Geodon: profile and news

Psych Drugs - Doctors Serve As Middle-Man Pushers  07 Mar 2006
...found that 19% of newly diagnosed Type 2 diabetic children were being treated with psychiatric drugs like Zyprexa, Risperdal, Geodon, Seroquel, Clozaril, and ... - Media Monitors Network,

State court rules man can't waive appeals  Feb 14, 2006
When asked by Associate Justice James Moore in October what medications were in his system, Hughes said he takes only one drug, Geodon, for schizophrenia. - Myrtle Beach Sun News,

Judges rescind death penalty  Feb 14, 2006
The judges looked up in the Physicians' Desk Reference and on the Internet possible side effects of the anti-psychotic drug Geodon, listing them as sedation ... - Baltimore Sun,

Pfizer Fourth-Quarter and Full-Year 2005 Financial Results Reflect ...  Jan 19, 2006
Accelerated Cost Savings - - - Lipitor Revenue Up 12 Percent Worldwide in 2005; Lyrica One of Most Successful Pfizer Launches Ever; Worldwide Geodon Revenue Up ... - PR Newswire (press release),

Pfizer Fourth-Quarter and Full-Year 2005 Financial Results Reflect ...  Jan 19, 2006
...therapeutic areas, including cardiovascular/metabolic diseases (Lipitor up 12 percent, Caduet up 272 percent); central nervous system disorders (Geodon up 26 ... - PR Newswire (press release),

CATIE Phase I Helps Clinicians Tailor Schizophrenia Treatment  Jan 12, 2006
...of the second-generation or atypical antipsychotics (olanzapine [Zyprexa], quetiapine [Seroquel], risperidone [Risperdal] and ziprasidone [Geodon]) and one ... - Psychiatric Times,

We need more studies like CATIE - says Principal Investigator  Jan 11, 2006
...assigned to one of four newer, 'atypical' antipsychotics: olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal), and ziprasidone (Geodon); or to ... - Pharma Times (subscription),

TODAY ON PHARMALIVE.COM  Jan 11, 2006
For example, Eli Lilly's antipsychotic drug Zyprexa competes against drugs like Bristol-Myers Squibb's (BMY) Abilify, Pfizer's (PFE) Geodon, AstraZeneca's (AZN ... - PharmaLive.com (press release),

Witnesses recount fatal store shooting  Jan 19, 2006
...shows in Central Florida. Also, Paxil, Clonazepam and Geodon prescribed for Teti were found in the kitchen. In an interview with ... - Ocala.com,

Lundbeck gets first nod for revived schizophrenia drug  Jan 18, 2006
...marketing potential remains to be seen, but a link to QT elevations has not proved a major problem for another schizophrenia drug, Pfizer's Geodon (ziprasidone ... - Pharma Times (subscription),

antipsychotics: Mortality risk may be greater with older drugs.  11 Dec 2005
Stelazine, Vesprin, Taractan, Haldol, Loxitane, Moban, Orap and Navane and the atypical drugs Abilify, Clozaril, Zyprexa, Seroquel, Risperdal and Geodon. ... - Evansville Courier & Press (subscription),

Risperdal, Geodon face tough generics  Nov 22, 2005
22 (UPI) -- A new physician survey indicates sales of two anti-psychotic drugs -- Janssen's Risperdal and Pfizer's Geodon -- may take a big hit when generic ... - United Press International

Generic Forms of Janssen's Risperdal and Pfizer's Geodon Not ...  Nov 22, 2005
...primary care physicians (PCPs) and psychiatrists expect the launch of generic forms of Janssen's Risperdal (risperidone) and Pfizer's Geodon (ziprasidone) to ... - PharmaLive.com (press release),

Risperdal, Geodon face tough generics  Nov 22, 2005
DC, United States (UPI) -- A new physician survey indicates sales of two anti-psychotic drugs -- Janssen`s Risperdal and Pfizer`s Geodon -- may take a big hit ... - Monsters and Critics.com,

