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Diamox: profile and news
Travel Medicine for Trekkers and Climbers in the Himalayan Region Mar 5, 2006 Just the facts about Lake Titicaca Feb 25, 2006 Ginkgo biloba reduces incidence and severity of acute mountain ... Feb 22, 2006 Oceanside, Carlsbad residents set sights on Mount Kilimanjaro Feb 12, 2006 Diamox Improves Sleep Apnea in Heart Failure Jan 16, 2006 Possibility of illness climbs at higher altitude Jan 30, 2006 HIGH ALTITUDE ILLNESS By Larry Rigsby MD (also an Everest climber) Jan 16, 2006 Paul Covell takes on the challenge of climbing Kilimanjaro Jan 11, 2006 Expand your high altitude smarts Jan 17, 2006 North, the only way out Nov 27, 2005 Kilimanjaro is just a great hike - but it could kill you all the ... Nov 9, 2005 American Autumn Shishapangma Expedition 2005: Advance Base Camp ... Sep 17, 2005 Medication-Induced Activation in Children and Adolescents Oct 3, 2005 across the roof of the world Sep 19, 2005 Blood pressure may rise during mountain visits Sep 10, 2005 Rockin' and rollin' on land Sep 11, 2005 HYPP: Hyperkalemic Periodic Paralysis 08 Sep 2005 Confessions of a Tourist: The unbearable contriteness of peeing Aug 27, 2005 Blood pressure rises when some travel to Summit Aug 20, 2005 A rocky return to solid ground Jul 18, 2005 Peak condition Jul 4, 2005 New-Age Herb for an Age-Old Problem Jun 22, 2005 Achieving peak performance Jul 3, 2005 Hale climbs, then runs Mount Kilimanjaro Jun 29, 2005 Not Your "Typical Patient": Cryptococcal Meningitis in an ... Jun 11, 2005 FDA Safety Labeling Changes: Crestor, Diamox Sequels, Femring Jun 8, 2005 New-Age Herb for an Age-Old Problem Jun 22, 2005 Not Your "Typical Patient": Cryptococcal Meningitis in an ... Jun 11, 2005 Newsreader falls ill on mountain Apr 23, 2005 Travel Q/A Apr 24, 2005 Travel Medicine for Trekkers and Climbers in the Himalayan Region Mar 6, 2005 Health Tip: Traveling Abroad? Mar 8, 2005 Ginkgo biloba reduces incidence and severity of acute mountain ... Feb 22, 2005 Other information Indication For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma Pharmacology Acetazolamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention. Acetazolamide is not a mercurial diuretic. Rather, it is a nonbacteriostatic sulfonamide possessing a chemical structure and pharmacological activity distinctly different from the bacteriostatic sulfonamides. Mechanism Of Action The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water. Drug Category Diuretics; Anticonvulsants; Carbonic Anhydrase Inhibitors; ATC:S01EC01 Brand Names/Synonyms Acetamidothiadiazolesulfonamide; Acetamox; Acetazolam; Acetazolamid; Acetazolamide; Acetazolamide Sodium; Acetazolamine; Acetazoleamide; Acetozalamide; Ak-Zol; Apo-Acetazolamide; Atenezol; Carbonic Anhydrase Inhibitor; Carbonic Anhydrase Inhibitor 6063; Cidamex; Dazamide; Defiltran; Dehydratin; Diacarb; Diakarb; Diamox; Diamox Sequels; Didoc; Diluran; Diuramid; Diureticum-Holzinger; Diuriwas; Diutazol; Donmox; Duiramid; Edemox; Eumicton; Fonurit; Glaupax; Glupax; Natrionex; Nephramid; Nephramide; Phonurit; Sk-Acetazolamide; Storzolamide; Vetamox Dosage Forms TABLET Absorption Not Available Interactions Interactions for Acetazolamide: (see WARNlNGS). DIAMOX®. modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy. By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone. Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable. Acetazolamide may increase the effects of other folic acid antagonists. Acetazolamide may increase or decrease blood glucose levels. Consideration should be taken in patients being treated with antidiabetic agents. Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect. Acetazolamide reduces urinary excretion of quinidine and may enhance its effect. Acetazolamide may prevent the urinary antiseptic effect of methenamine. Acetazolamide increases lithium excretion and the lithium may be decreased. Acetazolamide and sodium bicarbonate used concurrently increases the risk of renal calculus formation. Acetazolamide may elevate cyclosporine levels. Chemical IUPAC Name N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)ethanamide Chemical Formula C4H6N4O3S2 Half Life Not Available Drug Type Approved Drug # Accession No APRD00119 CAS Registry Number 59-66-5 |
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