Famvir: profile and news






One-day, High-dose Famciclovir (Famvir) Therapy Cuts Healing Time ...  06 Mar 2006
SAN FRANCISCO, CA -- March 6, 2006 -- A single high dose of famciclovir (Famvir) appears to reduce time to healing of herpes labialis vesicular lesions by 2 ... - DG News

Novartis Cold Sore Drug Shown to Be Effective  06 Mar 2006
New data demonstrates that a single dose of Novartis' prescription antiviral Famvir given to patients with recurrent cold sores at the onset of symptoms ... - International News Service,

Single-Dose Famvir(R) Treatment Found To Accelerate Healing Time ...  Mar 3, 2006
Famvir treatment also shown to reduce the duration of recurrent genital herpes outbreaks with a single day of therapy SAN FRANCISCO, March 3 /PRNewswire ... - PR Newswire (press release),

Single-Dose Famvir Treatment Found To Accelerate Healing Time of ...  Mar 3, 2006
...today at the American Academy of Dermatology (AAD) annual meeting demonstrated that a single dose of the prescription antiviral Famvir(R) (famciclovir tablets ... - PharmaLive.com (press release),

(PRN) - IMPART Media Group Closes $4.5 Million Equity Financing .. ...  Mar 3, 2006
Investors Conference ... [+. PRN) - Single-Dose Famvir(R) Treatment Found To Accelerate Healing Time of Cold Sore Outbreaks ... [+. PRN ... - Bolsamania.com,

Ask Dr. H | Adult chicken-pox vaccine may help prevent shingles  Feb 6, 2006
Antiviral drugs such as Valtrex and Famvir hasten the recovery if given within 48 hours and decrease both the incidence and duration of this intense nerve pain ... - Philadelphia Inquirer,

Shingles help is coming in new vaccine Ask Dr. H Mitchell Hecht  Feb 7, 2006
Antiviral drugs like Valtrex and Famvir hasten the recovery if given within 48 hours and decrease both the incidence and duration of this very painful nerve ... - Wilkes Barre Times-Leader,

Novartis: Strengthening Its Infectious Disease Portfolio  Feb 9, 2006
Currently, Novartis' ID portfolio consists of antivirals, including Famvir (famciclovir) and Denavir (penciclovir), and antifungals, specifically Lamisil ... - International News Service,

New vaccine can reduce incidence of shingles cases  Feb 14, 2006
Antiviral drugs such as Valtrex and Famvir hasten the recovery if given within 48 hours and decrease both the incidence and duration of this very painful nerve ... - Orlando Sentinel,

Single-Day Famvir (Famciclovir) Treatment Found To Shorten the ...  Jan 12, 2006
DORVAL, QUEBEC -- January 12, 2006 -- Results from a new study demonstrated that a single day of treatment with the antiviral Famvir* (famciclovir) stopped the ... - DG News

Novartis: strengthening its infectious disease portfolio  Feb 7, 2006
Currently, Novartis' ID portfolio consists of antivirals, including Famvir (famciclovir) and Denavir (penciclovir), and antifungals, specifically Lamisil ... - Pharmaceutical Business Review

Ask Dr. H | Adult chicken-pox vaccine may help prevent shingles  Feb 6, 2006
Antiviral drugs such as Valtrex and Famvir hasten the recovery if given within 48 hours and decrease both the incidence and duration of this intense nerve pain ... - Philadelphia Inquirer,

Shingles help is coming in new vaccine Ask Dr. H Mitchell Hecht  Feb 7, 2006
Antiviral drugs like Valtrex and Famvir hasten the recovery if given within 48 hours and decrease both the incidence and duration of this very painful nerve ... - Wilkes Barre Times-Leader,

DO MEN GO THROUGH MENOPAUSE?  Jan 19, 2006
...outbreaks if they are frequent. They are the antiviral drugs Valtrex, Famvir and Zovirax. DEAR DR. DONOHUE: Since ''sleep begets ... - Charlotte Sun-Herald,

New Study Shows One Single Dose of Famvir Significantly Reduces ...  Nov 9, 2005
DORVAL, QUEBEC -- November 9, 2005 -- Treatment with one single, 1500 mg dose of Famvir*(famciclovir) reduced healing time of herpes labialis lesions (cold ... - DG News

