Halcion: profile and news

Sleep aids a booming business  Mar 3, 2006
...(Some have described it as a metallic taste.). These relatively new drugs are replacing older sedatives such as Halcion, known in the trade as benzodiazepines. ... - San Francisco Chronicle,

Valley of the Dollars  Feb 14, 2006
Long before it there was morphine (Morpheus was the Greek god of dreams), and after it there were benzodiazepines, which include Valium and Halcion--the benzos ... - CNN/Money

Bristol-Myers Squibb Seeks To Expand Access To Its Most Recently ...  Feb 19, 2006
Reyataz should not be taken with the following medicines: ergot medicines, Versed®, Halcion®, Orap®, Propulsid®, Camptosar®, Crixivan®, Mevacor®, Zocor ... - Medical News Today (press release),

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ...  Feb 9, 2006
REYATAZ should not be taken with the following medicines: ergot medicines, Versed(R), Halcion(R), Orap(R), Propulsid(R), Camptosar(R), Crixivan(R), Mevacor(R ... - Finanzen.net,

Pill Pushers  Feb 8, 2006
Now that their Halcion days are over, they're talking about them—Reidy in his book, Hard Sell: The Evolution of A Viagra Salesman, and Slattery-Moschkau in ... - LongIslandPress.com,

Pill Pushers  09 Feb 2006
Now that their Halcion days are over, they're talking about them—Reidy in his book, Hard Sell: The Evolution of A Viagra Salesman, and Slattery-Moschkau in ... - LongIslandPress.com,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ...  09 Feb 2006
REYATAZ should not be taken with the following medicines: ergot medicines, Versed®, Halcion®, Orap®, Propulsid®, Camptosar®, Crixivan®, Mevacor®, Zocor ... - Yahoo! News (press release)

From the analyst's couch: Insomnia market  Jan 9, 2006
...receptor. The most popular benzodiazepine is triazolam (Halcion; Pfizer), which is available as a generic formulation. Triazolam ... - Nature.com (subscription),

Reduce platelet aggregation, blood clotting, inflammation, nervous ...  Jan 12, 2006
Coumarins could also interact with tranquilisers such as midazolam (Dormicum) and triazolam (Halcion) due to enzyme inhibition. ... - Health24.com,

Bristol-Myers Squibb and Gilead Announce Data Supporting ...  Jan 9, 2006
SUSTIVA should not be taken withHismanal(R) (astemizole), Propulsid(R) (cisapride), Versed(R)(midazolam), Halcion(R) (triazolam), ergot medicines (for example ... - Finanzen.net,

Companies Anticipate Filing New Drug Application in Second Quarter ...  Jan 9, 2006
SUSTIVA should not be taken with Hismanal® (astemizole), Propulsid® (cisapride), Versed® (midazolam), Halcion® (triazolam), ergot medicines (for example ... - Nieuwsbank (persbericht),

Sleep-deprived and over-medicated  Jan 15, 2006
Hospital and Natarajan of New Milford Hospital said these drugs are superior to the older benzodiazepine drugs — such as Valium and Halcion — that had been ... - Danbury News Times,

15 kilos of heroin seized in 2005  Jan 17, 2006
...period. The police also seized 250 ml of methadone, 26 tablets of DHC pills, two tablets of valium and four tablets of halcion. ... - Maltamedia Daily News,

Treating Insomnia: Sleeping Pills, Other Therapies  Jan 13, 2006
Older medications (like Halcion®) were in a class called benzodiazepines. They switch on a receptor in the brain which eventually triggers the sleep response. ... - WSOCtv.com,

Sleeping pills: Which works best?  12 Dec 2005
They're commonly prescribed for insomnia in place of older sedatives such as benzodiazepines (marketed under brands such as Halcion, ProSom and Restoril). ... - myDNA.com,

New Sleeping Pills Are Effective, But None Stands Out as the Best  Dec 8, 2005
The drugs are commonly prescribed for insomnia in place of older sedatives such as benzodiazepines (marketed under brands such as Halcion, ProSom and Restoril ... - Health Behavior News Service

Sleepless in Anytown, USA  Dec 5, 2005
They don't have the side effects linked to older medicines like Restoril, Dalmane and Halcion, which require increased doses to maintain their benefits. ... - Newsday,

Assessing and Treating Sleep Disturbances in Patients With ...  Dec 5, 2005
Short-acting agents, such as triazolam (Halcion) and temazepam (Restoril), are associated with less risk of daytime confusion and morning hangover. ... - Psychiatric Times,

Elderly Insomnia: Are Sedatives Risky?  Nov 11, 2005
Between 5% and 33% of older adults in North America and the UK are prescribed benzodiazepine (such as Halcion) and benzodiazepine-like medications (such as ... - WebMD

