Finasteride: profile and news

Thoroughbred Racing Roundup  07 Mar 2006
As a result, he said, the filly started on Lasix on Sunday. 'It looks like she`ll go a distance,' he added, eyeing the Acorn at Belmont Park. ... - Monsters and Critics.com,

California Vet Fined for Late Lasix Shot  Feb 24, 2006
Veterinarian Amy Lee Nevens has been fined $750 by the California Horse Racing Board for falsely reporting when she administered a Lasix shot last September at ... - BloodHorse,

Teammate turns the tables in Bonnie Miss  Mar 5, 2006
I left it up to him.". Jerkens also commented on Teammate's running on the anti-bleeder medication Lasix for the first time. "We ... - Brisnet.com

Shapiro Orders Additional Review of Intercontinental Incident  Mar 3, 2006
...qualified to understand the facts of the situation, the rules and laws of horse racing, the nuances involved in pre-race administration of Lasix (Salix), and ... - BloodHorse,

No Turf Battles for Harriett Lane  Mar 6, 2006
Racing on Lasix for the first time, Teammate, a 5-1 shot, rolled to a six-length win over Wonder Lady Anne L and five other 3-year-old fillies in the $150,000 ... - Los Angeles Times,

Garry Stevens arrives for Sandy Lane Gold Cup  Mar 1, 2006
Garry was asked his opinion on Lasix, and he replied that he would like to see zero tolerance on drugs through the racing world, although he accepts that they ... - Barbados Advocate,

Handling of violation questioned  Feb 24, 2006
The rules violation occurred when veterinarian Amy Lee Nevens gave Intercontinental a shot of Lasix at 12:10 pm, three hours and 25 minutes before the 3:35 ... - San Diego Union Tribune,

CHRB to look into drug violation  Feb 25, 2006
A drug rules violation occurred when veterinarian Amy Lee Nevens gave Intercontinental a shot of Lasix 20 minutes after deadline – a violation that normally ... - San Diego Union Tribune,

CHRB Orders a Review  Mar 4, 2006
She had filled out her report before she actually gave the furosemide (Lasix) injection and the report said the shot had been given at 11:30 am, about four ... - Los Angeles Times,

Lady Ballari is a Long Shot Trophy prospect  Mar 3, 2006
Jack De Freak won well on Lasix for the first time last Saturday and with his fitness not in doubt, could play a prominent role in the outcome against Open ... - Jamaica Observer,

PLETCHER TODD A  Mar 4, 2006
Teammate should get a good stalking trip along the inside, and with first-time Lasix, she will likely improve quite a bit further. ... - Brisnet.com

BEST BET -- Bullvons Bonnie (ninth)  Feb 15, 2006
A major driver improvement to Gingras and the addition of Lasix makes the mare a strong upset candidate. ... 2. Southwind Elian. Had a tough first trip on Lasix. ... - NorthJersey.com,

SANTA ANITA  Mar 1, 2006
She should have gained beneficial conditioning from this race and move forward in her second US start, particularly if equipped with Lasix. ... - Brisnet.com

HALL NAMES 12 FINALISTS  Mar 2, 2006
...command. Double Belle, beaten 28 lengths in only prior start, held second; big improvement with blinkers on, first time Lasix. THIRD ... - New York Post,

PEDIGREE HANDICAPPING  Feb 23, 2006
Racing without the use of Lasix, as many of Mott's debuters do, Shakespeare rated off a moderate pace before circling the field and winning easily under a hand ... - Brisnet.com

CHRB Medication Committee to Review Intercontinental Incident  Feb 27, 2006
Nevens reported that day she administered the Lasix at 11:30 am on both the Bleeder Treatment Report and the Confidential Veterinarian Report. ... - BloodHorse,

Music School trainer considers next move after loss in Southwest  Feb 27, 2006
...bit. Kingsfield also will race with anti-bleeder medication Lasix for the first time in his yet-tobe determined next start. “I ... - Arkansas Democrat-Gazette (subscription),

Diuretics reduce congestive heart failure death risk, studies show  Feb 14, 2006
...treating CHF. The studies involved three types of diuretics: thiazide, potassium-sparing and loop diuretics, such as Lasix. The ... - Pharmaceutical Business Review

Road to Derby through Arkansas?  Feb 24, 2006
...going 5-½ furlongs on June 11 and did not return until making his 3-year-old at today’s distance on this surface February 5. Racing with Lasix for the first ... - MSNBC

Veterinarian fined for falsifying bleeder medication report on ...  Feb 22, 2006
...advance. She put the time the Lasix shot was supposed to have been administered instead of the time she actually gave it to the horse. ... - Thoroughbred Times,

Stewards strike in feature  Feb 22, 2006
Francis had better luck aboard the Sidney Watson-trained SNOW PROSPECT (5-1) who underscored the benefit of Lasix first time with an easy victory in the sixth ... - Jamaica Gleaner,

CTL Claiming Series to highlight today's programme  Feb 24, 2006
Devon A Thomas. Not one to turn out winners on a regular basis, Parham has, however, put this one back on Lasix. This move coupled ... - Jamaica Observer,

