Estradiol: profile and news






Searching for Osteoarthritis Pain Relief?  07 Mar 2006
Excess acetaminophen can cause damage to the liver. Acetaminophen is also found in other pain medications such as Darvocet, Percocet, and Tylenol Cold. ... - DailyIndia.com,

Expert Warns of Overuse of Over-the-Counter Pain Medication  07 Mar 2006
...brand products, but it also is found in numerous other brand-name medications, including some varieties of Excedrin, FeverAll, Genapap, Percocet and more. ... - Newswise (press release)

First-Time Generic Approvals: Xanax XR, Dostinex, Percocet  Feb 3, 2006
...generic doses of oxycodone HCl plus acetaminophen 2.5/300-mg, 5/300-mg, 7.5/300-mg, and 10/300-mg tablets (made by Mikart, Inc; brand name Percocet, made by ... - Medscape (subscription)

Woman charged with forgery  Mar 5, 2006
Thirty-one separate warrants allege that Jessica Sebastian Pleasants used another person's name and birth date to obtain Oxycodone, Percocet, Roxicet and ... - Durham Herald Sun,

City woman charged for attempting to obtain fraudulent ...  Mar 4, 2006
Pharmacy. According to police, Smith entered the drive-thru of the pharmacy and handed the pharmacist a prescription for Percocet. ... - Bridgeton News,

State aiding Somerset nurse probe  Mar 2, 2006
Tina L. Henry, 41, of Boswell, and Roberta Yurkovich-Locher, 36, of Johnstown, are accused by borough police of taking Percocet and oxycodone from two patients ... - The Tribune-Democrat,

Ex-ghostbuster seeks to become chart-buster  Mar 5, 2006
...succession, the contents of his dream drug cabinet: "I’m on Ritalin, Coumadin, Zantac, Lipitor / Diazepam, Nexium, Prevacid, Percocet / Levitra, Levaquin ... - Columbus Dispatch,

Police file more charges against former nursing home employees  Mar 2, 2006
Henry gave Locher a Percocet tablet from a resident's prescription medication supply, according to police. Percocet is a prescription ... - Daily American Online (subscription),

Target 11 Investigates: Nurses On Narcotics  Feb 28, 2006
For two years that's how Cathy got her fix of Vicodin, Percocet and Darvacet. The hospital pharmacy finally caught on and Cathy was charged criminally. ... - WPXI.com,

Hottest Massage Trends  Feb 28, 2006
While for many people it is easier, and cheaper, to ease tension and soothe aches by popping a couple of Percocet and calling it a night, massage is becoming ... - Forbes

Police prepare for fallout from looming methadone fiasco  Mar 3, 2006
..."It's an effective and legal substitute for heroin or other narcotics (eg, morphine, percocet, percodan, dilaudid, codeine, etc.)," says the OATC's website. ... - SooToday.com

Endo Pharmaceuticals Reports Fourth Quarter and Full-Year 2005 ...  Feb 15, 2006
Percocet(R). Net sales of Percocet(R) were $29.7 million for the three months ended December 31, 2005 compared with $16.1 million in the same period in 2004. ... - MSN Money

License formally suspended in Hancock case  Mar 3, 2006
Infractions included reported shortages of Dilaudid and Percocet, both highly-addictive narcotic painkillers, leaving pharmacy technicians unsupervised to fill ... - Daily Mining Gazette,

GOOD MORNING LOWCOUNTRY  Mar 3, 2006
Then there was the failed Percocet poisoning. Then the Benadryl. Oh, did we mention the $300,000 in life insurance and retirement funds? ... - Charleston Post Courier (subscription),

Oxycodone a “problemâ€? drug in town: OPP  Feb 27, 2006
...prescription drugs that contain oxycodone – a narcotic opioid used for treating moderate to severe pain – which is found in OxyContin and percocet tablets. ... - Tillsonburg News,

Doctor Pleads to Illegal Distribution  Feb 19, 2006
...weren't patients from 2001 to 2004. The painkillers included Oxycontin, Percocet and hydrocodone. Under the plea deal, Weiss must ... - Lakeland Ledger,

A department divided Officer sues police chief for alleged ...  Feb 23, 2006
Kicak's suit alleges that Kennelly insisted an evidence bag contained 68 Percocet pills be placed in his desk instead of the evidence room. ... - Hamden Journal,

Notes From the Diaper Bag  Feb 23, 2006
...check my e-mail. The friendly “your order has been shipped� e-mail made me quickly reach for another Percocet. A few phone calls ... - Direct Marketing Intelligence (subscription),

Woman loses son to prescription drugs  Feb 24, 2006
...drugs. In recent years, drug abuse counselors started seeing more teens turn to pharmaceuticals like Vicodin, Percocet and Oxycontin. ... - WWAY NewsChannel 3,

Appeals court upholds decision against lawyer  Feb 17, 2006
Stuart D. Felsen, 37, was convicted by a Morris County jury in April 2004 of obtaining Percocet by fraud and forging the prescription he tried to pass off as ... - Dailyrecord.com,

