Dexedrine: profile and news

Treating ADD With Medication 06 Mar 2006
Other stimulant medications are pemoline, known as Cylert; dextroamphetamine, known as Dexedrine and Dextrostat; and d- and l-amphetamin racemic mixture, known ... - DailyIndia.com,

25 died while using hyperactivity drugs Feb 9, 2006
...or under. Ritalin was linked to three deaths and Concerta to five. One death was associated with the drug Dexedrine. "There's no ... - Newsday,

A Safe Stimulant? Feb 27, 2006
Dextroamphetamine, which has been around for a long time (originally under the brand name Dexedrine) is one of the four active ingredients in Adderall xr. ... - Forbes

Are games like drugs? Feb 27, 2006
Extremely addictive prescription amphetamines like Adderall and Dexedrine are prescribed to literally millions of people, including young children. ... - Ars Technica,

FDA Forgot A Few ADHD Drug Related Deaths and Injuries Feb 19, 2006
...casino. Jeremy had been diagnosed with ADHD and prescribed Dexedrine just days before the crime. ... girlfriend. Jeremy had taken 37 Dexedrine pills. ... - Media Monitors Network,

ADHD Individual Drug Risk Studies To Be Considered By Drug Safety ... Feb 8, 2006
Adverse Event Reporting System for amphetamine/dextroamphetamine (Shire’s Adderall, Adderall XR, and Dextrostat; GlaxoSmithKline’s Dexedrine and Dexedrine ... - FDA Advisory Committee

ADHD Drug Medication Guide On Potential Cardiac Risks Recommended ... Feb 9, 2006
...event rates for the ADHD drugs amphetamine/dextroamphetamine (Shire’s Adderall, Adderall XR, and Dextrostat; GlaxoSmithKline’s Dexedrine and Dexedrine ... - FDA Advisory Committee

Some students use ‘study drugs’ to cram Feb 22, 2006
Study drugs include several medications typically prescribed to treat attention deficit disorder; Adderall, Cylert, Ritalin and Dexedrine are the most common. ... - UWM Post,

Attention-Deficit Drugs Need Watching, US FDA Says (Update1) Feb 8, 2006
2004 review also cited five cases of sudden death and 17 serious events such as heart attacks or strokes in adults on Adderall or Dexedrine, another amphetamine ... - Bloomberg

Advisers urge heart risk warning on ADHD drugs Feb 9, 2006
Amphetamines for ADHD include Adderall and GlaxoSmithKline Plc's Dexedrine. Another ADHD drug, Eli Lilly and Co.'s Strattera, is not classified as a stimulant. ... - Reuters.uk,

US advisers urge heart risk warning on ADHD drugs Feb 9, 2006
Focalin. Amphetamines for ADHD include Adderall and GlaxoSmithKline Plc's Dexedrine. All of those drugs are stimulants. Another ... - Reuters.uk,

Advisers urge heart risk warning on ADHD drugs Feb 9, 2006
...another Novartis drug, Focalin. Amphetamines for ADHD include Adderall and GlaxoSmithKline Plc‘s Dexedrine. Another ADHD drug, Eli ... - Pierceland Herald,

Calling the Barrel Black Feb 17, 2006
Decades from now, when Ann Coulter is zonked out on Medicaid-funded Dexedrine in a government-sponsored assisted living facility, we will casually discuss the ... - Freezerbox

Coffee May Help Adults and Children With Attention Deficit and ... Feb 17, 2006
Kids diagnosed with ADD/ADHD are often given powerful drugs like Ritalin, Adderall, Dexedrine and Strattera, prescription medicines which increase the level of ... - YubaNet,

From Pastime to Nap Time Feb 5, 2006
They ingest whatever they can get their hands on: drugs marketed under such brand names as Ritalin, Adderall, Concerta, Cylert and Dexedrine, as well as pills ... - New York Times,

