Hydrocodone: profile and news






Viagra plus cholesterol drug improves impotence  06 Mar 2006
Specifically, investigators have found that in men who are not initially helped by Viagra (sildenafil), treatment with Lipitor (atorvastatin) seems to improve ... - Reuters.uk,

Impact of Atorvastatin on Cardiovascular Events on Older Patients ...  Feb 21, 2006
KISSIMMEE, FL -- February 21, 2006 -- A large 2003 study showed that the use of atorvastatin significantly reduced the risk of non-fatal myocardial infarction ... - DG News

Research and Markets: Pfizer's Atorvastatin + Torcetrapib ...  Feb 17, 2006
...resistor. Manufacturers are looking to novel products to protect their franchise, such as Pfizer's atorvastatin/torcetrapib. Increased ... - Genetic Engineering News,

Atorvastatin lowers plasma LDL cholesterol and CRP in type 2 ...  Feb 16, 2006
Atorvastatin lowers plasma low-density lipoprotein cholesterol and C-reactive protein in Japanese type 2 diabetic patients. According ... - TMCnet

Caduet (Amlodipine Besylate/Atorvastatin calcium), First Pill to ...  Feb 14, 2006
...announced today that Caduetâ„¢ (amlodipine besylate and atorvastatin calcium), the first treatment to address multiple risk factors for cardiovascular disease ... - DG News

Statin Therapy May Reduce Key Heart Disease Risk Factors in ...  Mar 3, 2006
...four statin groups: Two groups received atorvastatin daily for six weeks; one received 10 mg, and the other, 20 mg. Two groups received ... - eMaxHealth.com,

Today's Community Calendar  Mar 5, 2006
The first, "Torcetrapib/Atorvastatin - A Case Study in Innovation," will begin at 11:10 am in Iddles Auditorium L103 (Parsons Hall). ... - Portsmouth Herald News,

Pfizer steps up launches from global portfolio  Mar 2, 2006
Caduet, a new generation cardiovascular drug, is a combination of atorvastatin calcium (Lipitor) and amlodipine besylate (Norvasc). ... - Economic Times,

Driven by Blockbuster Drugs From Sanofi-Aventis and Pfizer, Market ...  Mar 1, 2006
Syndrome" finds that market growth will be driven by Sanofi-Aventis's Acomplia (rimonabant) and Pfizer's fixed-dose combination of atorvastatin and torcetrapib ... - PR Newswire (press release),

Finland Court prohibits Ranbaxy from marketing generic version of ...  Feb 22, 2006
The ruling involves Pfizer's patent (FI94958) that covers processes and intermediate compounds used to make atorvastatin, the active ingredient in Lipitor. ... - Hindu Business Line,

Finland stops Ranbaxy from selling Atovastatin  Feb 22, 2006
Atorvastatin, whose patent in Finland expires in February 2009, is estimated to have a market of $30-35 million in the European country. ... - Business Standard,

When Viagra Doesn't Work, Lipitor May Assist  Feb 21, 2006
PHILADELPHIA, June 21 - If Viagra (sildenafil) doesn't go the job, maybe all it needs is a kick start with Lipitor (atorvastatin), a small study here suggested ... - MedPage Today,

How can I prevent my children from becoming travel sick?  Mar 2, 2006
...been drunk. Crestor is metabolised by a slightly different pathway from Lipitor (atorvastatin) or Zocor (simvastatin). Lipostat ... - Times Online,

1 From the Harvard Medical School and Brigham and Women's Hospital ...  Feb 17, 2006
Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the ... - Am J Clin Nutr (subscription),

Keep your cholesterol in check with Simvastatin  Feb 9, 2006
...levels. The most prominent cholesterol drugs belong to the statin family, including Simvastatin and Atorvastatin to name a few. ... - LiveArticles.org,

CADUET, First Pill to Treat High Blood Pressure and High ...  Feb 14, 2006
...announced today that CADUET(TM) (amlodipine besylate and atorvastatin calcium), the first treatment to address multiple risk factors for cardiovascular disease ... - CNW Telbec (Communiqués de presse),

Cholesterol drug inhibits cancer cells in lab  Jan 31, 2006
Atorvastatin, the widely prescribed cholesterol-lowering "statin" drug has shown significant action against human bladder cancer cells in laboratory experiments ... - ABC Online,