Man accused of robbing pharmacy arrested  Feb 16, 2006
...pharmacy employees. He then stole the painkillers OxyContin and Percocet and fled in an unknown direction, police say. Minchillo ... - Business Gazette,

George Michael on the class C-List  Feb 27, 2006
Apparently in Britain, you can't take percocet and pass out in your car, but doing lines in a public club is no big deal at all. ... - Jossip,

In the Region  Feb 28, 2006
...$25,000 fine. Bailey was deemed impaired for having taken the drug Percocet, a pain-relieving narcotic, before driving Sept. 6. He ... - Akron Beacon Journal,

Health workers plead guilty to drug charges  Feb 27, 2006
Reggie Lloyd. The two men were caught in an undercover operation selling the drug in the form of OxyContin and Percocet. Assistant ... - The State,

Local Schools Battle Prescription Pill Abuse  Mar 2, 2006
Now it's their medicine cabinets.". The drugs of choice? Percocet, Lortab and Xanax -- to name a few. "This is very strong stuff," says Officer Jamei Hamrick. ... - State Journal,

Police investigate narcotics theft  Mar 3, 2006
...“We are aggressively investigating this case.�. The stolen products included morphine, oxycodone, oxycontin, Duragesic, Avensa, Dilaudid and Percocet. ... - Gallatin News Examiner,

Region briefs  Feb 28, 2006
Two men pleaded guilty Monday in federal court in Florence to conspiracy to possess with intent to distribute Oxycodone in the form of OxyContin and Percocet. ... - Florence Morning News,

Cherokee man bungles four tries to kill wife  Mar 1, 2006
...puking," he said, laughing some more. Two efforts to poison Norma Holcombe — once with Percocet, once with Benadryl — also failed. - Atlanta Journal Constitution (subscription),

Top Cop coverup in Hamden?  Feb 14, 2006
Now, he's accused by this 19-year veteran of the Hamden Police Department of stealing prescription drugs, the pain killer Percocet, seized in a drug raid ... - WTNH,

Man wanted in armed robbery  Feb 7, 2006
...the suspect tucked a handgun in the waistband of his pants and showed it to the pharmacist about 3:40 pm and demanded oxycodone, Percocet, methadone and ... - Newton TAB,

Surveillance Footage Of Pharmacy Robbery Released  Feb 14, 2006
Medical Center Drive In Gaithersburg. He got away with Oxycondin and Percocet. No one was hurt. Investigators said they believe ... - NBC 4.com,

Suspect Nabbed In Drug Robberies After Footage Prompts Tips  Feb 16, 2006
They believe Douglas Minchillo is the man who pulled two heists in which he got away not with cash, but with drugs including Oxycondin, Percocet and Vicodin. ... - WJLA,

Doctor Pleads Guilty to Illegally Distributing OxyContin  Feb 18, 2006
...from 2001 to 2004. Those painkillers include OxyContin, Percocet and hydrocodone. Sentencing has not been set. Under terms of the ... - First Coast News,

Police Searching For CVS Robber  Feb 6, 2006
...waistband. The man demanded a variety of drugs including oxycondine, Percocet, methadone, and Fentanyl patches and then fled the store. ... - Boston Channel.com,

Man pleads not guilty in drug case  Feb 14, 2006
...medicine without a license, drug tax stamp violation, third-offense possession of marijuana and possession of liquid steroids, Percocet, OxyContin and Dilaudid ... - Iowa City Press Citizen,

Marathoner running to rebuild clinic destroyed by Katrina  Feb 22, 2006
..."Nerve pain is the worst pain you can endure in your life," she said. "I lived on OxyContin and Percocet for 10 years," before kicking the drugs in rehab. ... - Miami Herald,

Pain doctor's wrongful death trial begins  Feb 21, 2006
He was first prescribed Percocet, then Celebrex, before an orthopedic specialist told him to return to work and follow up with him in four to six weeks ... - Roanoke Times,

Police news  Feb 26, 2006
Officers obtained a search warrant and found 0.68 grams of crack, $350 in suspected drug proceeds, several Percocet painkillers and drug paraphernalia. ... - The News Journal,

Jurors: Knox was not at fault  Feb 23, 2006
...physicians. At most, those doctors put him on Percocet and Celebrex and told him to come back if he still had pain in four to six weeks. ... - Roanoke Times,

Police Report  Feb 21, 2006
The man told police the thief took 25 Percocet tablets. The theft occurred sometime on Friday when the man was out paying bills, he told police. ... - Fairbanks Daily News-Miner,

Police Arrest Alleged Pharmacy Robber  Feb 16, 2006
They said Minchillo then obtained Oxycondin and Percocet and fled the store. Authorities also said that on Oct. 25, 2005, Minchillo ... - NBC 4.com,

Commissioner Says Detox Saved His Life  Feb 21, 2006
..."People who do not normally break the law who would never ever break the law, will break the law to stay out of Percocet or Oxycontin withdrawal," said rick ... - WCJB,

Charges Laid After Two Local Drug Busts  Feb 22, 2006
Both searches took place during the early morning hours of Friday, which revealed a quantity of crack cocaine, powder cocaine, percocet tablets, and marihuana ... - CD98.9,

