Emtricitabine: profile and news

Advances in First-Line and "Switch" Antiretroviral Strategies for ... Feb 2, 2006
The 418 study [7] was a randomized, open-label trial comparing once-daily tenofovir/emtricitabine together with lopinavir/ritonavir either once or twice daily ... - Medscape (subscription)

A Potential HIV Prophylactic? Feb 7, 2006
...daily injections of Gilead ’s combination drug, Truvada, and the group which received just one of Truvada’s constituent drugs, emtricitabine, caught the ... - Red Herring,

Simplified treatment regimens show promise in HIV-infected ... Feb 6, 2006
They treated the patients with a once-daily regimen of three anti-HIV drugs comprising ddI (didanosine, Videx / Videx EC), FTC (emtricitabine, Emtriva) and ... - Aidsmap,

Anti-Retrovirals in Africa, not a distant dream Feb 9, 2006
...of Medicine as reported in the Journal The New England Journal of Medicine that Antiretroviral combination drug of Tenofovir, Emtricitabine and Efavirenz is ... - MedIndia,

AIDS drug cocktail can block HIV transmission: study Feb 7, 2006
...said Monday that tests on rhesus macaques showed that preventative application of two anti-retroviral drugs, tenovir (TDF) and emtricitabine (FTC), can stop ... - TODAYonline,

CROI: AZT, 3TC and FTC achieve good concentrations in the female ... Feb 17, 2006
The antiretroviral drugs AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir) and FTC (emtricitabine, Emtriva) rapidly achieve high concentrations in the ... - Aidsmap,

Management of HIV/HBV Coinfection Feb 8, 2006
A management plan was developed and the patient initiated therapy with the fixed-dose combination of tenofovir and emtricitabine and ritonavir-boosted ... - Medscape (subscription)

Anti-Retrovirals in Africa, not a distant dream 09 Feb 2006
...of Medicine as reported in the Journal The New England Journal of Medicine that Antiretroviral combination drug of Tenofovir, Emtricitabine and Efavirenz is ... - MedIndia,

Study Sets New Gold Standard For Initial Antiretroviral Treatment ... Jan 25, 2006
...the researchers showed that after one year of treatment, a regimen of antiretroviral pills, called tenofovir DF (Viread) and emtricitabine (Emtriva), plus ... - Science Daily (press release)

Study Sets New Gold Standard for Antiretroviral HIV Treatment Jan 23, 2006
...the researchers showed that after one year of treatment, a regimen of antiretroviral pills called tenofovir DF (Viread) and emtricitabine (Emtriva), plus ... - Johns Hopkins Gazette,

Gilead Sciences Announces Fourth Quarter and Full Year 2005 ... Jan 30, 2006
...growth continues to be driven primarily by Gilead's HIV product franchise, including the continued strong uptake of Truvada(R) (emtricitabine and tenofovir ... - Genetic Engineering News,

Bristol-Myers Squibb and Gilead Announce Data Supporting ... Jan 9, 2006
...of a new formulation of the fixed-dose combination ofBristol-Myers Squibb's Sustiva(R) (efavirenz) and Gilead's Truvada(R)(emtricitabine and tenofovir ... - Finanzen.net,

Companies Anticipate Filing New Drug Application in Second Quarter ... Jan 9, 2006
...of a new formulation of the fixed-dose combination of Bristol-Myers Squibb's Sustiva® (efavirenz) and Gilead's Truvada® (emtricitabine and tenofovir ... - Nieuwsbank (persbericht),

Study compares HIV treatment options Jan 31, 2006
They were divided into two groups: the first received a combination of three drugs, tenofovir (Viread), emtricitabine (Emtriva) and efavirenz (Sustiva), all of ... - myDNA.com,

Health Beat Jan 26, 2006
...new pill does not have a name yet but it would combine those drugs now sold as Sustiva (efavirenz), Viread (tenofovir), and Emtriva (emtricitabine) that are ... - Bay Area Reporter,

Researchers find better HIV medication Jan 18, 2006
As an initial treatment, the once-daily combination of antiretroviral tenofovir DF (Viread), emtricitabine (Emtriva), and efavirenz (Sustiva), works better ... - Xinhua,

Data Comparing Viread(R) and Emtriva(R) to Combivir(R) as Part of ... Jan 18, 2006
...from a clinical trial (Study 934) comparing a once-daily treatment regimen of Viread(R) (tenofovir disoproxil fumarate), Emtriva(R) (emtricitabine) and Sustiva ... - Genetic Engineering News,

