Detrol: profile and news






What to do if you have an overactive bladder  Feb 6, 2006
Another medication that is frequently prescribed, tolterodine (Detrol), is very similar to Ditropan. Some studies found that Detrol ... - MSNBC

Positive Phase II Clinical Trial Results Announced By Antares ...  Feb 22, 2006
Treatment consists of oral medications such as Ditropan(R) (oxybutynin), Detrol(R) (tolterodine), Enablex(R) (darifenacin), Vesicare(R) (solifenacin) and ... - International News Service,

Neurologist's study of brain began with goldfish  Feb 22, 2006
...function. Common anticholinergic drugs are Detrol (tolterodine) and Ditropan (oxybutinin), which are used to treat overactive bladder. ... - CNN

What to do if you have an overactive bladder  Feb 6, 2006
Another medication that is frequently prescribed, tolterodine (Detrol), is very similar to Ditropan. Some studies found that Detrol ... - MSNBC

Pfizer Fourth-Quarter and Full-Year 2005 Financial Results Reflect ...  Jan 19, 2006
1) 1 * 129 138 (6) VFEND 112 83 34 40 33 19 72 50 45 - UROLOGY 727 769 (5) 410 461 (11) 317 308 3 VIAGRA 430 469 (8) 212 248 (15) 218 221 (1) DETROL/ DETROL LA ... - PR Newswire (press release),

Detrol LA Significantly Reduced Daytime and Nighttime Urinary ...  Nov 28, 2005
NEW YORK, NY -- November 28, 2005 -- Pfizer Inc's Detrol® LA (tolterodine tartrate extended release capsules) significantly improved lower urinary tract ... - DG News

Choosing Medicare drug plan is a chore  Nov 28, 2005
After 54 years of marriage, Clarence and Shirley Brooks have found a reason to split up. His Celebrex. Her Synthroid. His Norvase. Her Detrol LA. ... - MLive.com,

Max.md Awards Branding to DiMassimo  Nov 30, 2005
...open view on creativity.". Murray pointed to DiMassimo's work for Detrol, a Pfizer drug for incontinent women. The shop created a ... - Adweek,

The pros and cons of female hormone therapy  Nov 13, 2005
Check with your doctor before taking this. Q: After taking Detrol for overactive bladder, my vision became so blurred that I could barely see. ... - Houston Chronicle,

Statins affect memory?  Nov 14, 2005
Check with your doctor before taking this. Q. After taking Detrol for overactive bladder, my vision became so blurred that I could barely see. ... - Charlotte Observer,

Pfizer Stock - Not the Right Gift This Year  Dec 7, 2005
In addition, Pfizer's sales of Zoloft (an antidepressant) and Detrol (a drug to treat overactive bladders) were essentially flat, while sales of Viagra, an ... - New York Sun,

There's more to a plan than the price  Dec 3, 2005
The drugs used in the test were: Albuterol aerosol, Aricept, Avandia, Cozaar, Detrol LA, Fosamax, Lipitor, Lovastatin, Nexium and Lunesta. - St. Petersburg Times,

Don't be in a rush to change drug plan  Nov 15, 2005
Barbara Coden has four: Detrol, which treats an overactive bladder; Nexium, which treats acid reflux; Fosamax, which treats osteoporosis; and a replacement for ... - Detroit Free Press,

Store glasses will help you read tiny type, won't hurt the eyes  Nov 25, 2005
You can also try drugs such as Tofranil, DDAVP or Ditropan, Detrol, Vesicare, Sanctura or Enablex. But bedwetting may recur if the drugs are stopped. - Baltimore Sun,

Is it normal for adults to occasionally wet the bed?  Nov 20, 2005
You can also try drugs such as Tofranil, DDAVP or Ditropan, Detrol, Vesicare, Sanctura, or Enablex. But bed-wetting may recur if the drugs are stopped. - Boston Globe,

Suffering urinary incontinence in silence  Nov 16, 2005
Urge incontinence is often treated with drugs like tolterodine, sold as Detrol, and oxybutynin chloride, sold as Ditropan, that relax muscles in the urinary ... - Contra Costa Times,

Married Women Report More Sexual Woes Than Singles  Oct 2, 2005
Exercise and Physical Activity Hysterectomy Consanguinity – Inbreeding Preeclampsia Placenta Previa Related Drugs: Actonel Detrol LA Diflucan Ditropan ... - Scoopt.org,

