Fansidar: profile and news






Fansidar to be replaced by Dec  Feb 3, 2006
Fansidar SP, the drug currently being used to cure malaria could be replaced by another drug by December this year, health officials have said. ... - Malawi's Daily Times,

New Malawi drug to replace Fansidar by December  Feb 3, 2006
Health officials in Malawi have said Fansidar SP, a drug which is currently being used to cure malaria could be replaced by another drug by December. ... - African News Dimension,

New malaria treatment out  Mar 3, 2006
...said the switch to coartem, a first fixed-dose combination of artemether and lumefantrine, follows increased malaria parasite resistance to chloroquine/fansidar ... - New Vision,

New Malaria Drug Free  Feb 22, 2006
The new drug, which falls under the newly- adopted Artemisinin-based combination treatments, is to replace chloroquine and fansidar as a first line treatment ... - AllAfrica.com,

Why Pregnant Women Need Antenatal Care  Feb 8, 2006
Pregnant mothers are given preventive treatment of three tablets of Fansidar twice between 28 and 36 weeks even when they do not show symptoms of malaria. ... - AllAfrica.com,

first line of malaria treatment  Feb 7, 2006
Metakelfin. For severe malaria, quinine has been the drug of choice, while pregnant women have been using Fansidar for prevention. ... - East African,

Health Ministry Imports Stronger Malaria Drug  Feb 3, 2006
Coartem, the first fixed-dose combination of artemether and lumefantrine, is the first line treatment against malaria, replacing chloroquine and fansidar. - AllAfrica.com,

Fansidar to be replaced by Dec  Feb 3, 2006
Fansidar SP, the drug currently being used to cure malaria could be replaced by another drug by December this year, health officials have said. ... - Malawi's Daily Times,

New Malawi drug to replace Fansidar by December  Feb 3, 2006
Health officials in Malawi have said Fansidar SP, a drug which is currently being used to cure malaria could be replaced by another drug by December. ... - African News Dimension,

Why Pregnant Women Need Antenatal Care  Feb 8, 2006
Pregnant mothers are given preventive treatment of three tablets of Fansidar twice between 28 and 36 weeks even when they do not show symptoms of malaria. ... - AllAfrica.com,

Older drugs may be good stopgap treatment for malaria in Africa  Jan 25, 2006
...were fewer cases of malaria among children taking a combination of the older sulfadoxine-pyrimethamine (sold under the brand name Fansidar) and amodiaquine ... - innovations report,

first line of malaria treatment  Feb 7, 2006
Metakelfin. For severe malaria, quinine has been the drug of choice, while pregnant women have been using Fansidar for prevention. ... - East African,

Health ministry imports stronger malaria drug  Feb 2, 2006
Coartem, the first fixed-dose combination of artemether and lumefantrine, is the first line treatment against malaria, replacing chloroquine and fansidar. ... - New Vision,

Sh576m Used to Buy New Malaria Drugs  Jan 20, 2006
...it adopted artemisinin-class combination therapy as the first line treatment drug following the failure of sulpha-based drugs like Fansidar and Metakelfin to ... - AllAfrica.com,

WHO warns malaria drug makers  Jan 25, 2006
Indeed the artemisinin derivatives have now almost totally replaced hitherto common medications such as Fansidar and Chloroquine to become the malaria drugs of ... - Daily Nation (subscription),

Malaria about to strike Ethiopia once more  Jan 21, 2006
Melkamu has no laboratory, not even a fever thermometer. Fansidar tablets are the cheapest and only anti malarial available to the community nurse. ... - EiTB,

Malaria, AIDS, Avian Flu, and MRSA-will we survive?  Jan 19, 2006
A couple of days off work, some Fansidar, Mefloquin, Artemisin, and back to work as usual. I suppose also, the time frame must have some effect. ... - IPP Media - Guardian,

Global Fund Hailed in Fight Against HIV, Malaria  Dec 7, 2005
..."It has also allowed prompt case management of patients and increase the number of pregnant women who receive two doses of Fansidar. ... - AllAfrica.com,

Waist pain is normal in pregnancy  Dec 6, 2005
...industries across the country. I have branches in Warri and in Asaba. I do take Fansidar when I know I have malaria. If it doesn’t ... - Daily Sun,