WTO TRIPS agreement could benefit generics  Dec 7, 2005
Risperdal, Geodon face tough generics (November 22, 2005) -- A new physician survey indicates sales of two anti-psychotic drugs -- Janssen's Risperdal and ... - Science Daily (press release)

Ziprasidone Effective in Children and Adolescents with Bipolar ...  Nov 11, 2005
11, 2005 -- Children and adolescents who are experiencing the manic phase of bipolar disorder benefit from treatment with ziprasidone (Geodon), according to ... - DG News

'The worst day of my life'  Nov 28, 2005
Gaines says that her mental state has stabilized and that she is taking Geodon, an anti-psychotic drug, as well as a sleep aid "that helps calm me." Geodon is ... - Pioneer Press,

Shire/Noven Daytrana Second-Line? Physicians Should Consider Oral ...  Dec 2, 2005
The committee said the language should follow the example of Pfizer’s Geodon (ziprasidone) labeling, which urges consideration of other antipsychotic ... - FDA Advisory Committee

Mother who threw sons from bridge speaks out for first time  Nov 28, 2005
...wrong. Gaines said her mental state has stabilized. She takes Geodon, an anti-psychotic drug, and a sleep aid to calm her. Gaines ... - Pioneer Press,

Abilify plus an antidepressant for mood disorders  Nov 25, 2005
He explained: "Studies conducted so far in schizophrenia and bipolar disorder suggest that agents such as aripiprazole and ziprasadone (Geodon) may have ... - Reuters.uk,

International Approvals: Zeldox, Alfimeprase, Bronchitol  Nov 15, 2005
Ziprasidone HCl capsules and intramuscular injection (marketed by Pfizer as Geodon) were approved by the US Food and Drug Administration for the treatment of ... - Medscape (subscription)

(PRN) - Jordyn Taylor Ending a Year of Transition with Momentum .. ...  Nov 22, 2005
...(PRN) - Generic Forms of Janssen's Risperdal and Pfizer's Geodon Not Expected to Increase Prescribing Habits in Antipsychotic Drug Market ... [+. ... - Bolsamania.com,

Medicaid May Shrink $5.5 Bln Spending on Schizophrenia Drugs  Sep 28, 2005
Patients reported more side effects on Zyprexa than those taking the generic or the other drugs, J&J's Risperdal, AstraZeneca's Seroquel and Pfizer's Geodon. ... - Bloomberg

Prescription: Flexibility  Sep 27, 2005
They recruited nearly 1,500 patients with schizophrenia and assigned them randomly to traditional perphenazine and four atypicals (Geodon, Risperdal, Seroquel ... - National Review Online,

A Victory For Lilly--With Reservations  Sep 19, 2005
By comparison, patients taking Pfizer's (nyse: PFE - news - people ) Geodon, on average, experienced no weight gain and fewer of the neurological tremors that ... - Forbes

Zyprexa Edges Four Other Agents With Modest Benefit for ...  Sep 19, 2005
...in the Zyprexa arm than was observed among patients randomized Trilafon (perphenazine) - the first generation comparator arm - or to Geodon (ziprasidone) the ... - CNN

Zyprexa outperforms rivals in US study  Sep 20, 2005
In the study, Johnson & Johnson's Risperdal, AstraZeneca Plc's Seroquel, Pfizer Inc.'s Geodon and the older drug, perphenazine, had fewer side effects, such as ... - Indianapolis Star,

Most newer schizophrenia drugs no better - study  Sep 19, 2005
...quetiapine) from AstraZeneca Plc ; Risperdal (risperidone) from Janssen Pharmaceutica, a wholly owned unit of Johnson & Johnson ; Geodon (ziprasidone) from ... - Reuters AlertNet,

Most newer schizophrenia drugs no better - study  Sep 19, 2005
...was higher among the other four drugs: Seroquel (quetiapine) from AstraZeneca Plc ; Risperdal (risperidone) from Johnson & Johnson ; Geodon (ziprasidone) from ... - Reuters AlertNet,

