Gemcitabine: profile and news






Allos Therapeutics Reports 2005 Financial Results  07 Mar 2006
...the Company announced the publication of results from a pre-clinical study designed to compare the activity of a pralatrexate/gemcitabine combination relative ... - MSN Money

NCCN Announces Important Updates to Ovarian Cancer Clinical ...  07 Mar 2006
The regimens include gemcitabine (Gemzar, Lilly)/carboplatin (Paraplatin, Bristol Myers-Squibb) and carboplatin/paclitaxel (Taxol, Bristol Myers-Squibb). ... - Genetic Engineering News,

Point Therapeutics' Diabetes Program Presented at Keystone ...  07 Mar 2006
...cisplatin in metastatic melanoma, in combination with rituximab in advanced chronic lymphocytic leukemia, and in combination with gemcitabine in metastatic ... - Genetic Engineering News,

Millennium and Johnson & Johnson Pharmaceutical Research & ...  07 Mar 2006
...clinical trial results of VELCADE in NSCLC include: * Interim survival data from a Phase II study of VELCADE in combination with gemcitabine and carboplatin in ... - Yahoo! News (press release)

Gemcitabine Adds Benefit to Lung Cancer Chemotherapy  Feb 23, 2006
NEW YORK FEB 22, 2006 (Reuters Health) - Addition of gemcitabine to a standard chemotherapy regime in selected patients with non-small-cell lung cancer can ... - Cancerpage.com,

Scheduled Combination of Allos Therapeutics' Pralatrexate Plus ...  Feb 14, 2006
...publication of results from an Allos-sponsored pre-clinical study, designed to compare the activity of a pralatrexate (PDX)/gemcitabine combination relative to ... - PR Newswire (press release),

Threshold Pharmaceuticals Reports Fourth Quarter and Year End 2005 ...  Mar 1, 2006
...of glufosfamide for the second-line treatment of patients with pancreatic cancer and a Phase 2 study of glufosfamide in combination with gemcitabine for first ... - MSN Money

ImClone’s Erbitux Receives FDA Label In Head And Neck Cancer  Mar 2, 2006
Pharmaceuticals Inc., won approval for Tarceva in a second indication: advanced pancreatic cancer in treatment-naive patients in combination with gemcitabine. ... - BioWorld Online (subscription),

General Thoracic Surgery  Feb 9, 2006
OBJECTIVE: We report the preliminary results of a phase II trial undertaken to determine the feasibility and efficacy of gemcitabine and concurrent ... - The Journal of Thoracic and Cardiovascular Surgery

Combination of Alimta® and Gemzar® for Metastatic Breast Cancer  Feb 24, 2006
...of a phase II clinical trial published in the Annals of Oncology, the chemotherapy combination of Alimta® (pemetrexed) and Gemzar® (gemcitabine) produced a ... - Cancer Consultants (press release),

Lorus Announces the Presentation of Virulizin Phase 3 Clinical ...  Feb 1, 2006
The randomized, double-blind, multicenter phase 3 clinical trial compared Virulizin plus gemcitabine to placebo plus gemcitabine for the treatment of ... - DG News

The Cancer That Won't Quit  Feb 20, 2006
Cramer's Take) and co-marketed with Genentech (DNA:NYSE - commentary - research - Cramer's Take), was approved for use with gemcitabine chemotherapy for cancer ... - TheStreet.com

Coley Pharmaceutical Group Reports Fourth Quarter and Full Year ...  Feb 23, 2006
...of CPG 7909 (now known as PF-3512676) administered in combination with standard-of-care chemotherapy (paclitaxel/carboplatin or gemcitabine/cisplatin) as first ... - MSN Money

Lorus announces the presentation of Virulizin(R) Phase III ...  Feb 1, 2006
The randomized, double-blind, multicenter Phase III clinical trial compared Virulizin® plus gemcitabine to placebo plus gemcitabine for the treatment of ... - Yahoo! News (press release)

