Diastat: profile and news

Valeant Pharmaceuticals Reports Fourth Quarter and Full Year 2005 ... Feb 28, 2006
Infergen(R). Overall, promoted brands grew 33 percent in the 2005 fourth quarter and 44 percent for the full year, primarily from sales of Diastat(R), Migranal ... - Genetic Engineering News,

Valeant Pharmaceuticals Unveils Diastat AcuDial for Safe, Rapid At ... Sep 19, 2005
Valeant Pharmaceuticals International (NYSE:VRX) today announced the approval of Diastat(R) AcuDial (diazepam rectal gel) -- the only FDA approved at-home ... - Genetic Engineering News,

Valeant Pharmaceuticals Unveils Diastat AcuDial for Safe, Rapid At ... Sep 19, 2005
COSTA MESA, Calif.--(BUSINESS WIRE)--Sep 19, 2005 - Valeant Pharmaceuticals International (NYSE:VRX) today announced the approval of Diastat(R) AcuDial ... - PharmaLive.com (press release),

Survivor clings to life Sep 19, 2005
The Cogdills keep a vial of Diastat, a potent muscle relaxer used to calm seizures, handy in a kitchen cupboard. They fear this is the beginning of the end. ... - News & Observer,

Valeant Pharmaceuticals Reports Second Quarter 2005 Results ... Aug 5, 2005
The rapid integration of the Xcel sales force and new sales training has resulted in increased demand, corresponding acceleration of Diastat(R) sales, which ... - Forbes <**results**>

Comments a burden to special-needs child Jun 15, 2005
...restaurant. It was the kind of seizure that has to be stopped as quickly as possible using an emergency medicine called DiaStat. ... - South Bend Tribune,

Valeant Pharmaceuticals Reports First Quarter 2005 Results ... May 5, 2005
...acquired from Xcel Pharmaceuticals had total sales of $7.3 million since the acquisition date of March 1, 2005, of which $5.2 million were Diastat(R) sales. ... - Business Wire,

District divided on first aid issue Feb 22, 2005
The lawsuit arose when two educational aides in 2003 refused to be trained on how to administer Diastat, a gel form of Diazepam -- which is used to stop ... - Lancaster Eagle Gazette,

Valeant Pharmaceuticals Completes Acquisition of Xcel ... Mar 1, 2005
...clinical trial results are not always indicative of those seen in Phase 3 clinical trials, the possibility of entry of generic competition for Diastat, and the ... - Business Wire (press release),

Access Communications Inc. Hires 12 Executives for La Jolla ... Feb 16, 2005
In this role, she was responsible for managing the brand positioning for neurological products to include Diastat(R), Migranal(R), and Mysoline(R). Prior to ... - Yahoo News (press release)

Other information

Indication
For use as Sedative-hypnotic, antiaxiety and antidepressant

Pharmacology
Diazepam, a benzodiazepine, generates the same active metabolite as chlordiazepoxide and clorazepate. Diazepam is an antianxiety agent, sedative, amnestic, anticonvulsant, skeletal muscle relaxant, and anesthetic adjunct, and is used in the treatment of alcohol withdrawal, status epilepticus, and febrile seizures.

Mechanism Of Action
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ₁, which mediates sleep, and BNZ₂, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA_A) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Drug Category
Anesthetics; Anti-anxiety Agents; Muscle Relaxants; Hypnotics and Sedatives; Antiemetics; Anticonvulsants; Adjuvants; Benzodiazepines; ATC:N05BA01; ATC:N05BA17

Brand Names/Synonyms
Alboral; Aliseum; Alupram; Amiprol; An-Ding; Ansiolin; Ansiolisina; Apaurin; Apo-Diazepam; Apozepam; Armonil; Assival; Atensine; Atilen; Bensedin; Bialzepam; CB 4261; Calmocitene; Calmpose; Cercine; Ceregulart; Condition; DAP; Diacepan; Dialag; Dialar; Diapam; Diastat; Diazemuls; Diazemulus; Diazepa&Laquo;Mu&Raquo;; Diazepam; Diazepam Intensol; Diazepan; Diazetard; Dienpax; Dipam; Dipezona; Dizac; Domalium; Duksen; Duxen; E-Pam; Eridan; Eurosan; Evacalm; Faustan; Faustan,; Freudal; Frustan; Gewacalm; Gihitan; Horizon; Kabivitrum; Kiatrium; LA 111; LA III; La-Iii; Lamra; Lembrol; Levium; Liberetas; Mandrozep; Methyldiazepinone; Methyldiazepinone, Pharmaceutical; Morosan; Neurolytril; Noan; Novazam; Novo-Dipam; Paceum; Pacitran; Paranten; Paxate; Paxel; Plidan; Pms-Diazepam; Pro-Pam; Q-Pam; Q-Pam Relanium; Quetinil; Quiatril; Quievita; Relaminal; Relanium; Relax; Renborin; Ruhsitus; S.A. R.L.; Saromet; Sedapam; Sedipam; Seduksen; Seduxen; Serenack; Serenamin; Serenzin; Servizepam; Setonil; Sibazon; Sibazone; Solis; Sonacon; Stesolid; Stesolin; Tensopam; Tranimul; Tranqdyn; Tranquase; Tranquirit; Tranquo-Puren; Tranquo-Tablinen; Umbrium; Unisedil; Usempax Ap; Valaxona; Valeo; Valiquid; Valitran; Valium; Valrelease; Vatran; Velium; Vival; Vivol; Wy 3467; Wy-3467; Zetran; Zipan

Dosage Forms
tablets, injectable solution

Absorption
93%

Interactions
-->Interactions for Diazepam:
No information provided.

Chemical IUPAC Name
10-chloro-6-methyl-2-phenyl-3,6-diazabicyclo[5.4.0]undeca-2,8,10,12-tetraen-5-one

Chemical Formula
C16H13ClN2O

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00642

CAS Registry Number
439-14-5