Estradiol: profile and news
Searching for Osteoarthritis Pain Relief? 07 Mar 2006
Excess acetaminophen can cause damage to the liver. Acetaminophen is also found in other pain medications such as Darvocet, Percocet, and Tylenol Cold. ... - DailyIndia.com,
Expert Warns of Overuse of Over-the-Counter Pain Medication 07 Mar 2006
...brand products, but it also is found in numerous other brand-name medications, including some varieties of Excedrin, FeverAll, Genapap, Percocet and more. ... - Newswise (press release)
First-Time Generic Approvals: Xanax XR, Dostinex, Percocet Feb 3, 2006
...generic doses of oxycodone HCl plus acetaminophen 2.5/300-mg, 5/300-mg, 7.5/300-mg, and 10/300-mg tablets (made by Mikart, Inc; brand name Percocet, made by ... - Medscape (subscription)
Woman charged with forgery Mar 5, 2006
Thirty-one separate warrants allege that Jessica Sebastian Pleasants used another person's name and birth date to obtain Oxycodone, Percocet, Roxicet and ... - Durham Herald Sun,
City woman charged for attempting to obtain fraudulent ... Mar 4, 2006
Pharmacy. According to police, Smith entered the drive-thru of the pharmacy and handed the pharmacist a prescription for Percocet. ... - Bridgeton News,
State aiding Somerset nurse probe Mar 2, 2006
Tina L. Henry, 41, of Boswell, and Roberta Yurkovich-Locher, 36, of Johnstown, are accused by borough police of taking Percocet and oxycodone from two patients ... - The Tribune-Democrat,
Ex-ghostbuster seeks to become chart-buster Mar 5, 2006
...succession, the contents of his dream drug cabinet: "I’m on Ritalin, Coumadin, Zantac, Lipitor / Diazepam, Nexium, Prevacid, Percocet / Levitra, Levaquin ... - Columbus Dispatch,
Police file more charges against former nursing home employees Mar 2, 2006
Henry gave Locher a Percocet tablet from a resident's prescription medication supply, according to police. Percocet is a prescription ... - Daily American Online (subscription),
Target 11 Investigates: Nurses On Narcotics Feb 28, 2006
For two years that's how Cathy got her fix of Vicodin, Percocet and Darvacet. The hospital pharmacy finally caught on and Cathy was charged criminally. ... - WPXI.com,
Hottest Massage Trends Feb 28, 2006
While for many people it is easier, and cheaper, to ease tension and soothe aches by popping a couple of Percocet and calling it a night, massage is becoming ... - Forbes
Police prepare for fallout from looming methadone fiasco Mar 3, 2006
..."It's an effective and legal substitute for heroin or other narcotics (eg, morphine, percocet, percodan, dilaudid, codeine, etc.)," says the OATC's website. ... - SooToday.com
Endo Pharmaceuticals Reports Fourth Quarter and Full-Year 2005 ... Feb 15, 2006
Percocet(R). Net sales of Percocet(R) were $29.7 million for the three months ended December 31, 2005 compared with $16.1 million in the same period in 2004. ... - MSN Money
License formally suspended in Hancock case Mar 3, 2006
Infractions included reported shortages of Dilaudid and Percocet, both highly-addictive narcotic painkillers, leaving pharmacy technicians unsupervised to fill ... - Daily Mining Gazette,
GOOD MORNING LOWCOUNTRY Mar 3, 2006
Then there was the failed Percocet poisoning. Then the Benadryl. Oh, did we mention the $300,000 in life insurance and retirement funds? ... - Charleston Post Courier (subscription),
Oxycodone a “problem� drug in town: OPP Feb 27, 2006
...prescription drugs that contain oxycodone – a narcotic opioid used for treating moderate to severe pain – which is found in OxyContin and percocet tablets. ... - Tillsonburg News,
Doctor Pleads to Illegal Distribution Feb 19, 2006
...weren't patients from 2001 to 2004. The painkillers included Oxycontin, Percocet and hydrocodone. Under the plea deal, Weiss must ... - Lakeland Ledger,
A department divided Officer sues police chief for alleged ... Feb 23, 2006
Kicak's suit alleges that Kennelly insisted an evidence bag contained 68 Percocet pills be placed in his desk instead of the evidence room. ... - Hamden Journal,
Notes From the Diaper Bag Feb 23, 2006
...check my e-mail. The friendly “your order has been shipped� e-mail made me quickly reach for another Percocet. A few phone calls ... - Direct Marketing Intelligence (subscription),
Woman loses son to prescription drugs Feb 24, 2006
...drugs. In recent years, drug abuse counselors started seeing more teens turn to pharmaceuticals like Vicodin, Percocet and Oxycontin. ... - WWAY NewsChannel 3,
Appeals court upholds decision against lawyer Feb 17, 2006
Stuart D. Felsen, 37, was convicted by a Morris County jury in April 2004 of obtaining Percocet by fraud and forging the prescription he tried to pass off as ... - Dailyrecord.com,
Man accused of robbing pharmacy arrested Feb 16, 2006
...pharmacy employees. He then stole the painkillers OxyContin and Percocet and fled in an unknown direction, police say. Minchillo ... - Business Gazette,
George Michael on the class C-List Feb 27, 2006
Apparently in Britain, you can't take percocet and pass out in your car, but doing lines in a public club is no big deal at all. ... - Jossip,
In the Region Feb 28, 2006
...$25,000 fine. Bailey was deemed impaired for having taken the drug Percocet, a pain-relieving narcotic, before driving Sept. 6. He ... - Akron Beacon Journal,
Health workers plead guilty to drug charges Feb 27, 2006
