Flonase: profile and news
Glaxo Loses US Court Bid to Block Generic Flonase (Update1) 06 Mar 2006
GlaxoSmithKline Plc, the world's second-biggest drugmaker, lost a US bid to prevent sales of generic versions of its $900 million-a-year allergy drug Flonase. ... - Bloomberg
CRH, Infineon, Nokia, Telecom Italia: European Equity Preview 06 Mar 2006
Plc (GSK LN): The world's second-biggest drugmaker said it lost a US bid to prevent sales of generic versions of its $900 million-a-year allergy drug Flonase. ... - Bloomberg
GlaxoSmithKline blocks sales of competitor's generic Flonase Feb 27, 2006
...said Friday it obtained a temporary restraining order blocking the shipment and sales of a recently FDA-approved generic competitor to its Flonase nasal spray ... - Columbus Ledger-Enquirer,
FDA approves generic version of popular allergy drug Flonase Feb 28, 2006
WASHINGTON — Regulators approved the first generic version of Flonase on Feb. 22, touting ... nose. GlaxoSmithKline makes Flonase. Roxane ... - Wilkes Barre Times-Leader,
Glaxo shares slip as US clears generic Flonase Feb 23, 2006
...in GlaxoSmithKline fell as much as 1 percent in early trade on Thursday after US authorities cleared a generic version of its top-selling allergy spray Flonase ... - Scotsman,
Glaxo hit by generic Flonase but reaffirms outlook Feb 23, 2006
...in GlaxoSmithKline fell as much as 1 percent on Thursday after US authorities cleared a generic version of its top-selling allergy spray Flonase, but the group ... - Scotsman,
Glaxo Sues US FDA to Block Sale of Generic Flonase (Update3) Feb 23, 2006
23 (Bloomberg) -- GlaxoSmithKline Plc sued US regulators to block the sale of a generic form of the company's Flonase allergy drug, saying the copy may not ... - Bloomberg
Court grants Glaxo bid to halt generic Flonase Feb 24, 2006
Reuters) - A US court granted GlaxoSmithKline Plc's temporary motion to stop the marketing of generic forms of Glaxo's nasal spray Flonase, the company said on ... - MSN Money
Court grants Glaxo bid to halt generic Flonase Feb 24, 2006
Quote, Profile, Research) (GSK.N: Quote, Profile, Research) temporary motion to stop the marketing of generic forms of Glaxo's nasal spray Flonase, the company ... - Reuters
FDA approves generic version of Flonase nasal spray Feb 22, 2006
WASHINGTON – Regulators approved the first generic version of Flonase on Wednesday, touting the move in a rare press release and conference call with ... - San Diego Union Tribune,
US court grants Glaxo bid to halt generic Flonase Feb 24, 2006
US court granted GlaxoSmithKline Plc's (GSK.L: Quote, Profile, Research) temporary motion to stop the marketing of generic forms of Glaxo's nasal spray Flonase ... - Reuters
Glaxo shares slip as US clears generic Flonase Feb 23, 2006
Plc (GSK.L: Quote, Profile, Research) fell nearly 1 percent on Thursday after US authorities cleared a generic version of its top-selling allergy spray Flonase ... - Reuters
First Generic Version of Flonase Approved Feb 23, 2006
THURSDAY, Feb. 23 (HealthDay News) -- The US Food and Drug Administration has approved the first generic version of the anti-allergy medication Flonase. ... - Forbes
Glaxo says may take legal action over Flonase Feb 22, 2006
...legal action against the US Food and Drug Administration over the agency's approval of a generic version of its blockbuster allergy drug Flonase, a company ... - Reuters
Par Pharma halts generic Flonase shipments after GSK wins ... Feb 24, 2006
...a motion for a temporary restraining order to set aside the Food and Drug Administration's final approval decision for a generic version of Flonase nasal spray ... - Forbes
Glaxo rattled by generic Flonase Feb 23, 2006
...in GlaxoSmithKline Plc fell as much as one percent Thursday after US authorities cleared a generic version of its top-selling allergy spray Flonase, but the ... - CNN/Money
