Fosamax: profile and news
A PRONOUNCED IMPROVEMENT IN HEALTH 07 Mar 2006
...all about. Her dad was only 45 when he died of a heart attack. For weeks before, he had been prescribed valium for stress. The 43 ... - Glasgow Daily Record,
Called on the carpet 07 Mar 2006
...(A Japanese manufacturer sent them for good luck). No wonder Adams looked like she needed a Valium. “It's dizzying,� the “Junebug� star gasped. ... - San Diego Union Tribune,
Spotting the changes since we chose life 07 Mar 2006
..."I started stealing cars, smoking cannabis, drinking, taking Valium," he says. "I started stealing from my family for my cannabis and tablets." He was only 11. ... - Scotsman,
TV Review - Daz Sampson Wins Eurovision: Making Your Mind Up 07 Mar 2006
Also performing on Making Your Mind Up, we saw Four Story. Succinctly summed up by a 'judge' as "the musical equivalent of Valium". ... - hecklerspray,
Thief stole hospital equipment 07 Mar 2006
His memory was hazy, he said, because he had taken Valium and heroin. None of the computer equipment – worth £620 in total – was recovered. ... - News & Star,
IPD wants to fire officer charged in Valium case Feb 25, 2006
...pay Friday, and police officials say they will seek his firing in the wake of his arrest earlier this week for allegedly using an altered Valium prescription. ... - Indianapolis Star,
TennCare nixes pay for Valium Feb 24, 2006
NASHVILLE — TennCare is no longer paying for Valium and some other drugs used to treat anxiety and seizures, a move that some health care professionals ... - Knoxville News Sentinel (subscription),
Moms at War: Attacking Each Other, and Themselves Mar 5, 2006
The chairman knew my first name. As much as I loved my work, rocking our newborn son felt like mainlining Valium. I thought I might stay home. ... - Washington Post,
Thinking of Skipping November Elections? Ready for Nancy Pelosi ... Mar 5, 2006
This is far more serious than a wake-up call: Its a veritable political tsunami that will cause a rush on Valium and vomit bags in GOP congressional districts ... - ChronWatch,
Rhett Miller Finds His Way Feb 28, 2006
If I hadn't taken the entire bottom of Valium in addition to drinking the lighter fluid, I wouldn't have survived, because the Valium slowed down my system ... - Rolling Stone
Crazy for Cricket Mar 6, 2006
...million. Why is a sport that American comedian Robin Williams memorably described as "baseball on valium" suddenly such big business? ... - TIME
Driven to distraction Mar 5, 2006
Nicotine, valium, vicodin, marijuana, ecstasy, alcohol and cocaine. The words of the Queens of the Stone Age song The Feel Good ... - Oxford Student,
George Michael on Drug Arrest: My Own Stupid Fault Feb 27, 2006
...reports. Cannabis, anabolic steroids and tranquillisers such as Valium are Class C drugs, as well as some mild amphetamines. Possession ... - Fashion Monitor Toronto,
The 45-Minute Facelift Feb 28, 2006
Patients are given some Valium to help them relax. Purple pen marks show Dr. Farias how far to loosen the face of the skin surgically. ... - WLTX.com,
Chris Penn's Toxicology Report Reveals Drug Cocktail Feb 27, 2006
...drugs in his system. Besides marijuana and morphine, Valium, codeine and an antihistamine were also found in his system. The 40-year ... - All Headline News
Chris Penn had marijuana in his system Feb 27, 2006
Toxicologists investigating the death of the 'Reservoir Dogs' actor have said his body contained marijuana, morphine, Valium and codeine when he was found in ... - Tonight,
Tragic Death Of Sean Penn Brother, Chris, Blamed On Drugs Feb 27, 2006
...drugs in his system. Besides marijuana and morphine, Penn's system also contained Valium, codeine and an antihistamine. He was also ... - Post Chronicle
Bunyip hunt Mar 1, 2006
My wife called the ambulance around 3am. At the hospital, Dr No. 2 shot me full of morphine and Valium and examined me. Verdict: no permanent damage. ... - Sydney Morning Herald,
