Eloxatin: profile and news
Fire Department Tip Police To Walgreen's Robber 07 Mar 2006
Township. Police say Paul Wheat, 35, walked into the 24 hour pharmacy and demanded hydromorphone a narcotic early Thursday morning. ... - WXIX,
Man is arrested after robbery of narcotic at Walgreen's pharmacy Mar 3, 2006
...about 3:40 am Thursday, flashed a small pistol and took two bottles of hydromorphone, a narcotic, the sheriff's department said. ... - Cincinnati Post,
Local news in brief Mar 2, 2006
...decrease coughing. The Hamilton County Sheriff's Office said the man asked the pharmacist if the store had hydromorphone. When the ... - Cincinnati Post,
Anderson Township Pharmacy Robbed For Third Time Mar 2, 2006
...just after 3:30 am The pharmacist said a man entered the store and walked to the pharmacy. The man asked the pharmacist if he had hydromorphone. ... - Channel Cincinnati.com,
Man charged in pharmacy heist Mar 2, 2006
The sheriff’s office said that Wheat is the man who entered the store about 3:40 am displayed a handgun and demanded hydromorphone, and fled with two bottles ... - Cincinnati Enquirer,
Eighteen more indicted in Circuit Court Feb 28, 2006
...post release supervision. BONNIE SCOTT, 5350 Ballardsville Rd., Tupelo, entered a guilty plea to the sale of hydromorphone. She was ... - Northeast Mississippi Daily Journal,
Evaluation of a Single-Dose, Extended-Release Epidural Morphine ... Feb 22, 2006
At their first request for postoperative analgesia, patients who had received DepoDur were given an intravenous bolus of hydromorphone followed by placebo ... - Journal of Bone and Joint Surgery
Court hits record numbers Feb 21, 2006
...of sexual battery. JEFFERY ESTEP, 160 Smith Rd., Fulton, entered a plea of guilty to possession of hydromorphone. He was sentenced ... - Northeast Mississippi Daily Journal,
Pain Medicine Scientific Research Highlights Feb 26, 2006
10 to 30 blood concentrations have been reported for each of the following opioids: methadone, morphine, oxycodone, hydromorphone, hydrocodone, fentanyl, and ... - Medical News Today (press release),
KV Pharmaceutical Reports Record Revenues for Fiscal 2006 Third ... Feb 7, 2006
...strengths * Hydromorphone Hydrochloride 2, 4 and 8 mg. tablets - Hydromorphone Hydrochloride Tablets are indicated for the management ... - PR Newswire (press release),
Change in lawyer delays trial Feb 9, 2006
...and charged with sexual assault, assault causing bodily harm and numerous drug trafficking charges for possessing Oxycontin, hydromorphone, cocaine, Ecstasy ... - NorthernLife.ca,
Altea Therapeutics and Teikoku Seiyaku Co. Ltd. Enter into an ... Feb 1, 2006
The Company has completed initial Phase 2 clinical trials in the US with a daily hydromorphone patch for the rapid management of moderate to severe pain, and ... - PharmaLive.com (press release),
Change in lawyer delays trial 09 Feb 2006
...and charged with sexual assault, assault causing bodily harm and numerous drug trafficking charges for possessing Oxycontin, hydromorphone, cocaine, Ecstasy ... - NorthernLife.ca,
KV Pharmaceutical Reports Record Revenues for Fiscal 2006 Third ... Feb 7, 2006
...strengths * Hydromorphone Hydrochloride 2, 4 and 8 mg. tablets - Hydromorphone Hydrochloride Tablets are indicated for the management ... - PR Newswire (press release),
European Commission Approves Ionsys (Fentanyl HCl Iontophoretic ... Jan 30, 2006
Fentanyl is an opioid agonist and a Schedule II controlled substance with high potential for abuse similar to hydromorphone, methadone, morphine and oxycodone. ... - DG News
Altea Therapeutics and Teikoku Seiyaku Co. Ltd. Enter into an ... Feb 1, 2006
The Company has completed initial Phase 2 clinical trials in the US with a daily hydromorphone patch for the rapid management of moderate to severe pain, and ... - PharmaLive.com (press release),
Police share drug forfeit property sale Jan 24, 2006
Division. Campbell was sentenced to 20 years in prison and fined $10,000 for conspiracy to distribute hydromorphone, the release stated. - Charleston Gazette (subscription),
La Crosse County courts for Jan. 15, 2006 Jan 14, 2006
Jan. 13, and they found three Oxycodone pills and one table of hydromorphone in her purse. Andrew L. Meier, 18, of 940 12th Ave. ... - LaCrosse Tribune,
ALZA Corporation Modifies US Clinical Development Program for OROS ... Dec 1, 2005
1 /PRNewswire/ -- ALZA Corporation today announced that it is modifying the US clinical development program for OROS Hydromorphone (AP-77) for chronic pain. ... - PR Newswire (press release),
ALZA Corporation Modifies US Clinical Development Program for OROS ... Dec 2, 2005
