Fentanyl: profile and news

Celebrex Lawsuit Set for Trial in Alabama State Court  06 Mar 2006
Montgomery, Ala. (FV Newswire) - A Celebrex lawsuit has been set for trial on June 6 ... It will most likely be the first Celebrex case to be tried in the country. ... - FinanceVisor.com,

As trial looms, Celebrex eases Pfizer sales pain  Mar 2, 2006
Even as the painkiller Celebrex heads for its first product-liability trial, the drug is making a comeback of sorts for its maker, Pfizer Inc. ... - Chicago Tribune,

Short-term Celebrex seems safe for osteoarthritis  Feb 27, 2006
NEW YORK (Reuters Health) - The COX-2 inhibitor Celebrex (celecoxib) causes fewer gastrointestinal complications than traditional nonsteroidal anti ... - Reuters.uk,

Celebrex 'doubles risk' of heart attack  Mar 2, 2006
The findings of a study into popular painkiller Celebrex comes less than 18 months after a similar drug, Vioxx, was withdrawn from sale after studies showed it ... - Australian,

Celebrex Doubles Lawsuit Risk  Mar 1, 2006
By Rich Duprey. A newly published study says the painkiller Celebrex from Pfizer(NYSE: PFE) doubles a patient's risk of heart attack. ... - MSNBC

Pfizer's Celebrex raises heart attack risk -study  Feb 28, 2006
LONDON, March 1 (Reuters) - Celebrex, a commonly used painkiller and treatment for arthritis, doubles the risk of a heart attack, researchers said on Wednesday ... - Reuters

Study: Pfizer's Celebrex raises heart attack risks  Mar 1, 2006
MarketWatch) -- A group of researchers in New Zealand said Tuesday that a reanalysis of older studies conducted on Pfizer's pain reliever Celebrex show the ... - MarketWatch

Medsafe stands by Celebrex despite risk study  Feb 28, 2006
Celecoxib, made by Pfizer and marketed as Celebrex, is the most commonly used pain relief – inhibitor – drug in the treatment of arthritis and acute pain. ... - Stuff.co.nz,

Analysis: Celebrex ups heart-attack risk  Feb 28, 2006
28 (UPI) -- A meta-analysis released Tuesday indicates Pfizer's Celebrex increases the risk of a heart attack by over two-fold and experts are calling for ... - United Press International

Celebrex Lawsuit Set for Trial in Barbour County  Mar 2, 2006
Montgomery, Ala. -- A Celebrex lawsuit has been set for trial in the Circuit Court ... It will most likely be the first Celebrex case to be tried in the country. ... - WSFA,

First Celebrex lawsuit going to trial  Feb 27, 2006
NEW YORK (CNNMoney.com staff writer) - The first Celebrex lawsuit in the country, filed by a stroke survivor against the drug giant Pfizer, is going to trial ... - CNN/Money

EDITORIAL - Celebrex not a reason to celebrate  Feb 27, 2006
Just Google it and you’ll see the endless array of possibilities: Studies show, “Celebrex may contribute to heart disease,� “Celebrex may make you ... - University of Pittsburgh The Pitt News,

Pfizer Disputes New Zealand Celebrex Heart Attack Link Study ...  Mar 2, 2006
A New Zealand study found that People taking Celebrex were twice as likely to suffer a heart attack as those using other pain relief treatments. ... - Best Syndication,

Study Finds Celebrex Increases Risk Of Heart Attack  Mar 2, 2006
Wellington, New Zealand(AHN) - A new study shows that patients taking Celebrex are nearly twice as likely to experience a heart attack as people using other ... - All Headline News

Meta-Analysis Links Celebrex to Doubling of MI Risk  Mar 2, 2006
New Zealand, March 2-A meta-analysis of 10 published studies has added a new voice to the concern that long-term treatment with Celebrex (celecoxib)--the only ... - MedPage Today,

Celebrex safe for osteoarthritis  Mar 1, 2006
According to a study by Stanford University School of Medicine, Celebrex causes fewer gastrointestinal complications than traditional nonsteroidal anti ... - News-Medical.net,

Why Commercial Breaks During News Broadcasts Are Full Of Celebrex ...  Feb 24, 2006
Most news industry chatter these days never fails to touch upon on a declining interest in newspapers and networks scrambling to entice the kiddos to watch ... - CBS News

Celebrex Gets Passing Grades for Gastric and Cardiac Safety  Feb 23, 2006
A Stanford group reported in the March issue of the American Journal of Medicine that Celebrex (celecoxib) may be as effective as non-specific non-steroidal ... - MedPage Today,

