Fludara: profile and news
Treatment Response Linked with Symptom Improvement in CLL Feb 22, 2006
This trial included 241 patients with relapsed or refractory CLL; approximately half was treated with the chemotherapy agents Fludara® (fludarabine) and ... - Cancer Consultants (press release),
Addition of Cyclophosphamide to Fludarabine Improves Progression ... Jan 31, 2006
According to a recent article published in the journal Blood, the addition of cyclophosphamide (Cytoxan®) to fludarabine (Fludara®) improves anticancer ... - Cancer Consultants (press release),
Biopharmaceutical Industry Leader Joins Acologix, Inc. Board of ... Feb 15, 2006
As General Manager of Therapeutics at Berlex, Mr. Robin was responsible for the clinical development and commercialization of drugs such as Fludara(R) for ... - PharmaLive.com (press release),
Favrille Reports Fourth Quarter and Year End 2005 Financial ... Feb 9, 2006
...the last 10 years specifically dedicated to commercializing oncology products and managing leading brands such as Rituxan, Herceptin®, Fludara® and Taxotere ... - Yahoo! News (press release)
Favrille Reports Fourth Quarter and Year End 2005 Financial ... 09 Feb 2006
...the last 10 years specifically dedicated to commercializing oncology products and managing leading brands such as Rituxan, Herceptin®, Fludara® and Taxotere ... - Yahoo! News (press release)
Addition of Cyclophosphamide to Fludarabine Improves Progression ... Jan 31, 2006
According to a recent article published in the journal Blood, the addition of cyclophosphamide (Cytoxan®) to fludarabine (Fludara®) improves anticancer ... - Cancer Consultants (press release),
Genetic Features Predict Response of Chronic Lymphocytic Leukemia ... Jan 20, 2006
...among patients with chronic lymphocytic leukemia who are treated with the standard therapeutic combination of Rituxan® (rituximab) and Fludara® (fludarabine ... - Cancer Consultants (press release),
Revlimid® Shows Activity in Chronic Lymphocytic Leukemia Jan 26, 2006
More than 50% of the patients had disease progression following treatment with the commonly used chemotherapy agent Fludara® (fludarabine). ... - Cancer Consultants (press release),
Thalidomide Plus Fludara® Promising in CLL Nov 14, 2005
According to a recent article published in the journal Blood, the treatment combination of thalidomide plus Fludara® (fludarabine) appears promising for ... - Cancer Consultants (press release),
Nipent®/Cytoxan®/Rituxan® Shows High Activity in High-Risk ... Nov 23, 2005
November. One of the most active drug combinations for the treatment of CLL is Fludara® (fludarabine), Cytoxan and Rituxan. The ... - Cancer Consultants (press release),
Favrille Announces Appointment of David Guy as Chief Commercial ... Dec 5, 2005
10 years of experience specifically dedicated to commercializing oncology products and managing leading brands such as Rituxan, Herceptin(R), Fludara(R) and ... - PharmaLive.com (press release),
Favrille Announces Appointment of David Guy as Chief Commercial ... Dec 5, 2005
...years of experience specifically dedicated to commercializing oncology products and managing leading brands such as Rituxan, Herceptin®, Fludara® and Taxotere ... - Yahoo! News (press release)
Fludara® Plus Campath® Effective for Refractory Chronic ... Sep 15, 2005
...in an early on-line version of the Journal of Clinical Oncology, the treatment combination consisting of the chemotherapy agent Fludara (fludarabine) plus the ... - Cancer Consultants (press release),
Chemotherapy and Rituxan® Followed by Autologous Stem Cell ... Oct 5, 2005
However, there have been many additions to available therapies for low-grade lymphomas, including Rituxan®, Fludara® (fludarabine), and radioactive ... - Cancer Consultants (press release),
Genasense® Reduces Risk of Cancer Progression in Chronic ... Sep 20, 2005
Treatment for CLL may include chemotherapy (often including the agent Fludara), radiation therapy, biological therapy, and/or stem cell transplantation. ... - Cancer Consultants (press release),
CLAG-M Regimen Effective in Refractory Acute Myeloid Leukemia Sep 2, 2005
...trial to evaluate the treatment regimen CLAG-M. CLAG-M includes the chemotherapy agents cladribine (Leustatin®), fludarabine (Fludara®), cytarabine (Cytosar-U ... - Cancer Consultants (press release),
Pharma firms find oncology lucrative Aug 4, 2005
Zydus Cadila launched its Fludarabine (Fludara Oral) in June 2005. Swiss firm Roche plans to launch its cancer drug Avastin in India soon. ... - Financial Express
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Fludara®, Cyclophosphamide and Rituxan® Active in Early and Late ... Jun 24, 2005
Researchers from MD Anderson Cancer Center have reported that a regimen of Fludara (fludarabine), cyclophosphamide, and Rituxan (rituximab) produces results ... - Cancer Consultants (press release)
