Guanabenz: profile and news

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O'Connor stripped of medal Jul 3, 2005
O’Connor had claimed the drugs, fluphenazine and guanabenz which are used to treat high blood pressure in humans, were given to Waterford Crystal a month ... - Ireland Online,

doping saga will run to a sequel Mar 24, 2005
Connor was stolen. The name of the drug found in ABC Landliebe, said to be Guanabenz, was given to a Irish radio station. The FEI's ... - Telegraph.co.uk,

Other information

Indication
For management of High blood pressure

Pharmacology
Guanabenz, a centrally acting α-2 adrenergic agonist, is indicated for treatment of hypertension.

Mechanism Of Action
Guanabenz's antihypertensive effect is thought to be due to central alpha-adrenergic stimulation, which results in a decreased sympathetic outflow to the heart, kidneys, and peripheral vasculature in addition to a decreased systolic and diastolic blood pressure and a slight slowing of pulse rate. Chronic administration of guanabenz also causes a decrease in peripheral vascular resistance.

Drug Category
Sympatholytics; Antihypertensive Agents;

Brand Names/Synonyms
GBZ; Guanabenz; Guanabenz Acetate; Guanabenz [USAN:INN]; Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; HSDB 6535; Wy 8678; Wy 8678 base; Wy-8678; Wytensin; EINECS 225-750-8; Guanabenz(USAN)

Dosage Forms
Not Available

Absorption
Approximately 75% absorbed from gastrointestinal tract

Interactions
Not Available

Chemical IUPAC Name
(2,6-dichlorophenyl)methylideneaminoiminomethanediamine

Chemical Formula
C8H8Cl2N4

Half Life
6 hours.

Drug Type
Approved Drug

# Accession No
APRD00487

CAS Registry Number
5051-62-7