Schizophrenia drugs work poorly, study suggests  Sep 20, 2005
For example, if a patient's family has a history of diabetes, a psychiatrist might prescribe Geodon, which causes the smallest increase in blood sugar. ... - Boston Globe,

Study: Drug built in 1950s on par with new meds  Sep 19, 2005
...in the 1950s and now available as a generic drug, was as effective as Johnson & Johnson's Risperdal, AstraZeneca's Seroquel and Pfizer's Geodon in treatment of ... - Newark Star Ledger,

Most New Schizophrenia Drugs Fare No Better  Sep 20, 2005
...higher among the other four drugs: Seroquel (quetiapine) from AstraZeneca Plc; Risperdal (risperidone) from Janssen Pharmaceutica; Geodon (ziprasidone) from ... - All Headline News

Eli Lilly: double-edged results for Zyprexa  Sep 23, 2005
...namely Zyprexa (olanzapine), Johnson & Johnson's Risperdal (risperidone), AstraZeneca's Seroquel (quetiapine) and Pfizer's Geodon (ziprasidone), as well as the ... - Pharmaceutical Business Review

This Week in Health  Sep 23, 2005
The patients took one of four newer antipsychotics -- Zyprexa, Seroquel, Risperdal, Geodon -- or else perphenazine for 18 months. ... - Intelihealth.com,

Questions relating to Toilet Training at School  Sep 16, 2005
16. The common side effects associated with Geodon that Matthew takes includes the following = itching, constipation, inability to remain in a sitting position ... - Bella Online

Repligen Reports Initiation of a Clinical Study of Secretin in ...  Oct 6, 2005
Sales in the United States of antipsychotic drugs for schizophrenia including Zyprexa(TM), Risperdal(TM) and Geodon(TM) exceed $5 billion and the total cost ... - PharmaLive.com (press release),

No Best Drug for Schizophrenia, Report Concludes  Sep 19, 2005
...big surprise was that older generic drug perphenazine was just as effective as Zyprexa's main competitors -- Seroquel, Risperdal and Geodon -- and Zyprexa's ... - TechNewsWorld,

New drugs for schizophrenia are no more effective than older, less ...  Sep 20, 2005
Perphenazine costs 60 dollars a month, compared with Zyprexa, at 520 dollars; Seroquel, at 450 dollars; Risperdal, at 250 dollars; and Geodon, at 290 dollars. ... - TODAYonline,

Old anti-psychotic drugs just as effective  Sep 20, 2005
The new drugs -- Geodon from Pfizer, Risperdal from Johnson & Johnson, Seroquel from AstraZeneca and Zyprexa from Eli Lilly -- account for $10 billion in ... - World Peace Herald,

A Sea Change For Schizophrenia Treatment?  Sep 16, 2005
Eli Lilly's (nyse: LLY - news - people ) Zyprexa is likely to come out ahead in the study, but Pfizer's (nyse: PFE - news - people ) Geodon could also get a ... - Forbes

Study Finds Little Advantage in New Schizophrenia Drugs  Sep 19, 2005
1,493 people with the disorder and assigned them to receive one of five drugs: Risperdal, from Johnson & Johnson; Seroquel from AstraZeneca; Geodon from Pfizer ... - New York Times,

Treatment for mental illness falls short  Oct 2, 2005
These "atypical antipsychotics" were followed by other new-generation schizophrenia medications such as Risperdal, Seroquel and Geodon. ... - Houston Chronicle,

Why New Drugs Don't Live Up to the Hype  Sep 30, 2005
Zyprexa was out, and she was moved to Geodon (ziprasidone), another newfangled antipsychotic, which made her feel antsy at first but works quite well. ... - CNN