Email from TennCare spokeswoman Marilyn Elam explaining state's ... Feb 23, 2006
...effects of these two drugs. Examples of the most common brand names in this drug class are Valium and Xantax. These drugs are highly ... - Ashland City Times,
Hustonville woman charged with using teens to sell pills Feb 24, 2006
According to police, the two high school students said that Stevenson supplied them with Lortab, Xanax and Valium to sell. During ... - Danville Advocate,
IPD officer suspended in drug case Feb 24, 2006
...pharmacist, police said. Kuykendall, 34, tried to change a prescription for 20 Valium to read 50 Valium, police said. Polices said ... - Indianapolis Star,
Policeman charged with prescription forgery Feb 21, 2006
...said. Sheriff's Capt. Phil Burton said Kuykendall, 34, tried to change a prescription for 20 Valium to read 50 Valium. The pharmacist ... - Indianapolis Star,
Man arrested for forgery is IPD officer Feb 23, 2006
According to the Marion County Sheriff’s office police report, Kuykendall, allegedly altered a legitimate prescription for 20 Valium to read 50 Valium. ... - Mooresville / Decatur Times,
Murderer asks release from prison Feb 24, 2006
DOVER -- A woman convicted almost a quarter century ago of feeding her husband a Valium-laced macaroni salad before an accomplice fatally stabbed him 28 times ... - The News Journal,
IPD Officer Faces Felony Charges After Arrest At Pharmacy Feb 21, 2006
IPD officials said Kuykendall had a valid doctor's prescription for Valium, but pharmacists believe the prescription had been altered, changing the number of ... - INDYchannel.com,
Scams in the desert Mar 3, 2006
...strange grace notes. Some backyard dealers offer their artists prostitutes, Viagra, pornographic DVDs, even Valium. Good, quick ... - Australian,
Stop making sense Mar 4, 2006
He was in therapy for six months, took Valium (but is off it now) improved his diet, and - to the amazement of all - stopped smoking marijuana. ... - Guardian Unlimited,
Call it Bush cricket Mar 3, 2006
Although cricket has not gone down well with Americans, and Robin Williams describes it as baseball on valium, one hopes it is as great a pastime for Bush as ... - Trinidad & Tobago Express,
Seven arrested in meth bust Mar 3, 2006
...and charged with first-degree manufacturing of a controlled substance, second-degree possession of marijuana and possession of a controlled substance, valium. ... - Scottsboro Daily Sentinel,
Fruendt has a blast while ad-libbing for Bulldogs Mar 4, 2006
He no longer sprints up and down the sideline, pointing a finger this-a-way and motioning with his hands that-a-way like a wild man in dire need of Valium. ... - Aurora Beacon News,
Women need new, better tests for heart disease Mar 3, 2006
...when I had gone to my doctor and said, `I'm not feeling well,' '' she said. ``He said, `You're raising children. Take a Valium.'''. - Fort Wayne News Sentinel,
Midnight in Gainesville Mar 3, 2006
They sound like Franz Ferdinand on Valium sprinkled with a pinch of The Wallflowers — a semi-glam indie rock group with sharply clever lyrics we instantly ... - Hernando Today,
KILLER'S JAIL TERM 'RUBBISH' Mar 3, 2006
The court heard that a blood specimen taken from Grant revealed the presence of a drug. He said he had taken two valium tablets the night before. ... - Bristol Evening Post,
Medicines that made a difference Mar 3, 2006
Valium Benzodiazepine tranquillisers were seen as wonder treatments for emotional disorders such as anxiety when they were launched on the world in the early ... - Saga Health News,
Report: Penn had multiple drugs in system Feb 22, 2006
LOS ANGELES, CA, United States (UPI) -- A toxicology report revealed marijuana, morphine, Valium and codeine were in actor Chris Penn`s system when he died ... - Monsters and Critics.com,
PENN DRUG MIX Feb 23, 2006