December 01, 2005 /PRNewswire/ -- ALZA Corporation today announced that it is modifying the US clinical development program for OROS Hydromorphone (AP-77) for ... - PharmaLive.com (press release),
Bradshaw pleads guilty Dec 9, 2005
Bradshaw was accused of stealing oxycodone, methodone and hydromorphone on July 7 and July 9. He was working as a junior volunteer at the hospital and ... - Goldsboro News Argus,
J&J unit says looking at options for pain drug Dec 1, 2005
The decision to look at clinical development alternatives for the drug, Oros Hydromorphone, also known as AP-77, was not related to any safety issues, the ... - Reuters
Friend: Man had drugs Nov 30, 2005
In the indictment charging Douglas with murder and manslaughter, the defendant is accused of giving his son morphine and hydromorphone. ... - Oneonta Daily Star,
New River Pharmaceuticals Files New Drug Application on NRP104 for ... Dec 7, 2005
New River's management also stated that a Phase I/II dose ranging study is underway for NRP290, the company's hydromorphone derivative for the treatment of ... - PharmaLive.com (press release),
Man denies giving son drugs Dec 2, 2005
...of Corbin’s blood, urine and liver and determined the baby had consumed a potentially fatal dose of morphine as well as hydromorphone, another painkiller. ... - Oneonta Daily Star,
Jury selection to start in trial on infant's death Nov 27, 2005
Sidney. The grand jury indictment charged the father with illegally administering morphine and hydromorphone to the baby. Arrested ... - Press & Sun-Bulletin,
Morris resident accused in death of 14-month-old son Nov 29, 2005
H. Douglas Jr. The baby died of a drug overdose, specifically morphine and hydromorphone, according to court papers. Eight women ... - Press & Sun-Bulletin,
(PRN) - Pennsylvania Board of Game Commissioners Selects Roe as ... Dec 1, 2005
Conference ... [+. PRN) - ALZA Corporation Modifies US Clinical Development Program for OROS Hydromorphone (AP-77) ... [. PRN ... - Bolsamania.com,
Morphine levels in tot's blood were in fatal range Nov 30, 2005
Dr. James A. Terzian, of Vestal, said the autopsy showed the presence of morphine in Corbin Douglas Jr.'s blood, as well as morphine and hydromorphone in his ... - Press & Sun-Bulletin,
Officer: Dad apologized Dec 1, 2005
...injury occurred. Terzian said he also found evidence of hydromorphone, another painkiller, in the baby’s body. Douglas’ attorney ... - Oneonta Daily Star,
Jury finds Douglas innocent Dec 3, 2005
Corbin Douglas Jr., on Feb. 27 by allegedly feeding him the powerful painkillers morphine and hydromorphone. The five-day trial ... - Oneonta Daily Star,
Avitar Enters Rapidly Expanding Oral Fluid-Based Laboratory Drug ... Nov 29, 2005
08-3) Cocaine: Benzoylecgonine, (Coke) Opiates: Morphine (Durapmorph(R)), Codeine (Methylmorphine), 6-AM, Hydrocodone (Vicodin(R)), Hydromorphone (Dilaudid(R ... - PR Newswire (press release),
Teen indicted for hospital drug thefts Nov 10, 2005
Thomas Bradshaw II of Bradford Place is accused of stealing oxycodone, methodone and hydromorphone on July 7 and July 9. He was indicted on four felony counts ... - Goldsboro News Argus,
Drug suspect faces nine charges Nov 25, 2005
The charges allege Bryan illegally had the drug, also known as hydromorphone, on July 8 and 11, Aug. 2 and 9, court records show. ... - Shelbyville Times-Gazette,
Clinical Briefs For November 2005 31 Oct 2005
After acquiring new information that serious and potentially fatal adverse reactions can occur when Palladone (hydromorphone hydrochloride) extended release ... - U.S. Medicine,
Former FDA Commissioner’s Ownership of Stock in Regulated ... Oct 30, 2005
These include: Palladone (hydromorphone) – 2005; Bextra (valdecoxib) – 2005; Tysabri (natalizumab) – 2005; Vioxx (rofecoxib) – 2004; Duragesic Patch ... - Newsinferno.com,
Generic Moderate-Release Formulations Are More "Rugged" In Dose ... Oct 28, 2005
The potential for fatal reactions due to dose dumping led to the withdrawal of Purdue’s Palladone (hydromorphone extended-release) at the request of FDA. ... - FDA Advisory Committee
JOSEPH P. SMITH: HIS TROUBLED LIFE Oct 16, 2005
...birth to a baby girl. But five months later, Smith attempted to obtain hydromorphone with a fraudulent prescription. He was put in ... - Bradenton Herald,
European Authorities Recommend Approval for IONSYS Oct 17, 2005
Fentanyl is an opioid agonist and a Schedule II controlled substance with high potential for abuse similar to hydromorphone, methadone, morphine and oxycodone. ... - PharmaLive.com (press release),
Man arrested in series of drugstore robberies Oct 10, 2005
