Fluphenazine: profile and news

Risk of Serious Harm and/or Death With Potential IV/SC ... Feb 15, 2006
Some vials of Octreotide Acetate Omega 500 mcg/mL Lot 5J970 might contain fluphenazine 100 mg/mL as a result of a labelling error during the manufacturing ... - DG News

Reducing Nonadherence: New Formulations of Antipsychotic ... Feb 27, 2006
Long-acting injectable medications have been available for many years in the United States (eg, fluphenazine [Modecate] and haloperidol [Haldol]). ... - Psychiatric Times,

Sildenafil in the Treatment of Antipsychotic-Induced Erectile ... Mar 2, 2006
...disorder (N=3). They were taking the following antipsychotic medications: risperidone (N=17), olanzapine (N=12), clozapine (N=1), and fluphenazine decanoate (N ... - Am J Psychiatry (subscription)

Other information

Indication
For management of manifestations of psychotic disorders.

Pharmacology
Fluphenazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Fluphenazine has not been shown effective in the management of behaviorial complications in patients with mental retardation.

Mechanism Of Action
Fluphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Drug Category
Antipsychotics; Phenothiazines; ATC:N05AB02

Brand Names/Synonyms
Anatensol; Apo-Fluphenazine; Elinol; Fluorfenazine; Fluorophenazine; Fluorphenazine; Fluphenazine; Fluphenazine Decanoate; Fluphenazine Hcl; Modecate; Modecate Concentrate; Moditen; Moditen Enanthate; Moditen Hcl; Omca; Pacinol; Permitil; Permitil Concentrate; Perphenazine; Pms Fluphenazine; Prolixin; Prolixin Concentrate; Prolixin Decanoate; Prolixin Enanthate; Prolixine; S 94; SQ 4918; Sevinol; Siqualine; Siqualon; Tensofin; Triflumethazine; Valamina; Vespazine; Yespazine

Dosage Forms
LIQUID

Absorption
Not Available

Interactions
Interactions for Fluphenazine:

No information provided.

Chemical IUPAC Name
2-[4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol

Chemical Formula
C22H26F3N3OS

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00633

CAS Registry Number
69-23-8