Diazepam: profile and news
AT THE COURTHOUSE Mar 2, 2006
The four are the first to be sentenced in one of the Houston area's largest investigations into the illegal distribution of promethazine with codeine, known on ... - Houston Chronicle,
Coroner: Chris Penn died accidentally Feb 13, 2006
Penn had a prescription for promethazine with codeine, which "featured predominantly in his death.". By Nancy Ostertag, AFI via Getty Images. ... - USA Today
Chris Penn died accidentally from enlarged heart, medicine mix Feb 13, 2006
..."We know he had several prescriptions, including promethazine with codeine, which featured predominantly in his death," Harvey said. ... - San Francisco Chronicle,
Enlarged heart, meds mix found in Penn death Feb 14, 2006
24. "We know he had several prescriptions, including promethazine with codeine, which featured predominantly in his death," Harvey said. ... - Los Angeles Daily News,
Chris Penn's death ruled accidental Feb 14, 2006
Harvey described Penn's condition as "non-specific cardiomyopathy" and noted the actor had "several prescriptions, including promethazine with codeine, which ... - CBC Edmonton,
Coroner: Chris Penn's Death Accidental Feb 13, 2006
...accidentally. Harvey said Penn was taking several prescriptions that contributed to his death, most prominently promethazine with codeine. ... - E! Online
Chris Penn’s toxicology report revealed Feb 22, 2006
...obtained by Access Hollywood. The report also found traces of promethazine (an antihistamine) in his system. Chris, the younger ... - MSNBC
Indian Pharma going strong in third quarter Feb 23, 2006
In addition, it has been quite a good year for Zydus as it received approvals for Ribavirin Capsules, Promethazine Tablets and tentative approval for ... - Express Pharma Pulse,
When Abroad, Beware of Drug Name Confusion Feb 8, 2006
In both the United States and Britain, Sominex is the name of a sleep aid, but the British Sominex contains promethazine and the US Sominex contains ... - Diabetes Self Management
Penn's death accidental - coroner Feb 13, 2006
Most prominent among those drugs was promethazine and codeine. A detailed report is expected to be released within a few weeks, according to E!Online. - iAfrica.com,
Coroner: Chris Penn Died Of Enlarged Heart Feb 13, 2006
Harvey says Penn had several prescriptions, including promethazine with codeine, a highly addictive cough syrup, which featured predominantly in his death. ... - NBC 11.com,
Big Heart, Drug Cocktail Caused Penn's Death Feb 14, 2006
His blood also contained a mix of prescriptions, including promethazine with codeine, a highly addictive antihistimine, cough suppressant and pain reliever. ... - Zap2it.com
Coroner: Chris Penn's Death an Accident Feb 14, 2006
..."We know he had several prescriptions, including promethazine with codeine, which featured predominantly in his death," Harvey said of Penn, who was described ... - People Magazine
Coroner's report on Penn's death released Feb 14, 2006
...is anything but an accident," said county coroner spokesman Craig Harvey, adding: "We know he had several prescriptions, including promethazine with codeine ... - Digital Spy,
A friend in need Feb 16, 2006
They particularly noted a commonly prescribed cough syrup, promethazine with codeine. No illegal drugs were found in his system. ... - calendarlive.com,
LA Coroner rules that Chris Penn's death was an accident Feb 15, 2006
Harvey said: “We know he had several prescriptions, including promethazine with codeine, which featured predominantly in his death.� But he added: “We don ... - Earthtimes.org
Chris Penn's life, and tragic death Feb 18, 2006
...cardiomyopathy," compounded by the use of "multiple medications." Investigators particularly noted a commonly prescribed cough syrup, promethazine with codeine ... - The Journal News.com,
When Abroad, Beware of Drug Name Confusion Feb 8, 2006
In both the United States and Britain, Sominex is the name of a sleep aid, but the British Sominex contains promethazine and the US Sominex contains ... - Diabetes Self Management
Local briefs Jan 20, 2006
...other companions. Bradbury was also illegally in possession of methadone and a prescription drug called Promethazine. Drug paraphernalia ... - Enterprise-Record,
TT & Zydus Q3 results Jan 29, 2006
During the quarter under review, the group received approvals for Ribavirin Capsules, Promethazine Tablets and tentative approval for Gatifloxacin Tablets from ... - Business Standard,
Hall Sheriff reflects on loss of deputy Jan 10, 2006
When the autopsy was released by Dekalb County Medical Examiner Dr. Gerald T. Gowitt, his opinion was that a combination of Morphine and Promethazine led to ... - Access North Georgia,
Deputy in good condition after wreck Jan 18, 2006
