Fluphenazine_Decanoate: profile and news

Sildenafil in the Treatment of Antipsychotic-Induced Erectile ... Mar 2, 2006
N=3). They were taking the following antipsychotic medications: risperidone (N=17), olanzapine (N=12), clozapine (N=1), and fluphenazine decanoate (N=2). The ... - Am J Psychiatry (subscription)

Risk of Serious Harm and/or Death With Potential IV/SC ... Feb 15, 2006
...important safety information regarding possible signs, symptoms and treatment of overdose associated with fluphenazine (fluphenazine decanoate injection). ... - DG News

CATIE Phase I Helps Clinicians Tailor Schizophrenia Treatment Jan 12, 2006
...on patients who discontinued their Phase II treatment and were given open treatment with clozapine, one of the atypicals, fluphenazine decanoate (Prolixin) or ... - Psychiatric Times,

Economic Grand Rounds: Allocating Funds for Medications and ... Jul 14, 2005
These patients were being treated with first-generation depot antipsychotics (haloperidol or fluphenazine decanoate) but were being considered for a trial of ... - Psychiatric Services (subscription)

INVITED COMMENTARY ON... WHY AREN'T DEPOT ANTIPSYCHOTICS ... Apr 29, 2005
...schizophrenic patients. Relapse analyses of a two-year controlled study of fluphenazine decanoate and fluphenazine hydrochloride. Archives ... - Adv Psychiatric Treat (subscription)

Other information

Indication
For management of manifestations of psychotic disorders.

Pharmacology
Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.

Mechanism Of Action
Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Drug Category
Antipsychotics; Phenothiazines; ATC:N05AB02

Brand Names/Synonyms
Anatensol; Apo-Fluphenazine; Elinol; Fluorfenazine; Fluorophenazine; Fluorphenazine; Fluphenazine; Fluphenazine Decanoate; Fluphenazine Hcl; Modecate; Modecate Concentrate; Moditen; Moditen Enanthate; Moditen Hcl; Omca; Pacinol; Permitil; Permitil Concentrate; Perphenazine; Pms Fluphenazine; Prolixin; Prolixin Concentrate; Prolixin Decanoate; Prolixin Enanthate; Prolixine; S 94; SQ 4918; Sevinol; Siqualine; Siqualon; Tensofin; Triflumethazine; Valamina; Vespazine; Yespazine

Dosage Forms
LIQUID

Absorption
Not Available

Interactions
Interactions for Fluphenazine:

No information provided.

Chemical IUPAC Name
2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol

Chemical Formula
C22H26F3N3OS

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00633

CAS Registry Number
69-23-8