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HCTZ: profile and news
Diabetic wants to avoid taking drug Jan 16, 2006 Erratic Heart Rate Jan 23, 2006 Novartis New Phase III Data With SPP100 (aliskiren, Rasilez) ... Jan 19, 2006 Choosing Mom's new drug benefit gave me a headache Nov 17, 2005 Ranbaxy Receives Final Approval To Market Benazepril Hydrochloride ... Sep 9, 2005 Ranbaxy Receives Final Approval To Market Benazepril Hydrochloride ... Sep 9, 2005 Novartis Phase III Data With SPP100 (Aliskiren) Demonstrates ... Sep 20, 2005 Novartis Presents Positive Phase III Data on Key Compounds and ... Sep 19, 2005 (PRN) - The Ultimate Advantage in Healing a Broken Heart or ... Sep 9, 2005 FDA Safety Labeling Changes: Clozaril, Pegasys, Zestoretic Aug 17, 2005 Clinical Management of the Metabolic Syndrome Aug 1, 2005 Water Pills and Night Sweats Jul 19, 2005 Sun And Some Medicines Don't Mix Jul 26, 2005 Valsartan plus HCTZ lowers blood pressure better than Amlopidine Jun 20, 2005 New Data Reinforce Powerful Blood Pressure-lowering Efficacy with ... Jun 20, 2005 Ask Dr. Julie; Weight Loss Key for Steatohepatitis' Jun 24, 2005 Valsartan plus HCTZ lowers blood pressure better than Amlopidine Jun 20, 2005 New Data Reinforce Powerful Blood Pressure-lowering Efficacy with ... Jun 20, 2005 Ask Dr. Julie; Weight Loss Key for Steatohepatitis' Jun 24, 2005 Benicar and Benicar HCT significantly reduces systolic ... May 27, 2005 New Data Demonstrate That BENICAR(R) and BENICAR HCT(R) ... May 27, 2005 FDA Approvals: Hyzaar, Panzem, Decapinol Apr 21, 2005 Strong Operating Development in the First Quarter 2005 Apr 27, 2005 DR. HOOK- Med monikers: What's in a drug's name? Apr 14, 2005 The History of Antibiotics Apr 6, 2005 Dear Pharmacist: Many herbs can be used as diuretics Mar 8, 2005 BCBSNC Launches New Prescription Drug Savings Initiative Feb 17, 2005 Other information Indication For the treatment of high blood pressure and management of edema Pharmacology Thiazides promote water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. Mechanism Of Action As a diuretic, Hydrochlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like Hydrochlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of Hydrochlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. Drug Category Diuretics; Antihypertensive Agents; ATC:C03AA03 Brand Names/Synonyms Acuretic; Aldactazide; Aldoril; Apresazide; Aquarills; Aquarius; Bremil; Caplaril; Capozide; Chlorosulthiadil; Chlorothiazide; Chlorsulfonamidodihydrobenzothiadiazine Dioxide; Chlorzide; Cidrex; Dichlorosal; Dichlorotride; Dichlotiazid; Dichlotride; Diclotride; Dicyclotride; Dihydrochlorothiazid; Dihydrochlorothiazide; Dihydrochlorothiazidum; Dihydrochlorurit; Dihydrochlorurite; Dihydroxychlorothiazidum; Direma; Disalunil; Diu-Melusin; Diuril; Drenol; Dyazide; Esidrex; Esidrix; Esimil; Fluvin; H.H. 25/25; H.H. 50/50; HCTZ; HCZ; Hidril; Hidrochlortiazid; Hidroronol; Hidrotiazida; Hydril; Hydro-Aquil; Hydro-D; Hydro-Diuril; Hydrochlorothiazid; Hydrochlorothiazide; Hydrochlorothiazide Intensol; Hydrochlorthiazide; Hydrodiuretic; Hydrodiuril; Hydropres; Hydrosaluric; Hydrothide; Hydrozide; Hypothiazid; Hypothiazide; Hyzaar; Idrotiazide; Inderide; Ivaugan; Jen-Diril; Lopressor Hct; Lotensin Hct; Maschitt; Maxzide; Megadiuril; Microzide; Moduretic; Nefrix; Neo-Codema; Neoflumen; Newtolide; Oretic; Palonyl; Panurin; Perovex; Primogyn; Prinzide; Ro-Hydrazide; Servithiazid; Su 5879; Thiaretic; Thiazide, Hydrochloro-; Thiuretic; Thlaretic; Timolide; Unipres; Urodiazin; Vaseretic; Vetidrex; Ziac; Zide Dosage Forms Oral tablets, various strength Absorption 50-60% Interactions -->Interactions for Hydrochlorothiazide: When given concurrently the following drugs may interact with thiazide diuretics. Alcohol, barbiturates, or narcotics: potentiation of orthostatic hypotension may occur. Antidiabetic drugs: (oral agents and insulin) - dosage adjustment of the antidiabetic drug may be required. Other antihypertensive drugs: additive effect or potentiation. Cholestyramine and colestipol resins: Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins. Single doses of either cholestyramine or colestipol resins bind the hydrochlorothiazide and reduce its absorption from the gastrointestinal tract by up to 85 and 43 percent, respectively. Corticosteroids, ACTH: intensified electrolyte depletion, particularly hypokalemia. Pressor amines (e.g., norepinephrine): possible decreased response to pressor amines but not sufficient to preclude their use. Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine): possible increased responsiveness to the muscle relaxant. Lithium: generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity. Refer to the package insert for lithium preparations before use of such preparations with Hydrochlorothiazide. Non-steroidal Anti-inflammatory Drugs: In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when Hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Chemical IUPAC Name 9-chloro-5,5-dioxo-5$l^{6}-thia-2,4-diazabicyclo[4.4.0]deca-6,8,10-triene-8-sulfonamide Chemical Formula C7H8ClN3O4S2 Half Life 5.6 and 14.8 hours Drug Type Approved Drug # Accession No APRD00092 CAS Registry Number 58-93-5 |
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