Hydergine: profile and news

Complementary medicines in psychiatry Review of effectiveness and ... Feb 9, 2006
Results Potentially useful substances include ginkgo and hydergine as cognitive enhancers, passion flower and valerian as sedatives, St John’s wort and s ... - British Journal of Psychiatry (subscription),

Alzheimer's drug could make everyone brainier Jan 26, 2006
Sites based in America advertise a range of prescription-only pills for sale including Hydergine, the treatment for Alzheimer's for as little as $15.10 (£8.48 ... - The Observer,

Oil and gas shortages: Is there a refinery shortage too? Mar 29, 2005
...into twentieth century technology. When cleaner fuels like Hydergine are expected to dominate in the future the. Shoe market in ... - Marketplace (audio),

Other information

Indication
For use as an adjunct therapy for patients with dementia

Pharmacology
Ergoloid Mesylate may increase cerebral metabolism and blood flow. The role of this medication in the therapy of dementia is controversial. A recent controlled study in patients with Alzheimer's disease found that there was no advantage to the use of ergoloid mesylates compared to placebo, suggesting that ergoloid mesylates may lower scores on some cognitive and behavioral rating scales. Further study is needed to determine the risk-benefit profile of ergoloid mesylates in the treatment of dementia.

Mechanism Of Action
Ergoloid mesylates act centrally, decreasing vascular tone and slowing the heart rate, and acts peripherally to block alpha-receptors. One other possible mechanism is the effect of ergoloid mesylates on neuronal cell metabolism, resulting in improved oxygen uptake and cerebral metabolism, thereby normalizing depressed neurotransmitter levels.

Drug Category
Adrenergic alpha-Antagonists; Nootropic Agents; Vasodilator Agents; Sympatholytics; ATC:C04AE01

Brand Names/Synonyms
Alkergot; CCK 179; Circanol; Co-Dergocrine Mesylate; Deapril-St; Dihydroergotoxin Mesilat; Dihydroergotoxin Mesylate; Dihydroergotoxin Methanesulfonate; Dihydroergotoxine Mesilate; Dihydroergotoxine Mesylate; Dihydroergotoxine Methanesulfonate; Dihydroergotoxine Methanesulphonate; ERGOLOID MESYLATES; Ergoloid Mesylate; Ergoloid Mesylates; Ergoloid Mesylates [Usan]; Gerimal; Hydergin; Hydergine; Hydergine Lc; Hydrogenated Ergot Alkaloids; Ischelium; Redergin; Trigot

Dosage Forms
CAPSULE; LIQUID; POWDER; POWDER FOR SOLUTION; SOLUTION; SYRUP; TABLET

Absorption
Rapidly but incompletely (~ 25%) absorbed from the gastrointestinal tract. Approximately 50% of the absorbed dose is eliminated by first-pass metabolism.

Interactions
Drug Interactions for Ergoloid Mesylate:
No reported interactions.

Chemical IUPAC Name
Not Available

Chemical Formula
C33H45N5O5

Half Life
3.5 hours

Drug Type
Approved Drug

# Accession No
APRD00711

CAS Registry Number
8067-24-1