Haloperidol: profile and news






Medical panel reprimands state doctors  07 Mar 2006
Last year, the board asked Morgan for proof that several doses of narcotics, including several shipments of hydrocodone Morgan received between January 2000 ... - Charleston Gazette (subscription),

Prosecutors Say No Deal; Police Say Hydrocodone Not In System  Feb 17, 2006
However, investigators said during a Friday news conference that the blood test indicated that there was no hydrocodone in the coach's system. ... - Channel Oklahoma.com,

Howell’s death an accident, jury says  Mar 2, 2006
Howell died in the room Oct. 23 after taking a combination of the painkiller hydrocodone and alcohol. Henry Simmons, a toxicologist ... - Arkansas Democrat-Gazette (subscription),

Nearly 100 people charged in Operation Rx  Feb 28, 2006
She was charged with three counts of the sell of Schedule II drugs (oxycodone), three counts of the sell of Schedule III drugs (hydrocodone), one count of the ... - Oak Ridger,

KC man arrested in Harrisonville for possession  Mar 3, 2006
Officers also found several bottles containing prescription drugs including one with 20 hydrocodone pills and a bottle with 18 alprazolam pills. ... - Cass County Democrat Missourian,

Grand Jury hands down indictments  Mar 5, 2006
...controlled substance. Jimmy A. Spencer, 38, of Georgetown, for deception to obtain a dangerous drug, hydrocodone. Cheryl L. Walker ... - Georgetown News Democrat,

Pills send middle schooler to hospital  Feb 26, 2006
...taken. What was found in the pen were three tablets of Hydrocodone and 15 Ultram. ... two.�. Stacks said Hydrocodone is a different story. ... - Sherman Denison Herald Democrat,

Attorney: Investor’s overdose accidental  Feb 28, 2006
An autopsy revealed a lethal cocktail of alcohol, cocaine, Viagra, an antidepressant and the painkiller hydrocodone in his system. ... - Arkansas Democrat-Gazette (subscription),

Police say teacher altered prescription  Feb 28, 2006
Investigators with the Newton Police Department say Cook took a prescription for hydrocodone 7.5/750 milligram tablets to Medicap Pharmacy in Newton. ... - Hickory Daily Record,

St. Landry drug arrest  Mar 3, 2006
Deupties pulled over a Cadillac Escalade finding marijuana, hydrocodone, zanax, a handgun and equipment to manufacture pills. Clyde Moore Jr. ... - KATC,

Lincoln grand jury indicts man on burglary charges  Mar 3, 2006
The defendant also was charged with another count of trafficking in a controlled substance, second-degree, by possessing hydrocodone, a schedule III controlled ... - Danville Advocate,

AT THE COURTHOUSE  Mar 2, 2006
...the Houston area's largest investigations into the illegal distribution of promethazine with codeine, known on the street as "syrup," and hydrocodone, known by ... - Houston Chronicle,

School discovers drugs on student  Mar 3, 2006
...recovered 59 pills in all — 30 of the antidepressant Zoloft, five of the painkiller propoxyphene and 24 containing the painkiller hydrocodone mixed with an ... - Lawrence Journal World,

Former pharmacist sentenced for fraudulent prescriptions  Mar 4, 2006
...drugs home. A search of his home found hundreds of pills, including hydrocodone, alprazolam and diazepam, prosecutors said. At his ... - Billings Gazette,

A Day At The Doctor's Office  Feb 20, 2006
All medications are written by US Physicians and filled by US Pharmacies. Such medications as Hydrocodone, Vicodin, Lortab, Xanax are available. ... - DailyIndia.com,

Pharmacist Indicted  Feb 22, 2006
Alprazolam, Hydrocodone, Lornotil and Carisopodal are the narcotics that were allegedly sold or given away by Barnes to friends who didn't have a prescription. ... - WAFF,

Giving drugs to minors yields charges  Feb 15, 2006
...age 21. Ayers is also charged with felon in possession of a firearm, possession of Hydrocodone and Possession of Marijuana. The ... - Harlan Tribune,

67-year-old viewed as major dealer  Mar 1, 2006
...drug task force member Tim Glover testified that agents made multiple purchases from Shook, who was accused of selling morphine, hydrocodone and OxyContin for ... - The Decatur Daily,

Indictments handed down in Brown County  Feb 27, 2006
...paraphernalia. -- Jimmy Spencer, 37, of Georgetown, Ohio, was indicted on one count deception to obtain a dangerous drug -- hydrocodone. ... - Ledger Independent,

