Glimepiride: profile and news

Psych Drugs - Doctors Serve As Middle-Man Pushers 06 Mar 2006
...diagnosed Type 2 diabetic children were being treated with psychiatric drugs like Zyprexa, Risperdal, Geodon, Seroquel, Clozaril, and Abilify, according to ... - Media Monitors Network,

Drug makers release new Abilify versions Feb 7, 2006
...and Otsuka Pharmaceutical Co. announced the release of two new versions of their anti-psychotic medication Abilify on Tuesday. The ... - BusinessWeek

Bristol-Myers Squibb Company and Otsuka Pharmaceutical Announce ... Feb 8, 2006
...today announced two newly available options of Abilify® (aripiprazole) -- a 2 mg tablet strength and a nonrefrigerated oral solution (1 mg/mL). ... - DG News

Bristol-Myers Squibb Company and Otsuka Pharmaceutical Co., Ltd. ... Feb 7, 2006
...today announced two newly available options of ABILIFY(R) (aripiprazole) -- a 2 mg tablet strength and a nonrefrigerated oral solution (1 mg/mL). ... - PR Newswire (press release),

Trooper in murder-suicide had no alcohol or drugs in system Mar 2, 2006
...building enhancers. Authorities said they found an empty bottle of Abilify, a drug used to treat bipolar disorder, in Diaz's car. At ... - Newsday,

Patching into depression market Feb 28, 2006
EMSAM profits won't be hampered by too much overhead, because Bristol-Myers already has a sales staff focused on psychiatric drugs like Abilify, the treatment ... - CNN/Money

No Alcohol Or Drugs Found In Diaz's Body Mar 3, 2006
An empty bottle of Abilify, a drug used to treat bipolar disorder, was found in his car at Wolcott Park, where Diaz had parked the day of the killing before ... - Hartford Courant,

Bristol-Myers Squibb and Otsuka Pharmaceutical announce ... Feb 7, 2006
The Abilify 2 mg tablet equips physicians with an additional dosage strength to help them titrate patients to an effective dose. ... - News-Medical.net,

New formulations of BMS drug released Feb 9, 2006
Bristol-Myers Squibb and its Japanese partner Otsuka Pharmaceutical have introduced two new formulations of Abilify, the companies' drug for the treatment of ... - Pharmaceutical Business Review

Bush Acknowledges `Challenges' in Medicare Drug Plan (Update1) Feb 11, 2006
Insurers have directed him to give some of these patients' new drugs, switching them from Bristol-Myers Squibb Co.'s Abilify schizophrenia medicine to Eli ... - Bloomberg

(PRN) - Casino City Press Releases 2006 Online Gaming Business ... Feb 7, 2006
Announce Availability of 2 mg ABILIFY(R) (aripiprazole) Tablet and Nonrefrigerated Oral Solution ... [+. PRN) - US BioDefense, Inc. ... - Bolsamania.com,

Diaz's blood to be tested for steroids Feb 10, 2006
The police report further said a prescription slip for Abilify, a drug used to treat Bi-Polar disorder and schizophrenia was found in the car Diaz used the day ... - Newington Town Crier,

Bristol-Myers Squibb Company Reports Financial Results for the ... Jan 25, 2006
..."These investments are already returning solid results, with continued double-digit growth in PLAVIX(R), ABILIFY(R), ERBITUX(R) and REYATAZ(R) and the progress ... - PR Newswire (press release),

Bristol-Myers Catches a Cold Jan 25, 2006
Simply put, double-digit growth from a stable of drugs including Plavix, Abilify, Reyataz, and Erbitux weren't enough to outweigh losses to competition and ... - Motley Fool

Happy Pills Don't Make Me Happy Jan 20, 2006
Wellbutrin, Neurontin, Seroquel, Depakote, Effexor, Inderal, Trileptal, Paxil, Zyprexa, Lamictal, Abilify -- I've taken them all. ... - Pacific News Service,

