Etonogestrel: profile and news

Akzo Nobel planning IPO for pharma business Feb 7, 2006
...was attributed to strong performances from fertility treatment Puregon/Follistim (follitropin beta) and contraceptive Nuvaring (etonogestrel/ethinylestradiol). - Pharma Times (subscription),

Organon Launches First Nationwide Direct-To-Consumer Advertising ... Nov 8, 2005
...announced the launch of the first nationwide direct-to- consumer (DTC) advertising campaign for the contraceptive NuvaRing(R) (etonogestrel/ethinyl estradiol ... - PR Newswire (press release),

Lower Estrogen Exposure and Fewer Patient Telephone Callbacks ... Sep 9, 2005
FirstCall/ -- (Nasdaq: AKZOY) -- Organon USA today announced that new data show that estrogen exposure with NuvaRing(R) (etonogestrel/ethinyl estradiol vaginal ... - PR Newswire (press release),

Lower Estrogen Exposure and Fewer Patient Telephone Callbacks ... Sep 9, 2005
09, 2005 /PRNewswire-FirstCall/ -- -- Organon USA today announced that new data show that estrogen exposure with NuvaRing(R) (etonogestrel/ethinyl estradiol ... - PharmaLive.com (press release),

Taking one for the team Aug 30, 2005
Rather, it's a small plastic rod, implanted into the upper arm, that releases a steady dose of etonogestrel -- a synthetic form of progesterone -- directly ... - Macleans,

First line of defence Aug 30, 2005
The ring releases 15µg ethinyloestradiol and 120µg etonogestrel daily, and though this is equivalent to the dose seen in ultra-low oral preparations it seems ... - AustralianDoctor.com (subscription),

After 45 Years, Descendants of "The Pill" Rule Contraceptive Roost Jul 29, 2005
Research is under way - a Phase II clinical trial in Europe is evaluating implants with the progestin etonogestrel, for instance - but nothing is close to ... - MedPage Today <**results**>

Contraception During Perimenopause Jun 22, 2005
The three marketed implant systems today are levonorgestrel-releasing implants (Norplant and Jadelle), and a single etonogestrel- releasing implant \(Implanon ... - RedNova.com

Akzo Nobel's Organon to meet with FDA about Implanon action letter ... Jun 21, 2005
...of 2005. Implanon is a small, flexible rod, about the size of a matchstick, that contains etonogestrel, a progestin. Once inserted ... - Forbes

Organon Receives Approvable From FDA for Contraceptive Implant Jun 21, 2005
Organon received an Action letter from the US Food and Drug Administration (FDA) for its implantable contraceptive, Implanon(TM) (etonogestrel implant) which ... - Yahoo News (press release)

NuvaRing.com Receives Prestigious Award Nomination from ... Apr 26, 2005
...weeks. NuvaRing(r) delivers 15 micrograms of estrogen and 120 micrograms etonogestrel per day over three consecutive weeks. After ... - U.S. Newswire

Nuvaring®: No Interaction with Broad-Spectrum Antibiotics Avoids ... Apr 6, 2005
No differences in serum concentrations of the hormones released by NuvaRing - ethinyl estradiol and etonogestrel - were observed between subjects using ... - Medical News Today,

NuvaRing®: at least as reliable as the pill yet with once-a-month ... Mar 11, 2005
When this new data is pooled with all other European trials, NuvaRing - which releases 15 mcg EE and 120 mcg etonogestrel daily - has a Pearl Index of 0.49. ... - Medical News Today,

On the Pill and Fed Up with Irregular Bleeding? New Results Show ... Feb 15, 2005
...to compare the patterns of vaginal bleeding experienced with NuvaRing, a vaginal ring releasing 15 micrograms of estrogen and 120 micrograms etonogestrel a day ... - PharmaLive.com (press release),

Other information

Indication
For use as a female contraceptive (depot)

Pharmacology
Etonogestrel is used as a female contraceptive. Etonogestrel is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Etonogestrel tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.

Mechanism Of Action
Etonogestrel binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like etonogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Drug Category
Contraceptives; ATC:G03AC08

Brand Names/Synonyms
ETONOGESTREL; Etonogestrel [Usan:Inn]; Implanon; ORG 3236

Dosage Forms
Vaginal ring (slow-release)

Absorption
Not Available

Interactions
Interactions for Etonogestrel:
Etonogestrel may interact with the following medications: acetaminophen (Tylenol), antibiotics such as ampicillin and tetracycline, anticonvulsants (Dilantin, Phenobarbital, Tegretol, Trileptal, Topamax, Felbatol), antifungals (Gris-PEG, Nizoral, Sporanox), atorvastatin (Lipitor), clofibrate (Atromid-S), cyclosporine (Neoral, Sandimmune), HIV drugs classified as protease inhibitors (Agenerase, Crixivan, Fortovase, Invirase, Kaletra, Norvir, Viracept), morphine (Astramorph, Kadian, MS Contin), phenylbutazone, prednisolone (Prelone), rifadin (rifampin), St. John's wort, temazepam, theophylline (Theo-Dur), and vitamin C.

Chemical IUPAC Name
13-ethyl-17-ethynyl-17-hydroxy-11-methylidene-2,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one

Chemical Formula
C22H28O2

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00766

CAS Registry Number
54048-10-1