Reggie Lloyd. The two men were caught in an undercover operation selling the drug in the form of OxyContin and Percocet. Assistant ... - The State,
Local Schools Battle Prescription Pill Abuse Mar 2, 2006
Now it's their medicine cabinets.". The drugs of choice? Percocet, Lortab and Xanax -- to name a few. "This is very strong stuff," says Officer Jamei Hamrick. ... - State Journal,
Police investigate narcotics theft Mar 3, 2006
...“We are aggressively investigating this case.�. The stolen products included morphine, oxycodone, oxycontin, Duragesic, Avensa, Dilaudid and Percocet. ... - Gallatin News Examiner,
Region briefs Feb 28, 2006
Two men pleaded guilty Monday in federal court in Florence to conspiracy to possess with intent to distribute Oxycodone in the form of OxyContin and Percocet. ... - Florence Morning News,
Cherokee man bungles four tries to kill wife Mar 1, 2006
...puking," he said, laughing some more. Two efforts to poison Norma Holcombe — once with Percocet, once with Benadryl — also failed. - Atlanta Journal Constitution (subscription),
Top Cop coverup in Hamden? Feb 14, 2006
Now, he's accused by this 19-year veteran of the Hamden Police Department of stealing prescription drugs, the pain killer Percocet, seized in a drug raid ... - WTNH,
Man wanted in armed robbery Feb 7, 2006
...the suspect tucked a handgun in the waistband of his pants and showed it to the pharmacist about 3:40 pm and demanded oxycodone, Percocet, methadone and ... - Newton TAB,
Surveillance Footage Of Pharmacy Robbery Released Feb 14, 2006
Medical Center Drive In Gaithersburg. He got away with Oxycondin and Percocet. No one was hurt. Investigators said they believe ... - NBC 4.com,
Suspect Nabbed In Drug Robberies After Footage Prompts Tips Feb 16, 2006
They believe Douglas Minchillo is the man who pulled two heists in which he got away not with cash, but with drugs including Oxycondin, Percocet and Vicodin. ... - WJLA,
Doctor Pleads Guilty to Illegally Distributing OxyContin Feb 18, 2006
...from 2001 to 2004. Those painkillers include OxyContin, Percocet and hydrocodone. Sentencing has not been set. Under terms of the ... - First Coast News,
Police Searching For CVS Robber Feb 6, 2006
...waistband. The man demanded a variety of drugs including oxycondine, Percocet, methadone, and Fentanyl patches and then fled the store. ... - Boston Channel.com,
Man pleads not guilty in drug case Feb 14, 2006
...medicine without a license, drug tax stamp violation, third-offense possession of marijuana and possession of liquid steroids, Percocet, OxyContin and Dilaudid ... - Iowa City Press Citizen,
Marathoner running to rebuild clinic destroyed by Katrina Feb 22, 2006
..."Nerve pain is the worst pain you can endure in your life," she said. "I lived on OxyContin and Percocet for 10 years," before kicking the drugs in rehab. ... - Miami Herald,
Pain doctor's wrongful death trial begins Feb 21, 2006
He was first prescribed Percocet, then Celebrex, before an orthopedic specialist told him to return to work and follow up with him in four to six weeks ... - Roanoke Times,
Police news Feb 26, 2006
Officers obtained a search warrant and found 0.68 grams of crack, $350 in suspected drug proceeds, several Percocet painkillers and drug paraphernalia. ... - The News Journal,
Jurors: Knox was not at fault Feb 23, 2006
...physicians. At most, those doctors put him on Percocet and Celebrex and told him to come back if he still had pain in four to six weeks. ... - Roanoke Times,
Police Report Feb 21, 2006
The man told police the thief took 25 Percocet tablets. The theft occurred sometime on Friday when the man was out paying bills, he told police. ... - Fairbanks Daily News-Miner,
Police Arrest Alleged Pharmacy Robber Feb 16, 2006
They said Minchillo then obtained Oxycondin and Percocet and fled the store. Authorities also said that on Oct. 25, 2005, Minchillo ... - NBC 4.com,
Commissioner Says Detox Saved His Life Feb 21, 2006
..."People who do not normally break the law who would never ever break the law, will break the law to stay out of Percocet or Oxycontin withdrawal," said rick ... - WCJB,
Charges Laid After Two Local Drug Busts Feb 22, 2006
Both searches took place during the early morning hours of Friday, which revealed a quantity of crack cocaine, powder cocaine, percocet tablets, and marihuana ... - CD98.9,
Couple sentenced in drug case Feb 17, 2006
Detectives reportedly seized about $4,900 in cash, numerous pharmacy bottles of Oxycontin and Percocet, and a "large amount" of drug paraphernalia in the home. ... - St. Augustine Record,
Combatting drug abuse: Reducing crime, rebuilding lives Feb 22, 2006
...shyness," Lamb said. Fourteen hours before his session at the clinic, the patient said he took a 10 milligram Percocet. Lamb said ... - Ledger Independent,
Calais woman sentenced to 5 years in drug trafficking Feb 24, 2006
The arrests took place over months and included the seizure of a variety of prescription drugs, such as Tylox, Suboxon, Percocet, Loricet Xanax, Soma, morphine ... - Bangor Daily News,
State board reprimands pharmacist couple Feb 24, 2006
The board also alleged that Barbara Ann Pesciotta used stolen and forged prescription blanks to obtain the painkiller Percocet. ... - Asbury Park Press,
Other information
Indication
For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).