Celebrex Lawsuit Set for Trial in Alabama State Court  Mar 2, 2006
Montgomery, Ala. (PRWEB) March 2, 2006 -- A Celebrex lawsuit has been set for trial ... It will most likely be the first Celebrex case to be tried in the country. ... - PR Web (press release),

Date set for first Celebrex trial  Feb 28, 2006
...has set the date for what could be the first trial in the USA against Pfizer's blockbuster painkiller, the COX-2 inhibitor Celebrex (celecoxib), according to ... - Pharma Times (subscription),

Study finds Celebrex doubles heart attack risk  Mar 1, 2006
New Zealand researchers have published a meta-analysis suggesting that Pfizer's COX-2 inhibitor Celebrex doubles the risk of a heart attack. ... - Pharma Times (subscription),

Short spell of Celebrex may be safe for IBD  Feb 15, 2006
NEW YORK (Reuters Health) - In a study of patients with dormant ulcerative colitis, a 14-day course of the selective COX-2 inhibitor, Celebrex (celecoxib), did ... - Reuters.uk,

Further fears over arthritis drug  Mar 1, 2006
Renewed fears about the safety of arthritis drug Celebrex have been raised after scientists linked it to an increased risk of heart attacks. ... - BBC News,

Study Examines Celebrex and Heart Attacks  Mar 1, 2006
...(AP) People taking the pain reliever Celebrex were at nearly twice the risk for heart attacks as those using ... Celebrex, which is manufactured by Pfizer Inc. ... - CBS News

Celebrex Doubles Lawsuit Risk  Mar 1, 2006
A newly published study says the painkiller Celebrex from Pfizer (NYSE: PFE) doubles a patient's risk of heart attack. The study ... - Motley Fool

Trial Date for Celebrex Suit Set for June  Feb 27, 2006
Feb 27, 2006 (AP)— A judge set a June 6 trial date for a lawsuit filed by a woman who claims the arthritis medication Celebrex was to blame for a stroke she ... - ABC News

James Le Fanu on some less than rosy news for arthritis sufferers ...  Mar 3, 2006
...bad news for the drug companies this week, with a report that those patients who take the very popular (and profitable) anti-inflammatory drug Celebrex run a ... - Telegraph.co.uk,

Arthritis painkiller doubles risk to heart, says study  Feb 28, 2006
...a new study. Celebrex is the latest drug of its kind found to increase the risk of heart problems in clinical studies. Two other ... - Scotsman,

Pfizer Painkiller’s Bad Data  Mar 1, 2006
A new study concludes that Celebrex is no safer than similar drugs which have been pulled from the market. New Zealand scientists ... - Red Herring,

Study bolsters case against key Pfizer drug  Mar 1, 2006
A new study concluded that patients using Celebrex face an increased risk of heart attack, a finding that adds to scrutiny of the key Pfizer Inc. ... - Crain's New York Business,

Stock Futures Point to Bounce  Mar 1, 2006
...edged lower in Frankfurt trading as the Associated Press reported that a study from New Zealand showed that taking the company‘s Celebrex arthritis drug ... - Jackson News-Tribune,

Painkiller 'may double risk of heart attacks'  Feb 28, 2006
...according to a new study. The drug, Celebrex, is the third drug of its type to raise safety concerns. Vioxx was withdrawn by its ... - Telegraph.co.uk,

Cutting Through Pharmaceutical Media Spin  Mar 2, 2006
But the study," says Teitelbaum, "actually revealed something quite different: Natural remedies were far more effective than Celebrex for moderate to severe ... - PR Newswire (press release),

Pfizer`s COX 2 may be heart safe  Feb 22, 2006
WASHINGTON, DC, United States (UPI) -- Pfizer hopes a large-scale study released Wednesday that gives Celebrex a clean bill of health will give the COX-2 ... - Monsters and Critics.com,

Schaeffer's Midday Options Update Features Pfizer, Sirius ...  Mar 1, 2006
Associated Press, a group of researchers in New Zealand announced that a reanalysis of older studies performed on Pfizer's (NYSE:PFE) Celebrex pain reliever ... - Business Wire (press release),

New fears of wonder drug link to heart attacks  Mar 1, 2006
New research has found patients taking the prescription drug Celebrex are twice as likely to have heart attacks as those who are not. ... - Yorkshire Post Today,

