Flovent: profile and news

Steroid puff best for kids with persistent asthma Feb 10, 2006
NEW YORK (Reuters Health) - In a study of children with mild-to-moderate persistent asthma, treatment with fluticasone (Flovent), an inhaled steroid, was ... - Reuters.uk,

Bristol-Myers Squibb Seeks To Expand Access To Its Most Recently ... Feb 19, 2006
Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be used while taking Reyataz without first speaking with a health care ... - Medical News Today (press release),

Health Notes Feb 21, 2006
...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ... - Hampton Union,

More letters Feb 23, 2006
...of normal. The combined benefits of the Serevent and Flovent in the Advair disk have enormously improved my health. Patients should ... - Arizona Daily Star,

Gene may trigger rare esophageal disorder Feb 13, 2006
...inflammation. Most common is to swallow the normally inhaled asthma medicine Flovent, so that it temporarily coats inflamed tissue. ... - Miami Herald,

GlaxoSmithKline: Pliva Deal to Boost R&D Feb 15, 2006
Indeed, sales from these brands - Flovent (fluticasone), Seretide (salmeterol, fluticasone) and Serevent (salmeterol) - accounted for 21.3% of the company's ... - International News Service,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ... Feb 9, 2006
...wort, AcipHex(R), Nexium(R), Prevacid(R), Prilosec(R) or Protonix(R), Viagra(R), Levitra(R), Cialis(R), Vfend(R), Advair(R), Flonase(R), or Flovent(R) should ... - Finanzen.net,

Inhaler shortage costing consumers Feb 13, 2006
Zartman said that Albuterol inhalers have not been affected, but inhalers such as Flovent that use flourocarbons are causing pharmacists to "go to different ... - The Evening Sun,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ... Feb 9, 2006
John's wort, AcipHex®, Nexium®, Prevacid®, Prilosec® or Protonix®, Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be ... - Yahoo! News (press release)

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ... 09 Feb 2006
John's wort, AcipHex®, Nexium®, Prevacid®, Prilosec® or Protonix®, Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be ... - Yahoo! News (press release)

Inhaled Steroid Controls Asthma Better Than Oral Agent Jan 12, 2006
Their study compared the inhaled corticosteroid Flovent (fluticasone) with the oral leukotriene receptor antagonist Singulair (montelukast) for asthma control ... - CNN

Flomerics Announces Thermal, EMC, Antenna Training Schedule Jan 17, 2006
Flovent Introductory Training is designed to familiarize new and existing users with the use of Flovent to simulate and optimize heating, ventilation, and air ... - Ten Links,

Lung study helps with breathing Jan 23, 2006
York, a respirologist in internal medicine at the Wetaskiwin Hospital, is involved in research studying the effects of breathing medications Flovent and Advair ... - Wetaskiwin Times Advertiser,

New Product: 3D airflow software from Flomerics Nov 15, 2005
Product Briefing Outline: Flomerics has released Version 6 of its Flovent software for airflow prediction in buildings, with improved 3D visualization and ... - Fabtech

Health Notes Dec 6, 2005
...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ... - Exeter News-Letter,

GlaxoSmithKline Advair Growth To Moderate Nov 21, 2005
..."The risks have been well highlighted in the past and doctors are already familiar with them; plus GSK's Flovent (standalone steroid) may benefit - offsetting ... - New Ratings

GSK Advair Won't Be Hit By FDA Concerns >GSK Nov 21, 2005
...around 50%)...are unlikely to switch, many US physicians are likely to disregard the advice given the positive Advair experience, GSK's Flovent may catch ... - New Ratings

FDA issues asthma drugs alert Nov 29, 2005
Because LABAs used alone don't control asthma as well as inhaled steroids (such as Flovent) or leukotriene receptor antagonists (such as Singulair), LABAs are ... - Pittsburgh Post Gazette,

FDA seeks stronger warning for asthma meds Dec 1, 2005
Because studies show that LABAs used alone don’t control asthma as well as inhaled steroids (such as Flovent) or leukotriene receptor antagonists (such as ... - Quad City Times,

GlaxoSmithKline "add" Nov 21, 2005
Dresdner Kleinwort Wasserstein believes, however, that the sales of the company's Flovent standalone steroid would offset the anticipated moderation in Advair ... - New Ratings

48-Week Clinical Trial Data Provides Information Regarding ... Nov 18, 2005
Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be used while taking REYATAZ without first speaking with a healthcare ... - Yahoo! News (press release)

48-Week Clinical Trial Data Provides Information Regarding ... Nov 18, 2005
...wort, AcipHex(R), Nexium(R), Prevacid(R), Prilosec(R) or Protonix(R). Viagra(R), Levitra(R), Cialis(R), Vfend(R), Advair(R), Flonase(R), or Flovent(R) should ... - Biotech Intelligence (press release),