Express Scripts to pull Pfizer drugs - report  Oct 5, 2005
...best-selling prescription drug; the blood pressure medicine Norvasc; Viagra, the top-selling erectile dysfunction treatment, and incontinence medicine Detrol/LA ... - Reuters.uk,

Express Scripts to pull Pfizer drugs  Oct 5, 2005
Norvasc; blood pressure/cholesterol combination drug Caduet; Viagra, the top-selling erectile dysfunction treatment; and incontinence medicine Detrol/LA . ... - Reuters

Express Scripts to push generic prescriptions next year  Oct 5, 2005
...drugs.". Other Pfizer drugs the company is taking off of the formulary include Norvasc; Caduet; Viagra and Detrol/LA, reports said. ... - St. Louis Business Journal,

DRL gets FDA approval for nizatidine  Sep 19, 2005
...had received tentative approval for tolterodine tartrate tablets to treat incontinence. The drug is a generic version of Pfizers Detrol. - Sify,

ADHD drugs may cause weight loss, tics  Sep 20, 2005
...constipation. Calcium, Fosamax, Detrol, Effexor, Lipitor and Zyprexa are just a few of the medicines that can affect the digestive tract. ... - Jackson Clarion Ledger,

Sensex crosses 8400 mark  Sep 18, 2005
Ranbaxy Laboratories gained after receiving tentative approval from the US Food and Drug Administration to sell its version of Pfizer Inc.'s Detrol, which is ... - Hindu Business Line,

Ranbaxy Receives Tentative Approval to Market Tolterodine Tartrate ...  Sep 16, 2005
...manufacturing operations in 7 countries. * Detrol(R) Tablets is a registered trademark of Pharmacia and Upjohn Company (Pharmacia). - PR Newswire (press release),

Barbara Walters Grills John Roberts at Surprise Hearing  Sep 16, 2005
...on the new Martha Stewart show, I had my limo driver racing down I-95 faster than the Surgeon General could write President Bush a prescription for Detrol. ... - Spoof News (satire)

Esprit Pharma Appoints Christopher Dowd Senior Vice President ...  Sep 13, 2005
...was instrumental in the launch and/or promotion of major brands such as Viagra(R), Lipitor(R), Celebrex(R), Zoloft(R), Zyrtec(R), Aricept(R), and Detrol(R) LA ... - Business Wire (press release),

Is there a safe solution for chronic pain relief?  Sep 4, 2005
...constipation. Calcium, Fosamax, Detrol, Effexor, Lipitor and Zyprexa are just a few of the medicines that can affect the digestive tract. ... - Houston Chronicle,

Treating Bladder Control Problems  Aug 15, 2005
Enablex (Novartis Pharmaceuticals), Ditropan XL (Ortho-McNeil), Oxytrol (Watson Pharmaceuticals), VESIcare (Astellas/GlaxoSmithKline), Detrol (Pfizer), Sanctura ... - Philadelphia Inquirer,

Pennyroyal can repel insects  Aug 14, 2005
...liver. I have been taking Detrol for the last two years, yet my hourly trips to the bathroom (only during the night) have not eased. ... - Los Angeles Times,

Too much water can lead to drop in potassium; sport drinks may ...  Aug 23, 2005
Sports drinks may help. Q. I have been taking Detrol for the past two years, yet my hourly trips to the bathroom (only during the night) have not eased. ... - Jackson Clarion Ledger,

Acmemeds.com Improves Itself With 101 New Added Medications  Aug 20, 2005
...generic) 20 mg, Bentyl 10 mg, Bentyl 20 mg, Claritin D 12 hr, Claritin-D 24 hr,Cleocin T Gel 1.0% 30 gm,Colchicine 0.6 mg,Condylox (gel) 0.50%,Detrol LA 2 mg ... - PR Web (press release),

Changes to drug ads may be on the horizon  Aug 14, 2005
Sports drinks may help. Q: I have been taking Detrol for the past two years, yet my hourly trips to the bathroom (only during the night) have not eased. ... - Houston Chronicle,

You Don't Have to Live With Incontinence  Aug 3, 2005
He says when this happens, Vesicare, Detrol, Ditropan, Enablex, and other anti-cholinergics work very well to relax the bladder. ... - KFYR-TV

