Diprolene: profile and news

Taro tentatively OK'd for Diprolene Jan 26, 2006
HAWTHORNE, NY, Jan. 26 (UPI) -- Taro said Thursday it has been tentatively approved for a generic of Schering's Diprolene lotion. ... - United Press International

Taro medicated lotion gets tentative OK Jan 26, 2006
...said Thursday that regulators issued a tentative approval for its generic version of Schering Corp.'s Diprolene lotion for skin inflammation and itching. ... - BusinessWeek

Taro Medicated Lotion Gets Tentative OK Jan 26, 2006
...said Thursday that regulators issued a tentative approval for its generic version of Schering Corp.'s Diprolene lotion for skin inflammation and itching. ... - MSN Money

Taro Receives Tentative Approval for Augmented Betamethasone ... Jan 26, 2006
...betamethasone dipropionate lotion is safe and effective for use when compared with the reference listed drug product, Schering Corporation's Diprolene(R) Lotion ... - Genetic Engineering News,

Acmemeds.com Improves Itself With 101 New Added Medications Aug 20, 2005
Claritin-D 24 hr,Cleocin T Gel 1.0% 30 gm,Colchicine 0.6 mg,Condylox (gel) 0.50%,Detrol LA 2 mg,Detrol LA 4 mg,Diflucan 150 mg,Diflucan 200 mg,Diprolene AF 0.05 ... - PR Web (press release),

Taro Reports 4th Quarter and Full Year 2004 Results Feb 24, 2005
ANDA") approvals for five topical products: betamethasone dipropionate ointment (augmented), 0.05%, a generic version of Schering-Plough's Diprolene(R) ointment ... - Business Wire (press release),

Acne Treatment and Skin Care a Big Business. Proactiv Solution ... Feb 13, 2005
...dermatitis. Among these medications are Elidel, Atarax, Diprolene AF, Dovonex, Gris-Peg, Kenalog, Protopic and Synalar. Another ... - PR Leap (press release),

Other information

Indication
For relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses

Pharmacology
Betamethasone and its derivatives, betamethasone sodium phosphate and betamethasone acetate, are synthetic glucocorticoids. Used for its antiinflammatory or immunosuppressive properties, betamethasone is combined with a mineralocorticoid to manage adrenal insufficiency and is used in the form of betamethasone benzoate, betamethasone dipropionate, or betamethasone valerate for the treatment of inflammation due to corticosteroid-responsive dermatoses. Betamethasone and clotrimazole are used together to treat cutaneous tinea infections.

Mechanism Of Action
Betamethasone is a glucocorticoid Receptor Agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

Drug Category
Corticosteroid; Glucocorticoids; Anti-inflammatory, steroidal; Immunosuppressant; ATC:A07EA04; ATC:C05AA05; ATC:D07AC01; ATC:D07XC01; ATC:H02AB01; ATC:R01AD06; ATC:R03BA04; ATC:S01BA06; ATC:S01CB04; ATC:S02BA07; ATC:S03BA03

Brand Names/Synonyms
Alphatrex; Bebate; Becort; Bedifos; Beta-Methasone; Beta-Methasone Alcohol; Beta-Val; Betacorlan; Betacortril; Betaderm; Betadexamethasone; Betafluorene; Betamamallet; Betametasona [Inn-Spanish]; Betametasone [Dcit]; Betamethasone; Betamethasone Alcohol; Betamethasone Base; Betamethasone Cream; Betamethasone Dipropionate; Betamethasone Sodium Phosphate; Betamethasone Valearate; Betamethasone Valerate; Betamethasone [Usan:Ban:Inn:Jan]; Betamethasonum [Inn-Latin]; Betamethasonvalerat Mikron.; Betamethazone; Betapredol; Betasolon; Betatrex; Betnelan; Betsolan; Celestene; Celestone; Celestone Syrup and Tablets; Cidoten; Dermabet; Desacort-Beta; Diproderm; Diprolene; Diprolene Af; Diprosone; Flubenisolone; HSDB 3015; Hormezon; Lotrisone; Luxiq; Luxiqo; Maxivate; Methazon; Rinderon; Rinderon A; Sch 4831; Uticort; Valisone; Valnac; Visubeta

Dosage Forms
Syrup; Tablet

Absorption
Minimal if applied topically

Interactions
Interactions for Betamethasone:
APRD00513_IN,txt

Chemical IUPAC Name
9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Chemical Formula
C22H29FO5

Half Life
5.6 hours

Drug Type
Approved Drug

# Accession No
APRD00513

CAS Registry Number
378-44-9