Free Health Stuff for Your Kids Aug 19, 2005
...a steady supply of asthma and allergy medicines, including Claritin, Clarinex, Zyrtec, Allergra, Flonase, Nasonex, Rhinocort Aqua, Flovent, Pulmicort, Foradil ... - pediatrics.about.com

Helth Notes Aug 2, 2005
...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ... - Exeter News-Letter <**results**>

Pulmonary evaluation long overdue Jul 5, 2005
...colorless. My doctor has prescribed Ventolin and Flovent, but the Flovent seems to tighten my lungs so that it is hard to breathe. ... - The Spokesman Review (subscription)

Changes in Inhaler Devices for Asthma And COPD Jun 19, 2005
Flucatisone (Flovent Inhalation Aerosol), available as an HFA or CFC-propelled device, is a long-acting inhaled corticosteroid available in several dose ... - RedNova.com

Pharma Focus Now on Building Their Respiratory Portfolios Jun 29, 2005
...like Beconase (allergies), Becotide/Beclovent (asthma and chronic obstructive pulmonary disease), Flixonase/Flonase (allergies), Flixotide/Flovent (asthma and ... - PharmaLive.com (press release)

PRA International Adds Management Depth Jun 30, 2005
Finally, he brings four years of respiratory experience from GlaxoSmithKline where he was integral member of the Flovent® and Serevent® development teams. ... - PharmaLive.com (press release)

Free Health Stuff for Your Kids Jun 21, 2005
...a steady supply of asthma and allergy medicines, including Claritin, Clarinex, Zyrtec, Allergra, Flonase, Nasonex, Rhinocort Aqua, Flovent, Pulmicort, Foradil ... - pediatrics.about.com

Study suggests mild asthmatics could get relief with less medicine Apr 14, 2005
...of two drugs: an inhaled bronchodilator for immediate relief of symptoms, and daily use of an inhaled corticosteroid, such as Pulmacort or Flovent, to reduce ... - San Francisco Chronicle

MAP Pharmaceuticals Appoints New Vice President of Clinical and ... Mar 28, 2005
While at GlaxoSmithKline, he played a critical role in the development of Flovent HFA by designing, initiating and directing the product’s pivotal clinical ... - mysan.de (Pressemitteilung)

Health Notes Apr 8, 2005
...qualify. If you take Flovent, Combivent, Proventil, Advair, Pulmicort, Serevent, Atrovent or any other inhaler, the program may help. ... - Exeter News-Letter,

Tailoring therapies for asthmatic kids Feb 28, 2005
The tests use biomarkers to predict children's response to two popular asthma drugs -- Flovent, an inhaled steroid, and Singulair, one of a newer category of ... - Pittsburgh Post Gazette,

Novartis to Buy Hexal, Most of Eon Labs for $7.4 Bln (Update1) Feb 20, 2005
Drugs with combined sales of 3 billion euros, including GlaxoSmithKline Plc's Flovent and Altana AG's Protonix ulcer remedy, will lose German patent protection ... - Bloomberg

Other information

Indication
For the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma

Pharmacology
Fluticasone Propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.

Mechanism Of Action
Binds to the glucocorticoid receptor. Unbound corticosteroids cross the membranes of cells such as mast cells and eosinophils, binding with high affinity to glucocorticoid receptors (GR). The results include alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. In the management of asthma, the glucocorticoid receptor complexes down-regulates proinflammatory mediators such as interleukin-(IL)-1, 3, and 5, and up-regulates anti-inflammatory mediators such as IkappaB [inhibitory molecule for nuclear factor kappaB1], IL-10, and IL-12. The antiinflammatory actions of corticosteroids are also thought to involve release of cytosolic phospholipase A2 which controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Drug Category
Anti-allergic Agents; Dermatologic Agents; Bronchodilator Agents; Anti-inflammatory Agents; Adrenergic Agents; ATC:D07AC17; ATC:R01AD08; ATC:R03BA05

Brand Names/Synonyms
Advair Diskus 100/50; Advair Diskus 250/50; Advair Diskus 500/50; Cutivate; Flixonase; Flixotide; Flonase; Flovent; Flovent Diskus 100; Flovent Diskus 250; Flovent Diskus 50; Flovent Hfa; Flunase; Fluticasone Propionate

Dosage Forms
METERED-DOSE (AEROSOL)

Absorption
The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier.

Interactions
Drug Interactions for Fluticasone Propionate:

No Information Provided.

Chemical IUPAC Name
[6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propanoate

Chemical Formula
C25H31F3O5S

Half Life
10 hours

Drug Type
Approved Drug

# Accession No
APRD00065

CAS Registry Number
80474-14-2