Glipizide: profile and news






Pfizer's Exubera(R): A Unique Background Perspective  Jan 27, 2006
Pfizer, who marketed the oral anti-diabetic drug, Glucotrol® (glipizide), was interested in extending its diabetes franchise into insulin. ... - Market Wire (press release)

Preserving Competition, FTC Requires Divestitures Before Allowing ...  Jan 23, 2006
Par; 11) clozapine tablets from Teva, to be divested to Par; 12) tramadol/acetaminophen tablets from Teva, to be divested to Barr; 13) glipizide and metformin ... - PharmaLive.com (press release),

Generic Version of Metaglip Approved  Dec 7, 2005
This drug combines metformin with the sulfonylurea glipizide. ... Generic glipizide plus metformin is made by Teva Pharmaceuticals and CorePharma. ... - Diabetes Self Management

FDA Approvals: Avelox, Avandaryl, Trileptal  Dec 1, 2005
...data from the active-controlled study in patients aged 59 to 89 years, showing that adjunctive use of rosiglitazone with half-maximal doses of glipizide (20 mg ... - Medscape (subscription)

First-Time Generic Approvals: Metaglip, Zofran ODT, Floxin Otic  Nov 22, 2005
Nov. 22, 2005 — The US Food and Drug Administration (FDA) has approved first-time generic formulations of glipizide/metformin HCl 2.5-mg/250-mg, 2.5-mg/500-mg ... - Medscape (subscription)

Obesity is part of the sentence for prisoners  Nov 12, 2005
...(Trent Nelson/The Salt Lake Tribune ). on medications such as Glipizide, Glucophage, Protonix and Enalapril - all used to treat obesity. ... - Salt Lake Tribune,

Obesity is part of the sentence for prisoners  Nov 12, 2005
In 2004, the Utah Department of Corrections spent more than $80,000 on medications such as Glipizide, Glucophage, Protonix and Enalapril - all used to treat ... - Salt Lake Tribune,

Utah Prisoners Gain Weight At 3,000 Calories A Day  Nov 13, 2005
In 2004, the Utah Department of Corrections spent more than $80,000 on medications such as Glipizide, Glucophage, Protonix and Enalapril � all used to treat ... - KUTV,

Endocrinology & Metabolism News, September 2005  Oct 3, 2005
After administration of a single glyburide or glipizide dose to eight nursing women, drug was not detected in breast milk, and hypoglycemia was not observed in ... - Journal of Clinical Endocrinology and Metabolism,

Sitagliptin, a new investigational treatment for type 2 diabetes ...  Sep 14, 2005
...randomized to one of six treatment groups: placebo; sitagliptin (5mg, 12.5 mg, 25 mg, or 50 mg oral tablets twice daily); or the sulfonylurea, glipizide, 5 mg ... - EurekAlert,

Medicare sign-up deadline is looming  Sep 16, 2005
BY HIRAN RATNAYAKE / The News Journal. Betty Thomas takes half a tablet of Glipizide each day as part of her treatment for diabetes. ... - The News Journal,

Sitagliptin, Under Investigation For Type 2 Diabetes  Sep 15, 2005
Patients treated with glipizide had an average weight gain of 1.1 kilogram relative to placebo. Adverse event reports of hypoglycaemia ... - MedIndia,

Many meds don't mix with the sun  Sep 21, 2005
Antidiabetic agents: Acetohexamide (Dymelor), chlorpro-pamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Micronase ... - Pioneer Press,

Endocrinology & Metabolism News, September 2005  Sep 7, 2005
After administration of a single glyburide or glipizide dose to eight nursing women, drug was not detected in breast milk, and hypoglycemia was not observed in ... - Journal of Clinical Endocrinology and Metabolism,

Supplement of the Month - Cinnamon  Sep 6, 2005
...blood glucose to be excessively lowered when combined with agents that can cause hypoglycemia, such as sulfonylureas (Amaryl, glyburide or glipizide) or insulin ... - Diabetes Interview,

A TRUSS CAN BE A TEMPORARY FIX FOR A HERNIA  Jul 23, 2005
ANSWER: Glucotrol (glipizide) is an oral diabetes medicine used by many with type-2 diabetes, the kind of diabetes that can often be controlled without insulin ... - Charlotte Sun-Herald

Ask the internist: Variety of medications can help with diabetes ...  Jul 19, 2005
TZD. Sulfonylureas (eg glyburide, glipizide, glimepiride, others): These work by causing the pancreas to make more insulin. This ... - Billings Gazette <**results**>

Sitagliptin, an investigational treatment for type 2 diabetes  Jun 14, 2005
...were randomized to one of six treatment groups: placebo: Sitagliptin ( 5 mg, 12.5 mg, 25 mg, or 50 mg twice daily ); or the sulfonylurea Glipizide 5 mg ... - Xagena.it

Sitagliptin (MK-0431) for Type 2 Diabetes shows promise in Phase ...  Jun 11, 2005
Patients were randomized to one of six treatment groups: placebo; sitagliptin (5mg, 12.5 mg, 25 mg, or 50 mg twice daily); or the sulfonylurea, glipizide, 5 mg ... - Medical News Today

Top 10 Things to Know About Diabetes Pills  Jul 4, 2005
Sulfonylureas of the second generation are glipizide (brand names Glucotrol and Glucotrol XL), glyburide (Micronase, Glynase, and Diabeta), and glimepiride ... - About Diabetes

