Desoxyn: profile and news

Meth incidents jump Feb 26, 2006
...a common prescription drug in the United States called Methedrine and is still prescribed for attention deficit disorder and weight loss under the name Desoxyn ... - Pittsburgh Tribune-Review,

ADHD Individual Drug Risk Studies To Be Considered By Drug Safety ... Feb 8, 2006
Ritalin LA; Alliant’s Methylin and Methylin ER; UCB/Celltech’s Metadate ER and Metadate CD), methamphetamine (Ovation’s Desoxyn) and dexmethylphenidate ... - FDA Advisory Committee

Analysis: ADHD drug risks won't hurt sales Feb 9, 2006
The FDA report noted that conclusions about the safety of Ovation's Desoxyn and Novartis' Focalin could not be reached due to the relatively low use of these ... - United Press International

Analysis: ADHD drug risks won't hurt sales 09 Feb 2006
The FDA report noted that conclusions about the safety of Ovation's Desoxyn and Novartis' Focalin could not be reached due to the relatively low use of these ... - United Press International

Confronting crystal meth Nov 10, 2005
Doctors prescribe the drug to kids with attention deficit disorder under the brand name Desoxyn. ... Meth, or Desoxyn, is still prescribed to treat ADD. ... - Georgia Straight,

Avitar Enters Rapidly Expanding Oral Fluid-Based Laboratory Drug ... Nov 29, 2005
ORALscreen LAB5+ Amphetamines: (Dexedrine(R)), MDA (Love Pill), MDEA (Eve) Methamphetamines: (Desoxyn(R)), MDMA, Ecstasy THC: Delta-9-tetrahydrocannabinol ... - PR Newswire (press release),

What is Crystal Meth? Nov 9, 2005
It is also known as crystal, crank, tweak, go-fast, and dozens of other names. In medicine, it comes in tablet form, as the prescription drug, Desoxyn®. ... - WSOCtv.com,

Vancouver Sun Sep 24, 2005
...use continued in other wars, including Vietnam and in Iraq, and low-dose meth is still available, under the trade name Desoxyn (methamphetamine hydrochloride ... - Vancouver Sun (subscription),

Anorectics on Trial: A Half Century of Federal Regulation of ... Sep 6, 2005
In November 1943, Abbott Laboratories of Abbott Park, Illinois, submitted a New Drug Application (NDA) for desoxyephedrine (Desoxyn) to the FDA's Drug Division ... - Annals of Internal Medicine

Faster, Speedfreak! Cook! Cook! Aug 17, 2005
The more potent methamphetamine was developed in Japan in 1919, and initially marketed as a diet aid in the US under the brand name Desoxyn. ... - LA City Beat,

Niche drug market strategy raises Ovation Apr 11, 2005
Our niche is about 30 percent of that. For attention-deficit syndrome, our product Desoxyn is the drug of last resort, if Ritalin fails. ... - Chicago Sun-Times

Guest Viewpoint: Prohibition on marijuana does more harm than good Apr 8, 2005
Desoxyn (methamphetamine hydrochloride) and Ritalin (methylphenidate) affect the physiologies of children the same way as methamphetamine. ... - The Register-Guard,

Other information

Indication
For treatment of Attention Deficit Disorder with Hyperactivity (ADDH) and narcolepsy in children.

Pharmacology
Amphetamine and dextroamphetamine, non-catechloamine sypathomimetic agents, are used in combination to treat attention-deficit hyperactivity disorder (ADHD) or narcolepsy. Adderall consists of equivalent amounts of amphetamine aspartate, amphetamine sulfate, dextroamphetamine saccharate, and dextroamphetamine sulfate.

Mechanism Of Action
Amphetamine and dextroamphetamine stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems. Amphetamine may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetamines are believed to cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Modulation of serotonergic pathways may contribute to the calming affect.