Better Treatment for HIV Jan 18, 2006
Patients taking tenofovir disoproxil fumarate, emtricitabine, and efavirenz once a day were significantly more likely to have lower HIV RNA levels and higher ... - Ivanhoe,

Study gives high marks to new drugs Jan 19, 2006
The findings relate to a regimen of the new antiretroviral pills tenofovir DF (Viread) and emtricitabine (Emtriva), plus efavirenz (Sustiva). ... - United Press International

US stops trial of interrupted HIV treatment Jan 18, 2006
Journal of Medicine, showed that taking the three drugs Viread, known generically as tenofovir, Emtriva, known generically as emtricitabine, and Sustiva or ... - Reuters AlertNet,

Gilead HIV drug combo beats GSK rival in phase III trial Jan 20, 2006
The clinical trial (Study 934) compared a treatment regimen of Viread (tenofovir disoproxil fumarate), Emtriva (emtricitabine) and Sustiva (efavirenz) to a ... - Pharmaceutical Business Review

One AIDS treatment study proves promising, another harmful Jan 20, 2006
...international AIDS treatment study found that a once-daily combination of three antiretroviral medications - tenofovir DF (Viread), emtricitabine (Emtriva) and ... - The California Aggie Online

Drug price reduction makes Aids manageable Jan 25, 2006
...a non-exclusive licensing and distribution deal with Gilead Sciences to make generic versions of the ARVs, Truvada (a combination of emtricitabine and tenofovir ... - iAfrica.com,

Intermittent AIDS-treatment study is halted Jan 19, 2006
After one year of treatment, a regimen of antiretroviral pills – called tenofovir DF (Viread) and emtricitabine (Emtriva), plus efavirenz (Sustiva) – led ... - New Scientist (subscription),

New HIV Drug Regimen More Effective Than Existing Therapy Jan 18, 2006
The drugs -- tenofovir DF (Viread), emtricitabine (Emtriva) and efavirenz (Sustiva) -- are now available in just two pills (Sustiva plus a Viread-Emtriva ... - Forbes

Stress at work stresses heart Jan 20, 2006
The combination was of tenofovir DF and emtricitabine plus efavirenz fulfilled all in one tablet compared to triple cocktail of fixed dose of zidovudine and ... - Indian Express,

New HIV Regimen Outperforms Gold Standard Jan 19, 2006
...investigators here. The new kid on the block is a combination of Viread (tenofovir DF), Emtriva (emtricitabine), and Sustiva (efavirenz). In ... - CNN

Gilead and BMS to seek regulatory approval for efavirenz, Truvada ... Jan 10, 2006
BMS) announced that they now have data showing that a fixed dose combination pill combining Gilead’s Truvada (tenofovir and FTC [emtricitabine]) with BMS’s ... - Aidsmap,

ICAAC: Switching from Combivir to Truvada has benefits for ... Jan 11, 2006
Effects of switching from fixed dose zidovudine/lamivudine to fixed dose tenofovir/emtricitabine: maintenance of virologic suppression and other benefits. ... - Aidsmap,

Fat loss associated with Combivir but not Truvada Jan 23, 2006
Gallant JE et al. Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, efavirenz for HIV. N Engl J Med 354: 251 – 260, 2006. - Aidsmap,

NEWS RELEASE Jan 19, 2006
...from a clinical trial (Study 934) comparing a once-daily treatment regimen of Viread® (tenofovir disoproxil fumarate), Emtriva® (emtricitabine) and Sustiva ... - Financial News USA (press release),

Pharmasset Announces Five Clevudine Presentations at AASLD Nov 11, 2005
Antiviral response and resistance surveillance for HBeAg negative patients enrolled in a combination study evaluating emtricitabine plus Clevudine versus ... - PharmaLive.com (press release),

Preliminary 24-Week Data Evaluating the Impact of Switching from ... Nov 17, 2005
...experienced patients who switched fromtwice-daily Combivir(R) (lamivudine 150 mg/zidovudine 300 mg) toonce-daily Truvada(R) (emtricitabine and tenofovir ... - Finanzen.net,

Switching from twice-daily Combivir to once-daily Truvada in ... Nov 23, 2005
...experienced patients who switched from twice-daily Combivir ( Lamivudine 150 mg/Zidovudine 300 mg ) to once-daily Truvada ( Emtricitabine and Tenofovir ... - Xagena.it,

Ranbaxy announces new co-packaged triple ART combinations Dec 2, 2005
Efavirenz originators Merck and Bristol Myers Squibb are working with Gilead Sciences to coformulate efavirenz with tenofovir and emtricitabine (FTC) into one ... - Aidsmap,

