Diovan: profile and news

Registry would list low-cost medicines 07 Mar 2006
Care Quality Institute of New Jersey of various pharmacies in Mercer and Middlesex counties found prices for drugs such as Nexium, Plavix, Prevacid and Zocor ... - New Brunswick Home News Tribune,

Why oodles of choices is sometimes too much Mar 6, 2006
...of antacids. Prevacid and Nexium are among the most oft-prescribed drugs in the world. Not that you need a prescription. Nearly ... - The News Journal,

Ex-ghostbuster seeks to become chart-buster Mar 5, 2006
...off, in rapid succession, the contents of his dream drug cabinet: "I’m on Ritalin, Coumadin, Zantac, Lipitor / Diazepam, Nexium, Prevacid, Percocet / Levitra ... - Columbus Dispatch,

Wisconsin awards funds to encourage Abbott development in Kenosha Mar 3, 2006
14,000 at its Illinois headquarters. Its products include ENSURE nutritional supplements and Prevacid for the treatment of heartburn. - Chippewa Herald,

US court dismisses Abbott's action against Takeda Mar 3, 2006
...portion of Takeda's profit, claiming that Takeda forced TAP to continue to purchase its requirement of lansoprazole, the main ingredient in ulcer drug Prevacid ... - TMCnet

People leaving NJ bad & good Mar 5, 2006
Problems: The industry is struggling with generics along with its inability to replace aging drugs, such as Lipitor and Prevacid. ... - Dailyrecord.com,

HOME PAGE FOR THE WORLD'S BUSINESS LEADERS Mar 2, 2006
The industry is struggling with an onslaught of generics and an inability of its research labs to replace aging drugs like Lipitor and Prevacid with equivalent ... - Forbes

Rates on short-term T-bills jump Feb 28, 2006
Zegerid is one of a class of heartburn medicines, including Tap Pharmaceuticals' Prevacid and AstraZeneca's Nexium, called proton pump inhibitors, or PPIs. ... - San Diego Union Tribune,

The People's Pharmacy Feb 19, 2006
Q: I have been on acid-blocking drugs for years to treat heartburn. Initially, I was on Prilosec, then Prevacid and now Nexium. ... - Seattle Times,

Bristol-Myers Squibb Seeks To Expand Access To Its Most Recently ... Feb 19, 2006
Mevacor®, Zocor®, rifampin, St. John's wort, AcipHex®, Nexium®, Prevacid®, Prilosec® or Protonix®. Viagra®, Levitra®, Cialis ... - Medical News Today (press release),

Isotopes Select-A-Seat, Open House set for March 11 Feb 25, 2006
May 20 vs. Las Vegas Reggy - Waterbottle Giveaway courtesy of Prevacid. May 24 vs. Tucson Hat Night courtesy of Wells Fargo - Comcast. May 26 vs. ... - OurSports Central (press release),

Japanese diabetes drug progresses to third phase of clinical ... Feb 22, 2006
...maker has been stepping up development of new drugs to help mitigate the impact of the expiry of US patents on its main products -- ulcer drug Prevacid in 2009 ... - Newstarget.com,

Super Bowl QBs: Where are they now? Feb 3, 2006
They parlayed their reputations as winners into current endorsement deals with companies like Coors, Novartis and TAP Pharmaceutical, maker of Prevacid. ... - MSNBC

Rich Daly Joins TAP As Senior Marketing Executive Feb 2, 2006
44, will be responsible for leading the overall marketing strategy and initiatives for TAP's current and future brands - including Prevacid(R) (lansoprazole ... - International News Service,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ... Feb 9, 2006
John's wort, AcipHex(R), Nexium(R), Prevacid(R), Prilosec(R) or Protonix(R), Viagra(R), Levitra(R), Cialis(R), Vfend(R), Advair(R), Flonase(R), or Flovent(R ... - Finanzen.net,

Health News in Brief Statins may help with arthritis, study says Feb 5, 2006
Widely used proton pump inhibitor (PPI) drugs like Prilosec or Prevacid can reduce the risk of bleeding, abdominal surgery and death when used to treat life ... - Indianapolis Star,

People's Pharmacy: Iron supplement may combat pica Feb 18, 2006
12. Medications such as Prilosec, Protonix, Aciphex, Prevacid or Nexium might make it harder to get adequate amounts from food. ... - Bryan College Station Eagle,

Drug price postings legislation introduced Feb 9, 2006
...surveyed prices at chain drug stores within a 50-mile radius of the capital found that prices for such drugs as the heartburn medicine Prevacid differed by ... - Trenton Times,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ... Feb 9, 2006
John's wort, AcipHex®, Nexium®, Prevacid®, Prilosec® or Protonix®, Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be ... - Yahoo! News (press release)

Is peanut butter really safe against hiccups? Feb 16, 2006
...day. I have been on acid-blocking drugs for years to treat heartburn. Initially, I was on Prilosec, then Prevacid and now Nexium. I ... - Bradenton Herald,

