Flexeril: profile and news
SCIATICA -- BIG NERVE CAUSES BIG PROBLEMS 06 Mar 2006
...for something stronger than over-the-counter medicines, or he or she might combine a mild pain reliever with a muscle relaxant such as Flexeril or Robaxin. ... - Charlotte Sun-Herald,
First-Time Generic Approvals: Flexeril, Plavix, and AndroGel Feb 21, 2006
HCl 5-mg tablets (made by Mylan Pharmaceuticals Inc, Watson Laboratories Inc, Sandoz Inc, and Amide Pharmaceutical Inc; brand name Flexeril, made by McNeil ... - Medscape (subscription)
Mylan Gets FDA OK for Generic Flexeril Feb 6, 2006
...that its Mylan Pharmaceuticals unit gained Food and Drug Administration Approval to market a generic version of McNeil-PPC Inc.'s Flexeril muscle relaxant. ... - MSN Money
Ex-ghostbuster seeks to become chart-buster Mar 5, 2006
Diazepam, Nexium, Prevacid, Percocet / Levitra, Levaquin, Elavil, Fosamax / Plavix, Keflex, Next day FedEx / Zithromax, Avelox, Flexeril, Topamax / Prozac ... - Columbus Dispatch,
Mylan Announces FDA Approval for Cyclobenzaprine Hydrochloride ... Feb 6, 2006
Cyclobenzaprine Tablets are the AB-rated generic equivalent of McNeil's Flexeril(R) Tablets. US sales for the 5 mg strength of Flexeril ... - International News Service,
FDA approves Mylan's cyclobenzaprine Feb 6, 2006
WASHINGTON, Feb. 6 (UPI) -- Mylan said Monday it is cleared to sell cyclobenzaprine, the generic equivalent of McNeil's muscle relaxant Flexeril. ... - United Press International
Briefs: US Airways traffic falls as it cuts flights Feb 6, 2006
...tablets of cyclobenzaprine hydrochloride tablets. Cyclobenzaprine tablets are the generic equivalent of McNeil's Flexeril tablets. ... - Pittsburgh Tribune-Review,
Mylan wins approval for generic muscle relaxant Feb 6, 2006
The drug is a generic equivalent of McNeil's muscle relaxant Flexeril, which had US sales of $93 million for the year through the end of June 2005 for the 5-mg ... - Reuters
Business news briefs: 2/7/06 Feb 6, 2006
...received Food and Drug Administration approval to market Cyclobenzaprine Hydrochloride tablets, the generic version of McNeil's muscle relaxant Flexeril. ... ... - Pittsburgh Post Gazette,
Police Report Feb 1, 2006
A technician called her physician's assistant after seeing something had been scratched out. The prescription was supposed to be for Flexeril, records stated. ... - Fairbanks Daily News-Miner,
Mylan Gets FDA OK for Generic Flexeril Feb 6, 2006
...that its Mylan Pharmaceuticals unit gained Food and Drug Administration Approval to market a generic version of McNeil-PPC Inc.'s Flexeril muscle relaxant. ... - MSN Money
Mylan Announces FDA Approval for Cyclobenzaprine Hydrochloride ... Feb 6, 2006
Cyclobenzaprine Tablets are the AB-rated generic equivalent of McNeil's Flexeril(R) Tablets. US sales for the 5 mg strength of Flexeril ... - International News Service,
FDA approves Mylan's cyclobenzaprine Feb 6, 2006
WASHINGTON, Feb. 6 (UPI) -- Mylan said Monday it is cleared to sell cyclobenzaprine, the generic equivalent of McNeil's muscle relaxant Flexeril. ... - United Press International
Briefs: US Airways traffic falls as it cuts flights Feb 6, 2006
...tablets of cyclobenzaprine hydrochloride tablets. Cyclobenzaprine tablets are the generic equivalent of McNeil's Flexeril tablets. ... - Pittsburgh Tribune-Review,
Mylan wins approval for generic muscle relaxant Feb 6, 2006
The drug is a generic equivalent of McNeil's muscle relaxant Flexeril, which had US sales of $93 million for the year through the end of June 2005 for the 5-mg ... - Reuters
Business news briefs: 2/7/06 Feb 6, 2006
...received Food and Drug Administration approval to market Cyclobenzaprine Hydrochloride tablets, the generic version of McNeil's muscle relaxant Flexeril. ... ... - Pittsburgh Post Gazette,
Police Report Feb 1, 2006
A technician called her physician's assistant after seeing something had been scratched out. The prescription was supposed to be for Flexeril, records stated. ... - Fairbanks Daily News-Miner,
Team tackles Gulf’s other fish Jan 14, 2006
As a consequence, the following weekend was spent with heat-swaddled neck muscles spasming throughout a Flexeril-induced stupor of interminable tenacity. ... - The News-Press,
School custodian returned to work drunk, sexually assaulted co ... Nov 21, 2005
3 was a snowy day. It was snowing when he started work, and he took the muscle relaxant (Flexeril) three times during the day. It ... - Canadian Employment Law Today,
Tuesday, Oct. 4 police beat Oct 5, 2005
Markel allegedly had Flexeril in her possession and was arrested for possession of a controlled drug and possession of marijuana. ... - Tahlequah Daily Press,
Prosecution rests in murder case Oct 4, 2005
According to toxicology reports from Forbes' autopsy, the victim had about seven times the maximum therapeutic dosage of Flexeril in her system at the time of ... - Martins Ferry Times Leader,
What Ails You by Jackie Randa Sep 13, 2005
...into your doctor. A muscle relaxer such as Flexeril can be very helpful in relieving this sometimes persistent condition. If three ... - Desert Dispatch,
Toxicology Reports Eyed in Trial of Leroy Charley Sep 30, 2005
