Humalog: profile and news
Lilly Launches Humalog® Mix50/50™ Insulin In United States Feb 12, 2006
...with diabetes have different insulin needs, and today Eli Lilly and Company (NYSE: LLY) announces the launch of a new pre-mixed insulin, Humalog® Mix50/50 ... - Medical News Today (press release),
Lilly Launches Humalog Mix50/50 Insulin in United States Feb 7, 2006
Different people with diabetes have different insulin needs, and today Eli Lilly and Company announces the launch of a new pre-mixed insulin, Humalog(R) Mix50 ... - PharmaLive.com (press release),
Lilly launches Humalog Mix50/50 in US Feb 7, 2006
INDIANAPOLIS, Feb. 7 (UPI) -- Eli Lilly said Tuesday it launched in the United States its pre-mixed insulin diabetes medication, Humalog Mix50/50. ... - United Press International
Lilly Launches New Pre-Mixed Insulin Feb 7, 2006
The company says Humalog Mix50/50 is designed to provide blood sugar control for diabetics between meals but also includes a higher percentage of rapid-acting ... - Inside INdiana Business (press release),
Lilly launches new diabetes product Feb 8, 2006
By Staff Writer. Eli Lilly & Co have launched a new pre-mixed insulin product, Humalog Mix50/50, to control high blood sugar in patients with diabetes. ... - Pharmaceutical Business Review
How Will We Dilute Insulin? Jan 31, 2006
For her Humalog, we have diluting fluid—which is the same as NPH’s diluting fluid. But for Lantus, we can’t dilute it. So I’m stuck.�. ... - Diabetes Interview,
Is Regular the Next to Go? Jan 31, 2006
Bernstein prefers Regular to Humalog, because he feels it is more predictable and matches meal plans better for people who are following a lower-carbohydrate ... - Diabetes Interview,
Partnering is common in drug industry Feb 26, 2006
Lilly products that required critical work from partners include the insulins Humulin and Humalog; two diabetes medicines, Actos and Byetta; and the male ... - Indianapolis Star,
Olympic Notes Feb 19, 2006
While most skiers are backed by the sport's equipment makers, Freeman's main sponsors are drugmaker Eli Lilly & Co., which makes the Humalog insulin he injects ... - Richmond Times Dispatch,
Big challenge, bigger heart Feb 18, 2006
..."They didn't understand what you could do with them. Humalog, which is made by Eli Lilly (one of his sponsors) was only out about five years. ... - Houston Chronicle,
Lilly launches new diabetes product 09 Feb 2006
By Staff Writer. Eli Lilly & Co have launched a new pre-mixed insulin product, Humalog Mix50/50, to control high blood sugar in patients with diabetes. ... - Pharmaceutical Business Review
Is Regular the Next to Go? Jan 31, 2006
Bernstein prefers Regular to Humalog, because he feels it is more predictable and matches meal plans better for people who are following a lower-carbohydrate ... - Diabetes Interview,
Lilly Reports Q4 EPS of $.64, or $.80 Excluding Charges; 2005 EPS ... Jan 26, 2006
Diabetes Care Products In the fourth quarter of 2005, diabetes care revenue, composed primarily of Humalog(R), Humulin(R), Actos(R) and recently launched Byetta ... - PR Newswire (press release),
Lilly Reports Q4 EPS of $.64, or $.80 Excluding Charges; 2005 EPS ... Jan 26, 2006
In the fourth quarter of 2005, diabetes care revenue, composed primarily of Humalog(R), Humulin(R), Actos(R) and recently launched Byetta, increased 11 percent ... - Finanzen.net,
Eli Lilly Swings to Fourth-Quarter Profit Jan 26, 2006
...investor relations. The company is bulking up its marketing and manufacturing for the insulin medication Humalog. Excluding certain ... - CBS News
Will New Drugs Gild Lilly? Jan 26, 2006
Diabetes care was also an important source of revenue once again, with sales here up 11% on decent growth from Humalog and good growth from Byetta. ... - MSNBC