Optimising Herceptin-based Therapy in HER2-positive Metastatic ...  Feb 22, 2006
Another trial investigated trastuzumab/gemcitabine, but without any great success (ORRs <50%), as was the case for a pilot study on trastuzumab/capecitabine ... - DG News

MEDINET, Yokohama City University, Shin-Yokohama Medical Clinic ...  Feb 21, 2006
Specifically, they aim to assess the safety and efficacy of combination therapy of gemcitabine and activated autolymphocyte therapy in patients with ... - Japan Corporate News (press release),

Phenoxodiol Modulates Apoptotic Pathways in Cancer Cells  Feb 23, 2006
Pretreatment of epithelial ovarian carcinoma cells with phenoxodiol sensitized them to chemotherapy with carboplatin, paclitaxel, and gemcitabine by lowering ... - Cancerpage.com,

GEMOX Active in Recurrent Pancreatic Cancer  Feb 24, 2006
According to a an article recently published in the British Journal of Cancer, the chemotherapy combination consisting of Gemzar® (gemcitabine) plus Eloxatin ... - Cancer Consultants (press release),

Lorus shares up 18% on Virulizin trial results  Feb 1, 2006
Lilly is the manufacturer of the main drug used for pancreatic cancer, which is called gemcitabine or GEMZAR," he said in a telephone interview from Vancouver. ... - Toronto Star,

Eli Lilly sues to block generic Gemzar production  Feb 17, 2006
Lilly contends Teva would infringe two patents, one for the active ingredient gemcitabine and the other for using Gemzar to treat tumors. ... - Indianapolis Star,

Lorus' pancreatic cancer drug shows benefit  Feb 1, 2006
The late-stage trial compared Virulizin(R) plus gemcitabine to placebo plus gemcitabine for the treatment of chemonaive patients with locally advanced or ... - Reuters

Lung Cancer Drug Pipeline Update Lists All 243 Drugs for Lung ...  Feb 16, 2006
...chemotherapy drugs go off patent before 2012, Aventis' Taxotere (docetaxel), Bristol-Myers Squibb's Paraplatin (carboplatin) and Eli Lilly's Gemzar (gemcitabine ... - Genetic Engineering News,

Innovate Oncology to merge with Avantogen subsidiary  Feb 3, 2006
...in the clinical pilot study in which thirteen pancreatic cancer patients in stage III and VI of disease were treated with RP101, and gemcitabine plus cisplatin ... - Pharmaceutical Business Review

Therion completes enrollment in pancreatic cancer trial  Feb 13, 2006
...of a special protocol assessment (SPA) provided by the FDA, has enrolled 250 patients with pancreatic cancer who had received prior treatment with gemcitabine. ... - Pharmaceutical Business Review

Pancreatic cancer vax set for 06 filing  Feb 10, 2006
The trial will assess overall survivial in patients with metastatic pancreatic cancer who had received prior treatment with gemcitabine. ... - United Press International

Avantogen And Innovate Merge Key Oncology Program, RP101, RP101  Feb 7, 2006
...pilot study of RESprotect in which thirteen pancreatic cancer patients in stage III and VI of disease were treated with RP101, and gemcitabine plus cisplatin. ... - Medical News Today (press release),

Gemzar® Effective in Advanced Cutaneous T-Cell Lymphoma  Feb 3, 2006
According to a recent article published in the journal Cancer, treatment with the chemotherapy agent Gemzar® (gemcitabine) provides effective and well ... - Cancer Consultants (press release),

Meditech to Showcase Cancer Research at International Forum  Feb 2, 2006
...the treatment of. ?? Evaluation of hyaluronic acid as a pharmacologically active excipient for gemcitabine in the. ?? The effect of ... - PharmaLive.com (press release),

Pancreatic cancer a ’silent’ disease  Feb 13, 2006
Just after the FDA approved Tarceva’s use in combination with the chemotherapy drug gemcitabine in certain cases, Johns Hopkins University researchers ... - Ocala.com,