Options Update: Trading Options on Texas Instruments  Mar 1, 2006
...group of researchers in New Zealand announced that a reanalysis of older studies performed on Pfizer's (PFE: sentiment, chart, options) Celebrex pain reliever ... - Schaeffers Research,

Analysis: Pfizer's COX 2 may be heart safe  Feb 22, 2006
22 (UPI) -- Pfizer hopes a large-scale study released Wednesday that gives Celebrex a clean bill of health will give the COX-2 inhibitor a boost, but analysts ... - United Press International

Arthritis drug increases risk of heart attacks: study  Feb 28, 2006
Popular common arthritis drug Celecoxib, marketed as Celebrex, increases the risk of heart attacks more than two-fold, a study has found. ... - Stuff.co.nz,

Doc defends pain supplements, slams study  Feb 23, 2006
...taken by millions of Americans to relieve osteoarthritis knee pain -- which showed no overall benefit in reducing pain, compared to Celebrex and placebo, was ... - Science Daily (press release)

Drug linked to heart attack risk  Feb 28, 2006
A study found that patients taking the drug Celebrex were twice as likely to have heart attacks as those who did not. Like Vioxx ... - This is Nottingham,

US stocks set to rebound from prior-session losses  Mar 1, 2006
...from prior-session losses, helped by strength in European markets, but Pfizer Inc was under pressure after a critical study of its Celebrex painkiller drug. ... - Investor's Business Daily (subscription)

Glucosamine-Chondroitin Sulfate Can Ease Severe Pain  Feb 22, 2006
Results of the 1,583-patient Glucosamine-chondroitin Arthritis Intervention Trial (GAIT) suggested that treatment with Celebrex (celecoxib) was associated with ... - MedPage Today,

Scientist urges rethink after secondarthritis drug found to be ...  Feb 28, 2006
Celecoxib, which is marketed under the brand name Celebrex, is the most commonly used Cox-2 inhibitor drug and is manufactured by Pfizer. ... - ic Wales,

Ease joint pain without blockbuster drugs  Feb 28, 2006
Unfortunately, these drugs -- known by the brand names Celebrex, Vioxx and Bextra -- increased the risk of heart attack and stroke in some studies. ... - The News Journal,

US stocks set for modest rebound after selloff  Mar 1, 2006
European markets, but Pfizer Inc. was under pressure after a critical study of its Celebrex painkiller drug. Dow futures were up ... - Investor's Business Daily (subscription)

Bextra - What Did Pfizer Know? - Everything  Mar 5, 2006
And less than 2 months later, on February 14, 2005, the Associated Press announced a "new study has linked pain killers Vioxx, Celebrex and Bextra to increased ... - Scoop.co.nz (press release),

Study: Supplements fail to ease arthritis  Feb 22, 2006
...patients with arthritis knee pain received one of five treatments: either glucosamine or chondroitin, a combination of both, the painkiller Celebrex or dummy ... - Seattle Post Intelligencer

Agents Affecting Cytochrome P450 3A4 Isoenzyme System

Fentanyl is metabolized mainly via the human cytochrome P450 3A4 isoenzyme system (CYP3A4), therefore potential interactions may occur when DURAGESIC® is given concurrently with agents that affect CYP3A4 activity. Coadminstration with agents that induce 3A4 activity may reduce the efficacy of DURAGESIC®. The concomitant use of transdermal fentanyl with ritonavir or other potent 3A4 inhibitors such as ketoconazole, itraconazole, troleandomycin, clarithromycin, nelfinavir, and nefazadone may result in an increase in fentanyl plasma concentrations. The concomitant use of other CYP3A4 inhibitors such as diltiazem and erythromycin with transdermal fentanyl may also result in an increase in fentanyl plasma concentrations, which could increase or prolong adverse drug effects and may cause serious respiratory depression. In this situation, special patient care and observation are appropriate.

Central Nervous System Depressants

The concomitant use of DURAGESIC® (fentanyl transdermal system) with other central nervous system depressants, including but not limited to other opioids, sedatives, hypnotics, tranquilizers (e.g., benzodiazepines), general anesthetics, phenothiazines, skeletal muscle relaxants, and alcohol, may cause respiratory depression, hypotension, and profound sedation, or potentially result in coma or death. When such combined therapy is contemplated, the dose of one or both agents should be significantly reduced.

MAO Inhibitors

DURAGESIC® is not recommended for use in patients who have received MAOI within 14 days because severe and unpredictable potentiation by MAO inhibitors has been reported with opioid analgesics.