Prosecutors drop murder charge in death of junior college student  Feb 19, 2006
The witness initially told authorities she saw a drug sale of hydrocodone at Smith's home, Byrd said. Autopsy results found that ... - KATC,

More than $36,500 in drugs seized  Mar 2, 2006
The narcotics seizure included 86.5 grams of crack cocaine; 12.4 grams of cocaine; 68.8 grams of marijuana; and Xanax, OxyContin and hydrocodone pills. ... - Hickory Daily Record,

24 arrested in drug ring bust  Mar 1, 2006
...activity. Other accusations include delivery of the painkiller hydrocodone, delivery of methamphetamine and delivery of marijuana. ... - San Angelo Standard-Times,

Internet found to help drugs trafficking  Mar 2, 2006
Examples of these substances which are known to be increasingly abused and are sought after at illicit markets are hydrocodone and oxycodone, methadone ... - Computer Business Review,

Man held in imprisonment case  Feb 28, 2006
...three counts of endangering the welfare of a child, and one count of seventh-degree unlawful possession of a controlled substance, hydrocodone, all misdemeanors ... - Press & Sun-Bulletin,

Prosecutors drop murder charge in death of junior college student  Feb 19, 2006
Autopsy results found that he had lethal amounts of hydrocodone and methadone in his system. Byrd says the witness initially told ... - KLFY,

Woman to face theft, drug charges  Mar 1, 2006
On July 7, Nicole Wiltrout allegedly went to the Burns Drug Store in Scottdale and filled a hydrocodone prescription, according to the complaint, and on July ... - Connellsville Daily Courier,

News in brief from western Pennsylvania  Feb 27, 2006
Snyder allegedly wrote the prescriptions between 2001 and 2005 for Hydromet Syrup and Hydrocodone Compound - narcotic drugs typically prescribed for severe ... - Centre Daily Times,

News in brief from western Pennsylvania  Feb 27, 2006
Snyder allegedly wrote the prescriptions between 2001 and 2005 for Hydromet Syrup and Hydrocodone Compound — narcotic drugs typically prescribed for severe ... - Penn Live,

Knox County woman charged with TennCare fraud  Mar 2, 2006
She's accused of using her TennCare coverage to pay for a fake prescription for the painkiller Lorcet, a brand version of hydrocodone. ... - WATE.com,

Feds to take pain clinic case: US district attorney to handle ...  Feb 23, 2006
Napoli is accused of taking prescription forms from the pain clinic and forging them in order to obtain hydrocodone for himself in Stark County between Oct. ... - New Philadelphia Times Reporter,

Nurses Arrested In Prescription Drug Sweep  Feb 19, 2006
SCHENECTADY---A Scotia nurse is one of 14 people arrested in a prescription drug sweep, accused of conspiring with others to distribute the narcotic hydrocodone ... - North Country Gazette,

ON THE RECORD: W.Va. State Police felony arrest  Feb 28, 2006
Booth was charged with three counts of delivery of a controlled substance, (namely Hydrocodone, and Clonazepam), and conspiracy to commit crimes against the ... - Keyser Mineral Daily News Tribune,

Parsons sentenced for violating probation  Feb 27, 2006
Friday, Parsons admitted violating the terms of her probation and pleaded guilty to the charge of stealing Ambien and hydrocodone from an elderly lady whom ... - The Capital Journal,

Longville woman arrested on way to sell methamphetamines  Feb 25, 2006
...officers found over 20 grams of methamphetamine in a toolbox in the bed of her truck and also found a large plastic baggie containing hydrocodone and valium on ... - DeRidder Beauregard Daily News,

Judge’s Son Subject Of Professional Misconduct Probe  Feb 25, 2006
6 and charged with conspiring with 13 others over a 19-month period to possess and distribute the narcotic painkiller hydrocodone. ... - North Country Gazette,

ASK THE DOCTOR: Side effects from codeine just that, not allergic ...  Feb 28, 2006
A. Many people think they’re allergic to opioid pain medications, such as codeine, hydrocodone, morphine and oxycodone, but they are not. ... - The Patriot Ledger,

Alleged drug dealer denied bond reduction  Mar 1, 2006
...said that he attended Paris High School on a regular basis before his felony arrest for delivering a controlled substance containing hydrocodone to a person ... - Paris Beacon News (subscription),

Norman woman charged in carjacking  Feb 27, 2006
...false pretenses. ?Linda Diane Esgar, of Norman, obtaining controlled, dangerous substances (hydrocodone) by false pretenses. ?Kerry ... - Norman Transcript,