FDA Safety Labeling Changes: Emtriva, FazaClo, Climara/Climara Pro Sep 14, 2005
14, 2005 — The US Food and Drug Administration (FDA) approved safety labeling revisions in June to advise that discontinuation of emtricitabine therapy may ... - Medscape (subscription)

Emtriva: New Formulation and Labeling Changes Sep 29, 2005
ROCKVILLE, Md., Sept. 29, 2005 - On September 28, 2005, The Food and Drug Administration approved EMTRIVA (emtricitabine) Oral Solution 10 mg/mL. ... - PharmaLive.com (press release),

GB AIDS Drugs Plant “Pivotal�? Sep 7, 2005
Gilead announced a significant price reduction for Viread [tenofovir disoproxil fumarate] and Truvada [emtricitabine and tenofovir disoproxil fumarate] which ... - The Bahama Journal,

New drug cocktail beats standard HIV therapy Sep 2, 2005
The older twice-daily regimen features zidovudine and lamivudine, while the newer, once-daily treatment contains tenofovir and emtricitabine. ... - Macleans,

Gilead Reduces Prices for Viread and Truvada in the Developing ... Aug 29, 2005
...(Nasdaq:GILD) today announced a significant price reduction for Viread(R) (tenofovir disoproxil fumarate) and Truvada(R) (emtricitabine and tenofovir ... - PharmaLive.com (press release),

*vwd/BUSINESS WIRE: Gilead gibt aktuellen Entwicklungsstand zur ... Aug 10, 2005
...(Nasdaq:GILD) today announced that bioequivalence results from its second formulation of the fixed-dose combination of Truvada(R) (emtricitabine and tenofovir ... - Vereinigte Wirtschaftsdienste,

Gilead reports problems putting tenofovir, FTC and efavirenz into ... Aug 10, 2005
Efforts to combine tenofovir, emtricitabine (FTC) and efavirenz in one pill are still failing to produce a product that is bioequivalent to dosing the three ... - Aidsmap,

Gilead Reduces Prices for Viread® and Truvada® in the Developing ... Aug 30, 2005
...announced a significant price reduction for Viread® (tenofovir disoproxil fumarate) and Truvada® (emtricitabine and tenofovir disoproxil fumarate) made ... - Chemie.de (press release),

HIV: An Ever-changing Epidemic Aug 11, 2005
...products such as Combivir are under threat, with some physicians expecting the newer, once-daily FDCs – Gilead’s Truvada (tenofovir/emtricitabine) and GSK ... - PharmaLive.com (press release),

Another Thing You'd Think Would Be Simple Aug 10, 2005
Gilead, about one of whose drugs (Emtriva, emtricitabine) I wrote here, has already combined that one with another drug of theirs (Viread, tenofovir) to make a ... - Corante

Other information

Indication
For the treatment of HIV-1 infection in adults.

Pharmacology
Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Emtricitabine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Mechanism Of Action
Emtricitabine, a synthetic nucleoside analogue of cytidine, is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate. Emtricitabine substrate deoxycytidine 5'-triphosphate and by incorporating into nascent viral DNA, which results in chain termination. Emtricitabine 5'-triphosphate is a weak inhibitor of mammalian DNA polymerases alpha, beta, and epsilon and of mitochondrial DNA polymerase gamma. Emtricitabine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.

Drug Category
Anti-HIV Agents; ATC:J05AF09

Brand Names/Synonyms
524W91; BW 1592; BW 524W91; Coviracil; DRG-0208; Dotfc; Emtricitabine; Emtriva; FTC; Racivir; Truvada

Dosage Forms
TABLETS

Absorption
Rapidly absorbed (93%)

Interactions
-->Interactions for Emtricitabine:

The potential for drug interactions with EMTRIVA has been studied in combination with indinavir, stavudine, famciclovir, and tenofovir disoproxil fumarate. There were no clinically significant drug interactions for any of these drugs.

Chemical IUPAC Name
4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-pyrimidin-2-one

Chemical Formula
C8H10FN3O3S

Half Life
10 hours

Drug Type
Approved Drug

# Accession No
APRD00226

CAS Registry Number
143491-57-0

Emtricitabine: profile and news

Chemical IUPAC Name 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-pyrimidin-2-oneChemical Formula C8H10FN3O3SHalf Life 10 hoursDrug Type Approved Drug# Accession No APRD00226CAS Registry Number 143491-57-0

Chemical IUPAC Name
4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-pyrimidin-2-one

Chemical Formula
C8H10FN3O3S

Half Life
10 hours

Drug Type
Approved Drug

# Accession No
APRD00226

CAS Registry Number
143491-57-0