GSK motion to stop generic Flonase sales granted Feb 24, 2006
Two days after the Food and Drug Administration approved a generic version of GlaxoSmithKline's nasal spray Flonase, sales of generic Flonase have been halted ... - Philadelphia Business Journal,
FDA approves generic Flonase spray Feb 24, 2006
By JAN JARVIS. Fluticasone propionate nasal spray, a generic version of GlaxoSmithKline's Flonase, won approval Wednesday from the Food and Drug Administration. ... - Fort Worth Star Telegram,
Judge orders halt to sales of generic Flonase Feb 24, 2006
A federal judge today temporarily blocked two generic versions of GlaxoSmithKline PLC's asthma medicine Flonase, allowing the company to keep selling its more ... - philly.com,
Court grants Glaxo bid to halt generic Flonase Feb 24, 2006
...granted GlaxoSmithKline Plc‘s (GSK.L) (NYSE:GSK - news) temporary motion to stop the marketing of generic forms of Glaxo‘s nasal spray Flonase, the company ... - Leading The Charge,
Roxane Labs gets FDA approval for generic Flonase Feb 23, 2006
WASHINGTON -- Columbus-based Roxane Laboratories has won approval to produce the first generic version of Flonase, a move that should provide users of the ... - Columbus Dispatch,
First Generic of Glaxo's Flonase is Approved Feb 24, 2006
The FDA has approved Roxane Laboratories allergy relief nasal spray, a generic equivalent of GlaxoSmithKline's Flonase spray, causing shares in the UK-based ... - International News Service,
FDA approves generic version of Flonase Feb 22, 2006
WASHINGTON (Reuters) - US health regulators Wednesday said they have approved the first generic version of GlaxoSmithKline's allergy nasal spray Flonase. ... - CNN/Money
FDA approves generic competitor to Glaxo's Flonase Feb 22, 2006
Less than five months after GlaxoSmithKline's patent for blockbuster allergy treatment Flonase expired, US health regulators have given the green light to the ... - Raleigh Triangle Business Journal,
FDA OKs Generic Version of Flonase Feb 22, 2006
22, 2006 -- The FDA has approved the first generic version of the brand-name drug Flonase, a nasal spray that treats allergic and nonallergic nasal symptoms. ... - WebMD
FDA approves generic version of Flonase nasal spray Feb 23, 2006
...symptoms. Regulators have approved the first generic version of Flonase. ... And Flonase has had annual sales of more than $1 billion. GlaxoSmithKline's ... - WIS,
FDA approves generic version of Flonase nasal spray Feb 23, 2006
WASHINGTON - Regulators approved the first generic version of Flonase, touting the move as one that should provide users of the allergy drug a cheaper ... - Akron Beacon Journal,
FDA Approves First Generic Version of Flonase Feb 22, 2006
Food and Drug Administration (FDA) today approved Fluticasone Propionate Nasal Spray, the first generic version of the brand name drug Flonase, giving American ... - FDA.gov
FDA approves generic version of Flonase nasal spray Feb 22, 2006
Regulators have approved the first generic version of Flonase. ... And Flonase has had annual sales of more than one (b) billion dollars. ... - Ohio News Network,
Columbus Firm Wins Approval for Generic Flonase Feb 23, 2006
...(02/23/06 - WASHINGTON, DC) - A Columbus, Ohio, company has won approval to make and sell the first generic version of Flonase. ... - abc11tv.com,
Columbus firm wins approval for generic Flonase Feb 23, 2006
WASHINGTON A Columbus, Ohio, company has won approval to make and sell the first generic version of Flonase. Roxane Laboratories ... - WWAY NewsChannel 3,
Par Pharmaceutical Halts Shipment of Generic Flonase(R) Feb 24, 2006
...and Drug Administration's (FDA) final decision approving an abbreviated new drug application (ANDA) for a generic version of Flonase (fluticasone propionate ... - Finanzen.net,