BEST BET -- Lhasa Muscles (fifth)  Feb 26, 2006
2. Wildfire Bo. Returned with solid effort. 3. Futile Quest. Recovered nicely from a break to win first start on Lasix. SIXTH -- 1. Southwind Alden. ... - NorthJersey.com,

Risk Of Death From Congestive Heart Failure Reduced By Diuretics  Feb 19, 2006
...treating CHF. The studies involved three types of diuretics: thiazide, potassium-sparing and loop diuretics, such as Lasix. Sixty ... - Medical News Today (press release),

Ormond by the Sea is vulnerable  Feb 25, 2006
...them.". Williamson said Tally Up bled "a fair amount" in the Edgar, and believes the addition of Lasix also could help on Tuesday. ... - CBS SportsLine.com

This Looks to Be a Spot for a Drysdale Winner  Feb 16, 2006
Owned by Vinery Stables LLC, the 4-year-old Storm Cat colt will be treated with Lasix for the first time as he faces 11 in the $35,000 allowance at 1 1/16 ... - Los Angeles Times,

Stepping up to 'Achilles'  Feb 3, 2006
..."It was a pretty good effort first time out, particularly since it was accomplished without Lasix," said Friedman, who noted River City Rebel got a number of ... - CBS SportsLine.com

BUILDING OWNER-TRAINER RELATIONSHIPS  Feb 5, 2006
...putting the crupper around the horse’s neck (heaven forbid!) would be an extremely vivid example of incompetence, consider that use of Lasix® or failure to ... - Harnesslink,

Experts Continue Helping Confused Seniors Sort Through Medicare ...  Feb 6, 2006
..."It's hard paying $8 a prescription," he said. "I take insulin. I take Lasix. I take blood pressure medicine. I take diabetic medicine.". ... - WAVE,

Stay in the Shade Of Jade  Feb 10, 2006
...who ran a fair race in the first week of January, is also down in the weights sufficiently to have a decent chance, but with the visors and Lasix removed, he ... - Jamaica Observer,

PLETCHER TODD A  Feb 3, 2006
Trained by Allen Jerkens, the gray filly will be getting first-time Lasix on Saturday and owns nice enough numbers to threaten for part. ... - Brisnet.com

Kelly Clarkson gets the Grammy party started  Feb 9, 2006
...“You’re so pretty,’ the sweet Texas singer gushed as the gals, both wearing black, talked about their respective lasix surgery and music making, giggling ... - The Envelope,

ROAD TO THE TRIPLE CROWN  Feb 14, 2006
His well-documented improvement in form coincided with the addition of Lasix three starts back, and the Jennifer Pedersen trainee is now ready to test the ... - Brisnet.com

OAKLAWN GLANCE  Feb 5, 2006
11:25 am), Aqueduct (11:30 am), Gulfstream Park (11:50 am), Santa Anita (1 pm), Bay Meadows (1:15 pm), Portland Meadows (2:35 pm) FIRST-TIME LASIX TODAY Etbauer ... - Arkansas Democrat-Gazette (subscription),

IDEAL SOCIETY SERIES FINAL FRIDAY  Feb 2, 2006
...lengths. The Long Goodbye took his opening series leg at Balmoral on January 14 in 1:54 flat, his second start on lasix. Trained ... - Harnesslink,

No drug interactions of clinical importance have been identified. Finasteride does not appear to affect the cytochrome P450-linked drug-metabolizing enzyme system. Compounds that have been tested in man include antipyrine, digoxin, propranolol, theophylline, and warfarin and no clinically meaningful interactions were found.

Other concomitant therapy

Although specific interaction studies were not performed, finasteride doses of 1 mg or more were concomitantly used in clinical studies with acetaminophen, acetylsalicylic acid, a-blockers, analgesics, angiotensin-converting enzyme (ACE) inhibitors, anticonvulsants, benzodiazepines, beta blockers, calcium-channel blockers, cardiac nitrates, diuretics, H₂ antagonists, HMG-CoA reductase inhibitors, prostaglandin synthetase inhibitors (also referred to as NSAIDs), and quinolone anti-infectives without evidence of clinically significant adverse interactions.

Drug/Laboratory Test Interactions

Finasteride had no effect on circulating levels of cortisol, thyroid-stimulating hormone, or thyroxine, nor did it affect the plasma lipid profile (e.g., total cholesterol, low-density lipoproteins, high-density lipoproteins and triglycerides) or bone mineral density. In studies with finasteride, no clinically meaningful changes in luteinizing hormone (LH), follicle-stimulating hormone (FSH) or prolactin were detected. In healthy volunteers, treatment with finasteride did not alter the response of LH and FSH to gonadotropin-releasing hormone indicating that the hypothalamic-pituitary-testicular axis was not affected.

In clinical studies with PROPECIA (finasteride, 1 mg) in men 18-41 years of age, the mean value of serum prostate-specific antigen (PSA) decreased from 0.7 ng/mL at baseline to 0.5 ng/mL at Month 12. Further, in clinical studies with PROSCAR (finasteride, 5 mg) when used in older men who have benign prostatic hyperplasia (BPH), PSA levels are decreased by approximately 50%. These findings should be taken into account for proper interpretation of serum PSA when evaluating men treated with finasteride.