An autopsy report found that White died from cardiopulmonary arrest due to the combined adverse effects of morphine and promethazine given to him at the ... - Gainesville Times,
Cadila gets US FDA approval for Promethazine tablets Nov 20, 2005
MUMBAI: Cadila Healthcare Ltd on Monday said that it has received US Food Drug Administration (US FDA) approval to market Promethazine tablets 12.5 mg, 25 mg ... - Hindu Business Line,
Cadila gets US FDA approval for Promethazine tablets Nov 20, 2005
Mumbai, Nov 21, (PTI):Cadila Healthcare Ltd today said it has received US Food Drug Administration (US FDA) approval to market Promethazine tablets 12.5 mg, 25 ... - Hindu,
Cadila gets USFDA nod for Promethazine tablets Nov 20, 2005
Cadila Healthcare has received US Food and Drug Administration (USFDA) approval to market Promethazine tablets, 12.5 mg, 25 mg and 50 mg. ... - Business Standard,
Cadila gets US FDA approval for Promethazine tablets Nov 20, 2005
Cadila Healthcare Ltd said on Monday it has received US Food Drug Administration (US FDA) approval to market Promethazine tablets 12.5 mg, 25 mg and 50 mg in ... - Hindustan Times,
Cadila Healthcare gets USFDA approval for Promethazine Nov 21, 2005
Cadila Healthcare Ltd has received an approval from the US Food and Drug Administration (USFDA) to market Promethazine tablets (12.5 mg, 25 mg and 50 mg), an ... - Webindia123,
Cadila gets US FDA approval for Promethazine tablets Nov 21, 2005
Cadila Healthcare Ltd has received US Food Drug Administration (US FDA) approval to market Promethazine tablets 12.5 mg, 25 mg and 50 mg in the US. ... - MedIndia,
Cadila wins approval for anti-emetic drug Nov 21, 2005
...announced on Monday that it has received approval from the US FDA to market Promethazine Tablets 12.5 mg, 25 mg and 50 mg, an anti-emetic drug, in the US market ... - India Infoline.com,
Cadila Healthcare receives approval from US FDA Nov 21, 2005
Cadila Healthcare Ltd has received approval from the US FDA to market Promethazine Tablets 12.5 mg, 25 mg and 50 mg an anti-emetic drug, in the US market and ... - Myiris.com,
Indian shares ease, Colombo extends slide Nov 20, 2005
...rose 0.9 percent to 482 rupees after it said it had secured a US Food and Drug Administration approval to sell tablets of promethazine, an anti-allergic drug. ... - Reuters India,
Indices finally stump the uprising on profit booking Nov 21, 2005
...drug was Cadila. The company informed the exchanges that it received the approval for promethazine in tablet form. The market for ... - domain-B,
Pharmacists convicted of conspiring to illegally distribute ... Oct 4, 2005
...of six Houston-area pharmacists of conspiracy to unlawfully dispense and distribute controlled substances, namely hydrocodone and promethazine with codeine. ... - KHOU (subscription),
Borden Wrongful Death Lawsuit Dismissed Against TASER(TM) ... Oct 26, 2005
...included as causation of death in his autopsy report include, but are not limited to: obesity, lethal overdose of ephedrine, and overdose of promethazine. ... - Yahoo! News (press release)
A traffic stop led to convictions of 6 who illegally dispensed ... Oct 8, 2005
Testimony in the trial, and in one that ended with a hung jury in May for the same group, showed how the cough suppressant promethazine with codeine gets into ... - Houston Chronicle,
Pharmacists doled out gallons of drug so abused that Houston is ... Oct 4, 2005
Jurors in Hittner's downtown Houston court found the pharmacists guilty of filling fake prescriptions for promethazine with codeine, a narcotic known on the ... - Houston Chronicle,
6 pharmacists convicted in cough-syrup ring Oct 4, 2005
Today a Harris County jury found the pharmacists guilty of illegally distributing promethazine with codeine, a narcotic cough suppressant, as well as ... - Houston Chronicle,
Six pharmacists convicted in cough syrup abuse case Oct 4, 2005
Prosecutors said the pharmacists filled 2,500 gallons of promethazine with codeine, a narcotic commonly known as "syrup" among rappers, giving Houston the ... - KRIS-TV,
Six pharmacists convicted in cough syrup abuse case Oct 4, 2005
Prosecutors say the pharmacists filled 25-hundred gallons of promethazine with codeine, a narcotic commonly known as "syrup" among rappers, giving Houston the ... - KLTV,
Austin doctor, previously disciplined, caused patient's death ... Oct 10, 2005
...showed a mixture of ethanol (alcohol), carisoprodol (muscle relaxant), meprobamate (anti-anxiety agent), methadone (narcotic), promethazine (antihistamine) and ... - Austin American-Statesman (subscription),
My Philosophy Sep 29, 2005
..."Sittin' Sideways" is undeniable Houston flavor—that psychotropic production style sounds good even if you ain't sippin' on promethazine. ... - TheStranger.com,