Deadly Intestinal Bacteria on the Rise Feb 1, 2006
...released in December by McGill University researchers suggested that popular heartburn drugs _ proton pump inhibitors such as Prilosec, Prevacid and Nexium _ ... - Washington Post,

Former Super Bowl QBs: Where Are They Now? Feb 1, 2006
...reputations as winners into current endorsement deals with companies like Coors, Novartis (nyse: NVS - news - people ) and TAP Pharmaceutical, maker of Prevacid ... - Forbes

Drug price postings legislation introduced 09 Feb 2006
...surveyed prices at chain drug stores within a 50-mile radius of the capital found that prices for such drugs as the heartburn medicine Prevacid differed by ... - Trenton Times,

New 48 Week Clinical Trial Data Reported Comparing REYATAZ(R) ... 09 Feb 2006
John's wort, AcipHex®, Nexium®, Prevacid®, Prilosec® or Protonix®, Viagra®, Levitra®, Cialis®, Vfend®, Advair®, Flonase®, or Flovent® should not be ... - Yahoo! News (press release)

Takeda seen topping profit goal, drug sales solid Jan 26, 2006
Analysts polled by Reuters Estimates expect Takeda, the maker of ulcer drug Prevacid, to post 473 billion yen ($4.1 billion) in recurring profit -- pretax ... - Reuters

Popular Heartburn Drugs Help Fight Peptic Ulcers Jan 30, 2006
30 (HealthDay News) -- Widely used proton pump inhibitor (PPI) drugs like Prilosec or Prevacid can reduce the risk of bleeding, abdominal surgery and death ... - Forbes

New approach aids ulcers Jan 30, 2006
...treat heartburn and non-bleeding ulcers. Examples of these medicines include Prilosec and Prevacid. However, a summary of data from ... - myDNA.com,

Bad ulcers can be treated Jan 25, 2006
A review of studies in Asia, Europe and the United States shows proton pump inhibitor drugs such as Prilosec and Prevacid cut down the risk of bleeding ... - United Press International

INFECTION PLAYS MAJOR ROLE IN ULCERS Jan 24, 2006
There are a number of powerful medicines that can turn off acid production. Prilosec, Nexium, Aciphex, Prevacid, Pepcid, Tagamet and Zantac are among them. ... - Charlotte Sun-Herald,

Abbott Reports Record Sales, Earnings and Cash Flow in 2005 Jan 25, 2006
...$138 17.4 $148 18.6 $286 18.1 Abbott Vascular $46 33.1 $31 23.2 $77 29.0 TAP Pharmaceutical Products (not consolidated in Abbott's sales) Prevacid $632 33.2 ... - MSN Money

New Treatment for Bleeding Ulcers Reduces Surgery, Death Rates Jan 25, 2006
The heartburn drugs Prilosec™ and Prevacid® reduce the risk of bleeding, abdominal surgery and death when used to treat life-threatening peptic ulcers ... - EndoNurse,

New Treatment for Bleeding Ulcers Reduces Surgery, Death Rates Jan 25, 2006
WASHINGTON, DC -- January 25, 2006 -- The heartburn drugs Prilosec and Prevacid reduce the risk of bleeding, abdominal surgery and death when used to treat life ... - DG News

Ice craving could indicate deficiency Jan 31, 2006
12. Medications such as Prilosec, Protonix, Aciphex, Prevacid or Nexium might make it harder to get adequate amounts from food. ... - Charlotte Observer,

Generics Give Originators Heartburn Jan 20, 2006
...problem. Some of the best-known remedies are Nexium, from AstraZeneca (NYSE: AZN), and Prevacid, from TAP Pharmaceuticals. Japanese ... - Motley Fool

Takeda, other Japan drug makers post strong Q3 Jan 31, 2006
Takeda, which also makes the Actos diabetes and Prevacid ulcer drugs, kept its target for recurring profit -- pretax excluding special items -- at 465 billion ... - Reuters

Deadly intestinal bacteria on the rise in NJ Feb 2, 2006
...released in December by McGill University researchers suggested that popular heartburn drugs — proton pump inhibitors such as Prilosec, Prevacid and Nexium ... - Press of Atlantic City,

Johnson: Who's to blame for outrageous ER bill? Jan 10, 2006
...$1,169.15. If not, I need to become a Prevacid pusher. The semi-private room I wasn't in long enough to remember cost $2,374. The ... - Rocky Mountain News,

Some drug makers ending assistance programs Jan 22, 2006
TAP Pharmaceutical Products, maker of the popular heartburn drug Prevacid, which costs $4 per pill, said it is ending prescription assistance for elderly and ... - Fort Worth Star Telegram,

Medicare plan curtails other drug discounts Jan 22, 2006
Lake Forest-based TAP Pharmaceutical Products Inc., maker of the popular heartburn drug Prevacid, which costs $4 a pill, said it is ending prescription ... - Orlando Sentinel,