Regimen Consisting of Fludara®, Cytoxan® and Rituxan® Highly ... Jun 23, 2005
...to results recently published in the Journal of Clinical Oncology, the chemotherapy treatment combination consisting of the agents Fludara (fludarabine) and ... - Cancer Consultants (press release)
German Remedies launches Fludara Oral for lymphocytic leukaemia Jun 17, 2005
German Remedies, a part of the Zydus group, has launched Fludara Oral (fludarabine) for the treatment of chronic lymphocytic leukaemia. ... - Express Pharma Pulse
Hope for patients with Chronic lymphocytic leukemia Jun 29, 2005
For the first time in India ,German Remedies, a part of the Zydus group, has launched Fludara Oral (fludarabine) for the treatment of chronic lymphocytic ... - MedIndia
Allogeneic Mini-Transplant Effective for Refractory Chronic ... Jun 30, 2005
...evaluate the effectiveness of a mini-transplant in patients with CLL who had stopped responding to the commonly used chemotherapy agent Fludara® (fludarabine ... - Cancer Consultants (press release)
GRL to introduce new cancer drugs Jun 16, 2005
GRL recently launched a drug called Fludara Oral for the treatment of chronic lymphocytic leukaemia (a cancer of the lymphocytes). ... - Newindpress,
Fludara®, Cyclophosphamide and Rituxan® Active in Early and Late ... Jun 24, 2005
Researchers from MD Anderson Cancer Center have reported that a regimen of Fludara (fludarabine), cyclophosphamide, and Rituxan (rituximab) produces results ... - Cancer Consultants (press release),
Regimen Consisting of Fludara®, Cytoxan® and Rituxan® Highly ... Jun 23, 2005
...to results recently published in the Journal of Clinical Oncology, the chemotherapy treatment combination consisting of the agents Fludara (fludarabine) and ... - Cancer Consultants (press release),
German Remedies launches Fludara Oral for lymphocytic leukaemia Jun 17, 2005
German Remedies, a part of the Zydus group, has launched Fludara Oral (fludarabine) for the treatment of chronic lymphocytic leukaemia. ... - Express Pharma Pulse,
German Remedies launches Fludara Oral Jun 9, 2005
Cadila Healthcare Ltd has announced that German Remedies, a part of the Zydus Group, has launched Fludara Oral (Fludarabine) for the treatment of Chronic ... - Sify,
German Remedies launches Fludara Oral Jun 9, 2005
German Remedies, a part of the Zydus Group, has launched Fludara Oral (Fludarabine) for the treatment of Chronic Lymphocytic Leukaemia. ... - Business Standard,
GRL to introduce new cancer drugs Jun 16, 2005
GRL recently launched a drug called Fludara Oral for the treatment of chronic lymphocytic leukaemia (a cancer of the lymphocytes). ... - Newindpress,
Cadila launches leukemia drug Jun 9, 2005
Fludara, an orally administered drug, is being introduced for the first time in India and is a product of Berlex Inc, a US affiliate of Schering AG Germany ... - Sify,
German Remedies launches leukaemia drug Jun 9, 2005
German Remedies, part of the Ahmedabad-based Zydus group, has launched Fludara Oral (Fludarabine) for treatment of chronic lymphocytic leukaemia. ... - Business Standard,
Sensex slips 22 points, bank stocks too shed gains Jun 9, 2005
German Remedies, a part of the Zydus Group, has launched Fludara Oral (Fludarabine) for the treatment of Chronic Lymphocytic Leukaemia. ... - Myiris.com,
Therapy Involving Patient’s Immune Cells Effective for ... Apr 7, 2005
Prior to infusion of the T-cells, patients were first treated with chemotherapy consisting of Fludara® (fludarabine) and cyclophosphamide (Cytoxan®) to ... - Cancer Consultants,
Therapy Involving Patient’s Immune Cells Effective for ... 08 Apr 2005
Prior to infusion of the T-cells, patients were first treated with chemotherapy consisting of Fludara® (fludarabine) and cyclophosphamide (Cytoxan®) to ... - Cancer Consultants (press release),
Other information
Indication
For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Pharmacology
Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.
Mechanism Of Action
Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Drug Category
Immunosuppressive Agents; Antimetabolites; Antineoplastic Agents; ATC:L01BB05
Brand Names/Synonyms
FAMP; Fludara; Fludarabine; Fludarabine 5'-Monophosphate; Fludarabine Monophosphate; Fludarabine Phosphate; Fludarabine Phosphate [Usan:Ban]; Fludura
Dosage Forms
TABLET; POWDER FOR SOLUTION; IV Solution
Absorption
Not Available
Interactions
Interactions for Fludarabine:
The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe
pulmonary toxicity.
Chemical IUPAC Name
[5-(6-amino-2-fluoro-purin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid
Chemical Formula
C10H13FN5O7P
Half Life
20 hours
Drug Type
Approved Drug
# Accession No
APRD00594
CAS Registry Number
75607-67-9