UPDATE 2-Bristol-Myers sees 2006 profit falling 13-20 pct Jan 25, 2006
Bristol's Abilify schizophrenia drug, which does not cause weight gains seen with drugs such as Eli Lilly and Co.'s (LLY.N: Quote, Profile, Research) Zyprexa ... - Reuters

Bristol-Myers Net Surges Jan 25, 2006
...million. Sales of schizophrenia drug Abilify rose 17% to $224 million, while sales of baby formula Enfamil rose 24% to $277 million. ... - TheStreet.com

Bristol-Myers Net Rises on Lower Costs; Sales Drop (Update2) Jan 25, 2006
...million. Sales of the Abilify schizophrenia treatment, introduced in November 2002, increased 17 percent to $224 million. Revenue ... - Bloomberg

Bristol earnings up, but issues warning Jan 25, 2006
...cancer drug Erbitux, up 38 percent, AIDS treatment Reyataz, up 27 percent, blood-thinner Palvix, up 11 percent, and antipsychotic agent Abilify, up 17 percent ... - Newark Star Ledger,

New causes, treatments for Alzheimer's Jan 27, 2006
In the advanced stages of Alzheimers, I may prescribe anti-psychotic medications like Haldol, Zyprexa and Abilify to help control symptoms of sleeplessness ... - Contra Costa Times,

TODAY ON PHARMALIVE.COM Jan 11, 2006
For example, Eli Lilly's antipsychotic drug Zyprexa competes against drugs like Bristol-Myers Squibb's (BMY) Abilify, Pfizer's (PFE) Geodon, AstraZeneca's (AZN ... - PharmaLive.com (press release),

B-MS sales dip in Q4 on Pravachol competition Jan 26, 2006
...impact of generic competition were colorectal cancer drug Erbitux (cetuximab), Reyataz (atazanavir) for HIV, and the antipsychotic Abilify (aripiprazole) for ... - Pharma Times (subscription),

Bristol-Myers net triples as sales ease 1% Jan 25, 2006
...million. Its drug Abilify, an anti-psychotic medication used to treat schizophrenia, saw sales rise 17% to $224 million. Meanwhile ... - Investor's Business Daily (subscription)

Bristol-Myers posts profit, warns of 2006 downturn Jan 25, 2006
Bristol‘s Abilify schizophrenia drug, which does not cause weight gains seen with drugs such as Eli Lilly and Co.‘s (NYSE:LLY - news) Zyprexa, jumped 17 ... - Herald News Daily,

Medicare Woes Take High Toll on Mentally Ill Jan 21, 2006
...the insurer agreed to relax "prior authorization" requirements for a month, it was charging high co-payments for some drugs - $52 apiece for Abilify, an anti ... - New York Times,

New Medicare Prescription Drug Plan -- Off To A Bad Start Jan 22, 2006
..."Zyprexa, the most widely sold antipsychotic medication in America, is not covered," said O'Hagan. "Same thing with Abilify. And ... - Gotham Gazette,

CATIE Phase I Helps Clinicians Tailor Schizophrenia Treatment Jan 12, 2006
Aripiprazole (Abilify), Lieberman noted, was not approved until November 2002, so it could not be in Phase I. It was, however, added to Phase III of the study ... - Psychiatric Times,

Abilify plus an antidepressant for mood disorders Nov 25, 2005
NEW YORK (Reuters Health) - The atypical antipsychotic drug Abilify (aripiprazole) appears to enhance the response to antidepressants in patients with treatment ... - Reuters.uk,

Psychiatric Manifestations of HIV Infection and AIDS Dec 5, 2005
For this reason atypical antipsychotics with a low risk of EPS, such as quetiapine (Seroquel) and aripiprazole (Abilify), may be preferable in this population. ... - Psychiatric Times,

Pharma Reformulates Dec 5, 2005
Prevacid; growing products like Aricept for Alzheimer's disease, developed by Eisai and comarketed with Pfizer; and Otsuka's antipsychotic Abilify, sold with ... - Chemical & Engineering News