Eli Lilly Swings To 4Q Profit, Gives '06 Projections Jan 26, 2006
...said. Diabetes-care revenue in the quarter, comprised primarily of Humalog, Humulin, Actos and Byetta, rose 11% to $750.4 million. ... - Business Online,
And Then There Were Some Jan 30, 2006
...insulin. His regimen of Humalog at mealtimes coupled with Lente at bedtime provided him with what he considered great control. Then ... - Diabetes Interview,
Drug Maker's Efforts to Compete in Lucrative Insulin Market Are ... Jan 27, 2006
When in 1996 Lilly started selling Humalog, a synthetic insulin with speedier blood-sugar control, Novo needed four more years to get approval to market a ... - New York Times,
Zyprexa hurt Lilly revenue growth in '05 Jan 27, 2006
...topping $1 billion. They were the cancer compound Gemzar, the osteoporosis drug Evista and the insulins Humalog and Humulin. All four ... - Indianapolis Star,
Eli Lilly Reports 4Q Earnings of $700.6M Jan 26, 2006
...combined $750 million. The company is bulking up its marketing and manufacturing for the insulin medication Humalog. Analysts polled ... - Leading The Charge,
Kris Freeman Collects Third National Title Jan 9, 2006
Freeman, a diabetic who self-injects insulin from a Lilly Humalog pen six or eight times a day depending on elevation and other circumstances, said he battled ... - OUTDOORNEWSWIRE,
Making a difference in defeating diabetes Nov 19, 2005
For instance, a player could draw a Humalog Challenge Card (Humalog is a type of fast-acting insulin, Martha explained) that reads: "What do you do when you ... - Redlands Daily Facts,
SemBioSys reports positive plant produced insulin data Nov 29, 2005
Novo Nordisk, with 32 per cent (eg Novolin – $1.1 billion in 2004 – and Novolog), Eli Lilly, with 54 per cent (Humalog and Humulin, each grossing about $1 ... - DrugResearcher.com,
DRUGS IN DEVELOPMENT Nov 16, 2005
That will be followed by a second visit in which the Company's insulin patch, loaded with 150 units of Humalog (R) Insulin (Eli Lilly Co.), will be placed on ... - PharmaLive.com (press release),
Pfizer's Troubles Pull Down Drugmakers Nov 21, 2005
...in the third quarter, growing 1% to $1.0 billion, versus a 10% decline in the previous quarter, while sales of the diabetes care products Humalog, Humulin, and ... - Chemical & Engineering News
Chemist Richard DiMarchi honored for pharmaceutical research Nov 9, 2005
...drugs. He is responsible for the molecular design of Humalog, the first biosynthetic protein analog approved for human use. DiMarchi ... - Indiana University,
Interest in Inhaled Insulin Grows Sep 13, 2005
...to Skyler, the time to peak concentration of most inhaled insulins is nearly superimposable with the rapid-acting insulin analogs like Humalog (insulin lispro ... - Journal of American Medical Association (subscription),
Eli Lilly launches Humalog Mix variants Aug 10, 2005
...& Company (India) Private Limited, a 100 per cent subsidiary of Eli Lilly & Company of USA, has launched three different variations of “Humalog Mix�, an ... - Business Standard,
Humalog Mixture is the latest innovation in diabetes care Aug 19, 2005
Eli Lilly has unveiled its latest innovation in the area of diabetes care called 'Humalog Mix', the world's first insulin analog mixtures. ... - Express Pharma Pulse,
Information Regarding Insulin Storage and Switching Sep 3, 2005
...of regular insulin (eg Humulin R, Novolin R) may be substituted for another brand of regular insulin and for rapid-acting insulins (eg, Humalog, NovoLog), and ... - Community Dispatch (press release)
Eli Lilly to bring more diabetes products Aug 9, 2005