Pill's estrogen may decrease testosterone, sex drive Jan 17, 2006
Q. For several years I have been taking atenolol for my blood pressure, Zoloft for depression and Prevacid for acid reflux. During ... - The Spokesman Review,

Montreal study provides evidence that heartburn drugs expose ... Jan 24, 2006
People on popular prescription heartburn drugs - Prilosec, Prevacid and Nexium - seem more prone to getting a potentially dangerous diarrhoea caused by the bug ... - Newstarget.com,

New Treatment for Bleeding Ulcers Reduces Surgery, Death Rates Jan 24, 2006
Newswise — The heartburn drugs Prilosec and Prevacid reduce the risk of bleeding, abdominal surgery and death when used to treat life-threatening peptic ... - Newswise (press release)

Celebrex and Ilk May Help Prevent Breast Cancer Jan 30, 2006
...reductions for the regular intake of 325 mg of aspirin (OR=0.49; 95% CI= 0.26-0.95), and 200 mg of ibuprofen or 250 mg of naproxen (Aleve, Prevacid) (OR=0.37 ... - MedPage Today,

House Medicare Study Jan 25, 2006
Consumer Alert. The study looked at the drugs with the highest sales in the last year, everything from Celebrex to Prevacid. The ... - WNCT,

Web site a prescription for medication savings Jan 29, 2006
Institute. The heartburn medicine Prevacid sold for $173.99 at Rite-Aid, but could be purchased for $136.46 at Wal-Mart, the group found. ... - Trenton Times,

LIFELONG HEALTH : Guidelines say suppressant isn’t the way to ... Jan 29, 2006
...reflux. Only if the Prilosec does not relieve symptoms should a very expensive prescription drug, such as Nexium or Prevacid, be used. ... - Arkansas Democrat-Gazette (subscription),

Medicare rules inhibit aid Jan 23, 2006
Lake Forest-based TAP Pharmaceutical Products Inc., maker of the popular heartburn drug Prevacid, which costs $4 per pill, said it is ending prescription ... - Chicago Tribune,

Takeda diabetes drug starts US phase III studies Jan 20, 2006
...maker has been stepping up development of new drugs to help mitigate the impact of the expiry of US patents on its main products -- ulcer drug Prevacid in 2009 ... - Reuters

Deadly germ getting worse Jan 15, 2006
20 Journal of the American Medical Association also suggested that using the widely prescribed heartburn drugs Nexium, Prilosec and Prevacid may increase the ... - Laconia Citizen,

SIU doctor aims to teach elder care Jan 10, 2006
Researchers at McGill University in Montreal found that people on popular prescription heartburn drugs such as Prilosec, Prevacid and Nexium were more prone to ... - Belleville News-Democrat,

Student paints bright future by winning national contest Jan 22, 2006
In early December, Miller was selected as the winner of a nationwide contest sponsored by Tap Pharmaceuticals, the makers of the antacid Prevacid. ... - Baltimore Sun,

Birth-control pills might diminish sexual desire Jan 19, 2006
...permanently. For several years I have been taking atenolol for my blood pressure, Zoloft for depression and Prevacid for acid reflux. ... - Bradenton Herald,

Medicare drug plan hits some glitches Jan 7, 2006
Under his Cignature drug plan, he paid $30 this week for a month’s supply of the heartburn pill Prevacid after paying $280 in the past. ... - TheNewsTribune.com (subscription),

Other information

Indication
For the treatment of hypertension

Pharmacology
Valsartan, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Unlike the angiotensin receptor antagonist losartan, Valsartan does not have an active metabolite or possess uricosuric effects.

Mechanism Of Action
Valsartan competes with angiotensin II for binding at the AT₁ receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance.

Drug Category
Antihypertensive Agents; Angiotensin II Receptor Antagonists; ATC:C09CA03

Brand Names/Synonyms
Diovan; Diovan Hct; Valsarran; Valsartan; Valsartan [Usan:Inn]

Dosage Forms
TABLET

Absorption
Not Available

Interactions
-->Interactions for Valsartan:

No clinically significant pharmacokinetic interactions were observed when valsartan was coadministered with amlodipine, atenolol, cimetidine, digoxin, furosemide, glyburide, hydrochlorothiazide, or indomethacin. The valsartan-atenolol combination was more antihypertensive than either component, but it did not lower the heart rate more than atenolol alone.

Coadministration of valsartan and warfarin did not change the pharmacokinetics of valsartan or the time-course of the anticoagulant properties of warfarin.

CYP 450 Interactions: The enzyme(s) responsible for valsartan metabolism have not been identified but do not seem to be CYP 450 isozymes. The inhibitory or induction potential of valsartan on CYP 450 is also unknown.

As with other drugs that block angiotensin II or its effects, concomitant use of potassium sparing diuretics (e.g. spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine.

Chemical IUPAC Name
3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoicacid

Chemical Formula
C24H29N5O3

Half Life
6 hours

Drug Type
Approved Drug

# Accession No
APRD00133

CAS Registry Number
137862-53-4