Study shows antipsychotics are risky for dementia patients Nov 16, 2005
Drugs used in the studies were aripiprazole (Abilify), olanzapine (Zyprexa), quetiapine (Seroquel) and risperidone (Risperdal). ... - South Bend Tribune,

Older Antipsychotic Drugs No Safer Than New Ones Nov 30, 2005
...medications. The older medications included Thorazine and Haldol, while the newer or second generation drugs included Abilify and Clozaril. ... - Forbes

Risperdal, Geodon face tough generics Nov 22, 2005
The patent on Bristol-Myers Squibb/Otsuka's Abilify expires in 2009, while Eli Lilly's Zyprexa and AstraZeneca's Seroquel go off patent in 2011. ... - United Press International

This Week in Health Dec 2, 2005
...the short-term risk of death for patients taking older drugs such as Thorazine and Haldol with that of patients taking newer drugs such as Abilify and Clozaril ... - Intelihealth.com,

Other information

Indication
For concomitant use with insulin for the treatment of noninsulin-dependent (Type II) diabetes mellitus; For the treatment of hyperglycemia that cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic agent

Pharmacology
Glimepiride, like glyburide and glipizide, is a "second-generation" sulfonylurea agents. Glimepiride is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin.

Mechanism Of Action
The mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glimepiride likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.

Drug Category
Immunosuppressive Agents; Hypoglycemic Agents; Antiarrhythmic Agents; Sulfonylureas; ATC:A10BB12

Brand Names/Synonyms
Amarel; Amaryl; CCRIS 7083; CHEMBANK1624; Endial; Glimepirid; Glimepirida [Spanish]; Glimepiride; Glimepiride [Usan:Ban:Inn]; Glimepiridum [Latin]; Glimepride; HOE 490

Dosage Forms
Oral tablets with various strengths

Absorption
completely (100%) absorbed

Interactions
Many other medicines may increase or decrease the effects of glimepiride or affect your condition. Before taking glimepiride, tell your doctor if you are taking any of the following medicines: �� aspirin or another salicylate such as magnesium/choline salicylate (Trilisate), salsalate (Disalcid, others), choline salicylate (Arthropan), magnesium salicylate (Magan), or bismuth subsalicylate (Pepto-Bismol); �� a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil, Nuprin, others), ketoprofen (Orudis, Orudis KT, Oruvail), diclofenac (Voltaren, Cataflam), etodolac (Lodine), indomethacin (Indocin), nabumetone (Relafen), oxaprozin (Daypro), and naproxen (Anaprox, Naprosyn, Aleve); �� a sulfa-based drug such as sulfamethoxazole-trimethoprim (Bactrim, Septra), sulfisoxazole (Gantrisin), or sulfasalazine (Azulfidine); �� a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil); �� a beta-blocker such as propranolol (Inderal), atenolol (Tenormin), acebutolol (Sectral), metoprolol (Lopressor), and others; �� a diuretic (water pill) such as hydrochlorothiazide (HCTZ, Hydrodiuril), chlorothiazide (Diuril), and others; �� a steroid medicine such as prednisone (Deltasone, Orasone, others), methylprednisolone (Medrol, others), prednisolone (Prelone, Pediapred, others), and others; �� a phenothiazine such as chlorpromazine (Thorazine), fluphenazine (Prolixin, Permitil), prochlorperazine (Compazine), promethazine (Phenergan), and others; �� phenytoin (Dilantin); �� isoniazid (Nydrazid); �� rifampin (Rifadin, Rifamate); or �� over-the-counter cough, cold, allergy, or weight loss medications. You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above. Drugs other than those listed here may also interact with glimepiride or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Chemical IUPAC Name
3-ethyl-N,N-bis(3-ethyl-4-methyl-2-oxo-5H-pyrrol-2-yl)-4-methyl-2-oxo-5H-pyrrole-1-carboxamide

Chemical Formula
C24H34N4O5S

Half Life
~5 hours following single dose

Drug Type
Approved Drug

# Accession No
APRD00381

CAS Registry Number
93479-97-1