Fortovase: profile and news






Roche To Stop Selling Protease Inhibitor Fortovase Because of ...  Feb 8, 2006
15 it will stop selling its protease inhibitor Fortovase -- known generically as saquinavir -- in the US because of decreased demand for the drug and increased ... - Kaiser network.org,

Roche discontinues marketing of anti-HIV drug Fortovase  Feb 8, 2006
Following through on plans announced in late 2005, drugmaker Roche on Monday halted US sales of its HIV protease inhibitor Fortovase, citing low demand for the ... - The Advocate,

Roche to Focus Resources on Availability of Invirase, Now ...  Feb 6, 2006
February 6, 2006 -- Roche today announced that effective February 15, 2006, the company will discontinue the US sale and distribution of Fortovase®, the soft ... - DG News

Roche to Focus Resources on Availability of INVIRASE(R), Now ...  Feb 6, 2006
6 /PRNewswire/ -- Roche today announced that effective February 15, 2006, the company will discontinue the US sale and distribution of Fortovase(R), the soft ... - International News Service,

Roche to Focus Resources on Availability of INVIRASE(R), Now ...  Feb 6, 2006
...- Company Voluntarily Ceases Sale and Distribution of Fortovase(R) In the US - NUTLEY, NJ, Feb. 6 /PRNewswire/ -- Roche today announced ... - PR Newswire (press release),

UPDATE 1-Roche to discontinue US sales of AIDS drug  Feb 6, 2006
YORK, Feb 6 (Reuters) - Roche Holding AG (ROG.VX: Quote, Profile, Research) said on Monday it will discontinue US sales of its HIV drug Fortovase as another ... - Reuters

Roche to discontinue HIV treatment  Feb 8, 2006
Swiss drug manufacturer Roche is to discontinue US sales of its HIV protease inhibitor Fortovase, a soft-gel formulation of the active ingredient saquinavir. ... - Pharmaceutical Business Review

Roche discontinues marketing of anti-HIV drug Fortovase  09 Feb 2006
Following through on plans announced in late 2005, drugmaker Roche on Monday halted US sales of its HIV protease inhibitor Fortovase, citing low demand for the ... - The Advocate,

Roche to discontinue HIV treatment  09 Feb 2006
Swiss drug manufacturer Roche is to discontinue US sales of its HIV protease inhibitor Fortovase, a soft-gel formulation of the active ingredient saquinavir. ... - Pharmaceutical Business Review

Roche To Stop Selling Protease Inhibitor Fortovase Because of ...  Feb 8, 2006
15 it will stop selling its protease inhibitor Fortovase -- known generically as saquinavir -- in the US because of decreased demand for the drug and increased ... - Kaiser network.org,

Roche to Focus Resources on Availability of Invirase, Now ...  Feb 6, 2006
February 6, 2006 -- Roche today announced that effective February 15, 2006, the company will discontinue the US sale and distribution of Fortovase®, the soft ... - DG News

Roche to Focus Resources on Availability of INVIRASE(R), Now ...  Feb 6, 2006
6 /PRNewswire/ -- Roche today announced that effective February 15, 2006, the company will discontinue the US sale and distribution of Fortovase(R), the soft ... - International News Service,

UPDATE 1-Roche to discontinue US sales of AIDS drug  Feb 6, 2006
YORK, Feb 6 (Reuters) - Roche Holding AG (ROG.VX: Quote, Profile, Research) said on Monday it will discontinue US sales of its HIV drug Fortovase as another ... - Reuters

Roche to Focus Resources on Availability of INVIRASE(R), Now ...  Feb 6, 2006
...- Company Voluntarily Ceases Sale and Distribution of Fortovase(R) In the US - NUTLEY, NJ, Feb. 6 /PRNewswire/ -- Roche today announced ... - PR Newswire (press release),

Tipranavir continues to show benefit in treatment-experienced ...  Nov 30, 2005
...based on resistance testing, from a choice of ritonavir-boosted lopinavir (Kaletra), indinavir (Crixivan), saquinavir (Invirase / Fortovase) or amprenavir ... - Aidsmap,

Bristol-Myers drug said cuts HIV rebound  Nov 18, 2005
...include GlaxoSmithKline PLC's Agenerase and Lexiva, Boehringer Ingelheim's Aptivus, Merck & Co.'s Crixivan, Roche's Holding Ltd.'s Fortovase and Invirase ... - BusinessWeek