Sitagliptin, an investigational treatment for type 2 diabetes  Jun 14, 2005
...were randomized to one of six treatment groups: placebo: Sitagliptin ( 5 mg, 12.5 mg, 25 mg, or 50 mg twice daily ); or the sulfonylurea Glipizide 5 mg ... - Xagena.it,

Sitagliptin (MK-0431) for Type 2 Diabetes shows promise in Phase ...  Jun 12, 2005
...were randomized to one of six treatment groups: placebo; sitagliptin ( 5mg, 12.5 mg, 25 mg, or 50 mg twice daily ); or the sulfonylurea, glipizide, 5 mg ... - I-Newswire.com (press release)

Hello, Byetta  Jun 2, 2005
...who have been unable to achieve adequate blood glucose control with the oral diabetes drugs metformin or a sulfonylurea (such as glipizide, glyburide, or ... - Diabetes Self Management

State investigates death at East Bay nursing home  Apr 19, 2005
It found that facility staff failed to order the minimum supply of Glipizide for Louis Mangano when his prescription was depleted and that they illegally ... - Oakland Tribune

Daily drug regimen of Alice and Ken Heckman  Apr 16, 2005
Reduces high blood sugar in diabetics. 3) Glucotrol, glipizide. Another diabetes drug that stimulates the pancreas to release more insulin. ... - New York Newsday

Paws to Consider  Apr 19, 2005
...require supplementation with insulin while about a third of diabetic cats may be managed by dietary changes and/or oral hypoglycemic agents such as Glipizide. ... - Delphos Herald

Indian bulk drug suppliers lose pricing appeal  Apr 11, 2005
The case concerns the active ingredients salbutamol, theopylline, norfloxacin, ciprofloxacin, cloxacillin, doxycycline and glipizide. - in-PharmaTechnologist

Reminder: Keep medicines away from children  Apr 5, 2005
...derivatives (chloroquine, hydroxychloroquine), tricyclic antidepressants(amitriptyline, desipramine) and certain oral hypoglycemics (chlorpropamide, glipizide ... - Staten Island Advance,

Hospital fined $50,000 for error Nurse's mistake with diabetes ...  Mar 2, 2005
At about 8 pm on May 17, a male nurse gave Glipizide, a diabetes drug, to the woman and failed to note the medication in her chart. She did not have diabetes. ... - San Francisco Chronicle

Santa Rosa Hospital Fined In Patient's Death  Mar 3, 2005
The Class AA citation concerns the death of a 76-year-old woman diagnosed with colon cancer who was mistakenly given Glipizide, a medication for diabetes, by a ... - FoxReno.com,

Alterations in net glucose uptake and in the pancreatic B-cell ...  Feb 25, 2005
Diazoxide was used to inhibit, while glipizide or depolarization of the plasma membrane with a high extracellular K + concentration were used to stimulate ... - Journal of Endocrinology

BCBSNC Launches New Prescription Drug Savings Initiative  Feb 17, 2005
HCTZ (generic Inderide) quinapril/HCTZ (generic Accuretic) ORAL AGENTS FOR DIABETES (Drugs to Treat Non-Insulin Dependent Diabetes) glipizide (generic Glucotrol ... - PR Newswire (press release)

Epidural Hematoma Unrelated to Combined Spinal-Epidural Anesthesia ...  Feb 22, 2005
His current medications were neutral protamine Hagedorn (NPH) insulin, glipizide, lisinopril, and aspirin 81 mg daily, which was not discontinued before surgery ... - Anesthesia & Analgesia (subscription),


Other information


Indication
For the treatment of hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM)

Pharmacology
Glipizide, a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II.

Mechanism Of Action
Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

Drug Category
Hypoglycemic Agents; ATC:A10BB07

Brand Names/Synonyms
AC-120; Aldiab; Apamid; CHEMBANK72; Digrin; Dipazide; G117; Glibenese; Glibetin; Glican; Glide; Glidiab; Glipid; Glipizida [Inn-Spanish]; Glipizide; Glipizide Extended-Release Tablets; Glipizide [Usan:Ban:Inn]; Glipizidum [Inn-Latin]; Gluco-Rite; Glucolip; Glucotrol; Glucotrol Xl; Glucozide; Glupitel; Glupizide; Glyde; Glydiazinamide; K 4024; Melizide; Metaglip; Mindiab; Minidab; Minidiab; Minodiab; Napizide; Ozidia; Sucrazide; TK 1320

Dosage Forms
IR oral tablets and ER oral tablets

Absorption
uniform, rapid, and essentially complete

Interactions
-->Interactions for Glipizide:

Immediate and Extended Release Tablets

The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents, some azoles and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving glipizide, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for loss of control. In vitro binding studies with human serum proteins indicate that glipizide binds differently than tolbutamide and does not interact with salicylate or dicumarol. However, caution must be exercised in extrapolating these findings to the clinical situation and in the use of glipizide with these drugs.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving glipizide, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving glipizide, the patient should be observed closely for hypoglycemia.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known. The effect of concomitant administration of fluconazole and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers. All subjects received glipizide alone and following treatment with 100 mg of fluconazole as a single daily oral dose for seven days. The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).



Chemical IUPAC Name
N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-pyridine-2-carboxamide

Chemical Formula
C22H28N4O4S

Half Life
2-4 hours

Drug Type
Approved Drug

# Accession No
APRD00436

CAS Registry Number
29094-61-9

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