Couple sentenced in drug case  Feb 17, 2006
Detectives reportedly seized about $4,900 in cash, numerous pharmacy bottles of Oxycontin and Percocet, and a "large amount" of drug paraphernalia in the home. ... - St. Augustine Record,

Combatting drug abuse: Reducing crime, rebuilding lives  Feb 22, 2006
...shyness," Lamb said. Fourteen hours before his session at the clinic, the patient said he took a 10 milligram Percocet. Lamb said ... - Ledger Independent,

Calais woman sentenced to 5 years in drug trafficking  Feb 24, 2006
The arrests took place over months and included the seizure of a variety of prescription drugs, such as Tylox, Suboxon, Percocet, Loricet Xanax, Soma, morphine ... - Bangor Daily News,

State board reprimands pharmacist couple  Feb 24, 2006
The board also alleged that Barbara Ann Pesciotta used stolen and forged prescription blanks to obtain the painkiller Percocet. ... - Asbury Park Press,


Other information


Indication
For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Pharmacology
Estradiol, the principal intracellular human estrogen, is substantially more active than its metabolites, estrone and estriol, at the cellular level.

Mechanism Of Action
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

Drug Category
Anti-menopausal Agents; Anticholesteremic Agents; Estrogens; ATC:G03CA01; ATC:G03CA03; ATC:L02AA02; ATC:L02AA03

Brand Names/Synonyms
?-ESTRADIOL; Aerodiol; Agofollin; Alora; Altrad; Amnestrogen; Aquadiol; Bardiol; Beta-Estradiol; Cis-Estradiol; Cis-Oestradiol; Climaderm; Climara; Combipatch; Compudose; Compudose 200; Compudose 365; Corpagen; D-Estradiol; D-Oestradiol; Delestrogen; Depo-Estradiol; Dermestril; Dihydrofollicular Hormone; Dihydrofolliculin; Dihydromenformon; Dihydrotheelin; Dihydroxyesterin; Dihydroxyestrin; Dihydroxyoestrin; Dimenformon; Dimenformon Prolongatum; Diogyn; Diogynets; Divigel; Encore; Esclim; Estinyl; Estrace; Estraderm; Estraderm Tts; Estradiol; Estradiol Cypionate; Estradiol Valerate; Estradiol-17beta; Estradurin; Estraldine; Estrasorb; Estreva; Estrifam; Estring; Estring Vaginal Ring; Estroclim; Estroclim 50; Estrofem 2; Estrofem Forte; Estrogel; Estrogens, Esterified; Estrol; Estrovite; Evex; Evorel; Extrasorb; Femestral; Femestrol; Feminone; Femogen; Fempatch; Femring; Femtrace; Femtran; Follicyclin; Ginedisc; Ginosedol; Gynergon; Gynestrel; Gynodiol; Gynoestryl; Gynpolar; Innofem; Lamdiol; Lynoral; Macrodiol; Macrol; Menest; Menorest; Menostar; Microdiol; NSC-9895; Nordicol; Oestergon; Oestradiol; Oestradiol R; Oestrogel; Oestroglandol; Oestrogynal; Ovahormon; Ovasterol; Ovastevol; Ovociclina; Ovocyclin; Ovocycline; Ovocylin; Perlatanol; Primofol; Profoliol; Profoliol B; Progynon; Progynon Dh; Progynon-Dh; Ricifon; Ritsifon; Sandrena Gel; Sisare Gel; Sk-Estrogens; Soldep; Sotipox; Syndiol; Systen; Theelin, Dihydro-; Tradelia; Trial Sat; Trocosone; Vagifem; Vivelle; Zerella; Zumenon; Ô-Estradiol

Dosage Forms
DISC (SUSTAINED-RELEASE); GEL; IMPLANT; LIQUID; PATCH; RING (SLOW-RELEASE); SOLUTION; TABLET

Absorption
43%

Interactions
-->Interactions for Estradiol:

D. Drug and Laboratory Test Interactions

1. Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex, II-VII-X complex, and beta-thromboglobulin; decreased levels of anti-factor Xa and antithrombin III, decreased antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and activity.

2. Increased thyroid-binding globulin (TBG) leading to increased circulating total thyroid hormone levels, as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels by radioimmunoassay. T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and T3 concentrations are unaltered. Patients on thyroid replacement therapy may require higher doses of thyroid hormone.

3. Other binding proteins may be elevated in serum, i.e., corticosteroid binding globulin (CBG), sex hormone-binding globulin (SHBG), leading to increased total circulating corticosteroids and sex steroids, respectively. Free hormone concentrations may be decreased. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin).

4. Increased plasma HDL and HDL2 cholesterol subfraction concentrations, reduced LDL cholesterol concentration, increased triglyceride levels.

5. Impaired glucose tolerance.

6. Reduced response to metyrapone test.



Chemical IUPAC Name
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

Chemical Formula
C18H24O2

Half Life
36 hours

Drug Type
Approved Drug

# Accession No
APRD00311

CAS Registry Number
50-28-2

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