Niraj Bhatt: Balancing act ahead for pharma firms  Feb 19, 2006
...so far. The company faced a setback recently when Pfizer won a legal battle in a US court on the atorvastatin patent. Ranbaxy’s ... - Business Standard,

Prescription at a cost  Feb 20, 2006
The two top-selling statins - atorvastatin sold as Lipitor and simvastatin sold as Lipex and Zocor - cost the Government more than $770 million in the past ... - Australian,

Setback for Ranbaxy; Finnish court reverses earlier verdict on ...  Feb 21, 2006
Lipitor is the brand used by Pfizer for the cholesterol lowering drug Atorvastatin, the single largest selling drug in the world with annual sales of around ... - domain-B,

Statins To Reduce Cholesterol Levels  Feb 24, 2006
Six statins are currently approved for use in the US: Lipitor® (atorvastatin), Lescol® (fluvastatin), Mevacor® (lovastatin), Pravachol® (pravastatin), Zocor ... - WSOCtv.com,

Ranbaxy loses again with generic Lipitor  Feb 23, 2006
The ruling involves Pfizer's patent for processes and intermediate compounds used to make atorvastatin, the active ingredient in Lipitor. - Webindia123,

Use Of Statins Shows Improvement In Erectile Performance Of Some ...  Feb 23, 2006
The article is titled, "Can Atorvastatin Improve the Response to Sildenafil in Men with Erectile Dysfunction Not Initially Responsive to Sildenafil? ... - Science Daily (press release)

Statins Will Remain the Dominant Class in Treatment of Coronary ...  Feb 15, 2006
..."The launch of Pfizer's atorvastatin/torcetrapib combination pill will focus attention on low levels of high-density lipoprotein as a risk factor for coronary ... - PR Newswire (press release),

Researchers Take Aim At The Causes Of Heart Valve Disease  Jan 31, 2006
Pfizer's support, given under the foundation's Atorvastatin Research Award program, is aimed at determining whether Atorvastatin, a commonly prescribed anti ... - Medical News Today (press release),

Pfizer Driving Performance Through Growth of Current and New ...  Feb 10, 2006
...on industry's broadest pipeline, Pfizer expects to file five new medicines in 2006-07: maraviroc for HIV/AIDS, torcetrapib/atorvastatin for cholesterol ... - PR Newswire (press release),

Pfizer Driving Performance Through Growth of Current and New ...  Feb 10, 2006
Dr. LaMattina said Pfizer is targeting three additional NDA filings in 2007, including torcetrapib/atorvastatin for cholesterol management, the schizophrenia ... - MSN Money

Withdrawing Patients from Statin Therapy During Acute Phase of ...  Feb 17, 2006
Patients who continued using statins were switched to 20 mg/day of atorvastatin regardless of the dose of the drug they had previously been taking. ... - DG News

Roche to Focus Resources on Availability of Invirase, Now ...  Feb 6, 2006
...inhibitors, including Invirase, are used concurrently with other HMG-CoA reductase inhibitors that are also metabolized by the CYP3A4 pathway (eg, atorvastatin ... - DG News

High marks for below-average cholesterol  Feb 14, 2006
4,100 men and women recovering from heart attacks, half were assigned to ‘aggressive lipid-lowering therapy,’ which meant 80 mg of atorvastatin (Lipitor) a ... - ITP.net,

Case 4-2006 — A 79-Year-Old Woman with Myalgias, Fatigue, and ...  Feb 9, 2006
...simvastatin. Three years before admission, treatment with simvastatin was discontinued because of myalgias, and atorvastatin was started. ... - New England Journal of Medicine (subscription),

Intensifying research to fight diseases  Feb 3, 2006
...products also available are olmesartan (Olmetec) for high blood pressure, celecoxib capsules (Celebrex 400) for acute pain and atorvastatin calcium/amlodipine ... - INQ7.net,

Medical Spending To Treat Hyperlipidemia Up 350% 1996-2003, USA  Feb 14, 2006
Total expenditures for Lipitor (Atorvastatin), the top-selling drug, were 7.8 billion, while expenditures for Zocor (Simvastatin) totaled 5.5 billion. ... - Medical News Today (press release),