Substance Abuse Sense  Nov 24, 2005
Downers, sleeping pills, sleepers, stumblers, barbs, benzos, ludes, goofball, yellow jackets, pink ladies, phennies, red devil, Xanax, Valium, and Halcion. ... - Henderson Hall News,

Larry King and his many women  Dec 3, 2005
...divorce litigation�. Specifically, King was dependent on the sleeping pill, Halcion, through much of his relationship with Fox. It ... - Vanguard,

48-Week Clinical Trial Data Provides Information Regarding ...  Nov 18, 2005
REYATAZ should not be taken with the following medicines: ergot medicines, Versed®, Halcion®, Orap®, Propulsid®, Camptosar®, Crixivan®, Mevacor®, Zocor ... - Yahoo! News (press release)

Quest for rest fuels sleep business  Nov 21, 2005
While the newer sleeping pills are considered safer and less addictive than older sleeping aids such as Valium and Halcion, doctors and sleep experts worry ... - Centre Daily Times,

48-Week Clinical Trial Data Provides Information Regarding ...  Nov 18, 2005
REYATAZ should not be taken with the following medicines: ergot medicines, Versed(R), Halcion(R), Orap(R), Propulsid(R), Camptosar(R), Crixivan(R), Mevacor(R ... - Biotech Intelligence (press release),

Insomnia Sufferers Wake Up And Smell The Drug Marketing  Nov 25, 2005
Partners. Consumers shy away from older insomnia drugs such as Halcion and Valium because of the side effects, including grogginess. ... - Investor's Business Daily (subscription)

Abbott Receives FDA Approval for New Kaletra(R) (Lopinavir ...  31 Oct 2005
...ergonovine, ergotamine, and methylergonovine such as Cafergot(R), Migranal(R), DHE 45(R), Ergotrate Maleate, and Methergine, as well as Halcion(R), Hismanal(R ... - PR Newswire (press release),

Better sleep big business - but are restless nights or ads fueling ...  Oct 26, 2005
But while the newer sleeping pills are considered safer and less addictive than older sleeping aids such as Valium and Halcion, doctors and sleep experts worry ... - Fort Wayne News Sentinel,

The First Art Newspaper on the Net  Oct 11, 2005
In Rodney Graham's 26-minute video, Halcion Sleep (1994), he documents his sleepy ride in the back of a van through the rainy streets of Vancouver after ... - Art Daily

Mind-bending visions  Oct 1, 2005
..."Halcion Sleep," a 26-minute video by Canadian artist Rodney Graham, documents his rainy night ride through Vancouver, Canada, in the back seat of a car after ... - Calendar Live (subscription),

Patients' fear of dentists' drill, needle put to ease with ...  Oct 10, 2005
...effect the lasts up to four hours. Common sedatives include: Valium, Halcion, Xanax and Ativan. This mode of sedation is often called ... - Marin Independent-Journal,

The First Art Newspaper on the Net  11 Oct 2005
In Rodney Graham's 26-minute video, Halcion Sleep (1994), he documents his sleepy ride in the back of a van through the rainy streets of Vancouver after ... - Art Daily

Patients' fear of dentists' drill, needle put to ease with ...  Oct 10, 2005
...effect the lasts up to four hours. Common sedatives include: Valium, Halcion, Xanax and Ativan. This mode of sedation is often called ... - Marin Independent-Journal,

Mind-bending visions  Oct 1, 2005
..."Halcion Sleep," a 26-minute video by Canadian artist Rodney Graham, documents his rainy night ride through Vancouver, Canada, in the back seat of a car after ... - Calendar Live (subscription),

Drug must prove itself in crowded insomnia-remedy market  Sep 21, 2005
Older sleeping pills in the benzodiazepine hypnotics class cost even less: $57.59 for a 30-day supply of 0.25-mg Halcion pills and $67.59 for 15 mg of Dalmane. - Newsday,

Art | Videographer's oscillating art changes reality  Sep 18, 2005
...eerie. The films and videos include a piece that depicts Graham sleeping in the back of an automobile after taking the drug Halcion. ... - Philadelphia Inquirer,

Clubbed to death: Air thins for night-owls  Sep 10, 2005
...can be jailed. But on the other hand, you can take a prescribed drug like Halcion, murder someone, and get acquitted. You can carry ... - Jakarta Post,

Well-Protected Cat Naps  Sep 21, 2005
...root has shown promise as a way to wean the addicted off benzodiazepines, the group of sedatives and anti-anxiety medications (like Xanax, Halcion and Valium ... - Boise Weekly,

Alcohol withdrawal treatments studied  Aug 29, 2005
...limited data," Ntais said. Among the commonly known benzodiazepines are Halcion, Versed, Librium, Xanax and Valium. The review of ... - Monsters and Critics.com,

