Flucloxacillin: profile and news

Superbug: QE Nation's Worst ; HEALTH: League Tables Damning for ... Feb 7, 2006
...surgical incisions and wounds. Most strains of the bug now resistant to drugs methicillin and flucloxacillin. Other antibiotics can ... - International News Service,

Other information

Indication
For bacterial infection

Pharmacology
Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through Flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Mechanism Of Action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Flucloxacillin interferes with an autolysin inhibitor.

Drug Category
Anti-bacterial Agents; Penicillins; ATC:J01CF05

Brand Names/Synonyms
BRL 2039; FLOXACILLIN; Floxacillin; Floxacillin [Usan]; Floxapen; Fluclox; Flucloxacilina [Inn-Spanish]; Flucloxacillin; Flucloxacillin Sodium; Flucloxacillin-Sodium; Flucloxacilline [Inn-French]; Flucloxacillinum [Inn-Latin]; Sesamol

Dosage Forms
LIQUID

Absorption
Not Available

Interactions
Not Available

Chemical IUPAC Name
7-[3-(2-chloro-6-fluoro-phenyl)-5-methyl-oxazol-4-yl]carbonylamino-3,3-dimethyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylicacid

Chemical Formula
C19H17ClFN3O5S

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00609

CAS Registry Number
5250-39-5