Drug problems ruining sports Feb 14, 2006
...trade, and are necessary. Some of the brand names of the drugs being used are Ritalin, Adderall, Cylert and Dexedrine. If some of ... - Bermuda Sun,

Evelyn Pringle: ADHD Drugs - Cash Cow For Pharma Feb 14, 2006
...the journal Addiction. The specific focus of the study was the non-medical use of Ritalin, Dexedrine and Adderall. Based on his ... - Scoop.co.nz (press release),

PEOPLE'S PHARMACY Drug warnings too often ignored Jan 31, 2006
A: Adderall and similar drugs (Ritalin, Concerta, Dexedrine) help many children with attention-deficit (hyperactivity) disorder (ADD), but the medications can ... - Houston Chronicle,

Dangers of stimulant abuse Feb 1, 2006
Disorder or ADHD. Some common ADHD medications include Adderall, Concerta, Ritalin, Strattera and Dexedrine. Adderall, however, is ... - University Daily Kansan,

Art of Darkness Feb 1, 2006
Gaitskill wrote with invigorating honesty about masochists, Dexedrine addicts, and prostitutes, finding a weird beauty in their unsensational, everyday lives. ... - Chronogram,

Will herb for prostate help make hair grow? Feb 2, 2006
Adderall and similar drugs (Ritalin, Concerta, Dexedrine) help many children with attention-deficit (hyperactivity) disorder (ADD), but the medications can ... - Bradenton Herald,

ADD drug can upset stomach Jan 29, 2006
Adderall and similar drugs (Ritalin, Concerta, Dexedrine) help many children with attention-deficit (hyperactivity) disorder (ADD), but the medications can ... - Los Angeles Times,

Doctor to defend self before board Jan 26, 2006
15, the same day he made his agreement with the board, Schwartz allegedly prescribed 50 pills of Dexedrine , also known as methamphetamine , and 40 pills of ... - Santa Fe New Mexican,

Speeding past test stress 11 Dec 2005
Adderall - like its brother drugs Ritalin and Dexedrine - is a prescription amphetamine that increases focus and is only legally used by people with ... - Daily Iowan (subscription),

Sightseeing with Dear Leader Dec 9, 2005
Mr. Park sounded like somebody on Dexedrine reading from a guidebook as he rattled off anodyne statistics: North Korea's population, square kilometers, weather ... - Los Angeles Times,

On call: Pay attention to ADHD disorder, part II Nov 26, 2005
Products approved for ADHD treatment in children have the brand names of Ritalin, Concerta, Dexedrine, Adderall, Focalin, Metadate and others. ... - Waldo Village Soup,

Justices dilute award to doctor in TV news defamation lawsuit Nov 16, 2005
...checkup. The report also showed Jensen saying he might be able to give her Dexedrine, a drug not approved for weight loss. Sawyers ... - Salt Lake Tribune,

Ex-KTVX owner is ordered to pay doctor $700,000 Nov 16, 2005
Then he told her he would be willing to work with her if Fastin was not effective for her, perhaps by giving her Dexedrine, an amphetamine in the same family ... - Salt Lake City Deseret News,

Ever-popular stimulants hold danger as study aid Dec 5, 2005
...most-prescribed ADHD drug. Ritalin, Concerta and Dexedrine are other popular stimulants used to treat ADHD. The drugs have fallen ... - Louisville Courier-Journal,

Apathy and Its Treatment in Alzheimer's Disease and Other ... Dec 5, 2005
Psychostimulants such as methylphenidate and dextroamphetamine (Dexedrine, DextroStat) have been shown to reduce symptoms of apathy in case series of patients ... - Psychiatric Times,

A study in peril? Collegians pop ADHD drugs Nov 24, 2005
...most prescribed ADHD drug. Ritalin, Concerta and Dexedrine are other popular stimulants used to treat ADHD. The drugs have become ... - Denver Post,