Pharmacology
Estradiol, the principal intracellular human estrogen, is substantially more active than its metabolites, estrone and estriol, at the cellular level.
Mechanism Of Action
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
Drug Category
Anti-menopausal Agents; Anticholesteremic Agents; Estrogens; ATC:G03CA01; ATC:G03CA03; ATC:L02AA02; ATC:L02AA03
Brand Names/Synonyms
?-ESTRADIOL; Aerodiol; Agofollin; Alora; Altrad; Amnestrogen; Aquadiol; Bardiol; Beta-Estradiol; Cis-Estradiol; Cis-Oestradiol; Climaderm; Climara; Combipatch; Compudose; Compudose 200; Compudose 365; Corpagen; D-Estradiol; D-Oestradiol; Delestrogen; Depo-Estradiol; Dermestril; Dihydrofollicular Hormone; Dihydrofolliculin; Dihydromenformon; Dihydrotheelin; Dihydroxyesterin; Dihydroxyestrin; Dihydroxyoestrin; Dimenformon; Dimenformon Prolongatum; Diogyn; Diogynets; Divigel; Encore; Esclim; Estinyl; Estrace; Estraderm; Estraderm Tts; Estradiol; Estradiol Cypionate; Estradiol Valerate; Estradiol-17beta; Estradurin; Estraldine; Estrasorb; Estreva; Estrifam; Estring; Estring Vaginal Ring; Estroclim; Estroclim 50; Estrofem 2; Estrofem Forte; Estrogel; Estrogens, Esterified; Estrol; Estrovite; Evex; Evorel; Extrasorb; Femestral; Femestrol; Feminone; Femogen; Fempatch; Femring; Femtrace; Femtran; Follicyclin; Ginedisc; Ginosedol; Gynergon; Gynestrel; Gynodiol; Gynoestryl; Gynpolar; Innofem; Lamdiol; Lynoral; Macrodiol; Macrol; Menest; Menorest; Menostar; Microdiol; NSC-9895; Nordicol; Oestergon; Oestradiol; Oestradiol R; Oestrogel; Oestroglandol; Oestrogynal; Ovahormon; Ovasterol; Ovastevol; Ovociclina; Ovocyclin; Ovocycline; Ovocylin; Perlatanol; Primofol; Profoliol; Profoliol B; Progynon; Progynon Dh; Progynon-Dh; Ricifon; Ritsifon; Sandrena Gel; Sisare Gel; Sk-Estrogens; Soldep; Sotipox; Syndiol; Systen; Theelin, Dihydro-; Tradelia; Trial Sat; Trocosone; Vagifem; Vivelle; Zerella; Zumenon; Ô-Estradiol
Dosage Forms
DISC (SUSTAINED-RELEASE); GEL; IMPLANT; LIQUID; PATCH; RING (SLOW-RELEASE); SOLUTION; TABLET
Absorption
43%
Interactions
-->Interactions for Estradiol:
D. Drug and Laboratory Test Interactions
1. Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased
platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex,
II-VII-X complex, and beta-thromboglobulin; decreased levels of anti-factor Xa and antithrombin III, decreased
antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and
activity.
2. Increased thyroid-binding globulin (TBG) leading to increased circulating total thyroid hormone
levels, as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or
T3 levels by radioimmunoassay. T3 resin uptake is decreased, reflecting the elevated TBG. Free
T4 and T3 concentrations are unaltered. Patients on thyroid replacement therapy may require
higher doses of thyroid hormone.
3. Other binding proteins may be elevated in serum, i.e., corticosteroid binding globulin (CBG), sex
hormone-binding globulin (SHBG), leading to increased total circulating corticosteroids and sex steroids,
respectively. Free hormone concentrations may be decreased. Other plasma proteins may be increased
(angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin).
4. Increased plasma HDL and HDL2 cholesterol subfraction concentrations, reduced LDL
cholesterol concentration, increased triglyceride levels.
5. Impaired glucose tolerance.
6. Reduced response to metyrapone test.
Chemical IUPAC Name
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
Chemical Formula
C18H24O2
Half Life
36 hours
Drug Type
Approved Drug
# Accession No
APRD00311
CAS Registry Number
50-28-2