat ... - Xagena.it,
Icagen's Phase III Clinical Trial of ICA-17043 on Course Following ... Jan 30, 2006
The protocol allows for the enrollment of up to 150 patients who are concurrently taking hydroxyurea and for equal distribution of patients taking hydroxyurea ... - Genetic Engineering News,
Bristol-Myers drugs get new warnings Jan 26, 2006
The FDA said the company has notified healthcare professionals that both drugs -- which are hydroxyurea capsules -- have a possible side effect. ... - United Press International
Sickle cell mutation corrected in mice Jan 9, 2006
Of the children he treats, 33 require regular transfusion therapy and more than 50 adults and children take hydroxyurea, an anti-cancer drug that reduces pain ... - Milwaukee Journal Sentinel (subscription),
Advances in treatment of chronic myeloid leukaemia Jan 13, 2006
Prior therapy included Imatinib in 100 percent Hydroxyurea or Anagrelide in 86 percent, and Interferon alpha in 70 percent of patients. ... - Xagena.it,
New Predictor of Deadly Complication Identified in Sickle Cell ... 12 Dec 2005
Scientists at the National Heart, Lung, and Blood Institute (NHLBI) and investigators affiliated with the Multicenter Study of Hydroxyurea (MSH) Patients ... - PR Newswire (press release),
New Studies Identify Advances in Treatment Of Chronic Myeloid ... Dec 10, 2005
Prior therapy included imatinib in 100 percent hydroxyurea or anagrelide in 86 percent, and interferon alpha in 70 percent of patients. ... - PR Newswire (press release),
Gleevec® Plus Hydroxyurea May Have Activity in Glioblastomas Sep 23, 2005
...from Germany have reported clinical benefit in 57% of patients with refractory glioblastoma multiforme treated with Gleevec (imatinib) and hydroxyurea. ... - Cancer Consultants (press release),
Adult sickle cell drug hydroxyurea proves effective in young ... Sep 20, 2005
In the new study, 21 children from two to four years old who had sickle cell anemia were given the drug hydroxyurea orally as a flavored liquid formula. ... - News-Medical.net,
BLOOD TEST FOR DIABETES SHOWS BLOOD-SUGAR CONTROL FOR THE PAST FEW ... Sep 30, 2005
Other medicines include azathioprine and cyclosporine. DEAR DR. DONOHUE: In your article on polycythemia, you failed to mention hydroxyurea. ... - Charlotte Sun-Herald,
Sickle Cell Disease Causes Severe Pain Sep 22, 2005
Patients can get a stroke. The disease eventually affects the liver and the kidney. Several treatments show promise. One is a cancer drug called Hydroxyurea. ... - NBC 10.com,
Adult sickle cell drug good for youngsters Sep 19, 2005
In the recent study, 21 children from two to four years old with sickle cell anemia were given the drug hydroxyurea orally as a flavored liquid formula. ... - United Press International
Treatments for Sickle Cell Anemia Sep 13, 2005
Hydroxyurea (Droxia), a cancer medication, has been shown to reduce pain and complications in sickle cell anemia in adults. It is ... - rarediseases.about.com
Combination of Gleevec® and Hydrea® Offers Promise for ... Sep 21, 2005
...to a study published in the Annals of Oncology, treatment of progressive glioblastoma multiforme with imatinib (Gleevec®) and hydroxyurea (Hydrea®) was well ... - Cancer Consultants (press release),
Efavirenz may linger for up to eight weeks after treatment stops Sep 27, 2005
...for almost six months, and her viral load remained below 400 copies/ml 28 days after stopping a regimen of ddI (didanosine, Videx), hydroxyurea, 3TC (lamivudine ... - Aidsmap,
$11,000 raised against killer disease Sep 23, 2005
The Vanderveens enrolled their son in a clinical trial at Lucille Packard's Children's Hospital at Stanford for the drug, Hydroxyurea, which has shown promise ... - Piedmonter,
Apple Cider Vinegar: Alternative Medicine Miracle Sep 22, 2005
..."I was prescribed prednisone; methotrexate; hydroxyurea; several steroid ointments for topical therapy (too many to list), antibiotics and elavil for depression ... - SLCC Globe Link (subscription),
Can a new combination treatment prevent a secondary stroke in ... Sep 1, 2005
The five-year study, called Stroke With Transfusions Changing to Hydroxyurea (SWiTCH), is supported by a grant of more than $18 million from the National ... - News-Medical.net,
New ways to prevent stroke and reduce excess iron in sickle cell ... Sep 4, 2005
Clinical trial designed to determine if hydroxyurea can replace blood transfusions and if monthly blood withdrawal can substitute for daily injections to treat ... - I-Newswire.com (press release)
Initiation Of New Study To Help Children With Sickle Cell Anaemia Sep 1, 2005
The study named Stroke With Transfusions Changing to Hydroxyurea (SWiTCH ) has been designed to determine if hydroxyurea can replace blood transfusions and if ... - MedIndia,
National Study: New Ways To Prevent Stroke And Reduce Excess Iron ... Sep 1, 2005
The five-year study, called Stroke With Transfusions Changing to Hydroxyurea (SWiTCH), is supported by a grant of more than $18 million from the National ... - Science Daily (press release)