Klap: Down with uppers Nov 16, 2005
...game? In the '70s and '80s, Dexedrine was the "gold standard" of all uppers, according to one former player who used the stuff. ... - NorthJersey.com,

Avitar Enters Rapidly Expanding Oral Fluid-Based Laboratory Drug ... Nov 29, 2005
The solution is available in the three versions shown below. * ORALscreen LAB5+ Amphetamines: (Dexedrine(R)), MDA (Love Pill), MDEA (Eve) Methamphetamines ... - PR Newswire (press release),

More of baseball's secrets Nov 20, 2005
Or they might have come from players raiding their wives' supply of diet pills -- Dexedrine, usually -- at home. "The ballclub never had them," he said. ... - Fort Worth Star Telegram,

Armed robber still at large Nov 12, 2005
In September, a Logan man was charged with robbing a pharmacy; he reportedly passed a note to the pharmacist asking for OxyContin and Dexedrine and said if the ... - Provo Daily Herald,

CCHR Speaks Out regarding Tom Cruise Speaking Out Oct 9, 2005
School in Taber, Alberta. He was seeing a psychiatrist who prescribed him Dexedrine just prior to the shooting. Hundreds of thousands ... - OfficialWire,

Making the best decisions about ADHD treatments Oct 4, 2005
Drugs such as methylphenidate (Ritalin) and dextroamphetamine (Dexedrine) can help your child concentrate, feel calmer and think before acting. ... - Consumer Reports (subscription)

Second suspect charged with prescription forgery Sep 15, 2005
Dube after receiving a tip from a Worcester doctor who said that Dube was passing fake prescriptions in Massachusetts and Rhode Island for Dexedrine, a 5 ... - Shrewsbury Chronicle,

Logan man suspected of robbing pharmacy Sep 23, 2005
...a tan hat and red fleece jacket walked into the pharmacy on the south side of Smith's and passed a pharmacist a note demanding OxyContin and Dexedrine pills. ... - Logan Herald Journal,

Police: Robber made threat to infect pharmacy worker with HIV Sep 24, 2005
...at about 5 pm Thursday, just hours after he allegedly threatened pharmacists at Smith's Marketplace and forced them to give him OxyContin and Dexedrine pills. ... - Logan Herald Journal,

Man Charged In Alleged Robbery, Threat Sep 24, 2005
Police say the man went into a local grocery story Thursday night and passed a note to pharmacists that demanding the drugs OxyContin and Dexedrine. ... - KUTV,

Supreme Court limits driver's license suspension in drug case Sep 29, 2005
Court records show Freundt pleaded guilty in January 2001 to unlawfully obtaining Oxycontin, Percodan, Ritalin, Dexedrine and other pharmaceuticals for her ... - Centre Daily Times,

Second person under arrest 08 Sep 2005
Police arrested Dube after receiving a tip from a Worcester doctor who said the Shrewsbury man was passing fake prescriptions for Dexedrine, a 5-milligram pill ... - MetroWest Daily News,

Attention Deficit Hyperactivity Disorder 08 Sep 2005
...social situations. The first-line medications prescribed are the stimulants, which include Ritalin, Dexedrine, and Adderall. These ... - eMaxHealth.com,

Escapee 4th Out OF 9 School Shooters Who Were Taking Psychiatrys ... Sep 4, 2005
...to the Citizens Commission on Human Rights (CCHR) verified that the 14-year-old shooter had indeed been prescribed a speed-type drug called Dexedrine by an ... - The Open Press (press release)

Human Rights Group Speaks Out Regarding Tom Cruise Speaking Out Sep 4, 2005
School in Taber, Alberta. He was seeing a psychiatrist who prescribed him Dexedrine just prior to the shooting. Hundreds of thousands ... - The Open Press (press release)

Former county psychiatrist gets probation for drug offenses Aug 17, 2005
They also found a prescription issued to Gray's live-in girlfriend for Dexedrine, a drug used to treat narcolepsy and attention deficit disorder. ... - NapaNet Daily News,

