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Fenfluramine: profile and news
Combined, Genes and Environment Affect Health More Than They Do ... 06 Mar 2006 Mechanically stimulating the heart Feb 23, 2006 Ky. Judge Resigns After Fen-Phen Reprimand Feb 27, 2006 Kentucky judge resigns after public reprimand Feb 28, 2006 Judge resigns amid accusations he profited from diet drug case Feb 27, 2006 There's still no magic pill for weight loss Feb 19, 2006 Food firms seek diet bonanza Feb 19, 2006 Leading Doctor Cites Obesity Drugs in Attack on FDA Approval ... Feb 8, 2006 Experimental Obesity Drug APD356 Reported Effective in Small ... Feb 8, 2006 Food makers hunt for next big fad in dieting Feb 19, 2006 Acomplia could break the diet pill curse Feb 12, 2006 Wyeth Hoping to Settle Most Remaining "Fen-phen" Lawsuits in Next ... Feb 9, 2006 Researchers Take Aim At The Causes Of Heart Valve Disease Jan 31, 2006 Other information Indication For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Pharmacology Used to treat diabetes and obesity, Fenfluramine decreases caloric intake by increasing serotonin levels in the brain’s synapses. Fenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes. Mechanism Of Action Fenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin uptake and release of serotonin. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Drug Category Serotonin reuptake inhibitor; Anorexigenic Agents; Stimulants; ATC:A08AA02; ATC:A08AA04 Brand Names/Synonyms Acino; Adipomin; CHEMBANK1560; Dea No. 1670; F1884; Fenfluramina [Dcit]; Fenfluramine; Fenfluramine Hydrochloride; Fenfluraminum [Inn-Latin]; HSDB 3080; Obedrex; Pesos; Ponderax Pa; Ponderex; Pondimin; Rotondin; S 768 Dosage Forms TABLET Absorption Not Available Interactions Interactions for Fenfluramine: Fenfluramine may increase slightly the effect of antihypertensive drugs, e.g., guanethidine, methyldopa, reserpine. Other CNS depressant drugs should be used with caution in patients taking fenfluramine, since the effects may be additive. Chemical IUPAC Name N-ethyl-1-[3-(trifluoromethyl)phenyl]-propan-2-amine Chemical Formula C12H16F3N Half Life 20 hours Drug Type Approved Drug # Accession No APRD00319 CAS Registry Number 458-24-2 |
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