In one robbery charge, Rumore is accused of using the note to rob the same Walgreens in August of oxycodone, Oxycontin, morphine, Hydromorphone and Roxycodone. ... - St. Petersburg Times,
Pharmacies in Minority Areas Less Likely to Carry Pain Medications Oct 10, 2005
...release morphine, fentanyl and levorphanol); short acting (such as immediate release oxycodone, immediate release morphine and hydromorphone); and combination ... - Newswise (press release)
Hythiam Secures First Midwest Licensing Agreement For PROMETA(TM) ... Oct 12, 2005
...relievers such as: OxyContin(R), Vicodin(R), Codeine, Lorcet(R), Darvon(R), Morphine, Demerol, Percodan, Dilaudid, Percocet and Hydromorphone, has increased ... - Genetic Engineering News,
NEWS BRIEFS Oct 11, 2005
This is the second charge that Lesley faces and is currently under indictment for sale of hydromorphone stemming from a prior arrest. ... - Northeast Mississippi Daily Journal,
Inside and outside Sep 30, 2005
The point is, distraction keeps you from focusing solely on your pain/illness; it's easier to get than a shot of hydromorphone, too. ... - Stirling Community Press,
NEWS BRIEFS 11 Oct 2005
This is the second charge that Lesley faces and is currently under indictment for sale of hydromorphone stemming from a prior arrest. ... - Northeast Mississippi Daily Journal,
Man arrested in series of drugstore robberies 11 Oct 2005
In one robbery charge, Rumore is accused of using the note to rob the same Walgreens in August of oxycodone, Oxycontin, morphine, Hydromorphone and Roxycodone. ... - St. Petersburg Times,
Minority pharmacies: Less access to pain meds 11 Oct 2005
...release morphine, fentanyl and levorphanol); short acting (such as immediate release oxycodone, immediate release morphine and hydromorphone); and combination ... - myDNA.com,
Inside and outside Sep 30, 2005
The point is, distraction keeps you from focusing solely on your pain/illness; it's easier to get than a shot of hydromorphone, too. ... - Stirling Community Press,
NEWS BRIEFS Sep 14, 2005
7 on a Circuit Court capias after having been indicted by the Itawamba County Grand Jury on charges of sale of hydromorphone. The ... - Northeast Mississippi Daily Journal,
Man’s trial for son’s death to begin in Nov. Sep 22, 2005
...filed in June charges him with second-degree murder and second-degree manslaughter, alleging he "did illegally administer morphine and hydromorphone to Corbin H ... - Oneonta Daily Star,
COMPANY OF THE YEAR: Johnson & Johnson Sep 15, 2005
Other late-stage products in development for pain include Oros Hydromorphone, a potent, oral opioid in a once-a-day formulation, and R331333, the first new ... - Med Ad News (subscription),
Woman believed head of "doctor shopping" ring arrested in Conroe Sep 12, 2005
...drugs, including 1,531 Soma muscle relaxant pills, 392 Xanax anti-anxiety pills, 228 Vicodin (hydrocodone) pills, 17 Dilaudid (hydromorphone) pills and five ... - Conroe Courier,
The need to feed the habit ... Police: Understanding supply and ... Sep 9, 2005
As of last week, investigators had purchased 650 units of OxyContin, Lortab, hydrocodone, hydromorphone and more in controlled buys, and they had seized an ... - Princeton Times,
Other information
Indication
For the treatment of malignant neoplasm of colon, rectum, and ovary
Pharmacology
Oxaliplatin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Oxaliplatin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Mechanism Of Action
after activationm it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Drug Category
Antineoplastic Agents; ATC:L01XA03
Brand Names/Synonyms
DACPLAT; ELOXATIN; Eloxatin; OXALIPLATIN; Oxalatoplatin; Oxalatoplatinum; Oxaliplatin [Usan:Inn:Ban]; Oxaliplatino [Spanish]; Oxaliplatinum [Latin]; Oxaloplatine [French]; Oxaloplatino [Spanish]
Dosage Forms
Not Available
Absorption
Not Available
Interactions
Interactions for Oxaliplatin:
No specific cytochrome P450-based drug interaction studies have been conducted. No pharmacokinetic interaction
between 85 mg/m2 ELOXATIN and infusional 5-FU has been observed in patients treated every 2 weeks.
Increases of 5-FU plasma concentrations by approximately 20% have been observed with doses of 130 mg/m2
ELOXATIN dosed every 3 weeks. Since platinum containing species are eliminated primarily through the kidney,
clearance of these products may be decreased by coadministration of potentially nephrotoxic compounds; although, this
has not been specifically studied.
Chemical IUPAC Name
ethanedioate;platinum(+4)cation;(2-azanidylcyclohexyl)azanide
Chemical Formula
C8H12N2O4Pt
Half Life
Not Available
Drug Type
Approved Drug
# Accession No
APRD00186
CAS Registry Number
61825-94-3