Regional digest Aug 10, 2005
55, of 11 Canna Drive, was charged Monday in Westboro District Court with uttering a false prescription, forgery, distribution of Dexedrine, possession of ... - Worcester Telegram (subscription),

A sporting life: Speed was a drug to Paddy... Sep 4, 2005
The Belfast man, like many of his contemporaries, took Dexedrine - a form of 'speed' - to help him stay awake during endurance events like the famous Le Mans ... - Sunday Life,

The link between psychiatry's drugs and violence Aug 16, 2005
Rights by the boy's mother, just after the shooting, verified that the 14-year-old shooter had indeed been prescribed a speed-type drug called Dexedrine by an ... - PR Direct (press release),

Man charged with faking hundreds of prescriptions Aug 10, 2005
...was arrested last Friday after police received a call from a Worcester doctor who claimed Dube had passed off several forged prescriptions for Dexedrine, a 5 ... - Shrewsbury Chronicle,

Faster, Speedfreak! Cook! Cook! Aug 17, 2005
...pre-fame Elvis Presley had stolen his mother’s diet pills, but, by 1965, Johnny Cash found himself busted at the El Paso airport with 668 Dexedrine and 475 ... - LA City Beat,

e-PrescriptionDrugAddiction.com Provides an Overview of ... Aug 24, 2005
Stimulants speed up brain functions and are commonly prescribed for people with ADHD. Some well-known stimulants are Ritalin and Dexedrine. ... - Pressbox.co.uk (press release),

News in brief from California's North Coast Aug 18, 2005
Prosecutors said Gray, who was employed by the Napa County Department of Health and Human Services at the time, illegally prescribed Dexedrine - a drug used to ... - San Jose Mercury News,

Polypharmacy in children on the rise in the US 06 Aug 2005
According to the study, the most frequent combination were stimulants such as methylphenidate ( Ritalin ) or dextroamphetamine ( Dexedrine, Adderall ) commonly ... - I-Newswire.com (press release)

Ritalin May Slow Growth in Some Aug 5, 2005
Researchers analyzed 29 studies that included information on height variations among children taking Ritalin or the stimulant Dexedrine for ADHD. ... - WebMD

Many Kids Getting Multiple Psychiatric Medications Aug 2, 2005
The study found the most frequent combination included stimulants such as Ritalin, Dexedrine and Adderall -- commonly used to treat attention-deficit ... - Atlanta Journal Constitution (subscription)

In search of that extra edge Jul 21, 2005
...which was recently banned in Canada because of several instances of sudden death and stroke, and dexamphetamines—such as Dextrostat or Dexedrine. ... - Gateway.ualberta.ca

'Dream' turns to nightmare Jul 19, 2005
Mommy comes off like Doris Day on dexedrine, while Daddy (Nigel Reed) is an ineffectual lump whose sole purpose seems to be paying the bills. ... - Washington Times

Other information

Indication
For treatment of Attention Deficit Disorder with Hyperactivity (ADDH) and narcolepsy in children.

Pharmacology
Amphetamine and dextroamphetamine, non-catechloamine sypathomimetic agents, are used in combination to treat attention-deficit hyperactivity disorder (ADHD) or narcolepsy. Adderall consists of equivalent amounts of amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate.

Mechanism Of Action
Amphetamine and dextroamphetamine stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems. Amphetamine may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetamines are believed to cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Modulation of serotonergic pathways may contribute to the calming affect.