Avaian flu threat to stimulate antiviral market growth  Nov 11, 2005
...generic presence is bound to increase significantly with expected US patent expiries of key HSV/VZV products: Valtrex in 2009 and Famvir (famciclovir) in 2010. ... - Pharmaceutical Business Review

Radiation eases shingles pain  Oct 19, 2005
Anti-viral drugs -- such as GlaxoSmithKline's Zovirax and Valtrex, and Novartis's Famvir -- may reduce the risk of PHN if started quickly after the ... - Science Daily (press release)

Radiation May Wipe Out Shingles' Effects  Oct 18, 2005
Some antiviral drugs such as Zovirax, Valtrex, and Famvir have been shown to reduce the duration of postherpetic neuralgia if begun within the first three days ... - WebMD

Herpes connection  Aug 25, 2005
Acyclovir… has been available the longest, but it has to be taken more times per day than the newer medications, Valtrex®… and Famvir®.� Valtrex is ... - Georgia Straight,

Curtis Wong  Aug 4, 2005
...wife.". He calls in for meds: famvir, prednisone, ibuprofen. ... lotion. Tom, the pharmacist at MidTown says, "Curtis this famvir is high priced.". ... - Palladium-Item

Photo Quiz: Inflammatory Lesions on Every Finger  Jul 31, 2005
...also may occur.3 Treatment involves inhibition of viral replication with acyclovir (Zovirax), valacyclovir (Valtrex), or famciclovir (Famvir); symptomatic pain ... - RedNova.com

The Medical Minute: Shingles -- Good news about an old problem  Jul 20, 2005
...think the risk of PHN can be reduced by treating the shingles outbreak as soon as possible with one of several antiviral medications: Famvir, Valtrex or Zovirax ... - Penn State Live <**results**>

Common skin conditions and treatments  Jun 16, 2005
Treatment: Oral antiviral drugs, such as acyclovir, are given. Famciclovir (Famvir) may significantly reduce pain and recovery time. ... - Louisville Courier-Journal,

Common skin conditions and treatments  Jun 16, 2005
Treatment: Oral antiviral drugs, such as acyclovir, are given. Famciclovir (Famvir) may significantly reduce pain and recovery time. ... - Louisville Courier-Journal,

Dealing with risk of herpes  Mar 28, 2005
If my partner wears a condom and I'm on suppressive therapy (Famvir), how safe will it be? Antiviral medications such as Famvir ... - Los Angeles Times (subscription)

Old-fashioned treatment is good as gold  Mar 27, 2005
I don't want to transmit the herpes virus to him. If my partner wears a condom and I'm on suppressive therapy (Famvir), how safe will it be? ... - Houston Chronicle

Buy Herpes and Genital Warts Medication. Buy Acyclovir, Valtrex ...  Mar 6, 2005
...(PRLEAP.COM) According to the CDC, results of a nationally representative study show that genital herpes infection is common in the United States. ... - PR Leap (press release),

International Survey Reveals Need for Greater Understanding of ...  Feb 23, 2005
About Novartis Pharma AG Novartis Pharma AG is the maker of Famvir(R) (famciclover). Famvir is part of the Novartis Infectious Diseases ... - Canada NewsWire (press release),


Other information


Indication
For the treatment of acute herpes zoster (shingles); For the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.

Pharmacology
Famciclovir is a prodrug that undergoes rapid biotransformation to the active antiviral compound penciclovir. Penciclovir is an anti-viral drug which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). Therefore, herpes viral DNA synthesis and replication are selectively inhibited.

Mechanism Of Action
Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted to penciclovir triphosphate by cellular kinases. In vitro studies demonstrate that penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.

Drug Category
Prodrugs; Antivirals; Nucleosides and Nucleotides (08:18.32); ATC:J05AB09; ATC:S01AD07

Brand Names/Synonyms
CHEMBANK1696; FCV; Famciclovir; Famciclovir 98.5; Famciclovir [Usan:Ban:Inn]; Famciclovirum [Inn-Latin]; Famvir

Dosage Forms
Tablet

Absorption
77%

Interactions
Interactions for Famciclovir:

Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.

The conversion of 6-deoxy penciclovir to penciclovir is catalyzed by aldehyde oxidase. Interactions with other drugs metabolized by this enzyme could potentially occur.



Chemical IUPAC Name
[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)-butyl] acetate

Chemical Formula
C14H19N5O4

Half Life
10 hours

Drug Type
Approved Drug

# Accession No
APRD00600

CAS Registry Number
104227-87-4

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