...start next year. The company unveiled its analog insulin-pen Humalog Mix in India, priced at Rs 389 per cartridge. Gulati said the ... - Sify,
Insulin Lyspro Good for Treatment of Diabetic Ketoacidosis Aug 24, 2005
...of researchers from Sao Paulo University Medical School in Brazil conducted the study to compare the fast-acting insulin analog lispro (Humalog)to continuous ... - About Diabetes
New products from Eli Lilly every year Aug 10, 2005
Talking at the launch of its Humalog Mix, first insulin analog mixture here on Wednesday, Rajiv Gulati, chairman & managing director of Eli Lilly said the ... - Newindpress,
New booster for Eli Lilly Aug 11, 2005
The company has launched its latest innovation in diabetes care called Humalog Mix. “We expect a healthy growth in the current fiscal. ... - Calcutta Telegraph,
Diabetes Treatment Aug 28, 2005
Fast-acting insulin, such as Novolog and Humalog, are taken at meal times and become active within minutes and continue working for up to 4 hours. ... - eDiets.com,
Eli Lilly has some diabetics scrambling Aug 27, 2005
...mid-1980s. The new insulins are made using gene-cloning technology. Lilly's two major brands are Humulin and Humalog. Dr. John A ... - Indianapolis Star,
Clinical Trial Of An Insulin System In India Soon Aug 10, 2005
...person in 2008. Earlier, Eli Lilly had launched the world's first insulin analog mixture, Humalog Mix , into the Indian market. - Indlaw.com,
Lilly finds low-cost labor in China Aug 14, 2005
...offices. A Lilly factory in Suzhou manufactures Ceclor and repackages Prozac, Humulin, Humalog and Evista for the China market. ... - Indianapolis Star,
Tiger Lilly or Wilting Daisy? Jul 21, 2005
While the diabetes business didn't have any specific bad news, sales were down 1% as growth in Humalog was outweighed by declines in Humulin and Actos. ... - Motley Fool
Lilly Posts Q2 Loss on Zyprexa Settlement Jul 21, 2005
Diabetes Care Products In the second quarter of 2005, diabetes care revenue, composed primarily of Humalog®, Humulin®, and Actos®, decreased 1 percent, to ... - Inside INdiana Business (press release)
<**results**>
Medtronic Reports New Studies Confirming That Pump Therapy ... Jun 13, 2005
2) pump therapy is a safe and effective alternative to twice-a-day insulin injections (long-acting insulin NPH and short-acting insulin Humalog); and (3) using ... - Genetic Engineering News
Lilly: A Flowering of Diabetes Drugs Jun 9, 2005
Even today, 4 of its top 10 drugs are diabetes products, with Humulin and Humalog -- its two lab-synthesized human insulins -- each on track to top $1 billion ... - BusinessWeek
Other information
Indication
For treatment of diabetes (type I and II)
Pharmacology
Used in the treatment of type I and type II diabetes. The primary activity of insulin is the regulation of glucose metabolism. In muscle and other tissues (except the brain), insulin causes rapid transport of glucose and amino acids intracellularly. It also promotes anabolism, and inhibits protein catabolism. In the liver, insulin promotes the uptake and storage of glucose in the form of glycogen, inhibits gluconeogenesis, and promotes the conversion of excess glucose into fat.
Mechanism Of Action
Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism and catabolism.
Drug Category
Hypoglycemic Agents; insulins (68:20.08)
Brand Names/Synonyms
Humalog; Insulin Lispro; Humalog (Eli Lily); Insulin Lispro (Eli Lily)
Dosage Forms
LIQUID
Absorption
Not Available
Interactions
Not Available
Chemical IUPAC Name
Human Insulin
Chemical Formula
C257H387N65O76S6 >B chain
Half Life
30 hours (mammalian reticulocytes, in vitro).
Drug Type
Approved Drug
# Accession No
BIOD00065
CAS Registry Number
133107-64-9