Study: New Antipsychotic Drugs No Better Than Older Ones  Sep 20, 2005
Last year, the United States spent $10 billion on the newer antipsychotic drugs, which include medications such as Zyprexa, Risperdal, Seroquel and Geodon. ... - TheDay (subscription),

No magic bullet for schizophrenia  Sep 28, 2005
Participants were randomly assigned to take one of five drugs - Zyprexa, Seroquel, Risperdal, Geodon or perphenazine - for 18 months, a period picked because ... - Billings Gazette,

Old and New Schizophrenia Drugs: Study Shows Patient Satisfaction ...  Sep 26, 2005
It was also lower than the rates for the new drugs, Seroquel (quetiapine) at 82 percent, and Geodon (ziprasidone) at79 percent. ... - PharmExec.com,

Side Effects: Schizophrenia treatments still far from ideal  Oct 3, 2005
These “atypical antipsychotics� were followed by other new-generation schizophrenia medications, such as Risperdal, Seroquel and Geodon. ... - Winston-Salem Journal,

Miraculous They're Not  Sep 27, 2005
Led by Jeffrey Lieberman of Columbia University, the study found that atypicals such as Zyprexa, Risperdal, Geodon, and Seroquel were about as effective as an ... - Seattle Weekly,

Behavioral and Pharmacologic Treatment of Aggression in Children ...  Oct 3, 2005
Clozapine (Clozaril), quetiapine (Seroquel), olanzapine (Zyprexa) and ziprasidone (Geodon) have been evaluated in small or uncontrolled studies and case ... - Psychiatric Times,

Study finds no best schizophrenia drug  Sep 19, 2005
The big surprise was that older generic drug perphenazine was just as effective as Zyprexa's main competitors - Seroquel, Risperdal and Geodon - and Zyprexa's ... - Seattle Post Intelligencer

Study Finds No Best Schizophrenia Drug  Sep 19, 2005
The big surprise was that older generic drug perphenazine was just as effective as Zyprexa's main competitors _ Seroquel, Risperdal and Geodon _ and Zyprexa's ... - Washington Post,

Schizophrenia Study Slams Pharma  Sep 19, 2005
Effectiveness, or CATIE. The other drugs are Geodon from Pfizer; Risperdal from J&J; and Seroquel from AstraZeneca. Zyprexa is Lilly's ... - TheStreet.com

Schizophrenia Drugs Still Fall Short  Sep 19, 2005
...of those assigned to risperidone (Risperdal); 75 percent of those assigned to perphenazine; 79 percent of those assigned to ziprasidone (Geodon); and 82 ... - Forbes

Old antipsychotic drugs comparable to new drugs, study finds  Sep 20, 2005
...the older drug perphenazine or one of four atypicals: olanzapine (brand name Zyprexa), quetiapine (Seroquel), risperidone (Risperdal) or ziprasidone (Geodon). ... - Seattle Times,

Newer not necessarily better in world of anti-psychotics  Sep 20, 2005
1493 people with the disorder and assigned them to receive one of five drugs: Risperdal, from Johnson & Johnson; Seroquel from AstraZeneca; Geodon from Pfizer ... - The Age (subscription),

Study: Old medication as effective as new for treating ...  Sep 19, 2005
...older drug, Trilafon (perphenazine), was just as effective as three newer antipsychotics, Seroquel (quetiapine), Risperdal (risperidone) and Geodon (ziprasidone ... - Kansas City Star,

NIMH study to guide treatment choices for schizophrenia  Sep 19, 2005
...assigned to one of four newer, "atypical" antipsychotics: olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal), and ziprasidone (Geodon); or to ... - Medical News Today (press release),

Schizophrenia Drug Face-Off: No Clear Winner  Sep 19, 2005
...centers. Neither patients nor their doctors knew whether they were getting Zyprexa, Seroquel, Risperdal, Geodon, or the older Trilafon. ... - WebMD