Generic Flonase on the Way Feb 23, 2006
WASHINGTON, DC-February 23, 2006 - A Columbus company has won approval to make and sell the first generic version of Flonase. Roxane ... - 6abc.com,
Glaxo blocks Par's generic Flonase Feb 24, 2006
SPRING VALLEY, NY, Feb. 24 (UPI) -- Par said Friday a US District Court granted GlaxoSmithKline's motion to temporarily suspend approval of generic Flonase. ... - United Press International
GlaxoSmithKline blocks sales of generic competitor to Flonase Feb 26, 2006
...says it has obtained a temporary restraining order to block the shipment and sales of a recently approved generic competitor to its Flonase nasal spray for ... - Newswatch 50,
FDA Approves Generic Version Of Flonase Nasal Spray Feb 23, 2006
...(AHN) - The US Food and Drug Administration on Thursday approves Fluticasone Propionate Nasal Spray, the first generic version of the brand name drug Flonase. ... - All Headline News
GlaxoSmithKline Flonase Approval Expected Feb 23, 2006
0725 GMT [Dow Jones] GlaxoSmithKline's (GSK) FDA approval for its nasal spray Flonase is expected and has been factored into its guidance for the year, says ... - New Ratings
GSK blocks generic Flonase in USA, for now Feb 27, 2006
GlaxoSmithKline has temporarily fended off generic competition to its big-selling Flonase allergy treatment, winning a restraining order blocking the sale of ... - Pharma Times (subscription),
Par Pharmaceutical Begins Shipment of Generic Flonase(R) Feb 23, 2006
GSK) in the United States to distribute fluticasone propionate aqueous nasal spray, 50mcg, which is fully substitutable for GSK's Flonase(R). Flonase(R) is a ... - PR Newswire (press release),
Par Pharmaceutical Begins Shipment of Generic Flonase(R) Feb 23, 2006
...with GlaxoSmithKline (GSK) in the United States to distribute fluticasone propionate aqueous nasal spray, 50mcg, which is fully substitutable for GSK's Flonase ... - Yahoo! News (press release)
GSK's Flonase facing generic rival in USA Feb 23, 2006
GlaxoSmithKline is facing generic competition to a billion dollar-selling allergy spray Flonase in the USA, after the Food and Drug Administration cleared a ... - Pharma Times (subscription),
FDA Approves First Generic Form of Flonase Feb 23, 2006
The US Food and Drug Administration announced Wednesday it had approved the first generic version of the anti-allergy medication Flonase. ... - WFIE-TV,
US FDA ok's generic version of Glaxo allergy spray Feb 22, 2006
The first generic version of GlaxoSmithKline's (GSK.L: Quote, Profile, Research) (GSK.N: Quote, Profile, Research) widely-used allergy spray Flonase won US ... - Reuters.uk,
Judge grants Glaxo's motion to halt sales of competitor's drug Feb 24, 2006
Two days after the US Food and Drug Administration approved a generic version of GlaxoSmithKline's nasal spray Flonase, a judge has granted a temporary ... - Raleigh Triangle Business Journal,
US FDA ok's generic version of Glaxo allergy spray Feb 22, 2006
WASHINGTON (Reuters) - The first generic version of GlaxoSmithKline's widely-used allergy spray Flonase won US approval on Wednesday, but the British drugmaker ... - Reuters India,
Cash relief in store for allergy sufferers Feb 24, 2006
...relief. The Food and Drug Administration has approved fluticasone propionate, a generic version of Flonase nasal spray. Normally ... - WFAA (subscription),
For Generics, Bumpy Road to Pharmacy Feb 22, 2006
22 — A generic version of Flonase, a popular allergy spray, was approved for sale by federal drug regulators Wednesday. ... Flonase is a case in point. ... - New York Times,
Business news in brief Feb 24, 2006
PLC, which has a US headquarters in Philadelphia, sued the Food and Drug Administration to block the sale of a generic form of the allergy drug Flonase. ... - Philadelphia Inquirer,