New treatment may help with sickle cell Sep 1, 2005
Children in the study will be treated either with the standard regimen or with the Stroke with Transfusions Changing to Hydroxyurea protocol. ... - United Press International
Inherited Disease May Cause Premature Death Sep 1, 2005
..."Studies have shown that daily doses of hydroxyurea decrease the number of painful crises a person may experience and lengthen their life span as well," said Dr ... - Bethesda Journal,
Sickle Cell survivors honored Sep 4, 2005
...patients. Droxia, the prescription form of hydroxyurea, was approved by the FDA in 1998 and is available for adults with sickle cell. ... - Greensboro News Record,
THE FAMILY DOCTOR Aug 23, 2005
I have been diagnosed with polycythemia vera. I have received eight phlebotomies and now am taking hydroxyurea twice a day. What ... - Newsday,
Mortality in Sickle Cell Patients on Hydroxyurea Therapy Aug 1, 2005
Source: Bakanay SM, Dainer E, Clair B, et al. Mortality in sickle cell patients on hydroxyurea therapy. Blood. 2005;105:545–547. [Abstract/Free Full Text]. ... - AAP Grand Rounds (subscription)
Older drug better than new for blood cell disorder Jul 6, 2005
BOSTON, July 6 (Reuters) - The older generic drug hydroxyurea, if combined with a small dose of aspirin and given to people with thrombocythemia, is more ... - Reuters AlertNet
CME Questions Aug 1, 2005
...induced dyspnea. Understand which patients with sickle cell disease are likely to benefit most from hydroxyurea therapy. Describe ... - AAP Grand Rounds (subscription)
New thrombosis drug is less effective and more expensive than the ... Jul 15, 2005
The scientists conducted a randomised trial comparison of the new drug, called anagrelide, with the existing drug hydroxyurea. The ... - Medical News Today (press release)
Traditional therapy best for thrombocythemia Jul 13, 2005
Hydroxyurea, the traditional medication for thrombocythemia, is believed to have the most beneficial effect combined with aspirin when compared to the newer ... - myDNA.com
Finding to save government millions of pounds Jul 7, 2005
A new drug used for the treatment of Essential Thrombocythemia (ET) is less effective than the much cheaper and older drug Hydroxyurea. ... - I-Newswire.com (press release)
Maxim issued with novel cancer drug patent Jul 25, 2005
...occurs, termed S. Later, cell division, or mitosis occurs, in a phase called M. Antineoplastic drugs such as cytosine arabinoside, hydroxyurea, 6-mercaptopurine ... - Drug Researcher.com
Hydrea Trumps Agrylin as First Line Therapy for High Risk ... Jul 6, 2005
LONDON, July 6-Hydrea (hydroxyurea) plus aspirin should remain the first line of treatment for patients with high-risk thrombocythemia, researchers here ... - MedPage Today
Other information
Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia
Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. in vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Mechanism Of Action
Hydroxyurea is converted to a free radical nitroxide (NO) in vivo, and transported by diffusion into cells where it quenches the tyrosyl free radical at the active site of the M2 protein subunit of ribonucleotide reductase, inactivating the enzyme. The entire replicase complex, including ribonucleotide reductase, is inactivated and DNA synthesis is selectively inhibited, producing cell death in S phase and synchronization of the fraction of cells that survive. Repair of DNA damaged by chemicals or irradiation is also inhibited by hydroxyurea, offering potential synergy between hydroxyurea and radiation or alkylating agents. Hydroxyurea also increases the level of fetal hemoglobin, leading to a reduction in the incidence of vasoocclusive crises in sickle cell anemia. Levels of fetal hemoglobin increase in response to activation of soluble guanylyl cyclase (sGC) by hydroxyurea-derived NO.
Drug Category
Antisickling Agents; Antineoplastic Agents; ATC:L01A
Brand Names/Synonyms
Biosupressin; CCRIS 958; Carbamohydroxamic Acid; Carbamohydroximic Acid; Carbamohydroxyamic Acid; Carbamoyl Oxime; Carbamyl Hydroxamate; DRG-0253; Droxia; HU; Hidrix; Hydrea; Hydreia; Hydroxicarbamidum; Hydroxycarbamide; Hydroxycarbamine; Hydroxylurea; Hydroxyurea; Hydura; Hydurea; Idrossicarbamide [Dcit]; Litaler; Litalir; N-Carbamoylhydroxylamine; N-Hydroxyurea; Onco-Carbide; Oxyurea; SQ 1089; Sterile Urea; Ureaphil
Dosage Forms
CAPSULE
Absorption
Well absorbed from the gastrointestinal tract.
Interactions
-->Interactions for Hydroxyurea:
Prospective studies on the potential for hydroxyurea to interact with other drugs have not been
performed.
Concurrent use of hydroxyurea and other myelosuppressive agents or radiation therapy may increase the
likelihood of bone marrow depression or other adverse events.
Since hydroxyurea may raise the serum uric acid level, dosage adjustment of uricosuric medication may
be necessary.
Chemical IUPAC Name
hydroxyaminomethanamide
Chemical Formula
CH4N2O2
Half Life
3-4 hours
Drug Type
Approved Drug
# Accession No
APRD00023
CAS Registry Number
127-07-1