Study Looks at Tranquilizers Used to Ease Withdrawal  Aug 30, 2005
Researchers say that using benzodiazepines -- drugs like Valium, Halcion and Xanax -- to help ease withdrawal from alcohol addiction works better than a placebo ... - JoinTogether.org

Benzodiazepines effective against alcohol withdrawal seizures  Sep 3, 2005
...limited data," Ntais says. Among the commonly known benzodiazepines are Halcion, Versed, Librium, Xanax and Valium. In a second ... - I-Newswire.com (press release)

Got sheep?  Sep 2, 2005
Earlier sleep aids, like chloral hydrate and Valium, and the controversial Halcion in the 1980s, could interfere with concentration and thinking. ... - Monterey County Herald,

Doctors criticize sleeping-pill ads  Aug 18, 2005
...share. Older sleeping pills like Halcion worked by activating a chemical switch in the brain known as the benzodiazepine receptor. ... - Boston Globe,

Terror drug a mystery  Jul 30, 2005
...can be short-term memory loss with common sleeping pills, such as the class of medications known as benzodiazepines, which include Restorial, Halcion and Valium ... - Edmonton Sun

The Next Ambien?  Jul 21, 2005
...came 12 years ago, when Ambien hit pharmacy shelves in the US The drug is viewed as having fewer side effects than older sleep aids such as Halcion, which left ... - Forbes

Prescribed to Death  Jul 8, 2005
At least since the early 1980s, it’s been known that benzodiazepines (Valium, Ativan, Xanax, Halcion and many others) are highly addictive and especially ... - Squamish Chief

Prelief reduces acid, without side-effects  Jul 28, 2005
A:Sleeping pills can seem like a simple solution for insomnia, but drugs like Ativan (lorazepam), Dalmane (flurazepam), Halcion (triazolam), ProSom (estazolam ... - The Republican

What sedative could be behind hospital terror?  Jul 29, 2005
Wiens said the Health Canada-approved benzodiazepines are safe for seniors and children. Common sleeping pills include Restoril and Halcion. ... - Alberta Daily Herald Tribune

Sanofi gets wake-up call from sleeping pill rivals  Jul 14, 2005
...products marks a new era in insomnia treatment, which was tarnished in the 1990s by safety concerns over older benzodiazepine drugs such as Upjohn Co's Halcion ... - Reuters

New entries shake insomnia market's slumber  Jul 14, 2005
...of new products marks a new era in insomnia treatment, which was tarnished in the 1990s by safety concerns over older benzodiazepine drugs like Upjohn's Halcion ... - International Herald Tribune

Both pharmacodynamic and pharmacokinetic interactions have been reported with benzodiazepines. In particular, triazolam produces additive CNS depressant effects when coadministered with other psychotropic medications, anticonvulsants, antihistamines, ethanol, and other drugs which themselves produce CNS depression.

Drugs that inhibit triazolam metabolism via cytochrome P450 3A: The initial step in triazolam metabolism is hydroxylation catalyzed by cytochrome P450 3A (CYP 3A). Drugs which inhibit this metabolic pathway may have a profound effect on the clearance of triazolam .

Drugs and other substances demonstrated to be CYP 3A inhibitors of possible clinical significance on the basis of clinical studies involving triazolam (caution is recommended during coadministration with triazolam):

IsoniazidóCoadministration of isoniazid increased the maximum plasma concentration of triazolam by 20%, decreased clearance by 42%, and increased half-life by 31%.

Oral contraceptivesóCoadministration of oral contraceptives increased maximum plasma concentration by 6%, decreased clearance by 32%, and increased half-life by 16%.

Grapefruit juiceóCoadministration of grapefruit juice increased the maximum plasma concentration of triazolam by 25%, increased the area under the concentration curve by 48%, and increased half-life by 18%.

Drugs demonstrated to be CYP 3A inhibitors on the basis of clinical studies involving benzodiazepines metabolized similarly to triazolam or on the basis of in vitro studies with triazolam or other benzodiazepines (caution is recommended during coadministration with triazolam): Available data from clinic a l studies of benzodiazepines other than triazolam suggest a possible drug interaction with triazolam for the following: fluvoxamine, diltiazem, and verapamil. Data from in vitro studies of triazolam suggest a possible drug interact ion with triazolam for the following: sertraline and paroxetine. Data from in vitro studies of benzodiazepines other than triazolam suggest a possible drug interaction with triazolam for the following: ergotamine, cyclosporine, amiodarone, nicardipine, and nifedipine. Caution is recommended during coadministration of any of these drugs with triazolam.

Drugs that affect triazolam pharmacokinetics by other mechanisms:

RanitidineóCoadministration of ranitidine increased the maximum plasma concentration of triazolam by 30%, increased the area under the concentration curve by 27%, and increased half-life by 3.3%. Caution is recommended during coadministration with triazolam.