Par Pharmaceutical Reports Sales and Earnings for 2005 Feb 28, 2006
..."However, with the potential launch of generic Flonase(R), and several year-end product approvals and acquisitions, Par now looks forward to the resumed growth ... - MSN Money
STOCKWATCH GSK slips after US FDA approves generic version of ... Feb 23, 2006
...early trade after the US Food and Drug Administration last night granted marketing approval for the first generic challenger to its hayfever treatment Flonase. ... - Forbes
New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ... 09 Feb 2006
John's wort, AcipHex®, Nexium®, Prevacid®, Prilosec® or Protonix®, Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be ... - Yahoo! News (press release)
How you can keep winter's low humidity from hurting your health Feb 7, 2006
And if you use prescription nasal sprays such as Flonase, aim away from the septum, the sensitive, bony barrier that separates the nostrils. ... - Dallas Morning News (subscription),
Teen should wait on pill - and on sex Jan 24, 2006
I just got a prescription for Flonase for my hay fever allergies. ... Flonase, a steroid, comes in a nasal spray, which you squirt into your nose each day. ... - New York Newsday,
Teva-IVAX Merger Creates 'Exceptional Pipeline' Jan 30, 2006
For 2007, key potential generic launches include generic versions of Flonase, which is manufactured by GlaxoSmithKline (nyse: GSK - news - people ). ... - Forbes
SUSAN TOMPOR: Picking the right drug plan requires research Nov 16, 2005
...condition. She also takes Flonase for nasal allergy symptoms. ... condition. She's also started taking Flonase, which treats nasal allergy symptoms. ... - Detroit Free Press,
Unbearable news for the national parks Dec 3, 2005
...of freedom have 'bad-hair' days." And how about, "Give me your tired, your poor, your huddled masses yearning to breathe free -- with Flonase Nasal Spray?" Don ... - News & Observer,
IAG Research's First Publicized Pharmaceutical Advertising ... Nov 29, 2005
...use. Flonase's 30-second film noir ad communicating its use for the treatment of nasal allergies ranked second behind Zelnorm. IAG's ... - PharmaLive.com (press release),
48-Week Clinical Trial Data Provides Information Regarding ... Nov 18, 2005
Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be used while taking REYATAZ without first speaking with a healthcare ... - Yahoo! News (press release)
Health Products Research Reports Pediatricians Are 2nd Largest ... Nov 11, 2005
Most GSK sales presentations to pediatricians focused on asthma drug Advair Diskus(R) and/or Flonase(R) Nasal Spray for allergies; Abbott promoted antibiotic ... - PR Newswire (press release),
48-Week Clinical Trial Data Provides Information Regarding ... Nov 18, 2005
John's wort, AcipHex(R), Nexium(R), Prevacid(R), Prilosec(R) or Protonix(R). Viagra(R), Levitra(R), Cialis(R), Vfend(R), Advair(R), Flonase(R), or Flovent(R ... - Biotech Intelligence (press release),
This week, I received a few goodies. I did a Pepsi rebate and ... Sep 30, 2005
I also got a bunch of recipes from Azteca tortillas. The makers of Flonase sent me $5 coupons to use when I get my prescription. ... - Nashua Telegraph,
GYPSY OF THE MONTH: Renée Klapmeyer of 'The Producers' Oct 4, 2005
...too. She recently was a finalist for the “dumb blonde� part in a film noir-style commercial for the allergy medication Flonase. ... - Broadway World,
Breathing Clear with Butterbur Sep 13, 2005
...course. There’s over-the-counter Claritin and Claritin-D. Then there’s prescription-only Allegra, Zyrtec and Flonase. But allergy ... - Hollister Free Lance,
Nasal Sprays Sep 24, 2005
Vancenase and Beconase (beclomethasone), Nasarel (flunisolide), Rhinocort (budesonide), Nasonex (mometasone), and Flonase (fluticasone), to name a few, can get ... - allergies.about.com
