DiaBeta: profile and news






Sulfonylureas for Type 2 Diabetes Drugs Linked to Heart Deaths  Jan 17, 2006
A second group included 4,138 who received Diabeta (glyburide), and the third group included 1,537 who received the non-sulfonylurea drug metforminmetformin ... - CNN

Many meds don't mix with the sun  Sep 21, 2005
...agents: Acetohexamide (Dymelor), chlorpro-pamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Micronase), tolazamide (Tolinase ... - Pioneer Press,

Stanstead Pharmacy Fills Niche On Border  Jul 8, 2005
Such drugs, she said, include Diltiazem for high blood pressure, Lipitor for elevated cholesterol, DiaBeta for diabetes, and Fosamax for osteoporosis. ... - Caledonian Record <**results**>

Top 10 Things to Know About Diabetes Pills  Jul 4, 2005
Sulfonylureas of the second generation are glipizide (brand names Glucotrol and Glucotrol XL), glyburide (Micronase, Glynase, and Diabeta), and glimepiride ... - About Diabetes

Stanstead Pharmacy Fills Niche On Border  Jul 8, 2005
Such drugs, she said, include Diltiazem for high blood pressure, Lipitor for elevated cholesterol, DiaBeta for diabetes, and Fosamax for osteoporosis. ... - Caledonian Record,

Sweet Sorrow: The Relationship Between Depression and Diabetes ...  May 18, 2005
...if it includes insulin or sulfonylurea oral hypoglycemic medications (tolbutamide [Orinase], glipizide [Glucotrol], glyburide [Diabeta], glimepiride [Amaryl]). ... - Psychiatric Times,

Try safer shelving: coroner  Feb 13, 2005
...pharmacy's shelves - the prednisone drug under Deltasone, one of its commercial brand names, and the anti-diabetes drug under the name Diabeta, coroner Line ... - Montreal Gazette,

BCBSNC Launches New Prescription Drug Savings Initiative  Feb 17, 2005
Non-Insulin Dependent Diabetes) glipizide (generic Glucotrol) glipizide ER (generic Glucotrol XL) glyburide (generic Micronase, Diabeta) glyburide micronized ... - PR Newswire (press release)


Other information


Indication
For treatment and management of Type II diabetes mellitus

Pharmacology
Glyburide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Glyburide is twice as potent as the related second-generation agent glipizide.

Mechanism Of Action
Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

Drug Category
Hypoglycemic Agents; Antiarrhythmic Agents; Sulfonylureas; ATC:A10BB

Brand Names/Synonyms
Abbenclamide; Adiab; Apo-Glibenclamide; Azuglucon; Bastiverit; Benclamin; Betanase; Betanese 5; CHEMBANK74; Calabren; Cytagon; Daonil; Debtan; Dia-Basan; Diabeta; Diabiphage; Dibelet; Duraglucon; Euclamin; Euglucan; Euglucon; Euglucon 5; Euglykon; G106; G2539; GBN 5; Gen-Glybe; Gewaglucon; Gilemal; Glamide; Glibadone; Gliban; Gliben; Glibenbeta; Glibenclamid Al; Glibenclamid Basics; Glibenclamid Fabra; Glibenclamid Genericon; Glibenclamid Heumann; Glibenclamid Riker M.; Glibenclamid-Cophar; Glibenclamid-Ratiopharm; Glibenclamida [Inn-Spanish]; Glibenclamide; Glibenclamidum [Inn-Latin]; Glibenil; Glibens; Glibesyn; Glibet; Glibetic; Glibil; Gliboral; Glicem; Glidiabet; Glimel; Glimide; Glimidstata; Glisulin; Glitisol; Glubate; Gluben; Gluco-Tablimen; Glucobene; Glucohexal; Glucolon; Glucomid; Glucoremed; Glucoven; Glyben; Glybenclamide; Glybenzcyclamide; Glyburide; Glyburide [Usan]; Glycolande; Glycomin; Glynase; HB 419; HD 419; Hemi-Daonil; Hexaglucon; Humedia; KC-120; Lederglib; Libanil; Lisaglucon; Malix; Maninil; Med-Glionil; Melix; Micronase; Miglucan; Nadib; Neogluconin; Norglicem 5; Normoglucon; Novo-Glyburide; Orabetic; Pira; Praeciglucon; Prestab; Prodiabet; Renabetic; Semi-Daonil; Semi-Euglucon; Sugril; Suraben; Tiabet; UR 606; Yuglucon

Dosage Forms
Oral tablets

Absorption
Significant absorption within 1 hour and peak plasma levels are reached within 4 hours

Interactions
-->Interactions for Glyburide:

The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including nonsteroidal anti-inflammatory agents and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving MICRONASE, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving MICRONASE, the patient should be observed closely for loss of control.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phe-nothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimet-ics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving MICRONASE, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving MICRONASE, the patient should be observed closely for hypoglycemia.

A possible interaction between glyburide and ciprofloxacin, a fluoroquinolone antibiotic, has been reported, resulting in a potentiation of the hypoglycemic action of glyburide. The mechanism for this interaction is not known.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical or vaginal preparations of miconazole is not known. Metformin: In a single-dose interaction study in NIDDM subjects, decreases in glyburide AUC and Cmax were observed, but were highly variable. The single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmaco-dynamic effects, makes the clinical significance of this interaction uncertain. Coadministration of gly-buride and metformin did not result in any changes in either metformin pharmacokinetics or pharmaco-dynamics.



Chemical IUPAC Name
5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxy-benzamide

Chemical Formula
C23H28ClN3O5S

Half Life
10 hours

Drug Type
Approved Drug

# Accession No
APRD00233

CAS Registry Number
10238-21-8

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