Therion Completes Phase III Enrollment for PANVAC-VF Pancreatic ...  Feb 10, 2006
...of a Special Protocol Assessment (SPA) provided by the FDA, has enrolled 250 patients with pancreatic cancer who had received prior treatment with gemcitabine. ... - PR Newswire (press release),

ArQule Reports Fiscal 2005 Year End and Fourth Quarter Results  Feb 9, 2006
...will comprise two monotherapy studies, in leiomyosarcoma and in head and neck cancer, and two combination studies, in pancreatic cancer with gemcitabine and in ... - Business Wire (press release),

Gemzar® May Improve Results of Taxol®/Paraplatin® Regimen for ...  Feb 9, 2006
Researchers from Italy have reported that the addition Gemzar® (gemcitabine) to Taxol (paclitaxel)/Paraplatin (carboplatin) improves survival of patients with ... - Cancer Consultants (press release),

How Competition Can Compromise the Cause for Kidney Cancer ...  Feb 15, 2006
...discoveries in another.�. According to the editorial, a good example of this principle in action is the drug gemcitabine. First approved ... - PR Web (press release),

(PZ) Pharmexa Files the First Phase III Application  Feb 1, 2006
The trial will test GV1001 side by side with the current standard treatment, gemcitabine (a chemotherapeutic drug approved for the treatment of pancreatic ... - Houston Chronicle,

Good Results with Cytoreductive Surgery Plus Intraperitoneal ...  Feb 1, 2006
The chemotherapy regimen included topotecan and gemcitabine administered according to the Northeastern German Society of Gynecologic Oncology (NOGGO) scheme. ... - DG News


Other information


Indication
For the first-line treatment of patients with metastatic breast cancer , locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer and as first-line treatment for patients with adenocarcinoma of the pancreas

Pharmacology
Gemcitabine is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (or DNA synthesis phase of the cell cycle), stopping normal development and division. Gemcitabine blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Gemcitabine blocks the incorporation of the thymidine nucleotide into the DNA strand.

Mechanism Of Action
Gemcitabine inhibits thymidylate synthetase, leading to inhibition of DNA synthesis and cell death. Gemcitabine is a prodrug so activity occurs as a result of intracellular conversion to two active metabolites, gemcitabine diphosphate and gemcitabine triphosphate by deoxycitidine kinase. Gemcitabine diphosphate inhibits ribonucleotide reductase, the enzyme responsible for catalyzing synthesis of deoxynucleoside triphosphates required for DNA synthesis. Gemcitabine triphosphate (diflurorodeoxycytidine triphosphate) competes with endogenous deoxynucleoside triphosphates for incorporation into DNA.

Drug Category
Radiation-Sensitizing Agents; Immunosuppressive Agents; Antivirals; Antimetabolites; Antineoplastic Agents; ATC:L01BC05

Brand Names/Synonyms
CCRIS 8984; DDFC; Dfdc; GEO; Gemcin; Gemcitabina [Inn-Spanish]; Gemcitabine; Gemcitabine Hcl; Gemcitabine Hydrochloride; Gemcitabine [Usan:Ban:Inn]; Gemcitabinum [Inn-Latin]; Gemtro; Gemzar

Dosage Forms
lyophilized powder for injection

Absorption
100%

Interactions
-->Interactions for Gemcitabine:

No specific drug interaction studies have been conducted. For information on the pharmacokinetics of Gemzar and cisplatin in combination, see Drug Interactions under CLINICAL PHARMACOLOGY section.



Chemical IUPAC Name
4-amino-1-[3,3-difluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-pyrimidin-2-one

Chemical Formula
C9H11F2N3O4

Half Life
short infusions ranged from 32 to 94 minutes, and the value for long infusions vary from 245 to 638 minutes, depending on age and gender

Drug Type
Approved Drug

# Accession No
APRD00201

CAS Registry Number
95058-81-4

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org