Malaria: Will It Ever Be Conquered?  Nov 14, 2005
However, there is still chloroquine, quinine, fansidar and coartem with chloroquine and even quinine as well as fansidar fast losing out their effectiveness to ... - AllAfrica.com,

Spare a bottle for mosquito net, says Ntaba  Nov 28, 2005
On malaria treatment, Ntaba said the current Fansidar SP drug still remains a curative measure despite its 15 to 20 percent resistance to the malaria parasite ... - The Nation, Malawi,

Urgent Action Needed to Combat Risk of Malaria Epidemic  Oct 3, 2005
The emergency supply of Chloroquine, Sulphadoxine-pyrimethamine (Fansidar), and Quinine tablets and injections are urgently needed to combat a potentially ... - Addis Tribune,

New Malaria Drugs to Replace Chloroquine  Sep 14, 2005
...in the Ministry of Health, said Artemether and Lumefantrine would gradually replace the current line of anti-malarial drugs, chloroquine and fansidar, as the ... - AllAfrica.com,

Government to import malaria drugs  Sep 20, 2005
We will, however, continue to use Chloroquine and Fansidar, the traditional drugs used for treatment in some areas,� he said. ... - Chronicle,

NAFDAC Seizes N100m Fake Pharmaceutical Products  Sep 29, 2005
Antidiabetes, Analgesics and Antiasthmatics, and that the fake drugs included such drugs as Aldomet, Moduretic, Ampiclox, Augmentin, Ventolin, and Fansidar. - AllAfrica.com,

African specialists discuss treating malaria in pregnant women  Oct 3, 2005
This strategy rests on administering up to three doses of the anti-malarial drug Fansidar to women during their routine ante-natal consultations. ... - People's Daily Online,

Grow the Anti-Malarial Plant  Sep 21, 2005
The Ministry of health has decided to replace chloroquine and fansidar combination with artemether and lumefantrine as the first line malaria treatment. ... - AllAfrica.com,

Many meds don't mix with the sun  Sep 21, 2005
Anti-malaria agents: Chloroquine (Aralen), hydroxychloroquine (Plaquenil), pyrimetha-mine (Daraprim), pyrimetha- mine/sulfadoxine (Fansidar), quinine. ... - Pioneer Press,

Malaria fight in Africa needs better donor coordination and more ...  08 Sep 2005
...because of resistance to traditional first-line anti-malarial treatments, such as chloroquine (CQ) and sulfadoxine pyrimethamine (SP or Fansidar) by Plasmodium ... - ReliefWeb (press release),

Fansidar could have a new lease on life as a protective malaria ...  Aug 19, 2005
The project is supported by a AUD$3.7 million grant to PNGIMR from the Bill and Melinda Gates Foundation. Fansidar is a 20-year-old malaria drug. ... - RxPG NEWS,

Co-trimoxazole in Malawi: risks may outweigh benefits  Aug 24, 2005
Strains of malaria in Malawi are still around 80% sensitive to sulfadoxine-pyrimethamine (Fansidar), which remains the recommended first-line treatment for the ... - Aidsmap,

Uganda Fails to Pick $28m Malaria Cash  Aug 23, 2005
The ministry's malaria programme decided to discontinue the use of chloroquine and fansidar in 2002 when it was found to have a terribly high failure rate of ... - AllAfrica.com,

Of herbs and old wives’ cures  Aug 17, 2005
WHO then recommended the use of sulfadoxine/pyrimethamine (SP) drugs that include Metakelfin and Fansidar for first line treatment. ... - Standard,

Uganda to Launch Malaria Treatment  Jul 20, 2005
Uganda will soon launch a new stronger anti-malaria drug combination to replace the Chloroquine+Fansidar, which has become weaker as the first-line treatment ... - AllAfrica.com

Ugandan Turns to Shrub for Producing Malaria Drug  Jul 27, 2005
Jul. 26--KAMPALA -- Uganda will launch a new antimalarial drug combination to replace the common chloroquine plus fansidar or quinine drugs, which have become ... - RedNova.com