Study finds no clear choice in schizophrenia drugs  Sep 20, 2005
Participants were assigned to take one of five drugs -- Zyprexa, Seroquel, Risperdal, Geodon or perphenazine -- for 18 months, a period picked because therapy ... - News & Observer,

schizophrenia Drug study Shows Most Worked Poorly  Sep 20, 2005
In the study, Johnson & Johnson's Risperdal, AstraZeneca's Seroquel, Pfizer's Geodon and the older drug, perphenazine, had fewer side effects, such as weight ... - AXcess News,

Duke, UNC authors say schizophrenia, depression drugs aren't much ...  Sep 19, 2005
...perphenazine -- now sold only as a generic medication -- to four newer drugs: olanzapine, quetiapine (Seroquel), risperidone (Risperdal) and ziprasidone (Geodon ... - Durham Herald Sun,

Many meds don't mix with the sun  Sep 21, 2005
Compa-zine), quetiapine (Seroquel), risperidone (Risperdal), thioridazine (Mellaril), thiothixene (Navane), trifluoperazine (Stelazine), ziprasidone (Geodon). ... - Pioneer Press,

Long-Term Study Shows Pfizer's Geodon Has Comparable Efficacy With ...  Aug 13, 2005
The antipsychotic Geodon® (ziprasidone HCl) is as effective as Zyprexa (olanzapine) in maintenance treatment of patients with schizophrenia, but has ... - Medical News Today (press release),

Patients with Acute Bipolar Mania Show Rapid and Significant ...  Aug 18, 2005
...simultaneous symptoms of mania and depression) episodes showed significant improvements by day two of treatment with Pfizer Inc's Geodon® (ziprasidone HCl ... - Medical News Today (press release),

Vioxx fallout puts focus on drugs safety  Aug 27, 2005
...dementia. The new boxed warnings also applied to anti-psychotic drugs - Abilify, Zyprexa, Risperdal, Clorazil, Geodon and Symbyax. ... - Sunday Business Post,

Damaging children for the sake of profits  Aug 25, 2005
...in the use of SSRIs and other antidepressants, and high-priced schizophrenia drugs called "atypical antipsychotics," like Risperdal, Zyprexa, and Geodon. ... - Online Journal,

Access Communications Inc. Hires Medical Director  Aug 23, 2005
...for Zelnorm(R) (for irritable bowel syndrome with constipation and chronic idiopathic constipation), Betaseron, Miacalcin, Geodon, Sandostatin and a number of ... - dBusinessNews Newark (press release),

Access Communications Inc. Hires Medical Director  Aug 22, 2005
...brainstorming for Zelnorm® (for irritable bowel syndrome with constipation and chronic idiopathic constipation), Betaseron, Miacalcin, Geodon, Sandostatin and ... - Yahoo News (press release)

CyDex gets approval in Japan for Captisol  Aug 16, 2005
...other drugs. Pfizer also markets Zeldox/Geodon for injection, which uses Captisol, in the United States and Europe. In addition ... - Kansas City Business Journal,

August 24 DC Protest - Why Are Atypical Drug Users Mad?  Aug 17, 2005
...hence widely prescribed drugs such as Zyprexa (Eli Lilly) Risperdal (Johnson & Johnson) Abilify (Bristol-Myers Squibb), Clozril (Novartis), Geodon (Pfizer). ... - Independent Media TV

Second-Generation Antipsychotics and the Risk of Insulin ...  Aug 15, 2005
The medications are aripiprazole (Abilify), clozapine (Clozaril), olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperdal) and ziprasidone (Geodon ... - Psychiatric Times,

Japan approves drug delivery technology  Aug 16, 2005
In addition to Vfend, Pfizer markets a second Captisol-based drug, an injectable formulation of schizophrenia drug Zeldox/Geodon (ziprasidone mesylate), in the ... - in-PharmaTechnologist,

Our experience with Risperdal - know the side effects  Jul 24, 2005
At this time we decided to switch to Geodon, a similar medication but with less side effects, but a new one relating to heart problems. ... - Bella Online

