Diamox: profile and news






Travel Medicine for Trekkers and Climbers in the Himalayan Region  Mar 5, 2006
For example, you cannot use Diamox or Acetazolamide if you are allergic to sulfa. It might be wise to take Diamox and see how you ... - Everest News,

Just the facts about Lake Titicaca  Feb 25, 2006
...info. Altitude sickness can occur above 2,400 metres. Before you go, ask your doctor about Diamox, a preventative medicine. Once ... - Toronto Star,

Ginkgo biloba reduces incidence and severity of acute mountain ...  Feb 22, 2006
I would especially recommend it for those situations in which I might consider Diamox: abrupt ascent, past history of AMS, and those who really need to avoid ... - Everest News,

Oceanside, Carlsbad residents set sights on Mount Kilimanjaro  Feb 12, 2006
Troy McMahan said they will take a prescription drug called Diamox to combat altitude sickness, which can produce symptoms such as headaches, nausea, dizziness ... - North County Times,

Diamox Improves Sleep Apnea in Heart Failure  Jan 16, 2006
16 - A night-time dose of Diamox (acetazolamide) -- a mild diuretic and respiratory stimulant -- reduces central sleep apnea in patients with heart failure ... - MedPage Today,

Possibility of illness climbs at higher altitude  Jan 30, 2006
Acetazolamide (Diamox) is a prescription medication sometimes taken to treat or prevent AMS. Other medicines can be taken to relieve headaches or nausea. ... - Newark Star Ledger,

HIGH ALTITUDE ILLNESS By Larry Rigsby MD (also an Everest climber)  Jan 16, 2006
If rapid ascent is inevitable acetazolamide or Diamox is helpful. ... Diamox should not be given to persons with a history of sulfa or sulfphonamide allergy. ... - Everest News,

Paul Covell takes on the challenge of climbing Kilimanjaro  Jan 11, 2006
Daniel our guide persuaded her to leave the decision until the morning, which she did, and with the aid of Diamox, the mountain sickness drug she made a ... - Bucks Free Press,

Expand your high altitude smarts  Jan 17, 2006
...sickness,� he said. Levine said there are a few medications available, with Diamox being the most effective. “It helps speed ... - Summit Daily News,

North, the only way out  Nov 27, 2005
...later. Generous doses of Diamox days earlier might have prevented the problem, but I wasn't worried; it couldn't happen to me. The ... - The Coloradoan,

Kilimanjaro is just a great hike - but it could kill you all the ...  Nov 9, 2005
He also favours taking a prophylactic, acetazolamide (marketed as Diamox), which reduces the chances of suffering altitude sickness and reduces the severity if ... - Cape Argus (subscription),

American Autumn Shishapangma Expedition 2005: Advance Base Camp ...  Sep 17, 2005
Pico de Orizaba in Mexico. I reached this altitude (summit) stoked on Diamox and was gasping uncontrollably for air. And now I feel ... - Everest News,

Medication-Induced Activation in Children and Adolescents  Oct 3, 2005
...are known to occur with alcohol, antihistamines, barbiturates, tricyclic antidepressants, acetazolamide (Dazamide, Diamox), benzodiazepines, steroids, bromides ... - Psychiatric Times,

across the roof of the world  Sep 19, 2005
But with the help of medicine - western Diamox and Chinese Hongjingtian - I convince myself I have mastered the elements, so I rush up the last 100m to the ... - Guardian Unlimited,

Blood pressure may rise during mountain visits  Sep 10, 2005
...said. Currently, the only drug available is Diamox, which simply makes the patient urinate more and breathe deeper and faster. Oxygen ... - Vail Daily News,

Rockin' and rollin' on land  Sep 11, 2005
...temporary. Currently she is taking acetazolamide (Diamox) for vestibular migraines, but she said she can't tell if it's helping. ... - Sun-Sentinel.com,

HYPP: Hyperkalemic Periodic Paralysis  08 Sep 2005
Provide access to a white salt block or feed loose salt. 3. Administer acetazolamide (Diamox), a diuretic (2 mg/kg orally twice a day). ... - TheHorse.com,

Confessions of a Tourist: The unbearable contriteness of peeing  Aug 27, 2005
I had started taking the drug Diamox to help me cope with South America’s rarified altitude (talking about what drugs you’re on — another backpacker habit ... - The Sunday Times,

Blood pressure rises when some travel to Summit  Aug 20, 2005
...said. Currently, the only drug available is Diamox, which simply makes the patient urinate more and breathe deeper and faster. Oxygen ... - Summit Daily News,

A rocky return to solid ground  Jul 18, 2005
...temporary. Now she is taking acetazolamide (Diamox) for vestibular migraines, but she said she couldn't tell if it was helping. ... - Los Angeles Times <**results**>

Peak condition  Jul 4, 2005
In addition to acclimatizing, Brown says she will take a prescription medication called Diamox that eases high-altitude symptoms on the day she summits Whitney ... - Los Angeles Times

New-Age Herb for an Age-Old Problem  Jun 22, 2005
For years there wasn'ta whole lot you could do about it beyond popping Diamox or dexamethasone, both prescription meds with serious side effects, or retreating ... - Skiing Magazine

Achieving peak performance  Jul 3, 2005
All night, this went on. So the next night and for three thereafter, he popped a quarter tablet of Diamox, which treats altitude sickness, to help him sleep. ... - Daily Press

