Follitropin_Beta: profile and news

Akzo Nobel planning IPO for pharma business Feb 7, 2006
The increase was attributed to strong performances from fertility treatment Puregon/Follistim (follitropin beta) and contraceptive Nuvaring (etonogestrel ... - Pharma Times (subscription),

Follistim AQ Vial Now Available in 75 IU and 150 IU Presentations Oct 5, 2005
NJ, October 05, 2005 /PRNewswire/ -- Organon Pharmaceuticals Inc USA announces today the availability of Follistim(R) AQ (follitropin beta injection) 75 IU and ... - PharmaLive.com (press release),

Follistim(R) AQ Vial Now Available in 75 IU and 150 IU ... Oct 5, 2005
5 /PRNewswire/ -- Organon Pharmaceuticals Inc USA announces today the availability of Follistim® AQ (follitropin beta injection) 75 IU and 150 IU ... - Yahoo! News (press release)

Follistim AQ Vial Now Available in 75 IU and 150 IU Presentations Oct 5, 2005
ROSELAND, NJ -- October 5, 2005 -- Organon Pharmaceuticals Inc USA announces today the availability of Follistim(R) AQ (follitropin beta injection) 75 IU and ... - DG News

Follistim(R) AQ Cartridge, The First Pre-Mixed Fertility Treatment ... Aug 24, 2005
24 /PRNewswire/ -- Today Organon USA announces the availability of a 900 IU presentation of Follistim(R) AQ Cartridge (follitropin beta injection) for use with ... - PR Newswire (press release),

Other information

Indication
For treatment of female infertility

Pharmacology
Used for the treatment of female infertility, Follitropin beta or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of Follitropin beta is the primary hormone responsible for follicular recruitment and development.

Mechanism Of Action
FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.

Drug Category
Fertility Agents; gonadotropins (68:18.00)

Brand Names/Synonyms
Follitropin beta chain precursor;Follicle-stimulating hormone beta subunit;FSH-beta;FSH-B; Follistim (Organon)

Dosage Forms
SOLUTION

Absorption
Not Available

Interactions
Not Available

Chemical IUPAC Name
Human follicle stimulating hormone

Chemical Formula
C975H1513N267O304S26 >beta chain

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
BIOD00064

CAS Registry Number
9002-68-0