Diabinese: profile and news

Many meds don't mix with the sun Sep 21, 2005
Antidiabetic agents: Acetohexamide (Dymelor), chlorpro-pamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Micronase ... - Pioneer Press, <**results**>

Top 10 Things to Know About Diabetes Pills Jul 4, 2005
Second World War. Chlorpropamide (brand name Diabinese) is the only first-generation sulfonylurea still in use today. This pill ... - About Diabetes

Other information

Indication
For managing hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM).

Pharmacology
Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide is twice as potent as the related second-generation agent glipizide.

Mechanism Of Action
Sulfonylureas such as Chlorpropamide likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

Drug Category
Hypoglycemic Agents; Sulfonylureas; ATC:A10BB02

Brand Names/Synonyms
Adiaben; Apo-Chlorpropamide; Asucrol; Catanil; Chlorodiabina; Chloronase; Chloropropamide; Chlorpropamid; Chlorpropamide; Chlorpropamide Bp/ Usp; Clorpropamide; Diabaril; Diabechlor; Diabenal; Diabenese; Diabeneza; Diabet-Pages; Diabetoral; Diabinese; Diamel Ex; Dynalase; Glisema; Glucamide; Hexathane; Insulase; Meldian; Melitase; Mellinese; Millinese; Novo-Propamide; Oradian; P 607; P-607; Stabinol; U-9818

Dosage Forms
TABLET

Absorption
Not Available

Interactions
-->Interactions for Chlorpropamide:

The hypoglycemic action of sulfonylurea may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for loss of control.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving DIABINESE, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving DIABINESE, the patient should be observed closely for hypoglycemia.

Since animal studies suggest that the action of barbiturates may be prolonged by therapy with chlorpropamide, barbiturates should be employed with caution. In some patients, a disulfiram-like reaction may be produced by the ingestion of alcohol.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known.

Chemical IUPAC Name
N-(4-chlorophenyl)sulfonylmethanamide

Chemical Formula
C10H13ClN2O3S

Half Life
36 hours

Drug Type
Approved Drug

# Accession No
APRD00029

CAS Registry Number
94-20-2