‘We must rescue malaria patients from treatment failure’  Jul 25, 2005
...of who live in the rural areas where they cannot afford to spend N1,200-N1,400 for a cost of illness of malaria as against chloroquine and fansidar which may ... - Vanguard

Surviving Malaria With New Treatment Regimen  Jul 19, 2005
..."They can not afford to spend N1200 or N1400 for an illness like malaria as against chloroquine and fansidar, which may cost them something in the ... - AllAfrica.com

Parents of blinded girl to sue Seremban hospital  Jul 5, 2005
...their only daughter, a former student of SM Tunku Ampuan Durah, Seremban, suffered from Steven Johnson Syndrome (secondary) after being given fansidar, an anti ... - Malay Mail <**results**>

Parents of blinded girl to sue Seremban hospital  Jul 5, 2005
...their only daughter, a former student of SM Tunku Ampuan Durah, Seremban, suffered from Steven Johnson Syndrome (secondary) after being given fansidar, an anti ... - Malay Mail

Society Backs Stronger Malaria Medicine  Jun 24, 2005
Charity Ngilu said that due to rising resistance, the ministry had decided to phase out sulphadoxine/pyrimethamine (SP) drugs such as Fansidar and Metakelfin ... - AllAfrica.com

Burundi: New ECHO and UNICEF supported drug policy prevents child ...  Jun 28, 2005
...“When we used fansidar and chloroquine in the past, the follow-up results always tested positive for malaria, but with the new drug it is negative most of ... - ReliefWeb (press release)

Scientists on the warpath as malaria fights back  Jun 11, 2005
...resistance to these drugs developed very fast and we shifted to using a combination of drugs known as chamoquine, which is made up of fansidar and metakelfin ... - Standard,


Other information


Indication
For the treatment of toxoplasmosis and acute malaria; For the prevention of malaria in areas non-resistant to pyrimethamine

Pharmacology
Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid precursors involved in growth. This activity is highly selective against plasmodia and Toxoplasma gondii. Pyrimethamine possesses blood schizonticidal and some tissue schizonticidal activity against malaria parasites of humans. However, the 4-amino-quinoline compounds are more effective against the erythrocytic schizonts. It does not destroy gametocytes, but arrests sporogony in the mosquito. The action of pyrimethamine against Toxoplasma gondii is greatly enhanced when used in conjunction with sulfonamides.

Mechanism Of Action
Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver.

Drug Category
Antiprotozoals; Antimalarials; Folic Acid Antagonists; ATC:P01BD01

Brand Names/Synonyms
4753 R.P.; BW 5063; CD; Chloridin; Chloridine; Chloridyn; Darachlor; Daraclor; Darapram; Daraprim; Daraprime; Diaminopyritamin; Disulone; Erbaprelina; Ethylpyrimidine; Fansidar; Khloridin; Malacid; Malocid; Malocide; Maloprim; NSC-3061; Pirimecidan; Pirimetamin; Pirimetamina; Primethamine; Pyremethamine; Pyrimethamin; Pyrimethamine; Pyrimethamine Hcl; RP 4753; Tindurin; Tinduring; WR 2978

Dosage Forms
TABLET

Absorption
Well absorbed with peak levels occurring between 2 to 6 hours following administration

Interactions
-->Interactions for Pyrimethamine:

Pyrimethamine may be used with sulfonamides, quinine and other antimalarials, and with other antibiotics. However, the concomitant use of other antifolic drugs or agents associated with myelosuppression including sulfon-amides or trimethoprim-sulfamethoxazole combinations, proguanil, zidovudine, or cytostatic agents (e.g., methotrex-ate) while the patient is receiving pyrimethamine, may increase the risk of bone marrow suppression. If signs of folate deficiency develop, pyrimethamine should be discontinued. Folinic acid (leucovorin) should be administered until normal hematopoiesis is restored. Mild hepatotoxicity has been reported in some patients when lorazepam and pyrimethamine were administered concomitantly.



Chemical IUPAC Name
5-(4-chlorophenyl)-6-ethyl-pyrimidine-2,4-diamine

Chemical Formula
C12H13ClN4

Half Life
96 hours

Drug Type
Approved Drug

# Accession No
APRD00599

CAS Registry Number
58-14-0

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