Filgrastim: profile and news

America Readies for the Worst Mar 3, 2006
...a dirty bomb explosion, such as DTPA (flushes americium and plutonium out of the body), Prussian Blue (traps cesium in the intestine) and Filgrastim (speeds up ... - Jerusalem Post,

Health: More Asian Pacific Islanders Needed For Marrow Donations Feb 15, 2006
To increase the number of blood-forming cells in the bloodstream, donors receive daily injections of a drug called Filgrastim for five days before the ... - New California Media,

Croatia's Pliva, Australia's Mayne end erythropoietin development ... Feb 22, 2006
G-CSF is a generic version of Amgen Inc's Neupogen (filgrastim) for the regulation of white blood cell production in the treatment of cancer patients with ... - Forbes

Intensive Therapy May Benefit Women With Breast Cancer of a Poor ... Feb 14, 2006
An aggressive approach to chemotherapy consisting of adjuvant dose-intensive epirubicin and cyclophosphamide administered with filgrastim and progenitor cell ... - Cancerpage.com,

Sequential High-Dose Chemotherapy with Stem Cell Support Promising ... Feb 13, 2006
...cells. Patients also received Neupogen® (filgrastim), which is an agent that stimulates the body to produce white blood cells. ... - Cancer Consultants (press release),

Amgen Continues Manufacturing Expansion with Additional $1 Billion ... Feb 2, 2006
In Puerto Rico Amgen expects to enlarge its NEUPOGEN(R) (Filgrastim) and Neulasta(R) (pegfilgrastim) bulk protein manufacturing facility, licensed in 2005, as ... - Genetic Engineering News,

Other information

Indication
Increases leukocyte production, for treatment in non-myeloid cancer,neutropenia and bone marrow transplant

Pharmacology
Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Filgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation.

Mechanism Of Action
Filgrastim binds to the G-CSF receptor. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Filgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, Filgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase

Drug Category
Immunomodulatory Agents; Anti-infective Agents; Antineutropenic Agents; hematopoietic agents (20:16.00)

Brand Names/Synonyms
Granulocyte colony-stimulating factor precursor;G-CSF;Pluripoietin;Filgrastim;Lenograstim; Neupogen (Amgen Inc.)

Dosage Forms
SOLUTION

Absorption
Not Available

Interactions
Not Available

Chemical IUPAC Name
Human granulocyte colony stimulating factor

Chemical Formula
C845H1343N223O243S9

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
BIOD00072

CAS Registry Number
143011-72-7