Drug Category
Adrenergic Agents; Dopamine Agents; Dopamine Uptake Inhibitors; Adrenergic Uptake Inhibitors; Central Nervous System Stimulants; Amphetamines; Sympathomimetics; ATC:N06BA01

Brand Names/Synonyms
Actedron; Adipan; Allodene; Amphetamine; Amphetamine Sulfate; Anorexide; Anorexine; Benzebar; Benzedrine; Benzolone; Desoxyn; Dexampex; Dexedrine; Dextroamphetamine Sulfate; Dextrostat; Elastonon; Fenamin; Fenylo-izopropylaminyl; Ferndex; Finam; Isoamycin; Isoamyne; Isomyn; Mecodrin; Methampex; Methamphetamine HCL; Norephedrane; Norephedrine, deoxy-; Novydrine; Oktedrin; Ortedrine; Paredrine; Percomon; Phenamine; Phenedrine; Phenylisopropylamine; Profamina; Propisamine; Psychedrine; Raphetamine; Rhinalator; Simpatedrin; Simpatina; Sympamin; Sympamine; Sympatedrine; Weckamine; amphetamine base; dl-Amphetamine; dl-Benzedrine; m-Methoxyamphetamine; alpha-Methylbenzeneethaneamine; beta-Aminopropylbenzene; (+/-)-Desoxynorephedrine; (+/-)-beta-Phenylisopropylamine; (+/-)-Benzedrine; (+/-)-Desoxynorephedrine; 1-Methyl-2-phenylethylamine; 1-Phenyl-2-aminopropane; 3-Methoxy-a-methylbenzeneethanamine; 3-Methoxyamphetamine; 3-Methoxyphenylisopropylamine; Amphetamine (Narcotics); DL-alpha-Methylphenethylamine; [1-(3-Methoxyphenyl)-2-propyl]amine; dl-1-Phenyl-2-aminopropane; m-Methoxy-a-methylphenethylamine; racemic-Desoxynor-ephedrine

Dosage Forms
tablets combining the neutral sulfate salts of dextroamphetamine and amphetamine, with the dextroisomer of amphetamine saccharate and 6, I-amphetamine aspartate.

Absorption
It forms easily absorbed molecules that are highly lipid soluble

Interactions
Acidifying agents - Gastrointestinal acidifying agents (guanethidine,reserpine, glutamic acid HCl,ascorbic acid, fruit juices, etc.) lower absorption of amphetamines. Urinary acidifying agents -(ammonium chloride, sodium acid phosphate, etc.) Increase the concentration of the ionized species of the amphetamine. Primary excretion - Both Groups of agents lower blood levels and efficacy of amphetamines. Adrenergic blockers - Adrenergic blockers are inhibited by amphetamines. Alkalinizing agents -Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.)increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentate the actions of amphetamines. Antidepressants, tricyclic - Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated. MAO inhibitors - MAO antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism. This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other monoamines from adrenergic nerve endings, this can cause headaches and other signs of hypertensive crisis. A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results. Antihistamines - Amphetamines may counteract the sedative effect of antihistamines. Antihypertensives - Amphetamines may antagonize the hypotensive effects of antihypertensives. Chlorpromazine - Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat amphetamine poisoning. Ethosuximide - Amphetamines may delay intestinal absorption of ethosuximide. Haloperidol - Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines. Lithium carbonate - The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate. Meperidine - Amphetamines pone the analgesic effect of meperidine. Methenamine therapy - Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy. Norepinephrine - Amphetamines enhance the adrenergic effect of norepinephrine. Phenobarbital - Amphetamines may delay intestinal absorption of phenobarbital; co-administration of phenobarbital may produce a synergistic anticonvulsant action. Phenytoin - Amphetamines may delay intestinal absorption of phenytoin; co-administration of phenytoin may produce a synergistic anticonvulsant action. Propoxyphene - In cases of propoxyphene overdose, amphetamine CNS stimulation is potentiated and fatal convulsions can occur. Veratrum alkaloids - Amphetamines inhibit the hypotensive effect of veratrum alkaloids. Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. This increase is greatest in the evening. Amphetamines may interfere with urinary steroid determinations.

Chemical IUPAC Name
1-phenylpropan-2-amine

Chemical Formula
C9H13N

Half Life
10 hours

Drug Type
Approved Drug

# Accession No
APRD00480

CAS Registry Number
300-62-9