Strong demand for statin drugs pushes up sales  Feb 14, 2006
Known as “statin drugs� or “statins,� Lipitor (atorvastatin) and Zocor (simvastatin) work by blocking the liver enzyme responsible for the production ... - Wilkes Barre Times-Leader,

Do Lackluster Trial Findings Mean New Avenues Are Needed for Heart ...  Feb 9, 2006
The less than anticipated degree of effectiveness of high-dose (80 mg/d) atorvastatin in reducing the risk of major coronary events among patients with ... - Journal of American Medical Association (subscription),

Pfizer earnings projections disappoint  Feb 14, 2006
Pfizer is also targeting three additional new drug application (NDA) filings in 2007, including torcetrapib/atorvastatin for cholesterol management, the ... - Pharmaceutical Business Review

Pfizer's Norvasc reduces cardiovascular events  Feb 8, 2006
...who had normal to mildly elevated cholesterol levels (not typical candidates for lipid-lowering treatment), received Lipitor 10mg (atorvastatin calcium) or ... - Express Pharma Pulse,

Sudden Statin Withdrawal Worsens Stroke Outcome  Feb 17, 2006
...prior to stroke. Three days after the onset of stroke, all patients were started on atorvastatin 20 mg daily. Early neurologic deterioration ... - Medscape (subscription)

Pfizer mulling OTC business sale  Feb 8, 2006
...amlodipine), the loss of revenues from its COX-2 inhibitor franchise and more competition in the marketplace for its cholesterol-lowerer Lipitor (atorvastatin ... - Pharma Times (subscription),

Pfizer's updated 2006 forecast disappoints  Feb 13, 2006
In addition, sales of the firm's flagship drug, the cholesterol-lowerer Lipitor (atorvastatin), are likely to be dented by competition in the form of Merck & ... - Pharma Times (subscription),

Dr Reddy`s to sell 2 Merck generics  Feb 1, 2006
Simvastatin, which raked in $5.2 billion in global sales in 2004, is the biggest drug in terms of sales after Pfizer’s Lipitor (atorvastatin). ... - Business Standard,

Statins may not affect CD4 cell count responses to HIV treatment ...  Feb 1, 2006
...lower cholesterol levels. They prescribed pravastatin (Lipostat), atorvastatin (Lipitor) or rosuvastatin (Crestor). In contrast, they ... - Aidsmap,


Other information


Indication
For relief of moderate to moderately severe pain

Pharmacology
Hydrocodone, a semisynthetic opiate agonist and hydrogenated ketone derivative, is similar to other phenanthrene derivatives, such as codeine. Used as an analgesic, hydrocodone is combined with acetaminophen, ibuprofen, or aspirin to treat pain. Used as an antitussive, hydrocodone is combined with phenylephrine, pseudoephedrine, phenylpropanolamine, guaifenesin, pyrilamine, pheniramine, or chlorpheniramine.

Mechanism Of Action
Hydrocodone acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Hydrocodone primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as Hydrocodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Drug Category
Narcotics; Antitussives; Analgesics; Antitussives; ATC:R05DA03

Brand Names/Synonyms
Bekadid; Codeinone, Dihydro-; Codinovo; Dea No. 9193; Dico; Dicodid; Dihydrocodeinone; HSDB 3097; Hidrocodona [Inn-Spanish]; Hydrocodon; Hydrocodone; Hydrocodonum [Inn-Latin]; Hydrocone; Hydroconum; Idrocodone [Dcit]; Multacodin

Dosage Forms
Tablets; Syrup; Liquid mixtures with other analgesics.

Absorption
well absorbed from the GI track

Interactions
Interactions for Hydrocodone:

Patients receiving other narcotic analgesics, antipsychotics, antianxiety agents, or other CNS depressants (including alcohol) concomitantly with hydrocodone and acetaminophen tablets may exhibit an additive CNS depression. When combined therapy is contemplated, the dose of one or both agents should be reduced.

The use of MAO inhibitors or tricyclic antidepressants with hydrocodone preparations may increase the effect of either the antidepressant or hydrocodone.

The concurrent use of anticholinergics with hydrocodone may produce paralytic ileus.



Chemical IUPAC Name
4,5-epoxy-3-methoxy-17-methylmorphinan-6-one

Chemical Formula
C18H21NO3

Half Life
1.25-3 hours

Drug Type
Approved Drug

# Accession No
APRD00591

CAS Registry Number
125-29-1

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org