Fiorinal: profile and news

COMPLETE BREAKDOWN OF WWE WELLNESS PROGRAM Feb 27, 2006
...class, including, but not limited to, Amobarbital (Amytal), Butabarbital (Butisol), Butalbital (Anolor 300, Esgic, Fioricet, Fiorinal), Phenobarbital (Luminol ... - Pro Wrestling Insider,

Headache sufferer finally gets a shot of relief Jan 12, 2006
Hobday was taking a range of medications, including 222s with codeine, Imitrex-type drugs, Fiorinal. "They just sort of impaired me," she says. ... - Toronto Star,

Asthma drug warning causes alarm Dec 8, 2005
My husband is a walking drugstore. He suffers from depression and migraine headaches and takes Neurontin, Zoloft, Zyprexa, diazepam, Prilosec and Fiorinal. ... - Bradenton Herald,

Avitar Enters Rapidly Expanding Oral Fluid-Based Laboratory Drug ... Nov 29, 2005
Amytal(R)), Butabarbital (Butisol(R)) Pentobarbital (Nembutal(R)), Phenobarbital (Luminal(R)), Secobarbital (Seconal(R)), Butalbital (Fiorinal(R)) Company ... - PR Newswire (press release),

Ask the Clinician: Answers to Readers' Questions Oct 4, 2005
I have tried many medications that didn't work. A doctor put me on Fiorinal with Codeine and for the first time this med worked. ... - headaches.about.com <**results**>

The WorldтАЩs Greatest Doctor Jul 5, 2005
...that helped take the edge offтАФa concoction I called the тАЬmigraine mocha:тА? a cocktail of a controlled substance known as тАЬFiorinal,тА? dark chocolate ... - spainmedia.com

Drugs seized from home Jun 11, 2005
Police say they found a small amount of cocaine, drug paraphernalia, and a variety of prescription drugs including dilaudid, morphine and fiorinal. ... - Brampton Guardian,

Prescribed and OTC drug abuse тАУ Trend, Effects and Precautions Apr 24, 2005
...central nervous system depressants, and include benzodiazepines (Valium, Klonopin, Xanax, etc.), barbiturates (phenobarbital, Mebaral, Fiorinal, etc.) and ... - DCEAlumni.com

/FIRST ADD -- NYTU041B -- Pfizer Inc Earnings/ Apr 19, 2005
...or with over-the-counter migraine medications, such as Imitrex, Maxalt, Excedrin Migraine, non- steroidal anti-inflammatory drugs, and Fiorinal/Fioricet. ... - PR Newswire

Medical board removes doctor's license for sexual misconduct Apr 7, 2005
He also is alleged to have prescribed Fiorinal Number 3, a controlled substance, to a patient for a headache and continued giving her the drug between November ... - Columbus Ledger-Enquirer

Symptoms of vertigo Apr 4, 2005
...for nausea and vomiting, fluid pills can be given to reduce excess fluid in the inner ear canals and in the body in general, and fiorinal (prescription), is ... - Khalsa News Network

Finding her way after years of fog Mar 30, 2005
They weren't enough. She had to have her jaw broken and rewired to fit. They gave her Fiorinal for the pain. Addiction was just around the corner. ... - Rocky Mountain News,

A Prescription for Teen Danger Feb 27, 2005
...central nervous system depressants, and include benzodiazepines (Valium, Klonopin, Xanax, etc.), barbiturates (phenobarbital, Mebaral, Fiorinal, etc.) and ... - substanceabuse.about.com

8 arrested in drug bust, Lafourche sheriff says Mar 10, 2005
...possession with intent to distribute cocaine, possession with intent to distribute hydrocodone, possession with intent to distribute Fiorinal, possession with ... - 2TheAdvocate,

Well-known surgeon surrenders license Feb 18, 2005
Dr. Gregory L. Brown, 52, became addicted to the arthritis drug Ultram in 2003, then became addicted to a second drug, Fiorinal with codeine, according to the ... - Kentucky.com,

Surgeon gives up medical license Feb 19, 2005
...which he agreed to give up his license, Brown became addicted to the arthritis drug Ultram in 2003, then became addicted to a second drug, Fiorinal with codeine ... - Louisville Courier-Journal,

Other information

Indication
For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.

