Enoxaparin: profile and news

Wockhardt wins USFDA nod for Ranitidine OTC version Feb 27, 2006
Wockhardt Ltd announced on Monday that, it has received United States Food & Drug Administration (US FDA) approval for marketing Ranitidine 75mg tablets as an ... - India Infoline.com,

Wockhardt receives US FDA approval for Ranitidine OTC version Feb 27, 2006
Pharmaceutical and biotechnology company Wockhardt Limited has received the US FDA approval for marketing Ranitidine 75mg tablets as an over-the-counter (OTC ... - domain-B,

New US tonic for Wockhardt Feb 27, 2006
Mumbai, Feb. 27: Wockhardt Ltd today said it will soon launch anti-ulcer drug Ranitidine in the US. The United States Food & Drug ... - Calcutta Telegraph,

Indices firm ahead of tomorrow's budget announcement Feb 27, 2006
Wokhardt has received US FDA approval to market ranitidine tablets in the US. The company said the current market for the drug is $61 million per annum. ... - domain-B,

Misdosing of Medications Prompts Most Poison Calls About Young ... Mar 1, 2006
Fifty-nine percent of ingestions involved medications, most commonly ranitidine (11%), metoclopramide (9%), acetaminophen (8%), and Dimetapp Infant Drops (6 ... - AAP Grand Rounds (subscription)

Common practice of prescribing H2 blockers to treat acid reflux in ... Feb 24, 2006
The cause of the disorder is unknown. Common H2 blockers are cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac), and nizatidine (Axid). ... - News-Medical.net,

Class-action suit filed against Omnicare Feb 6, 2006
...said it believes the government is investigating allegations of substitution of three generic drugs: substituting capsules for tablets of Ranitidine, a generic ... - Louisville Business First,

H 2 Blockers in Preemies Raise Necrotizing Enterocolitis Risk Feb 9, 2006
H 2 blockers such as Tagamet (cimetidine), Pepcid (famotidine), Zantac (ranitidine), and Axid (nizatidine) are commonly given to neonates to treat or prevent ... - MedPage Today,

The Gita Mathai Column:Ooch, my stomach hurts Feb 14, 2006
Chemists formulated ranitidine and the omeprazole group of medicines. These blocked, inhibited and suppressed acid production. They worked well in theory. ... - Newindpress,

Omnicare Shares Skid on Downgrade Sparked by Raid Feb 5, 2006
Omnicare, the federal government and "certain states" are investigating allegations that the company has been substituting antacid drug Ranitidine capsules for ... - ChallengerNKY.com,

Shareholder Class Action Filed Against Omnicare, Inc. by the Law ... Feb 13, 2006
...two 7.5-milligram Buspirone anti-anxiety tablets for one 15-milligram tablet, Fluoxetine anti-depression tablets for capsules and Ranitidine heartburn capsules ... - Yahoo! News (press release)

Acid Reflux: Is the Medication Worse Than the Condition? FLAVORx ... 09 Feb 2006
In addition, the active ingredient, Ranitidine HCl, has a very bitter taste and sulfur-like odor, which are both masked with a strong peppermint flavor that ... - PR Web (press release),

H 2 Blockers in Preemies Raise Necrotizing Enterocolitis Risk 09 Feb 2006
H 2 blockers such as Tagamet (cimetidine), Pepcid (famotidine), Zantac (ranitidine), and Axid (nizatidine) are commonly given to neonates to treat or prevent ... - MedPage Today,

Common Reflux Treatment Linked to Life Threatening Bowel Infection ... 09 Feb 2006
The cause of the disorder is unknown. Common H2 blockers are cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac), and nizatidine (Axid). ... - Kansas City infoZine,

Probe News Punishes Omnicare Jan 17, 2006
...two 7.5-milligram Buspirone anti-anxiety tablets for one 15-milligram tablet, Fluoxetine anti-depression tablets for capsules and Ranitidine heartburn capsules ... - TheStreet.com

Omnicare subpoenaed in generic drug probe Jan 16, 2006
...the investigation. Substituting capsules for tablets of Ranitidine, a generic form of the heartburn drug Zantac. Giving tablets ... - Louisville Business First,

It's Enough to Give Him an Ulcer! Jan 20, 2006
...with GastroGard.". Other treatment options, according to Andrews, include ranitidine, the human equivalent of Zantac. Daily dosage ... - TheHorse.com,

Update 1-Omnicare says gets subpoena from US Attorney Jan 13, 2006
It said it believes the government was looking into the substitution of capsules for tablets of Ranitidine, a generic of GlaxoSmithKline's (GSK.L: Quote ... - Reuters

Omnicare drug 'relationships' come under federal scrutiny Jan 13, 2006
Omnicare said that the federal government and the states are investigating the company's decision to substitute capsules for tablets of ranitidine, which is ... - Cincinnati Post,

Business digest Jan 17, 2006
The company said the government and several states are investigating allegations of drug substitutions involving ranitidine (an anti-heartburn medication ... - Cincinnati Enquirer,

Dr. Reddy's Reports Q3 FY06 Revenue of Rs. 5,902 Million; YoY ... Jan 24, 2006
This decrease was primarily on account of decline in sales of ranitidine hydrochloride partially offset by higher sales of naproxen and sertraline. ... - Genetic Engineering News,