Druggist charged with forgery  Feb 25, 2006
In Sycamore she allegedly took prescriptions containing hydrocodone, albuterol and Clonazepam. Hydrocodone also is known as Vicodin. ... - Dekalb Daily Chronicle,

Crocker pleads guilty to selling drugs  Feb 19, 2006
According to court records, David Crocker purchased Alprazolam (Xanax), Diazepam, and Hydrocodone Bitartrate from Mark Redmon, who was then a pharmacy ... - Park Hills Daily Journal,

92 charged in drug sting  Feb 28, 2006
...methadone. Besides OxyContin, they bought oxycodone, hydrocodone, alprazolam (Xanax), diazepam (Valium), Klonopin and morphine. ... - Oak Ridger,

New River Provides Clinical Test Results on NRP290 and Receives ...  Feb 7, 2006
...companies. NRP290 is a hydrocodone derivative under investigation for the treatment of pain (moderate to moderately severe). The ... - International News Service,

My procreating days are over. Yes!  Feb 14, 2006
I’m writing this column in the throes of a perfectly legal, doctor-prescribed hydrocodone bender, so it’s possible I may reveal more about myself than I ... - Yes! Weekly,

State police round up more than 25 suspected drug dealers in ...  Feb 9, 2006
The suspects are being charged with the delivery of a controlled substance, like Methadone, Oxycodone and Hydrocodone. The arrests ... - WVNS-TV,

2 arrested for possession of heroin  Feb 17, 2006
...block of 60th Avenue Drive West. Deputies also found 37 Hydrocodone pills in a clear plastic baggie. Dailey told deputies she did ... - Bradenton Herald,


Other information


Indication
For the treatment of schizophrenic patients who require prolonged parenteral antipsychotic therapy also used in Tourette's syndrome and Severe hyperactivity

Pharmacology
Haloperidol is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Haloperidol has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Haloperidol has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

Mechanism Of Action
The precise mechanism whereby the therapeutic effects of Haloperidol are produced is not known. Its effect on the central nervous system is thought to be associated with the competitive blockade of postsynaptic dopamine D2 receptors in the mesolimbic dopaminergic system and an increased turnover rate of brain dopamine.

Drug Category
Antidyskinetics; Antipsychotics; Antiemetics; Butyrophenones; Dopamine Antagonists; ATC:N05AD01

Brand Names/Synonyms
ALDO; Aloperidin; Aloperidol; Aloperidolo; Aloperidon; Apo-Haloperidol; Bioperidolo; Brotopon; Dozic; Dozix; Einalon S; Eukystol; Galoperidol; Haldol; Haldol Decanoate; Haldol La; Haldol Solutab; Halidol; Halojust; Halol; Halopal; Haloperido; Haloperidol; Haloperidol Decanoate; Haloperidol Intensol; Haloperidol Lactate; Halopidol; Halopoidol; Halosten; Keselan; Lealgin Compositum; Linton; Mixidol; Novo-Peridol; Pekuces; Peluces; Peridol; Pernox; Pms Haloperidol; R 1625; R-1625; Serenace; Serenase; Serenelfi; Sernas; Sernel; Sigaperidol; Ulcolind; Uliolind; Vesalium

Dosage Forms
INJECTION; ORAL SOLUTION; TABLET

Absorption
Oral-60%

Interactions
-->Interactions for Haloperidol:

An encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN, and FBS) followed by irreversible brain damage has occurred in a few patients treated with lithium plus HALDOL. A causal relationship between these events and the concomitant administration of lithium and HALDOL has not been established; however, patients receiving such combined therapy should be monitored closely for early evidence of neurological toxicity and treatment discontinued promptly if such signs appear.

As with other antipsychotic agents, it should be noted that HALDOL may be capable of potentiating CNS depressants such as anesthetics, opiates, and alcohol.

In a study of 12 schizophrenic patients coadministered oral haloperidol and rifampin, plasma haloperidol levels were decreased by a mean of 70% and mean scores on the Brief Psychiatric Rating Scale were increased from baseline. In 5 other schizophrenic patients treated with oral haloperidol and rifampin, discontinuation of rifampin produced a mean 3.3-fold increase in haloperidol concentrations. Thus, careful monitoring of clinical status is warranted when rifampin is administered or discontinued in haloperidol-treated patients.




Chemical IUPAC Name
4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one

Chemical Formula
C21H23ClFNO2

Half Life
3 weeks

Drug Type
Approved Drug

# Accession No
APRD00538

CAS Registry Number
52-86-8


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