Pharmacology
Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.

Mechanism Of Action
Caffeine stimulates medullary, vagal, vasomotor, and respiratory centers, promoting bradycardia, vasoconstriction, and increased respiratory rate. This action was previously believed to be due primarily to increased intracellular cyclic 3′,5′-adenosine monophosphate (cyclic AMP) following inhibition of phosphodiesterase, the enzyme that degrades cyclic AMP. It is now thought that xanthines such as caffeine act as agonists at adenosine-receptors within the plasma membrane of virtually every cell. As adenosine acts as an autocoid, inhibiting the release of neurotransmitters from presynaptic sites but augmenting the actions of norepinephrine or angiotensin, antagonism of adenosine receptors promotes neurotransmitter release. This explains the stimulatory effects of caffeine. Blockade of the adenosine A1 receptor in the heart leads to the accelerated, pronounced "pounding" of the heart upon caffeine intake.

Drug Category
Central Nervous System Stimulants; Anorexigenic Agents; Phosphodiesterase Inhibitors; ATC:N06BC01

Brand Names/Synonyms
Acetaminophen; Alert-Pep; Anoquan; Butal Compound; Butalbital; Butalbital Compound; CFF; Cafamil; Cafcit; Cafecon; Cafeina; Cafergot; Caffedrine; Caffedrine Caplets; Caffein; Caffeine; Caffeine Pure; Caffeine, Anhydrous; Caffeine, Monohydrate; Caffeine, Synthetic; Caffine; Cafipel; Coffein; Coffeine; Compound 65; Darvon Compound; Darvon Compound-65; Dasin; Dexitac; Dexitac Stay Alert Stimulant; Dhc Plus; Diurex; Durvitan; Eldiatric C; Enerjets; Ercatab; Esgic; Esgic-Plus; Femcet; Fioricet; Fiorinal; Guaranine; Hycomine; Invagesic; Invagesic Forte; Keep Alert; Kofein; Koffein; Lanorinal; Mateina; Maximum Strength Snapback Stimulant Powders; Medigesic Plus; Methyltheobromide; Methyltheobromine; Migergot; Miudol; Monomethyl Derivative of Theophylline; NCI-C02733; NSC 5036; Natural Caffeinum; Nix Nap; No-Doz; Nodaca; Nodoz Maximum Strength Caplets; Norgesic; Norgesic Forte; Organex; Orphengesic; Orphengesic Forte; Pep-Back; Phensal; Propoxyphene Compound 65; Propoxyphene Compound-65; Quick Pep; Refresh'n; Sk 65 Compound; Stim; Synalgos-Dc; Thein; Theine; Theobromine Me; Theophylline Me; Triad; Ultra Pep-Back; Vivarin; Wake-Up; Wigraine

Dosage Forms
CAPSULE; DROPS; LIQUID; PILL; TABLET

Absorption
Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.

Interactions
Interactions for Caffeine:

Cytochrome P450 1A₂ (CYP1A₂) is known to be the major enzyme involved in the metabolism of caffeine. Therefore, caffeine has the potential to interact with drugs that are substrates for CYP1A₂, inhibit CYP1A₂, or induce CYP1A₂.

Few data exist on drug interactions with caffeine in preterm neonates. Based on adult data, lower doses of caffeine may be needed following coadministration of drugs which are reported to decrease caffeine elimination (e.g., cimetidine and ketoconazole) and higher caffeine doses may be needed following coadministration of drugs that increase caffeine elimination (e.g., phenobarbital and phenytoin).

Caffeine administered concurrently with ketoprofen reduced the urine volume in 4 healthy volunteers. The clinical significance of this interaction in preterm neonates is not known.

Interconversion between caffeine and theophylline has been reported in preterm neonates. The concurrent use of these drugs is not recommended.

Chemical IUPAC Name
1,3,7-trimethyl-3,7-dihydropurine-2,6-dione

Chemical Formula
C8H10N4O2

Half Life
3 to 7 hours in adults, 65 to 130 hours in neonates

Drug Type
Approved Drug

# Accession No
APRD00673

CAS Registry Number
58-08-2