ACTOR Chris Penn had marijuana, morphine, Valium and high-strength codeine in his system when he died, a toxicology report has revealed. ... - Mirror.co.uk,
Toxicologist: Penn had drugs in his system Feb 24, 2006
Access Hollywood is reporting that a toxicology report has found that actor Chris Penn's body had Valium, morphine and marijuana along with an antihistamine ... - AZ Central.com,
IPD Officer Suspended After Pharmacy Arrest Feb 24, 2006
Kuykendall was arrested after a CVS worker alerted authorities to a Valium prescription the officer tried to fill, police said. ... - INDYchannel.com,
TennCare Follows Feds, won't Cover Some Anxiety, Seizure Drugs Feb 24, 2006
NASHVILLE, Tenn -TennCare is no longer paying for Valium and some other drugs used to treat anxiety and seizures. It's a move that ... - WREG,
IPD Officer Arrested on Prescription Suspicions Feb 21, 2006
Officer Kuykendall is an eight year veteran of IPD. Now he faces felony charges, accused of altering a valid prescription for Valium. ... - WISH,
Penn Intoxicated Before Death Feb 24, 2006
...in his system. Besides marijuana and morphine, Chris Penn's system also contained Valium, codeine and an antihistamine. The 40-year ... - Hollywood.com
TennCare won't pay for anxiety, seizure drugs Feb 24, 2006
TennCare is no longer paying for Valium and some other drugs used to treat anxiety and seizures. It's a move some health care professionals question as unsafe. ... - WVLT,
Teens and controlled substances Feb 24, 2006
...you. With so many adults relying on Lortabs, Valium and other pills, our kids view them as harmless as cigarettes or tobacco dip. ... - Danville Advocate,
IPD Officer Arrested On Prescription Suspicions Feb 20, 2006
Indianapolis Police department. Now he faces felony charges, accused of altering a valid prescription for Valium. "My understanding ... - WISH,
Other information
Indication
For the treatment and prevention of osteoporosis in women and Paget's disease of bone in both men and women
Pharmacology
Alendronate, a second-generation bisphosphonate is the first member of a group of drugs which strengthens bone. Alendronate is used to reduce hypercalcemia in tumor-induced bone disease, to treat corticosteroid-induced osteoporosis and Paget's disease, and to prevent osteoporosis in postmenopausal women.
Mechanism Of Action
The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Alendronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.
Drug Category
Antiresorptives; Bisphosphonates; Antihypocalcemic Agents; ATC:M05BA04
Brand Names/Synonyms
ALENDRONIC ACID; Acide Alendronique [Inn-French]; Acido Alendronico [Inn-Spanish]; Acidum Alendronicum [Inn-Latin]; Adronat; Alendronate; Alendronate Sodium; Alendronic Acid; Alendronic Acid [Ban:Inn]; Alendros; Arendal; CHEMBANK1709; Fosamax; MK 217; Onclast
Dosage Forms
10 mg (Rx) Fosamax lactose 40 mg (Rx) Fosamax lactose
Absorption
Relative to an intravenous (IV) reference dose, the mean oral bioavailability of alendronate in women was 0.7% for doses ranging from 5 to 40 mg when administered after an overnight fast and two hours before a standardized breakfast. Oral bioavailability of the 10 mg tablet in men (0.59%) was similar to that in women (0.78%) when administered after an overnight fast and 2 hours before breakfast.
Interactions
Intravenous ranitidine was shown to double the bioavailability of oral alendronate.
The clinical significance of this increased bioavailability and
whether similar increases will occur in patients given oral H2-antagonists
is unknown; no other specific drug interaction studies were performed.
Products containing calcium and other multivalent cations likely will interfere
with absorption of alendronate.
Chemical IUPAC Name
(4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid
Chemical Formula
C4H13NO7P2
Half Life
>10 years
Drug Type
Approved Drug
# Accession No
APRD00561
CAS Registry Number
66376-36-1