Halothane: profile and news

Army Officer Takes MDF to Task Over Presidential Pilot 07 Mar 2006
Hospital in Blantyre shows that Mwale paid K243,365.65 medical care, accommodation, major theatre, oxygen and nitrous oxide, halothane/ Fluothane, guardians ... - AllAfrica.com,

Upper Airway Collapsibility in Anesthetized Children Feb 21, 2006
A secondary aim was to compare differences in upper airway collapsibility after the administration of sevoflurane or halothane. ... - Anesthesia & Analgesia (subscription),

The Ventilatory Stimulant Doxapram Inhibits TASK Tandem Pore (K 2P ... Feb 21, 2006
...brainstem. Acidic pH values and hypoxia inhibit TASK-1 and TASK-3 channel function, and halothane enhances this function. These ... - Anesthesia & Analgesia (subscription),

The Tongue Flap: An Iatrogenic Difficult Airway? Feb 21, 2006
...airway. Anesthesia was induced with IV ketamine 75 mg followed by ventilation with oxygen and nitrous oxide 50:50 and 1% halothane. ... - Anesthesia & Analgesia (subscription),

Pharmacokinetics and Pharmacodynamics of a 0.1 mg/kg Dose of ... Feb 21, 2006
Pharmacodynamic results were comparable to those obtained in pediatric studies during halothane or opioid anesthesia with the exception of a longer recovery to ... - Anesthesia & Analgesia (subscription),

Going Under Feb 6, 2006
...he adds. Drugs used for inhalation anesthesia in horses include halothane, isoflurane, and sevoflurane, says Hubbell. For intravenous ... - TheHorse.com,

Routine Inhaled Induction in Adults: A Safe Practice? Feb 14, 2006
...nasal). The authors refer to anesthesiologists’ concerns over the risks of halothane and the relative safety of sevoflurane. Though ... - Anesthesia & Analgesia (subscription),

Other information

Indication
For the induction and maintenance of general anesthesia

Pharmacology
Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.

Mechanism Of Action
Halothane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Halothane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Halothane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.

Drug Category
Anesthetics; Anesthetics, Inhalation; General Anesthetics; ATC:N01AB01

Brand Names/Synonyms
Alotano; Alotano [Dcit]; Anestan; Bromchlortrifluoraethanum; Bromochlorotrifluoroethane; CCRIS 6244; Cf3chclbr; Chalothane; Fluktan; Fluorotane; Fluorothane; Fluothane; Freon 123b1; Ftorotan; Ftorotan [Russian]; Ftuorotan; HSDB 6753; Halan; Halotan; Halotano; Halotano [Inn-Spanish]; Halothan; Halothane; Halothane [Anaesthetics, Volatile]; Halothane [Ban:Inn:Jan]; Halothanum [Inn-Latin]; Halsan; Narcotan; Narcotane; Narcotann Ne-Spofa; Narcotann Ne-Spofa [Russian]; Narkotan; Phthorothanum; Rhodialothan

Dosage Forms
SOLUTION

Absorption
Not Available

Interactions
Interactions for Halothane:

FLUOTHANE augments the action of non-depolarising muscle relaxants and the muscle relaxant effects of aminoglycosides.

FLUOTHANE may augment the hypotension caused by the ganglionic-blocking effect of tubocurarine.

Caution should be exercised during the administration of adrenaline to patients anaesthetised with FLUOTHANE as arrhythmias may be precipitated. For this reason the dose of adrenaline should be restricted and an antiarrhythmic agent administered as appropriate. Caution should also be applied for other sympathomimetics, and for aminophylline and theophylline and tricyclic antidepressants, which may also precipitate arrhythmias.

Chemical IUPAC Name
2-bromo-2-chloro-1,1,1-trifluoro-ethane

Chemical Formula
C2HBrClF3

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00598

CAS Registry Number
151-67-7