Efudex: profile and news

Valeant Pharmaceuticals Reports Fourth Quarter and Full Year 2005 ... Feb 28, 2006
...brands grew 33 percent in the 2005 fourth quarter and 44 percent for the full year, primarily from sales of Diastat(R), Migranal(R), Efudex(R), Bedoyecta(TM ... - Genetic Engineering News,

3M rethinks prescription for success Feb 12, 2006
A key competitor for treating precancerous lesions — a skin cream called Efudex — also comes with a lengthy list of potential side effects and has never ... - Pioneer Press,

Painful gout is caused by uric acid crystals forming in joints Dec 5, 2005
Treatment continues for two to four weeks. Two brand names are Efudex and Fluoroplex. Q: Is carob a more healthful food than chocolate? ... - Arizona Republic,

Valeant Pharmaceuticals Reports Second Quarter 2005 Results ... Aug 5, 2005
...were particularly strong. Global brand growth of 25 percent was led by increased sales of Efudex(R) and Kinerase(R). The impact ... - Forbes

Treatment of Verruca Plantaris with a Combination of Topical ... Jul 21, 2005
...home: 17% liquid salicylic acid (DuoFilm; Schering-Plough Corp, Kenilworth, New Jersey), followed by either 5.0% fluorouracil cream (Efudex; ICN Pharmaceuticals ... - Journal of the American Podiatric Medical Association

Better Breast Cancer Care? Jun 1, 2005
...around the world set out to study how the drug docetaxel (also known as Taxotere) compares to the drug fluorouracil (known as Fluoroplex, Carac, Efudex or 5-FU ... - Ivanhoe

MDs, like rest of us, seek a healthy profit May 8, 2005
After some research, she opted for the third and it worked out. It was Efudex, a form of chemotherapy. ... "Do you know anything of Efudex?". ... - Atlanta Journal Constitution (subscription)

Valeant Pharmaceuticals Reports First Quarter 2005 Results ... May 5, 2005
...brands. The global brand growth in the quarter was primarily from sales of Efudex(R), Oxsoralen(R), Mestinon(R) and Kinerase(R). ... - Business Wire,

Valeant Pharmaceuticals Reports Fourth Quarter and Full Year 2004 ... Feb 24, 2005
Sales of global brands increased 4 percent in the 2004 fourth quarter and 24 percent in the year and reflect increased sales of Efudex(R), Oxsoralen(R ... - Business Wire (press release),

Valeant Pharma posts 4Q profit on sales Feb 24, 2005
...with a 53 percent increase in fourth quarter sales to $43.3 million from $28.2 million last year, due to increased sales of skin cancer drug Efudex and sales ... - BusinessWeek

Epidermodysplasia Verruciformis, Skin Troubles and Cures Feb 24, 2005
...the diagnosis of EV. I currently am being treated with Accutane, Efudex, and Aldera. I also have had numerous surgeries. I am very ... - Express Newsline,

Other information

Indication
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, rectum, breast, stomach and pancrease.

Pharmacology
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand.

Mechanism Of Action
Fluorouracil inhibits thymidylate synthetase, leading to inhibition of DNA and RNA synthesis and cell death.

Drug Category
Immunosuppressive Agents; Antimetabolites; Antimetabolites; Antineoplastic Agents; ATC:L01BC02

Brand Names/Synonyms
5 Fluorouracil; Adrucil; Arumel; Carac; Carzonal; Effluderm; Efudex; Efudix; Efurix; FT-207; FU; Fluoroblastin; Fluoroplex; Fluorouracil; Fluracil; Fluracilum; Fluri; Fluril; Fluro Uracil; Ftoruracil; Kecimeton; NSC 19893; NSC-19893; Phthoruracil; Phtoruracil; Queroplex; Timazin; U 8953; U-8953; URF; Ulup

Dosage Forms
Topical preparations, Solution for injection

Absorption
28-100%

Interactions
-->Interactions for Fluorouracil:

No information available.

Chemical IUPAC Name
5-fluoro-1H-pyrimidine-2,4-dione

Chemical Formula
C4H3FN2O2

Half Life
10-20 minutes

Drug Type
Approved Drug

# Accession No
APRD00516

CAS Registry Number
51-21-8