Blood test performed during the autopsy also showed a 0.27 mg per milliliter reading for cyclobenzaprine, a drug commonly prescribed as Flexeril, a pain ... - Wheeling News Register,
McNeil Consumer & Specialty Pharmaceuticals Statement Regarding ... Sep 13, 2005
...pharmaceutical products. Prescription products include CONCERTA(R) (methylphenidate HCl) and FLEXERIL(R) (cyclobenzaprine HCl) 5 mg. The ... - PR Newswire (press release),
Expiration Dates Observed on Foods, But Not Always on Medications Sep 20, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl extended-release tablets) and FLEXERIL(R) (cyclobenzaprine HCl 5 mg tablets). ... - PharmaLive.com (press release),
McNeil Consumer & Specialty Pharmaceuticals Statement Regarding ... Sep 13, 2005
...pharmaceutical products. Prescription products include CONCERTA® (methylphenidate HCl) and FLEXERIL® (cyclobenzaprine HCl) 5 mg. The ... - Yahoo! News (press release)
Parents May Not Be Aware of FDA Guidelines for Treating Children ... 08 Sep 2005
Prescription products include CONCERTA(R) (methylphenidate HCl extended-release tablets) and FLEXERIL(R) (cyclobenzaprine HCl 5 mg tablets). ... - PR Newswire (press release),
McNeil Consumer & Specialty Pharmaceuticals Announces Agreement ... Sep 1, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl) [CII] for attention deficit hyperactivity disorder and FLEXERIL(R) (cyclobenzaprine HCl) 5 mg ... - PR Newswire (press release),
Acmemeds.com Improves Itself With 101 New Added Medications Aug 20, 2005
...generic) 5% 60 gm,Elimite 5% 60 gm,Esgic Plus (generic) 500 mg,Estradiol 1 mg,Estradiol 2 mg,Eurax 10% 60 ml solution,Evista 60 mg,Flexeril (generic) 10 mg ... - PR Web (press release),
IT’S CATCHING Jul 24, 2005
...taught. Congenital ichthyosis, myositis ossificans, spondylolisthesis, calling for Celebrex, Flexeril, oxycodone hydrochloride. ... - New Yorker
Bid for prescription drugs leads to arrest Jul 13, 2005
...to reports, a doctor who worked at both hospitals contacted police after concluding that Paschal already had been given a prescription for Percocet and Flexeril ... - Daytona Beach News-Journal
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Pain doctor accused of negligence Jun 27, 2005
...of painkillers and psychotropic drugs that the accusation says were prescribed by Stanich, including Xanax, Zyprexa, lorazepam, Flexeril, Ultram, amitriptyline ... - San Diego Union Tribune
Data Shows That ADHD Patients on CONCERTA (Methylphenidate HCl) ... Jun 28, 2005
...pharmaceutical products. Prescription products include CONCERTA(R) (methylphenidate HCl) and FLEXERIL(R) (cyclobenzaprine HCl) 5 mg. The ... - PharmaLive.com (press release)
Data Shows That ADHD Patients on CONCERTA(R) (Methylphenidate HCl) ... Jun 28, 2005
...pharmaceutical products. Prescription products include CONCERTA® (methylphenidate HCl) and FLEXERIL® (cyclobenzaprine HCl) 5 mg. The ... - Yahoo News (press release)
Ex-nanny sentenced today in kids' deaths Jun 24, 2005
During the trial, the prosecution argued that Barreto was impaired on the prescribed painkiller Vicodin and the muscle-relaxant Flexeril, as well as alcohol ... - Alameda Times-Star
Nanny gets 30 years to life for killing of children Jun 25, 2005
...three-week trial, the prosecution argued that Barreto was impaired by the prescribed painkiller Vicodin and the muscle-relaxant Flexeril — in addition to ... - San Mateo County Times
Downed by Law Jun 15, 2005
...neck] and thoracic [upper back] pain." Rodriguez was diagnosed with an upper back sprain and prescribed Motrin (for pain and swelling) and Flexeril (a muscle ... - Silicon Valley's Metro,
Other information
Indication
For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions
Pharmacology
Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness to and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.
Mechanism Of Action
Like the tricyclic antidepressants, cyclobenzaprine exhibits anticholinergic activity, potentiation of norepinephrine, and antagonism of reserpine. Cyclobenzaprine does not directly act on the neuromuscular junction or the muscle but relieves muscle spasms through a central action, possibly at the brain stem level. Cyclobenzaprine binds to the serotonin receptor and is considered a 5-HT2 receptor antagonist that reduces muscle tone by decreasing the activity of descending serotonergic neurons.
Drug Category
Tranquilizing Agents; Muscle Relaxants; Antidepressants; Skeletal Muscle Relaxants; ATC:M03BX08
Brand Names/Synonyms
Cyclobenz; Cyclobenzaprine; Cyclobenzaprine Hcl; Flexeril; Flexiban; MK-130; Proeptatriene; Proheptatriene; RP-9715
Dosage Forms
"D"-shaped, film coated tablets
Absorption
Well absorbed after oral administration
Interactions
-->Interactions for Cyclobenzaprine:
FLEXERIL may have life-threatening interactions with MAO inhibitors.
FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.
Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting
compounds.
Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol.
Chemical IUPAC Name
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine
Chemical Formula
C20H21N
Half Life
18 hours (range 8-37 hours)
Drug Type
Approved Drug
# Accession No
APRD00213
CAS Registry Number
303-53-7