Treating weak bladder begins with simple steps  Jul 27, 2005
The old standbys are Detrol (tolterodine) and Ditropan (oxybutynin), which stop spasms by blocking a chemical that makes muscles contract but have the side ... - South Bend Tribune

Pfizer Inc Second-Quarter 2005 Performance Report  Jul 20, 2005
...up 16 percent), Xalatan/Xalacom (up 17 percent), Camptosar (up 58 percent, benefiting from the recent acquisition of rights in Europe), and Detrol/Detrol LA ... - Yahoo News (press release)

See the stars for whatever ails you  Jul 24, 2005
...drug Pravachol. • Actress Debbie Reynolds did an ad for Pfizer's Detrol for overactive bladder; she has the condition. • Talk ... - SunHerald.com

AT A GLANCE  Jul 20, 2005
Altace, which he has used. Actress Debbie Reynolds | In an ad for Pfizer's Detrol for overactive bladder; she has the condition. - Myrtle Beach Sun News

Cops investigating Shore CVS after 2 people get wrong drugs  Jul 18, 2005
Scaiella had been taking a blood thinner, Plavix, for a week, when her doctor had actually prescribed Detrol La for a bladder control problem. ... - Newark Star Ledger

WAYS TO CONTROL AN OVERACTIVE BLADDER  Jul 20, 2005
...changing it. Detrol is another medicine that has been a standby. Newer drugs include Sanctura, Enablex and VESIcare. Limiting your ... - Charlotte Sun-Herald

Wrong drugs doled out to two senior citizens  Jul 20, 2005
Can you believe it?". Although the vial label read Detrol LA, the drug Scaiella's doctor prescribed, the vial contained Plavix, a blood thinner. ... - Asbury Park Press


Other information


Indication
For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence)

Pharmacology
Tolterodine is a competitive muscarinic receptor antagonist. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. After oral administration, tolterodine is metabolized in the liver, resulting in the formation of the 5-hydroxymethyl derivative, a major pharmacologically active metabolite. The 5-hydroxymethyl metabolite, which exhibits an antimuscarinic activity similar to that of tolterodine, contributes significantly to the therapeutic effect. Both tolterodine and the 5-hydroxymethyl metabolite exhibit a high specificity for muscarinic receptors, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Tolterodine has a pronounced effect on bladder function. The main effects of tolterodine are an increase in residual urine, reflecting an incomplete emptying of the bladder, and a decrease in detrusor pressure, consistent with an antimuscarinic action on the lower urinary tract.

Mechanism Of Action
Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, act as competitive antagonists at muscarinic receptors. This results in inhibition of bladder contraction, decrease in detrusor pressure, and an incomplete emptying of the bladder.

Drug Category
Antispasmodics; Anti-Incontinence Agents; Genitourinary Smooth Muscle Relaxants; ATC:G04BD07

Brand Names/Synonyms
CHEMBANK1673; Detrol; Detrol La; Tolterodina [Inn-Spanish]; Tolterodine; Tolterodine L-Tartrate; Tolterodine Tartrate; Tolterodine [Inn]; Tolterodinum [Inn-Latin]; Tolterondine Tartrate

Dosage Forms
CAPSULE (SUSTAINED-RELEASE)

Absorption
Not Available

Interactions
-->Interactions for Tolterodine:

CYP3A4 Inhibitors: Ketoconazole, an inhibitor of the drug metabolizing enzyme CYP3A4, significantly increased plasma concentrations of tolterodine when coadministered to subjects who were poor metabolizers (see CLINICAL PHARMACOLOGY, Variability in Metabolism and Drug-Drug Interactions). For patients receiving ketoconazole or other potent CYP3A4 inhibitors such as other azole antifungals (eg, itraconazole, miconazole) or macrolide antibiotics (eg, erythromycin, clarithromycin) or cyclosporine or vinblastine, the recommended dose of DETROL LA is 2 mg daily.

Drug-Laboratory-Test Interactions

Interactions between tolterodine and laboratory tests have not been studied.



Chemical IUPAC Name
2-[3-[bis(1-methylethyl)amino]-1-phenyl-propyl]-4-methyl-phenol

Chemical Formula
C22H31NO

Half Life
1.9-3.7 hours

Drug Type
Approved Drug

# Accession No
APRD00146

CAS Registry Number
124937-51-5

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