EMLA: profile and news

HUNGRY GARDENER - Stock options Feb 23, 2006
Cultivars may mature to as little as 4 feet tall if grafted to an M27 super-dwarfing apple rootstock, or as much as 22 feet tall if you use EMLA 26 or another ... - OregonLive.com,

Routine Inhaled Induction in Adults: A Safe Practice? Feb 14, 2006
...needle stick discomfort is a modality of good patient care," there are other ways to achieve this, including, but not limited to, topical creams (EMLA and LMX ... - Anesthesia & Analgesia (subscription),

A Comparison of a Needle-Free Injection System for Local ... Jan 29, 2006
In this study, we compared the effectiveness of J-Tip® versus eutectic mixture of local anesthetics (EMLA®) to facilitate IV cannulation and provide adequate ... - Anesthesia & Analgesia (subscription),

What the experienced hands of plastic surgeons can do... Jan 24, 2006
The students were Subash Chalan, Madan Barja, Mrutyunjay Majhi, Babaji Badnayak, Basanti chalan, Maheswar Chalan, Lokesh Bankia, Ambuji Bhumika, Emla Ganga and ... - The Statesman,

Journal of the American Podiatric Medical Association Nov 29, 2005
BROWNE J, FUNG M, DONNELLY M, ET AL: The use of EMLA reduces the pain associated with digital ring block for ingrowing toenail correction. ... - Journal of the American Podiatric Medical Association

AstraZeneca Provides Additional Support to Hurricane Victims Nov 17, 2005
...cilexetil), ATACAND HCT® (candesartan cilexetil-hydrochlorothiazide), CASODEX® (bicalutamide), CRESTOR® (rosuvastatin calcium), EMLA Cream (lidocaine 2.5 ... - Yahoo! News (press release)

AstraZeneca Provides Additional Support to Hurricane Victims Nov 17, 2005
...cilexetil), ATACAND HCT(R) (candesartan cilexetil-hydrochlorothiazide), CASODEX(R) (bicalutamide), CRESTOR(R) (rosuvastatin calcium), EMLA Cream (lidocaine 2.5 ... - PR Newswire (press release),

AstraZeneca Pledges More Than $1 Million in Contributions and ... Sep 1, 2005
...cilexetil), ATACAND HCT® (candesartan cilexetil-hydrochlorothiazide), CASODEX® (bicalutamide), CRESTOR® (rosuvastatin calcium), EMLA Cream (lidocaine 2.5 ... - Yahoo! News (press release)

AstraZeneca Pledges More Than $1 Million in Contributions and ... Sep 1, 2005
...cilexetil), ATACAND HCT(R) (candesartan cilexetil-hydrochlorothiazide), CASODEX(R) (bicalutamide), CRESTOR(R) (rosuvastatin calcium), EMLA Cream (lidocaine 2.5 ... - PR Newswire (press release),

State has standards for safe body piercing Aug 23, 2005
EMLA cream that can be applied 30 minutes prior to piercing is sometimes used as an anesthetic to eliminate the associated pain. ... - Newark Star Ledger,

Joint Panel Review of the Eastmain-1-A and Rupert Diversion ... Aug 2, 2005
Eric Giroux Panel Manager 1141, route de l'Eglise, 2nd floor Box 9514 Sainte-Foy, QC G1V 4B8 Tel.: (418) 649-6442 Fax: (418) 649-6443 giroux@emla-examen.ca For ... - CNW Telbec (Communiqués de presse) <**results**>

Rawi Competition To Develop Islamic Culture, Knowledge Jul 4, 2005
...among youths. The most popularly chosen Rawi was the 'Ab Ta Diol Emla,' while two other schools chose ` Wa Lam Ma I.'. Participants ... - Bru Direct

Lifeline ; News in Brief Jun 17, 2005
...your doctor about one of these numbing agents: dorsal penile nerve block (DPNB); lidocaine (the same medication dentists use); ring block; or EMLA topical cream ... - RedNova.com,

Small pleasures May 19, 2005
For in-ground planting of trees and shrubs that mature to 12 feet tall or less: Plant apples (NP) grafted to EMLA 27 for a 6-foot tree, or EMLA 9 for an 8- to ... - OregonLive.com,

AJ Nye Back in Hospital Mar 1, 2005
Oh, by the way....I'll be sure to have 'good prizes' ready for him for when the needle draws start , and we use Emla, which numbs the skin, so that helps too! ... - WTVG,

Other information

Indication
For use as Dermal anesthesia

Pharmacology
Lidocaine is an anesthetic agent indicated for production of local or regional anesthesia and in the treatment of ventricular tachycardia occurring during cardiac manipulation, such as surgery or catheterization, or which may occur during acute myocardial infarction, digitalis toxicity, or other cardiac diseases. The mode of action of the antiarrhythmic effect of Lidocaine appears to be similar to that of procaine, procainamide and quinidine. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole. The sinoatrial node is, however, unaffected. In contrast to the latter 3 drugs, Lidocaine in therapeutic doses does not produce a significant decrease in arterial pressure or in cardiac contractile force. In larger doses, lidocaine may produce circulatory depression, but the magnitude of the change is less than that found with comparable doses of procainamide.

Mechanism Of Action
Lidocaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.

Drug Category
Antiarrhythmic Agents; Anesthetics; Antiarrhythmic Agents; ATC:C01BB01; ATC:C05AD01; ATC:D04AB01; ATC:N01BB02; ATC:R02AD02; ATC:S01HA07; ATC:S02DA01

Brand Names/Synonyms
Lignocaine; Cappicaine; Maricaine; Leostesin; Gravocain; Esracaine; Anestacon; Duncaine; Isicaina; After Burn Double Strength Gel; After Burn Double Strength Spray; After Burn Gel; After Burn Spray; Alphacaine; Anestacon Jelly; Dalcaine; DermaFlex; Dilocaine; Emla; L-Caine; Lanabiotic; Lidocaine; Lidoderm; Lidoject-1; Lidoject-2; Norwood Sunburn Spray; Octocaine; Octocaine-100; Octocaine-50; Rocephin Kit; Xylocaine; Xylocaine 5% Spinal; Xylocaine Dental Ointment; Xylocaine Endotracheal; Xylocaine Test Dose; Xylocaine Viscous; Xylocaine-MPF; Xylocaine-MPF with Glucose; Xylocard; Zilactin-L

Dosage Forms
CREAM; GEL; IMPLANT; JELLY; KIT; LIQUID; OINTMENT; SOLUTION; SPRAY

Absorption
Information derived from diverse formulations, concentrations and usages reveals that lidocaine is completely absorbed following parenteral administration, its rate of absorption depending, for example, upon various factors such as the site of administration and the presence or absence of a vasoconstrictor agent.

Interactions
Interactions for Lidocaine: The administration of local anesthetic solutions containing epinephrine or norepinephrine to patients receiving monoamine oxidase inhibitors or tricyclic antidepressants may produce severe, prolonged hypertension. Phenothiazines and butyrophenones may reduce or reverse the pressor effect of epinephrine. Concurrent use of these agents should generally be avoided. In situations when concurrent therapy is necessary, careful patient monitoring is essential. Concurrent administration of vasopressor drugs (for the treatment of hypotension related to obstetric blocks) and ergot-type oxytocic drugs may cause severe, persistent hypertension or cerebrovascular accidents.

Chemical IUPAC Name
2-diethylamino-N-(2,6-dimethylphenyl)-ethanamide

Chemical Formula
C14H22N2O

Half Life
109 minutes

Drug Type
Approved Drug

# Accession No
APRD00479

CAS Registry Number
137-58-6