City Councilman resigns Jan 12, 2006
...and July 5. Those drugs included hydrocodone, marijuana, OxyContin, Zyrtec 10, buspirone hydrochloride and ranitidine. He also is ... - Myrtle Beach Sun News,

Ranitidine Zeptag beats Everball 109-97 Dec 2, 2005
Ranitidine Zeptag continues to wax hot in the ongoing Everball Basketball Tournament by routing Everball Sport Club 109-97 last Wednesday at the Evergold gym. ... - The Mandanao Daily Mirror,

Booster shot Dec 4, 2005
In ’04-05, over 80% of Shasun’s revenues was derived from three mature products, Ibuprofen, Ranitidine and Nizatidine with Ibuprofen alone accounting for ... - Economic Times,

Holiday heartburn Dec 6, 2005
...long.". Katz said Zantac (common name ranitidine) works for approximately six hours, but takes an "hour or so" to take effect. Two ... - Jackson Hole Star-Tribune,

Horse Racing Authority amends drug rules Nov 14, 2005
...changed, including the creation of a new class of drugs -- Class D drugs -- that will include certain medications, including Omeprozole, Ranitidine and DMSO ... - Louisville Business First,

Kentucky Horse Racing Authority modifies drug rules Nov 14, 2005
A new classification of drugs has been created, Class D, which will include Omeprozole, Ranitidine, and DMSO, which were formerly Class C drugs. ... - Thoroughbred Times,

Kentucky Horse Racing Authority Gives Final Approval to Drug ... Nov 15, 2005
...were changed, including the creation of a new class of drugs--Class D drugs--that will include certain medications, including omeprozole, ranitidine, and DMSO ... - TheHorse.com,

Holiday Treats Present Temptations and Challenges for Children ... Nov 22, 2005
Examples include nizatidine (Axid(R) OS), ranitidine, famotidine and cimetidine(i). -- Find a treatment that is easy for the child to take - large pills or ... - PR Newswire (press release),

Book Excerpt: Laminitis Nov 16, 2005
...administered. Addition of anti-ulcer medications such as omeprazole or ranitidine may be worthwhile considerations. Phenylbutazone ... - TheHorse.com,

Holidays Present Challenges for Children With GERD Nov 23, 2005
...is called H2-blockers. Examples include nizatidine (Axid® OS), ranitidine, famotidine and cimetidine. -- Find a treatment that ... - EndoNurse,

Holiday Treats Present Temptations and Challenges for Children ... Nov 22, 2005
Examples include nizatidine (Axid® OS), ranitidine, famotidine and cimetidine(i). -- Find a treatment that is easy for the child to take - large pills or harsh ... - Market Wire (press release)

Other information

Indication
For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism

Pharmacology
Enoxaparin is a highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Enoxaparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Enoxaparin is a well known and commonly used anticoagulant which has antithrombotic properties. Enoxaparin is indicated for the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin. Enoxaparin inhibits reactions that lead to the clotting of blood and the formation of fibrin clots both in vitro and in vivo. Enoxaparin acts at multiple sites in the normal coagulation system. Small amounts of Enoxaparin in combination with antithrombin III (Enoxaparin cofactor) can inhibit thrombosis by inactivating activated Factor X and inhibiting the conversion of prothrombin to thrombin. Once active thrombosis has developed, larger amounts of Enoxaparin can inhibit further coagulation by inactivating thrombin and preventing the conversion of fibrinogen to fibrin. Enoxaparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.

Mechanism Of Action
The mechanism of action of Enoxaparin is antithrombin-dependent. It acts mainly by accelerating the rate of the neutralization of certain activated coagulation factors by antithrombin, but other mechanisms may also be involved. The antithrombotic effect of Enoxaparin is well correlated to the inhibition of factor Xa. Enoxaparin interacts with Antithrombin III, Prothrombin and Factor X.

Drug Category
Fibrinolytic Agents; Anticoagulants; Heparins; ATC:B01AB05

Brand Names/Synonyms
Enoxaparin; Enoxaparin Sodium; Heparin; Heparin Sodium; Heparin Sodium Salt; Lovenox; Lovenox Hp; Low Molecular Weight Heparin Sodium

Dosage Forms
Solution for subcutaneous injection

Absorption
~100% following subcutaneous injection

Interactions
-->Interactions for Enoxaparin:

Unless really needed, agents which may enhance the risk of hemorrhage should be discontinued prior to initiation of Lovenox Injection therapy. These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, sali-cylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone. If co-administration is essential, conduct close clinical and laboratory monitoring.

Chemical IUPAC Name
6-[5-acetylamino-4,6-dihydroxy-2-(sulfooxymethyl)tetrahydropyran-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxy-tetrahydropyran-2-yl)oxy-6-(hydroxymethyl)-3-sulfoamino-4-sulfooxy-tetrahydropyran-2-yl]oxy-4-hydroxy-5-sulfooxy-tetrahydropyran-2-carboxylicacid

Chemical Formula
(C26H40N2O36S5)n

Half Life
4.5 hours

Drug Type
Approved Drug

# Accession No
APRD00068

CAS Registry Number
9005-49-6