Gantrisin: profile and news

Many meds don't mix with the sun Sep 21, 2005
...saquinavir (Fortovase, Invirase), sulfamethoxazole/tri-methoprim (Bactrim), sulfasala-zine (Azulfidine), sulfisoxazole (Gantrisin), terconazole (Terazol ... - Pioneer Press,

Medical Self-Care Jul 30, 2005
...and then attacking with an appropriate medication. The typical prescription for UTI is a sulfa drug, either Gantrisin or Azo-Gantrisin. ... - Mother Earth News

Other information

Indication
Treatment of severe, repeated, or long-lasting urinary tract infections;Bacterial meningitis;Middle ear infections;Toxoplasmosis;Malaria;Other bacterial infections

Pharmacology
Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Mechanism Of Action
Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Drug Category
Anti-Infectives; Sulfonamides;

Brand Names/Synonyms
Accuzole; Alphazole; Amidoxal; Astrazolo; Azo Gantrisin; Azosulfizin; Bactesulf; Barazae; Chemouag; Cosoxazole; Dorsulfan; Dorsulfan Warthausen; Entusil; Entusul; G-Sox; Ganda; Gantrisin; Gantrisine; Gantrisona; Gantrosan; Isoxamin; J-Sul; Koro-Sulf; NU 445; Neazolin; Neoxazol; Norilgan-S; Novazolo; Novosaxazole; Pancid; Renosulfan; Resoxol; Roxosul; Roxosul Tablets; Roxoxol; SI; Saxosozine; Sk-Soxazole; Sodizole; Sosol; Soxamide; Soxazole; Soxisol; Soxitabs; Soxo; Soxomide; Stansin; Sulbio; Sulfadimethylisoxazole; Sulfafurazol; Sulfafurazole; Sulfagan; Sulfagen; Sulfaisoxazole; Sulfalar; Sulfapolar; Sulfasan; Sulfasol; Sulfasoxazole; Sulfazin; Sulfisin; Sulfisonazole; Sulfisoxasole; Sulfisoxazol; Sulfisoxazole; Sulfisoxazole Dialamine; Sulfisoxazole Diolamine; Sulfizin; Sulfizol; Sulfizole; Sulfofurazole; Sulfoxol; Suloxsol; Sulphadimethylisoxazole; Sulphafuraz; Sulphafurazol; Sulphafurazole; Sulphafurazolum; Sulphaisoxazole; Sulphisoxazol; Sulphofurazole; Sulsoxin; Thiasin; Tl-Azole; U.S.-67; Unisulf; Urisoxin; Uritrisin; Urogan; V-Sul; Vagilia

Dosage Forms
TABLET; Oral Suspension; Eye Drops

Absorption
Not Available

Interactions
[an error occurred while processing this directive]

Chemical IUPAC Name
4-amino-N-(3,4-dimethyloxazol-5-yl)-benzenesulfonamide

Chemical Formula
C11H13N3O3S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00595

CAS Registry Number
127-69-5