Drug Category
Adrenergic Agents; Dopamine Agents; Dopamine Uptake Inhibitors; Adrenergic Uptake Inhibitors; Central Nervous System Stimulants; Amphetamines; Sympathomimetics; ATC:N06BA01

Brand Names/Synonyms
Actedron; Adipan; Allodene; Amphetamine; Amphetamine Sulfate; Anorexide; Anorexine; Benzebar; Benzedrine; Benzolone; Desoxyn; Dexampex; Dexedrine; Dextroamphetamine Sulfate; Dextrostat; Elastonon; Fenamin; Fenylo-izopropylaminyl; Ferndex; Finam; Isoamycin; Isoamyne; Isomyn; Mecodrin; Methampex; Methamphetamine HCL; Norephedrane; Norephedrine, deoxy-; Novydrine; Oktedrin; Ortedrine; Paredrine; Percomon; Phenamine; Phenedrine; Phenylisopropylamine; Profamina; Propisamine; Psychedrine; Raphetamine; Rhinalator; Simpatedrin; Simpatina; Sympamin; Sympamine; Sympatedrine; Weckamine; amphetamine base; dl-Amphetamine; dl-Benzedrine; m-Methoxyamphetamine; alpha-Methylbenzeneethaneamine; beta-Aminopropylbenzene; (+/-)-Desoxynorephedrine; (+/-)-beta-Phenylisopropylamine; (+/-)-Benzedrine; (+/-)-Desoxynorephedrine; 1-Methyl-2-phenylethylamine; 1-Phenyl-2-aminopropane; 3-Methoxy-a-methylbenzeneethanamine; 3-Methoxyamphetamine; 3-Methoxyphenylisopropylamine; Amphetamine (Narcotics); DL-alpha-Methylphenethylamine; [1-(3-Methoxyphenyl)-2-propyl]amine; dl-1-Phenyl-2-aminopropane; m-Methoxy-a-methylphenethylamine; racemic-Desoxynor-ephedrine

Dosage Forms
tablets combining the neutral sulfate salts of dextroamphetamine and amphetamine, with the dextroisomer of amphetamine saccharate and 6, I-amphetamine aspartate.

Absorption
It forms easily absorbed molecules that are highly lipid soluble

Interactions
Acidifying agents - Gastrointestinal acidifying agents (guanethidine,reserpine, glutamic acid HCl,ascorbic acid, fruit juices, etc.) lower absorption of amphetamines. Urinary acidifying agents -(ammonium chloride, sodium acid phosphate, etc.) Increase the concentration of the ionized species of the amphetamine. Primary excretion - Both Groups of agents lower blood levels and efficacy of amphetamines. Adrenergic blockers - Adrenergic blockers are inhibited by amphetamines. Alkalinizing agents -Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.)increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentate the actions of amphetamines. Antidepressants, tricyclic - Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated. MAO inhibitors - MAO antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism. This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other monoamines from adrenergic nerve endings, this can cause headaches and other signs of hypertensive crisis. A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results. Antihistamines - Amphetamines may counteract the sedative effect of antihistamines. Antihypertensives - Amphetamines may antagonize the hypotensive effects of antihypertensives. Chlorpromazine - Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat amphetamine poisoning. Ethosuximide - Amphetamines may delay intestinal absorption of ethosuximide. Haloperidol - Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines. Lithium carbonate - The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate. Meperidine - Amphetamines pone the analgesic effect of meperidine. Methenamine therapy - Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy. Norepinephrine - Amphetamines enhance the adrenergic effect of norepinephrine. Phenobarbital - Amphetamines may delay intestinal absorption of phenobarbital; co-administration of phenobarbital may produce a synergistic anticonvulsant action. Phenytoin - Amphetamines may delay intestinal absorption of phenytoin; co-administration of phenytoin may produce a synergistic anticonvulsant action. Propoxyphene - In cases of propoxyphene overdose, amphetamine CNS stimulation is potentiated and fatal convulsions can occur. Veratrum alkaloids - Amphetamines inhibit the hypotensive effect of veratrum alkaloids. Drug/Laboratory Test Interactions Amphetamines can cause a significant elevation in plasma corticosteroid levels. This increase is greatest in the evening. Amphetamines may interfere with urinary steroid determinations.

Chemical IUPAC Name
1-phenylpropan-2-amine

Chemical Formula
C9H13N

Half Life
10 hours

Drug Type
Approved Drug

# Accession No
APRD00480

CAS Registry Number
300-62-9