Glucotrol_XL: profile and news

Andrx Corporation Reports 2005 Third Quarter Results  Nov 8, 2005
The decrease is primarily due to decreases from our generic versions of Glucotrol XL(R), supplied by Pfizer, OTC Claritin-D(R) 24, K-Dur(R) and Glucophage(R ... - PharmaLive.com (press release),

Karen A. Dawes Elected a Director of Repligen Corporation  Sep 15, 2005
Ms. Dawes has directed the launch of numerous pharmaceuticals including Glucotrol/Glucotrol XL(R), Zoloft(R), and Cardura(R) for Pfizer. ... - PR Newswire (press release),

'A LIFE SAVER': PROGRAM MAKES DRUGS MORE AVAILABLE  Aug 19, 2005
The majority of the drugs patients received included Norvasc, a blood pressure medicine; Lipitor, a cholesterol medicine; and Glucotrol XL, which controls ... - Pine Bluff Commercial, <**results**>

Top 10 Things to Know About Diabetes Pills  Jul 4, 2005
Sulfonylureas of the second generation are glipizide (brand names Glucotrol and Glucotrol XL), glyburide (Micronase, Glynase, and Diabeta), and glimepiride ... - About Diabetes

A prescription for helping  Jun 28, 2005
...pressure. Eighteen Pfizer medicines, including Celebrex, Glucotrol XL, Lipitor, Viagra, Zyrtec and Zoloft, will be available. To ... - Wilson Daily Times (subscription),

Industry's biggest manufacturers enter generics through loophole  Apr 10, 2005
Andrx, for example, makes an authorized version of Pfizer's Glucotrol XL for diabetes, while Ivax has an agreement to launch an authorized copy of Pfizer's ... - Sun-Sentinel.com,

BCBSNC Launches New Prescription Drug Savings Initiative  Feb 17, 2005
ORAL AGENTS FOR DIABETES (Drugs to Treat Non-Insulin Dependent Diabetes) glipizide (generic Glucotrol) glipizide ER (generic Glucotrol XL) glyburide (generic ... - PR Newswire (press release)

Immediate and Extended Release Tablets

The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, some azoles and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving glipizide, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for loss of control. In vitro binding studies with human serum proteins indicate that glipizide binds differently than tolbutamide and does not interact with salicylate or dicumarol. However, caution must be exercised in extrapolating these findings to the clinical situation and in the use of glipizide with these drugs.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving glipizide, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for hypoglycemia.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known. The effect of concomitant administration of fluconazole and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers. All subjects received glipizide alone and following treatment with 100 mg of fluconazole as a single daily oral dose for seven days. The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).