Pharmasset Appoints Lynn B. Hill as Vice President, Alliance & ...  Sep 27, 2005
...development of Pegasys(r) for the treatment of Hepatitis B and Hepatitis C, and she contributed to the regulatory efforts for Invirase(r) and Fortovase(r) for ... - PharmaLive.com (press release),

Many meds don't mix with the sun  Sep 21, 2005
...norfloxacin (Noroxin), ofloxacin (Floxin), oxytetracycline (Terra-mycin), pyrazinamide, ritonavir (Norvir), saquinavir (Fortovase, Invirase), sulfamethoxazole ... - Pioneer Press,

Roche to Pull HIV/AIDS Drug Due to Dwindling Demand  Aug 4, 2005
Roche has decided to discontinue the sale and distribution of the HIV/AIDS drug Fortovase (saquinavir), the company announced today, because clinical demand ... - Daily News Central

New Study Results Find That Patients Treated With Boosted INVIRASE ...  Jul 25, 2005
The efficacy of INVIRASE with ritonavir or FORTOVASE (with or without ritonavir coadministration) has not been compared against the efficacy of antiretroviral ... - PharmaLive.com (press release)

Roche reinforces its HIV portfolio  Aug 2, 2005
Although Roche currently has five marketed HIV drugs - Fuzeon, Hivid, Invirase, Fortovase and Viracept (EU only) - Hivid and Fortovase are to be withdrawn from ... - Pharmaceutical Business Review

FDA List Serve - Fortovase Distribution to be Discontinued  May 27, 2005
...of Nutley, New Jersey, has issued a Dear Health Care Provider letter to inform the clinical community that commercial distribution of Fortovase, the 200-mg soft ... - PharmaLive.com (press release),

Committee for Medicinal Products for Human Use Post-authorisation ...  May 27, 2005
...opinion?? to recommend the variations to the terms of the marketing authorisation for the medicinal products Invirase and Fortovase. ... - PharmaLive.com (press release),

500mg Invirase tablet approved in Europe  May 27, 2005
The 500mg tablet cuts the pill burden substantially for people taking saquinavir, and is also better tolerated than the Fortovase formulation of saquinavir ... - Aidsmap,

Risk of diabetes increased by being HIV-positive and on HAART  Jun 3, 2005
...patients taking the four most commonly used protease inhibitors: ritonavir (Norvir), nelfinavir (Viracept), saquinavir (Invirase / Fortovase) and indinavir ... - Aidsmap,

Roche will discontinue two anti-HIV drugs  Apr 1, 2005
The company will stop production of its nucleoside reverse transcriptase inhibitor Hivid, also known as ddC, and its protease inhibitor Fortovase. ... - The Advocate,

US Approves Pegasys and Copegus as First Hepatitis C Treatment for ...  Feb 28, 2005
Medications developed by Roche for HIV include Fortovase and Invirase (two formulations of saquinavir), administered in combination with ritonavir, and ... - PharmaLive.com (press release),

HIV Drugs Pose Heart Risk  Feb 21, 2005
...and saquinavir. Brand names include Kaletra, Viracept, Crixivan, Norvir and Fortovase all pose the potential risk. The findings ... - 365Gay.com

HIV Patients May Be At Risk Of Heart Problems When Taking Protease ...  Feb 21, 2005
...indinavir, ritonavir and saquinavir. Brand names include Kaletra, Viracept, Crixivan, Norvir and Fortovase. The researchers emphasize ... - Science Daily (press release)


Other information


Indication
HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues

Pharmacology
Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs.

Mechanism Of Action
Saquinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.

Drug Category
Anti-HIV Agents; Anti-HIV Agents; ATC:J05AE01

Brand Names/Synonyms
Fortovase; Invirase; ROC; SAQUINAVIR; SQV; Saquinavir; Saquinavir Mesylate; Saquinavir [Usan]

Dosage Forms
INVIRASE (saquinavir mesylate) capsules and FORTOVASE (saquinavir) soft gelatin capsules

Absorption
Absolute bioavailability of saquinavir administered as INVIRASE averaged 4%

Interactions

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