Austin doctor, previously disciplined, caused patient's death ... 11 Oct 2005
...showed a mixture of ethanol (alcohol), carisoprodol (muscle relaxant), meprobamate (anti-anxiety agent), methadone (narcotic), promethazine (antihistamine) and ... - Austin American-Statesman (subscription),
A traffic stop led to convictions of 6 who illegally dispensed ... Oct 8, 2005
Testimony in the trial, and in one that ended with a hung jury in May for the same group, showed how the cough suppressant promethazine with codeine gets into ... - Houston Chronicle,
Pharmacists convicted of conspiring to illegally distribute ... Oct 4, 2005
...of six Houston-area pharmacists of conspiracy to unlawfully dispense and distribute controlled substances, namely hydrocodone and promethazine with codeine. ... - KHOU (subscription),
Pharmacists doled out gallons of drug so abused that Houston is ... Oct 4, 2005
Jurors in Hittner's downtown Houston court found the pharmacists guilty of filling fake prescriptions for promethazine with codeine, a narcotic known on the ... - Houston Chronicle,
6 pharmacists convicted in cough-syrup ring Oct 4, 2005
Today a Harris County jury found the pharmacists guilty of illegally distributing promethazine with codeine, a narcotic cough suppressant, as well as ... - Houston Chronicle,
Six pharmacists convicted in cough syrup abuse case Oct 4, 2005
Prosecutors said the pharmacists filled 2,500 gallons of promethazine with codeine, a narcotic commonly known as "syrup" among rappers, giving Houston the ... - KRIS-TV,
Six pharmacists convicted in cough syrup abuse case Oct 4, 2005
Prosecutors say the pharmacists filled 25-hundred gallons of promethazine with codeine, a narcotic commonly known as "syrup" among rappers, giving Houston the ... - KLTV,
DEA shuts 4,600 rogue pharmacy sites Sep 27, 2005
According to the indictment, the drugs included alprazolam (Xanax), hydrocodone, phentermine hydrochloride, and promethazine cough syrup with codeine. ... - Register,
Crackdown targets Web drug sales Sep 22, 2005
According to the indictment, the drugs included hydrocodone, phentermine hydrochloride (part of Fen-Phen), alprazolam (Xanax) and promethazine cough syrup with ... - Fort Worth Star Telegram,
My Philosophy Sep 29, 2005
..."Sittin' Sideways" is undeniable Houston flavor—that psychotropic production style sounds good even if you ain't sippin' on promethazine. ... - TheStranger.com,
Other information
Indication
For use as Sedative-hypnotic, antiaxiety and antidepressant
Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. Diazepam is an antianxiety agent, sedative, amnestic, anticonvulsant, skeletal muscle relaxant, and anesthetic adjunct, and is used in the treatment of alcohol withdrawal, status epilepticus, and febrile seizures.
Mechanism Of Action
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Drug Category
Anesthetics; Anti-anxiety Agents; Muscle Relaxants; Hypnotics and Sedatives; Antiemetics; Anticonvulsants; Adjuvants; Benzodiazepines; ATC:N05BA01; ATC:N05BA17
Brand Names/Synonyms
Alboral; Aliseum; Alupram; Amiprol; An-Ding; Ansiolin; Ansiolisina; Apaurin; Apo-Diazepam; Apozepam; Armonil; Assival; Atensine; Atilen; Bensedin; Bialzepam; CB 4261; Calmocitene; Calmpose; Cercine; Ceregulart; Condition; DAP; Diacepan; Dialag; Dialar; Diapam; Diastat; Diazemuls; Diazemulus; Diazepa&Laquo;Mu&Raquo;; Diazepam; Diazepam Intensol; Diazepan; Diazetard; Dienpax; Dipam; Dipezona; Dizac; Domalium; Duksen; Duxen; E-Pam; Eridan; Eurosan; Evacalm; Faustan; Faustan,; Freudal; Frustan; Gewacalm; Gihitan; Horizon; Kabivitrum; Kiatrium; LA 111; LA III; La-Iii; Lamra; Lembrol; Levium; Liberetas; Mandrozep; Methyldiazepinone; Methyldiazepinone, Pharmaceutical; Morosan; Neurolytril; Noan; Novazam; Novo-Dipam; Paceum; Pacitran; Paranten; Paxate; Paxel; Plidan; Pms-Diazepam; Pro-Pam; Q-Pam; Q-Pam Relanium; Quetinil; Quiatril; Quievita; Relaminal; Relanium; Relax; Renborin; Ruhsitus; S.A. R.L.; Saromet; Sedapam; Sedipam; Seduksen; Seduxen; Serenack; Serenamin; Serenzin; Servizepam; Setonil; Sibazon; Sibazone; Solis; Sonacon; Stesolid; Stesolin; Tensopam; Tranimul; Tranqdyn; Tranquase; Tranquirit; Tranquo-Puren; Tranquo-Tablinen; Umbrium; Unisedil; Usempax Ap; Valaxona; Valeo; Valiquid; Valitran; Valium; Valrelease; Vatran; Velium; Vival; Vivol; Wy 3467; Wy-3467; Zetran; Zipan
Dosage Forms
tablets, injectable solution
Absorption
93%
Interactions
-->Interactions for Diazepam:
No information provided.
Chemical IUPAC Name
10-chloro-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one
Chemical Formula
C16H13ClN2O
Half Life
Not Available
Drug Type
Approved Drug
# Accession No
APRD00642
CAS Registry Number
439-14-5