Two Pfizer products lead prescription price increases Sep 16, 2005
...s antibiotic Levaquin; the generic drug hydrocodone/acetaminophen, a version of Abbott’s Vicodin; GlaxoSmithKline PLC’s allergy drug Flonase; and Pfizer ... - Kansas City Star,
Mountain bikes beckon a new generation Sep 17, 2005
..."Mountain biking has really been embraced as a marketing tool," says Tony Moll, with Raleigh's Bike Rack bike store. "Flonase, Allegra -- you see it all over.". ... - News & Observer,
Drugs can help during allergy season Sep 24, 2005
Dziadzio said there are a range of medications from prescription antihistamines such as Allegra to nasal steroids such as Flonase that can help control symptoms ... - Stevens Point Journal,
Ear infections: Why they occur, how to prevent them Sep 7, 2005
...infections. One very effective medication is a nasal steroid spray such as Flonase or Nasonex. They shrink inflammation in the nose. ... - Daily Independent,
Research Shows Patients With Allergic Rhinitis Prefer NASONEX(R) ... Sep 6, 2005
...results of a head-to-head study comparing the scent and taste of NASONEX(R) (mometasone furoate monohydrate) Nasal Spray, 50 mcg* to Flonase(R) (fluticasone ... - PR Newswire (press release),
Health care's potholes Sep 2, 2005
...cost. The reason: "Hay fever treated with Flonase," a commonly prescribed nasal spray that relieves irritation and inflammation. ... - San Francisco Chronicle,
Companies and some Californians indicted for selling fake drugs Aug 31, 2005
Florida. Among the drugs stolen include allergy medicine Flonase, migraine reliever Imitrex and acne medicine Accutane. Prosecutors ... - San Jose Mercury News,
DTC Ads: “Reports of My Demise Are Greatly Exaggerated� Aug 12, 2005
Crestor was the main decliner. • GlaxoSmithKline chopped expenses 14%, from $369 million to $318 million. Flonase was the big loser there. ... - Brandweek Magazine,
Free Health Stuff for Your Kids Aug 19, 2005
...companies also supply doctors with a steady supply of asthma and allergy medicines, including Claritin, Clarinex, Zyrtec, Allergra, Flonase, Nasonex, Rhinocort ... - pediatrics.about.com
Other information
Indication
For the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma
Pharmacology
Fluticasone Propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.
Mechanism Of Action
Binds to the glucocorticoid receptor. Unbound corticosteroids cross the membranes of cells such as mast cells and eosinophils, binding with high affinity to glucocorticoid receptors (GR). The results include alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. In the management of asthma, the glucocorticoid receptor complexes down-regulates proinflammatory mediators such as interleukin-(IL)-1, 3, and 5, and up-regulates anti-inflammatory mediators such as IkappaB [inhibitory molecule for nuclear factor kappaB1], IL-10, and IL-12. The antiinflammatory actions of corticosteroids are also thought to involve release of cytosolic phospholipase A2 which controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Drug Category
Anti-allergic Agents; Dermatologic Agents; Bronchodilator Agents; Anti-inflammatory Agents; Adrenergic Agents; ATC:D07AC17; ATC:R01AD08; ATC:R03BA05
Brand Names/Synonyms
Advair Diskus 100/50; Advair Diskus 250/50; Advair Diskus 500/50; Cutivate; Flixonase; Flixotide; Flonase; Flovent; Flovent Diskus 100; Flovent Diskus 250; Flovent Diskus 50; Flovent Hfa; Flunase; Fluticasone Propionate
Dosage Forms
METERED-DOSE (AEROSOL)
Absorption
The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier.
Interactions
Drug Interactions for Fluticasone Propionate:
No Information Provided.
Chemical IUPAC Name
[6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]propanoate
Chemical Formula
C25H31F3O5S
Half Life
10 hours
Drug Type
Approved Drug
# Accession No
APRD00065
CAS Registry Number
80474-14-2