ONLINE EXTRA: Forensic psychiatric evaluation for Jason McLaughlin  Jul 23, 2005
By April 2004, Jason's medications were changed from Zyprexa to Geodon because the Zyprexa made him too tired. However, the Geodon ... - Grand Forks Herald

New Warning on Antipsychotic Drugs Used to Treat Older People  Jul 19, 2005
...which include Abilify (aripiprazole), Zyprexa (olanzapine), Seroquel (quetiapine), Risperdal (risperidone), Clozaril (clozapine), and Geodon (ziprasidone), are ... - RedNova.com

Pfizer Inc Second-Quarter 2005 Performance Report  Jul 20, 2005
Additional strong performers include Aromasin (up 86 percent), Zyvox (up 39 percent), Relpax (up 34 percent), Geodon (up 32 percent), and Vfend (up 28 percent ... - Yahoo News (press release)

Studies could alter treatment for depression, schizophrenia  Jul 27, 2005
...antipsychotic medication) or one of four newer drugs: Eli Lilly & Co.'s Zyprexa, Johnson & Johnson's Risperdal, AstraZeneca PLC's Seroquel or Pfizer's Geodon. ... - Pittsburgh Post Gazette

Drug-drug interactions can be pharmacodynamic (combined pharmacologic effects) or pharmacokinetic (alteration of plasma levels). The risks of using ziprasidone in combination with other drugs have been evaluated as described below. Based upon the pharmacodynamic and pharmacokinetic profile of ziprasidone, possible interactions could be anticipated:

Pharmacodynamic Interactions

1. Ziprasidone should not be used with any drug that prolongs the QT interval .
2. Given the primary CNS effects of ziprasidone, caution should be used when it is taken in combination with other centrally acting drugs.
3. Because of its potential for inducing hypotension, ziprasidone may enhance the effects of certain antihypertensive agents.
4. Ziprasidone may antagonize the effects of levodopa and dopamine agonists.

Pharmacokinetic Interactions

The Effect of Other Drugs on Ziprasidone

Carbamazepine Carbamazepine is an inducer of CYP3A4; administration of 200 mg BID for 21 days resulted in a decrease of approximately 35% in the AUC of ziprasidone. This effect may be greater when higher doses of carbamazepine are administered.

Ketoconazole Ketoconazole, a potent inhibitor of CYP3A4, at a dose of 400 mg QD for 5 days, increased the AUC and C _max of ziprasidone by about 35-40%. Other inhibitors of CYP3A4 would be expected to have similar effects.

Cimetidine Cimetidine at a dose of 800 mg QD for 2 days did not affect ziprasidone pharmacokinetics.

Antacid The coadministration of 30 mL of MAALOX with ziprasidone did not affect the pharmacokinetics of ziprasidone.

In addition, population pharmacokinetic analysis of schizophrenic patients enrolled in controlled clinical trials has not revealed evidence of any clinically significant pharmacokinetic interactions with benztropine, propranolol, or lorazepam.

Effect of Ziprasidone on Other Drugs

In vitro studies revealed little potential for ziprasidone to interfere with the metabolism of drugs cleared primarily by CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4, and little potential for drug interactions with ziprasidone due to displacement.

Lithium Ziprasidone at a dose of 40 mg BID administered concomitantly with lithium at a dose of 450 mg BID for 7 days did not affect the steady-state level or renal clearance of lithium.

Oral Contraceptives Ziprasidone at a dose of 20 mg BID did not affect the pharmacokinetics of concomitantly administered oral contraceptives, ethinylestradiol (0.03 mg) and levonorgestrel (0.15 mg).

Dextromethorphan Consistent with in vitro results, a study in normal healthy volunteers showed that ziprasidone did not alter the metabolism of dextromethorphan, a CYP2D6 model substrate, to its major metabolite, dextrorphan. There was no statistically significant change in the urinary dextromethorphan/dextrorphan ratio.