Hale climbs, then runs Mount Kilimanjaro  Jun 29, 2005
...ago. "The only saving grace were the hallucinations produced each evening by the altitude sickness medicine I was taking (Diamox). ... - Cincinnati Enquirer

Not Your "Typical Patient": Cryptococcal Meningitis in an ...  Jun 11, 2005
...working properly. Dexamethasone (Decadron) and acetazolamide (Diamox) were initiated to decrease edema and CSF production. The LP ... - RedNova.com,

FDA Safety Labeling Changes: Crestor, Diamox Sequels, Femring  Jun 8, 2005
On March 15, the FDA approved revisions to the safety labeling for acetazolamide extended-release capsules (Diamox Sequels, made by Duramed Pharmaceuticals, Inc ... - Medscape (subscription)

New-Age Herb for an Age-Old Problem  Jun 22, 2005
For years there wasn'ta whole lot you could do about it beyond popping Diamox or dexamethasone, both prescription meds with serious side effects, or retreating ... - Skiing Magazine

Not Your "Typical Patient": Cryptococcal Meningitis in an ...  Jun 11, 2005
...working properly. Dexamethasone (Decadron) and acetazolamide (Diamox) were initiated to decrease edema and CSF production. The LP ... - RedNova.com,

Newsreader falls ill on mountain  Apr 23, 2005
..."The group gave me a birthday box full of goodies: lots of lollies, Diamox altitude sickness tablets, Strepsils, and Vasoline for my chapped lips," Adams said. ... - Melbourne Herald Sun

Travel Q/A  Apr 24, 2005
...you are quickly ascending from low to high altitudes and then partaking in rigorous activities, you might want to talk to a doctor about Diamox, a preventative ... - Sun-Sentinel.com,

Travel Medicine for Trekkers and Climbers in the Himalayan Region  Mar 6, 2005
For example, you cannot use Diamox or Acetazolamide if you are allergic to sulfa. It might be wise to take Diamox and see how you ... - Everest News,

Health Tip: Traveling Abroad?  Mar 8, 2005
If appropriate for your trip, remember to pack malaria tablets, water purification tablets, diamox for mountain sickness, motion sickness tablets and ... - ABC News

Ginkgo biloba reduces incidence and severity of acute mountain ...  Feb 22, 2005
I would especially recommend it for those situations in which I might consider Diamox: abrupt ascent, past history of AMS, and those who really need to avoid ... - Everest News,


Other information


Indication
For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Pharmacology
Acetazolamide is a potent carbonic anhydrase inhibitor, effective in the control of fluid secretion, in the treatment of certain convulsive disorders and in the promotion of diuresis in instances of abnormal fluid retention. Acetazolamide is not a mercurial diuretic. Rather, it is a nonbacteriostatic sulfonamide possessing a chemical structure and pharmacological activity distinctly different from the bacteriostatic sulfonamides.

Mechanism Of Action
The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.

Drug Category
Diuretics; Anticonvulsants; Carbonic Anhydrase Inhibitors; ATC:S01EC01

Brand Names/Synonyms
Acetamidothiadiazolesulfonamide; Acetamox; Acetazolam; Acetazolamid; Acetazolamide; Acetazolamide Sodium; Acetazolamine; Acetazoleamide; Acetozalamide; Ak-Zol; Apo-Acetazolamide; Atenezol; Carbonic Anhydrase Inhibitor; Carbonic Anhydrase Inhibitor 6063; Cidamex; Dazamide; Defiltran; Dehydratin; Diacarb; Diakarb; Diamox; Diamox Sequels; Didoc; Diluran; Diuramid; Diureticum-Holzinger; Diuriwas; Diutazol; Donmox; Duiramid; Edemox; Eumicton; Fonurit; Glaupax; Glupax; Natrionex; Nephramid; Nephramide; Phonurit; Sk-Acetazolamide; Storzolamide; Vetamox

Dosage Forms
TABLET

Absorption
Not Available

Interactions
Interactions for Acetazolamide:

(see WARNlNGS).

DIAMOX®. modifies phenytoin metabolism with increased serum levels of phenytoin. This may increase or enhance the occurrence of osteomalacia in some patients receiving chronic phenytoin therapy. Caution is advised in patients receiving chronic concomitant therapy.

By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Caution is advised when beginning, discontinuing, or changing the dose of DIAMOX in patients receiving primidone.

Because of possible additive effects with other carbonic anhydrase inhibitors, concomitant use is not advisable.

Acetazolamide may increase the effects of other folic acid antagonists.

Acetazolamide may increase or decrease blood glucose levels. Consideration should be taken in patients being treated with antidiabetic agents.

Acetazolamide decreases urinary excretion of amphetamine and may enhance the magnitude and duration of their effect.

Acetazolamide reduces urinary excretion of quinidine and may enhance its effect.

Acetazolamide may prevent the urinary antiseptic effect of methenamine.

Acetazolamide increases lithium excretion and the lithium may be decreased.

Acetazolamide and sodium bicarbonate used concurrently increases the risk of renal calculus formation.

Acetazolamide may elevate cyclosporine levels.



Chemical IUPAC Name
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)ethanamide

Chemical Formula
C4H6N4O3S2

Half Life
Not Available

Drug Type
Approved Drug

# Accession No
APRD00119

CAS Registry Number
59-66-5

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